Putative translation elongation factor 1-beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation elongation factor 1-beta, putative

Species:

Leishmania major

UniProt:

Q4Q3C1_LEIMA

TriTrypDb:

LmjF.34.0840 , LMJLV39_340015000 , LMJSD75_340015100

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 22
NetGPI	no	yes: 0, no: 23

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	3
GO:0005853	eukaryotic translation elongation factor 1 complex	2	24
GO:0032991	protein-containing complex	1	24
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

Q4Q3C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3C1

Function

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Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009059	macromolecule biosynthetic process	4	3
GO:0009987	cellular process	1	3
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	3

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	24
GO:0003746	translation elongation factor activity	4	24
GO:0005085	guanyl-nucleotide exchange factor activity	3	3
GO:0005488	binding	1	24
GO:0008135	translation factor activity, RNA binding	3	24
GO:0030234	enzyme regulator activity	2	3
GO:0030695	GTPase regulator activity	4	3
GO:0045182	translation regulator activity	1	24
GO:0060589	nucleoside-triphosphatase regulator activity	3	3
GO:0090079	translation regulator activity, nucleic acid binding	2	24

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	61	63	PF00675	0.562
CLV_PCSK_KEX2_1	94	96	PF00082	0.767
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.767
CLV_PCSK_SKI1_1	128	132	PF00082	0.653
CLV_PCSK_SKI1_1	134	138	PF00082	0.638
CLV_PCSK_SKI1_1	142	146	PF00082	0.572
CLV_PCSK_SKI1_1	20	24	PF00082	0.533
CLV_PCSK_SKI1_1	49	53	PF00082	0.521
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.678
DOC_MAPK_gen_1	197	205	PF00069	0.368

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W7	Leptomonas seymouri	63%	100%
A0A0N1HZF7	Leptomonas seymouri	80%	100%
A0A0S4JC29	Bodo saltans	56%	100%
A0A0S4JK70	Bodo saltans	68%	97%
A0A1X0P9D3	Trypanosomatidae	58%	100%
A0A1X0PA37	Trypanosomatidae	71%	100%
A0A3Q8IVV7	Leishmania donovani	70%	100%
A0A3R7MFZ8	Trypanosoma rangeli	54%	100%
A0A3S5H7W1	Leishmania donovani	95%	99%
A0A422N8N9	Trypanosoma rangeli	71%	100%

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