Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3C9_LEIMA

TriTrypDb:

LmjF.34.0770 , LMJLV39_340014100 , LMJSD75_340014100

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q3C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3C9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.681
CLV_NRD_NRD_1	209	211	PF00675	0.700
CLV_NRD_NRD_1	7	9	PF00675	0.537
CLV_PCSK_KEX2_1	111	113	PF00082	0.491
CLV_PCSK_KEX2_1	209	211	PF00082	0.692
CLV_PCSK_KEX2_1	7	9	PF00082	0.538
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.476
DOC_ANK_TNKS_1	51	58	PF00023	0.758
DOC_USP7_MATH_1	125	129	PF00917	0.773
LIG_14-3-3_CanoR_1	112	120	PF00244	0.681
LIG_14-3-3_CanoR_1	155	162	PF00244	0.639
LIG_14-3-3_CanoR_1	34	42	PF00244	0.668
LIG_BIR_II_1	1	5	PF00653	0.720
LIG_FHA_1	71	77	PF00498	0.664
LIG_FHA_2	165	171	PF00498	0.755
LIG_FHA_2	51	57	PF00498	0.816
LIG_LIR_Gen_1	170	180	PF02991	0.619
LIG_LIR_Gen_1	25	31	PF02991	0.812
LIG_LIR_Nem_3	170	175	PF02991	0.733
LIG_LIR_Nem_3	25	30	PF02991	0.812
LIG_NRP_CendR_1	209	212	PF00754	0.787
LIG_Pex14_1	179	183	PF04695	0.411
LIG_Pex14_2	175	179	PF04695	0.411
LIG_Pex14_2	183	187	PF04695	0.411
LIG_SH2_STAP1	12	16	PF00017	0.751
LIG_SH2_STAP1	121	125	PF00017	0.661
LIG_SH2_STAP1	185	189	PF00017	0.513
LIG_SH2_STAT5	121	124	PF00017	0.625
LIG_SH2_STAT5	182	185	PF00017	0.524
LIG_SH2_STAT5	206	209	PF00017	0.587
MOD_CK1_1	139	145	PF00069	0.710
MOD_CK1_1	2	8	PF00069	0.639
MOD_CK1_1	40	46	PF00069	0.789
MOD_CK1_1	50	56	PF00069	0.707
MOD_CK2_1	147	153	PF00069	0.711
MOD_CK2_1	164	170	PF00069	0.699
MOD_CK2_1	68	74	PF00069	0.563
MOD_CK2_1	90	96	PF00069	0.674
MOD_GlcNHglycan	187	190	PF01048	0.506
MOD_GlcNHglycan	56	60	PF01048	0.548
MOD_GSK3_1	33	40	PF00069	0.764
MOD_GSK3_1	42	49	PF00069	0.748
MOD_GSK3_1	68	75	PF00069	0.593
MOD_N-GLC_1	38	43	PF02516	0.575
MOD_NEK2_1	187	192	PF00069	0.513
MOD_NEK2_1	195	200	PF00069	0.486
MOD_NEK2_1	3	8	PF00069	0.725
MOD_NEK2_1	42	47	PF00069	0.718
MOD_NEK2_1	72	77	PF00069	0.671
MOD_NEK2_2	119	124	PF00069	0.688
MOD_PIKK_1	111	117	PF00454	0.741
MOD_PIKK_1	154	160	PF00454	0.633
MOD_PKA_1	111	117	PF00069	0.686
MOD_PKA_2	111	117	PF00069	0.669
MOD_PKA_2	154	160	PF00069	0.745
MOD_PKA_2	33	39	PF00069	0.696
MOD_PKB_1	32	40	PF00069	0.667
MOD_Plk_1	38	44	PF00069	0.755
MOD_Plk_2-3	90	96	PF00069	0.691
MOD_SUMO_rev_2	130	140	PF00179	0.744
TRG_DiLeu_BaEn_4	132	138	PF01217	0.804
TRG_ENDOCYTIC_2	177	180	PF00928	0.513
TRG_ER_diArg_1	209	212	PF00400	0.513
TRG_ER_diArg_1	7	9	PF00400	0.740
TRG_NES_CRM1_1	62	74	PF08389	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBG5	Leptomonas seymouri	42%	89%
A0A3S7X7I7	Leishmania donovani	91%	100%
A4HAI6	Leishmania braziliensis	64%	98%
E9AHS7	Leishmania infantum	91%	100%
E9B4P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%