MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3D1_LEIMA

TriTrypDb:

LmjF.34.0750 , LMJLV39_340013900 , LMJSD75_340013900

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3D1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.429
CLV_NRD_NRD_1	34	36	PF00675	0.435
CLV_NRD_NRD_1	460	462	PF00675	0.544
CLV_PCSK_FUR_1	34	38	PF00082	0.434
CLV_PCSK_KEX2_1	184	186	PF00082	0.440
CLV_PCSK_KEX2_1	34	36	PF00082	0.448
CLV_PCSK_KEX2_1	462	464	PF00082	0.598
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.523
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.468
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.598
CLV_PCSK_SKI1_1	129	133	PF00082	0.379
CLV_PCSK_SKI1_1	252	256	PF00082	0.337
CLV_PCSK_SKI1_1	338	342	PF00082	0.398
CLV_PCSK_SKI1_1	345	349	PF00082	0.398
CLV_PCSK_SKI1_1	36	40	PF00082	0.446
CLV_PCSK_SKI1_1	438	442	PF00082	0.478
DEG_APCC_DBOX_1	337	345	PF00400	0.432
DEG_Nend_UBRbox_3	1	3	PF02207	0.456
DOC_CYCLIN_RxL_1	247	259	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	318	324	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.411
DOC_MAPK_FxFP_2	74	77	PF00069	0.406
DOC_MAPK_gen_1	183	192	PF00069	0.439
DOC_PP1_RVXF_1	396	402	PF00149	0.398
DOC_PP1_SILK_1	51	56	PF00149	0.491
DOC_PP2B_LxvP_1	282	285	PF13499	0.415
DOC_PP2B_LxvP_1	318	321	PF13499	0.444
DOC_PP4_FxxP_1	223	226	PF00568	0.306
DOC_PP4_FxxP_1	74	77	PF00568	0.406
DOC_PP4_MxPP_1	1	4	PF00568	0.450
DOC_USP7_UBL2_3	15	19	PF12436	0.558
DOC_USP7_UBL2_3	398	402	PF12436	0.367
DOC_WW_Pin1_4	167	172	PF00397	0.485
DOC_WW_Pin1_4	202	207	PF00397	0.451
DOC_WW_Pin1_4	236	241	PF00397	0.444
DOC_WW_Pin1_4	79	84	PF00397	0.466
DOC_WW_Pin1_4	97	102	PF00397	0.406
LIG_14-3-3_CanoR_1	209	216	PF00244	0.514
LIG_14-3-3_CanoR_1	35	41	PF00244	0.450
LIG_14-3-3_CanoR_1	362	368	PF00244	0.527
LIG_14-3-3_CanoR_1	436	441	PF00244	0.531
LIG_14-3-3_CanoR_1	90	95	PF00244	0.515
LIG_Actin_WH2_2	114	131	PF00022	0.372
LIG_APCC_ABBA_1	25	30	PF00400	0.410
LIG_BRCT_BRCA1_1	109	113	PF00533	0.381
LIG_deltaCOP1_diTrp_1	29	40	PF00928	0.417
LIG_EH_1	218	222	PF12763	0.365
LIG_eIF4E_1	250	256	PF01652	0.325
LIG_FHA_1	100	106	PF00498	0.485
LIG_FHA_1	442	448	PF00498	0.559
LIG_FHA_2	157	163	PF00498	0.581
LIG_FHA_2	257	263	PF00498	0.388
LIG_LIR_Apic_2	72	77	PF02991	0.400
LIG_LIR_Gen_1	133	143	PF02991	0.330
LIG_LIR_Gen_1	380	390	PF02991	0.351
LIG_LIR_Gen_1	64	75	PF02991	0.386
LIG_LIR_Nem_3	110	116	PF02991	0.371
LIG_LIR_Nem_3	133	138	PF02991	0.333
LIG_LIR_Nem_3	199	204	PF02991	0.394
LIG_LIR_Nem_3	380	386	PF02991	0.337
LIG_LIR_Nem_3	394	400	PF02991	0.377
LIG_LIR_Nem_3	64	70	PF02991	0.381
LIG_LYPXL_SIV_4	378	386	PF13949	0.426
LIG_PCNA_PIPBox_1	106	115	PF02747	0.491
LIG_PCNA_yPIPBox_3	421	429	PF02747	0.533
LIG_Pex14_2	221	225	PF04695	0.349
LIG_Pex14_2	397	401	PF04695	0.499
LIG_SH2_CRK	379	383	PF00017	0.341
LIG_SH2_CRK	67	71	PF00017	0.362
LIG_SH2_NCK_1	150	154	PF00017	0.457
LIG_SH2_NCK_1	379	383	PF00017	0.318
LIG_SH2_NCK_1	67	71	PF00017	0.361
LIG_SH2_SRC	150	153	PF00017	0.441
LIG_SH2_STAP1	23	27	PF00017	0.422
LIG_SH2_STAP1	250	254	PF00017	0.322
LIG_SH2_STAP1	379	383	PF00017	0.341
LIG_SH2_STAT5	146	149	PF00017	0.440
LIG_SH2_STAT5	235	238	PF00017	0.528
LIG_SH2_STAT5	379	382	PF00017	0.341
LIG_SH2_STAT5	383	386	PF00017	0.339
LIG_SH2_STAT5	67	70	PF00017	0.357
