KR domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3D0_LEIMA

TriTrypDb:

LmjF.34.0760 , LMJLV39_340014000 , LMJSD75_340014000

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q3D0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3D0

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	2
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	7	2
GO:0008152	metabolic process	1	2
GO:0009060	aerobic respiration	6	2
GO:0009987	cellular process	1	2
GO:0010257	NADH dehydrogenase complex assembly	6	2
GO:0015980	energy derivation by oxidation of organic compounds	4	2
GO:0016043	cellular component organization	3	2
GO:0019646	aerobic electron transport chain	6	2
GO:0022607	cellular component assembly	4	2
GO:0022900	electron transport chain	4	2
GO:0022904	respiratory electron transport chain	5	2
GO:0032981	mitochondrial respiratory chain complex I assembly	7	2
GO:0033108	mitochondrial respiratory chain complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	2
GO:0045333	cellular respiration	5	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0051082	unfolded protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.718
CLV_NRD_NRD_1	112	114	PF00675	0.459
CLV_NRD_NRD_1	171	173	PF00675	0.590
CLV_NRD_NRD_1	267	269	PF00675	0.591
CLV_NRD_NRD_1	280	282	PF00675	0.528
CLV_NRD_NRD_1	306	308	PF00675	0.465
CLV_PCSK_KEX2_1	112	114	PF00082	0.456
CLV_PCSK_KEX2_1	158	160	PF00082	0.614
CLV_PCSK_KEX2_1	171	173	PF00082	0.537
CLV_PCSK_KEX2_1	267	269	PF00082	0.593
CLV_PCSK_KEX2_1	280	282	PF00082	0.528
CLV_PCSK_KEX2_1	306	308	PF00082	0.469
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.575
CLV_PCSK_SKI1_1	128	132	PF00082	0.438
CLV_PCSK_SKI1_1	159	163	PF00082	0.614
CLV_PCSK_SKI1_1	175	179	PF00082	0.522
CLV_PCSK_SKI1_1	203	207	PF00082	0.507
CLV_PCSK_SKI1_1	306	310	PF00082	0.514
DEG_APCC_DBOX_1	202	210	PF00400	0.520
DEG_APCC_DBOX_1	377	385	PF00400	0.445
DOC_CKS1_1	7	12	PF01111	0.673
DOC_CYCLIN_RxL_1	122	136	PF00134	0.536
DOC_MAPK_gen_1	112	119	PF00069	0.417
DOC_MAPK_gen_1	126	134	PF00069	0.436
DOC_MAPK_gen_1	372	379	PF00069	0.589
DOC_MAPK_gen_1	400	410	PF00069	0.603
DOC_MAPK_MEF2A_6	112	119	PF00069	0.417
DOC_MAPK_MEF2A_6	126	134	PF00069	0.436
DOC_MAPK_MEF2A_6	403	412	PF00069	0.492
DOC_PP1_RVXF_1	64	71	PF00149	0.616
DOC_PP2B_LxvP_1	130	133	PF13499	0.530
DOC_PP4_FxxP_1	182	185	PF00568	0.363
DOC_USP7_MATH_1	196	200	PF00917	0.715
DOC_USP7_MATH_1	335	339	PF00917	0.561
DOC_USP7_MATH_1	83	87	PF00917	0.638
DOC_WW_Pin1_4	287	292	PF00397	0.488
DOC_WW_Pin1_4	297	302	PF00397	0.527
DOC_WW_Pin1_4	329	334	PF00397	0.516