LIG_SH3_3	384	390	PF00018	0.474
LIG_SH3_3	82	88	PF00018	0.439
LIG_TYR_ITIM	377	382	PF00017	0.341
LIG_TYR_ITSM	63	70	PF00017	0.354
LIG_UBA3_1	340	345	PF00899	0.412
LIG_WRC_WIRS_1	325	330	PF05994	0.457
MOD_CDK_SPxK_1	236	242	PF00069	0.430
MOD_CDK_SPxxK_3	202	209	PF00069	0.447
MOD_CDK_SPxxK_3	97	104	PF00069	0.407
MOD_CK1_1	448	454	PF00069	0.721
MOD_CK2_1	97	103	PF00069	0.434
MOD_GSK3_1	117	124	PF00069	0.459
MOD_GSK3_1	13	20	PF00069	0.498
MOD_GSK3_1	165	172	PF00069	0.516
MOD_GSK3_1	441	448	PF00069	0.616
MOD_NEK2_1	117	122	PF00069	0.462
MOD_NEK2_1	165	170	PF00069	0.505
MOD_NEK2_1	256	261	PF00069	0.386
MOD_NEK2_1	312	317	PF00069	0.385
MOD_NEK2_1	377	382	PF00069	0.349
MOD_NEK2_1	441	446	PF00069	0.482
MOD_NEK2_1	48	53	PF00069	0.535
MOD_NEK2_2	245	250	PF00069	0.357
MOD_PIKK_1	156	162	PF00454	0.547
MOD_PIKK_1	348	354	PF00454	0.517
MOD_PK_1	49	55	PF00069	0.421
MOD_PKA_1	36	42	PF00069	0.454
MOD_PKA_2	208	214	PF00069	0.413
MOD_PKA_2	267	273	PF00069	0.604
MOD_PKA_2	36	42	PF00069	0.422
MOD_PKA_2	361	367	PF00069	0.544
MOD_PKA_2	48	54	PF00069	0.400
MOD_Plk_1	17	23	PF00069	0.563
MOD_Plk_1	196	202	PF00069	0.442
MOD_Plk_1	29	35	PF00069	0.440
MOD_Plk_1	330	336	PF00069	0.496
MOD_Plk_1	65	71	PF00069	0.358
MOD_Plk_2-3	186	192	PF00069	0.459
MOD_Plk_4	196	202	PF00069	0.485
MOD_Plk_4	250	256	PF00069	0.351
MOD_Plk_4	377	383	PF00069	0.341
MOD_Plk_4	436	442	PF00069	0.526
MOD_Plk_4	49	55	PF00069	0.406
MOD_Plk_4	65	71	PF00069	0.358
MOD_Plk_4	90	96	PF00069	0.499
MOD_ProDKin_1	167	173	PF00069	0.483
MOD_ProDKin_1	202	208	PF00069	0.444
MOD_ProDKin_1	236	242	PF00069	0.439
MOD_ProDKin_1	79	85	PF00069	0.467
MOD_ProDKin_1	97	103	PF00069	0.408
MOD_SUMO_for_1	334	337	PF00179	0.443
MOD_SUMO_rev_2	158	166	PF00179	0.616
MOD_SUMO_rev_2	18	27	PF00179	0.435
MOD_SUMO_rev_2	337	347	PF00179	0.418
MOD_SUMO_rev_2	459	464	PF00179	0.540
MOD_SUMO_rev_2	8	17	PF00179	0.464
TRG_DiLeu_BaEn_1	420	425	PF01217	0.449
TRG_DiLeu_BaEn_2	196	202	PF01217	0.374
TRG_DiLeu_BaEn_2	341	347	PF01217	0.417
TRG_DiLeu_BaEn_4	342	348	PF01217	0.422
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.351
TRG_ENDOCYTIC_2	150	153	PF00928	0.452
TRG_ENDOCYTIC_2	28	31	PF00928	0.415
TRG_ENDOCYTIC_2	379	382	PF00928	0.340
TRG_ENDOCYTIC_2	383	386	PF00928	0.338
TRG_ENDOCYTIC_2	389	392	PF00928	0.374
TRG_ENDOCYTIC_2	67	70	PF00928	0.363
TRG_ER_diArg_1	182	185	PF00400	0.420
TRG_ER_diArg_1	33	35	PF00400	0.420
TRG_ER_diArg_1	461	464	PF00400	0.490
TRG_ER_diArg_1	54	57	PF00400	0.411
TRG_NES_CRM1_1	126	141	PF08389	0.296
TRG_NLS_MonoExtN_4	34	39	PF00514	0.489
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA50	Leptomonas seymouri	90%	94%
A0A0N1PBN6	Leptomonas seymouri	27%	67%
A0A0S4JJ07	Bodo saltans	70%	100%
A0A1X0NY35	Trypanosomatidae	26%	67%
A0A1X0P990	Trypanosomatidae	74%	96%
A0A3Q8IE69	Leishmania donovani	97%	100%
A0A3R7MZ34	Trypanosoma rangeli	27%	69%
A0A3R7N7Y7	Trypanosoma rangeli	71%	97%
A4HAI4	Leishmania braziliensis	93%	93%
C9ZN08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	98%
C9ZVC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	68%
E9AHS5	Leishmania infantum	97%	100%
E9AWF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	69%
E9B4P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QB18	Leishmania major	27%	68%
V5BJD7	Trypanosoma cruzi	72%	97%