DOC_WW_Pin1_4	372	377	PF00397	0.568
DOC_WW_Pin1_4	6	11	PF00397	0.744
LIG_14-3-3_CanoR_1	112	118	PF00244	0.520
LIG_14-3-3_CanoR_1	143	148	PF00244	0.645
LIG_14-3-3_CanoR_1	183	189	PF00244	0.607
LIG_14-3-3_CanoR_1	249	259	PF00244	0.685
LIG_14-3-3_CanoR_1	306	312	PF00244	0.538
LIG_14-3-3_CanoR_1	336	340	PF00244	0.541
LIG_14-3-3_CanoR_1	358	366	PF00244	0.659
LIG_14-3-3_CanoR_1	378	382	PF00244	0.313
LIG_14-3-3_CanoR_1	383	390	PF00244	0.499
LIG_Actin_WH2_2	435	451	PF00022	0.607
LIG_Actin_WH2_2	99	114	PF00022	0.467
LIG_APCC_ABBA_1	30	35	PF00400	0.672
LIG_BIR_II_1	1	5	PF00653	0.740
LIG_BRCT_BRCA1_1	226	230	PF00533	0.447
LIG_deltaCOP1_diTrp_1	352	357	PF00928	0.616
LIG_eIF4E_1	303	309	PF01652	0.571
LIG_FHA_1	160	166	PF00498	0.541
LIG_FHA_1	214	220	PF00498	0.574
LIG_FHA_1	231	237	PF00498	0.298
LIG_FHA_1	90	96	PF00498	0.447
LIG_FHA_2	41	47	PF00498	0.585
LIG_FHA_2	7	13	PF00498	0.668
LIG_FHA_2	79	85	PF00498	0.637
LIG_GBD_Chelix_1	228	236	PF00786	0.502
LIG_Integrin_RGD_1	172	174	PF01839	0.452
LIG_LIR_Apic_2	181	185	PF02991	0.359
LIG_LIR_Gen_1	283	294	PF02991	0.509
LIG_LIR_Gen_1	462	470	PF02991	0.664
LIG_LIR_Nem_3	129	134	PF02991	0.536
LIG_LIR_Nem_3	146	152	PF02991	0.678
LIG_LIR_Nem_3	164	170	PF02991	0.581
LIG_LIR_Nem_3	253	259	PF02991	0.448
LIG_LIR_Nem_3	283	289	PF02991	0.496
LIG_LIR_Nem_3	300	305	PF02991	0.581
LIG_LIR_Nem_3	386	392	PF02991	0.640
LIG_LIR_Nem_3	462	467	PF02991	0.657
LIG_LIR_Nem_3	56	60	PF02991	0.531
LIG_LYPXL_yS_3	57	60	PF13949	0.643
LIG_SH2_CRK	149	153	PF00017	0.725
LIG_SH2_CRK	305	309	PF00017	0.531
LIG_SH2_STAT5	110	113	PF00017	0.533
LIG_SH2_STAT5	231	234	PF00017	0.421
LIG_SH2_STAT5	29	32	PF00017	0.662
LIG_SH2_STAT5	315	318	PF00017	0.459
LIG_SH2_STAT5	69	72	PF00017	0.566
LIG_SH3_3	185	191	PF00018	0.644
LIG_SH3_3	384	390	PF00018	0.594
LIG_SH3_3	4	10	PF00018	0.751
LIG_SUMO_SIM_anti_2	116	121	PF11976	0.415
LIG_SUMO_SIM_anti_2	90	97	PF11976	0.473
LIG_TRAF2_1	235	238	PF00917	0.586
LIG_WRC_WIRS_1	389	394	PF05994	0.581
MOD_CDC14_SPxK_1	375	378	PF00782	0.555
MOD_CDK_SPxK_1	372	378	PF00069	0.557
MOD_CDK_SPxxK_3	329	336	PF00069	0.569
MOD_CK1_1	192	198	PF00069	0.712
MOD_CK1_1	258	264	PF00069	0.684
MOD_CK1_1	297	303	PF00069	0.517
MOD_CK1_1	359	365	PF00069	0.638
MOD_CK2_1	151	157	PF00069	0.565
MOD_CK2_1	388	394	PF00069	0.575
MOD_CK2_1	40	46	PF00069	0.571
MOD_CK2_1	433	439	PF00069	0.554
MOD_CK2_1	78	84	PF00069	0.626
MOD_CMANNOS	353	356	PF00535	0.628
MOD_Cter_Amidation	265	268	PF01082	0.656
MOD_DYRK1A_RPxSP_1	6	10	PF00069	0.688
MOD_GlcNHglycan	153	156	PF01048	0.642
MOD_GlcNHglycan	191	194	PF01048	0.734
MOD_GlcNHglycan	237	242	PF01048	0.548
MOD_GlcNHglycan	252	255	PF01048	0.673
MOD_GlcNHglycan	329	332	PF01048	0.574
MOD_GlcNHglycan	84	88	PF01048	0.726
MOD_GSK3_1	192	199	PF00069	0.692
MOD_GSK3_1	325	332	PF00069	0.628
MOD_GSK3_1	356	363	PF00069	0.510
MOD_GSK3_1	433	440	PF00069	0.511
MOD_GSK3_1	79	86	PF00069	0.634
MOD_GSK3_1	87	94	PF00069	0.536
MOD_N-GLC_1	196	201	PF02516	0.631
MOD_NEK2_1	161	166	PF00069	0.548
MOD_NEK2_1	219	224	PF00069	0.513
MOD_NEK2_1	230	235	PF00069	0.470
MOD_NEK2_1	250	255	PF00069	0.660
MOD_NEK2_1	327	332	PF00069	0.555
MOD_NEK2_1	370	375	PF00069	0.580
MOD_NEK2_1	408	413	PF00069	0.492
MOD_NEK2_1	427	432	PF00069	0.491
MOD_NEK2_1	433	438	PF00069	0.500
MOD_NEK2_2	28	33	PF00069	0.621
MOD_PIKK_1	213	219	PF00454	0.509
MOD_PIKK_1	325	331	PF00454	0.582
MOD_PK_1	113	119	PF00069	0.466
MOD_PK_1	224	230	PF00069	0.463
MOD_PKA_2	250	256	PF00069	0.688
MOD_PKA_2	335	341	PF00069	0.585
MOD_PKA_2	359	365	PF00069	0.703
MOD_PKA_2	377	383	PF00069	0.317
MOD_PKB_1	358	366	PF00069	0.520
MOD_Plk_1	219	225	PF00069	0.520
MOD_Plk_1	322	328	PF00069	0.548
MOD_Plk_4	115	121	PF00069	0.436
MOD_Plk_4	126	132	PF00069	0.426
MOD_Plk_4	224	230	PF00069	0.407
MOD_Plk_4	258	264	PF00069	0.648
MOD_Plk_4	322	328	PF00069	0.548
MOD_Plk_4	40	46	PF00069	0.617
MOD_Plk_4	408	414	PF00069	0.611
MOD_Plk_4	433	439	PF00069	0.569
MOD_Plk_4	91	97	PF00069	0.458
MOD_ProDKin_1	287	293	PF00069	0.491
MOD_ProDKin_1	297	303	PF00069	0.517
MOD_ProDKin_1	329	335	PF00069	0.518
MOD_ProDKin_1	372	378	PF00069	0.557
MOD_ProDKin_1	6	12	PF00069	0.739
TRG_DiLeu_BaEn_1	91	96	PF01217	0.531
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.626
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.571
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.622
TRG_ENDOCYTIC_2	149	152	PF00928	0.686
TRG_ENDOCYTIC_2	167	170	PF00928	0.577
TRG_ENDOCYTIC_2	29	32	PF00928	0.548
TRG_ENDOCYTIC_2	305	308	PF00928	0.512
TRG_ENDOCYTIC_2	57	60	PF00928	0.643
TRG_ER_diArg_1	111	113	PF00400	0.458
TRG_ER_diArg_1	17	20	PF00400	0.629
TRG_ER_diArg_1	170	172	PF00400	0.523
TRG_ER_diArg_1	267	269	PF00400	0.593
TRG_ER_diArg_1	280	282	PF00400	0.522
TRG_ER_diArg_1	305	307	PF00400	0.479
TRG_ER_diArg_1	357	360	PF00400	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN2	Leptomonas seymouri	65%	98%
A0A0S4IVY0	Bodo saltans	25%	100%
A0A1X0P965	Trypanosomatidae	32%	100%
A0A3Q8IIA0	Leishmania donovani	94%	100%
A4HAI5	Leishmania braziliensis	78%	100%
E9AHS6	Leishmania infantum	94%	100%
E9B4P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BEX5	Trypanosoma cruzi	34%	100%