Putative 60S ribosomal protein L13a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L13a, putative

Species:

Leishmania major

UniProt:

Q4Q3B9_LEIMA

TriTrypDb:

LmjF.34.0860 , LMJLV39_150007400 , LMJSD75_340015300

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	3
GO:0005737	cytoplasm	2	3
GO:0005840	ribosome	5	3
GO:0015934	large ribosomal subunit	4	16
GO:0022625	cytosolic large ribosomal subunit	5	3
GO:0032991	protein-containing complex	1	16
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0044391	ribosomal subunit	3	16
GO:0110165	cellular anatomical entity	1	4
GO:1990904	ribonucleoprotein complex	2	16
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q3B9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3B9

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	16
GO:0006417	regulation of translation	6	3
GO:0006518	peptide metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009058	biosynthetic process	2	16
GO:0009059	macromolecule biosynthetic process	4	16
GO:0009889	regulation of biosynthetic process	4	3
GO:0009890	negative regulation of biosynthetic process	5	3
GO:0009892	negative regulation of metabolic process	4	3
GO:0009987	cellular process	1	16
GO:0010468	regulation of gene expression	5	3
GO:0010556	regulation of macromolecule biosynthetic process	5	3
GO:0010558	negative regulation of macromolecule biosynthetic process	6	3
GO:0010605	negative regulation of macromolecule metabolic process	5	3
GO:0010608	post-transcriptional regulation of gene expression	6	3
GO:0010629	negative regulation of gene expression	6	3
GO:0017148	negative regulation of translation	7	3
GO:0019222	regulation of metabolic process	3	3
GO:0019538	protein metabolic process	3	16
GO:0031323	regulation of cellular metabolic process	4	3
GO:0031324	negative regulation of cellular metabolic process	5	3
GO:0031326	regulation of cellular biosynthetic process	5	3
GO:0031327	negative regulation of cellular biosynthetic process	6	3
GO:0034248	regulation of amide metabolic process	5	3
GO:0034249	negative regulation of amide metabolic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	16
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	16
GO:0043043	peptide biosynthetic process	5	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043603	amide metabolic process	3	16
GO:0043604	amide biosynthetic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044260	obsolete cellular macromolecule metabolic process	3	16
GO:0044271	cellular nitrogen compound biosynthetic process	4	16
GO:0048519	negative regulation of biological process	3	3
GO:0048523	negative regulation of cellular process	4	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0051171	regulation of nitrogen compound metabolic process	4	3
GO:0051172	negative regulation of nitrogen compound metabolic process	5	3
GO:0051246	regulation of protein metabolic process	5	3
GO:0051248	negative regulation of protein metabolic process	6	3
GO:0060255	regulation of macromolecule metabolic process	4	3
GO:0065007	biological regulation	1	3
GO:0071704	organic substance metabolic process	2	16
GO:0080090	regulation of primary metabolic process	4	3
GO:1901564	organonitrogen compound metabolic process	3	16
GO:1901566	organonitrogen compound biosynthetic process	4	16
GO:1901576	organic substance biosynthetic process	3	16
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	3
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0003729	mRNA binding	5	3
GO:0003735	structural constituent of ribosome	2	16
GO:0005198	structural molecule activity	1	16
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.526
CLV_NRD_NRD_1	13	15	PF00675	0.520
CLV_NRD_NRD_1	200	202	PF00675	0.487
CLV_NRD_NRD_1	5	7	PF00675	0.503
CLV_NRD_NRD_1	76	78	PF00675	0.281
CLV_PCSK_KEX2_1	111	113	PF00082	0.281
CLV_PCSK_KEX2_1	78	80	PF00082	0.281
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.281
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.281
CLV_PCSK_SKI1_1	103	107	PF00082	0.281
CLV_PCSK_SKI1_1	112	116	PF00082	0.281
CLV_PCSK_SKI1_1	15	19	PF00082	0.548
CLV_PCSK_SKI1_1	189	193	PF00082	0.619
CLV_PCSK_SKI1_1	202	206	PF00082	0.414
CLV_PCSK_SKI1_1	43	47	PF00082	0.281
CLV_PCSK_SKI1_1	49	53	PF00082	0.281
CLV_PCSK_SKI1_1	79	83	PF00082	0.397
DOC_MAPK_gen_1	18	27	PF00069	0.498
DOC_MAPK_gen_1	207	215	PF00069	0.492
DOC_MAPK_MEF2A_6	18	26	PF00069	0.512
DOC_PP1_RVXF_1	160	167	PF00149	0.500
DOC_PP2B_PxIxI_1	21	27	PF00149	0.322
DOC_USP7_MATH_1	116	120	PF00917	0.317
DOC_USP7_MATH_1	196	200	PF00917	0.459
DOC_USP7_MATH_1	2	6	PF00917	0.664
DOC_USP7_UBL2_3	111	115	PF12436	0.264
DOC_USP7_UBL2_3	15	19	PF12436	0.481
DOC_USP7_UBL2_3	198	202	PF12436	0.521
LIG_14-3-3_CanoR_1	100	106	PF00244	0.315
LIG_14-3-3_CanoR_1	14	22	PF00244	0.472
LIG_14-3-3_CanoR_1	152	157	PF00244	0.495
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_BIR_III_1	1	5	PF00653	0.582
LIG_BIR_III_3	1	5	PF00653	0.582
LIG_BRCT_BRCA1_1	94	98	PF00533	0.306
LIG_LIR_Gen_1	151	160	PF02991	0.497
LIG_LIR_Nem_3	151	157	PF02991	0.498
LIG_SH2_CRK	154	158	PF00017	0.501
LIG_SH2_STAP1	168	172	PF00017	0.503
LIG_SH2_STAT5	109	112	PF00017	0.281
LIG_SH2_STAT5	154	157	PF00017	0.530
LIG_SH2_STAT5	72	75	PF00017	0.281
LIG_SH3_3	134	140	PF00018	0.520
LIG_SUMO_SIM_anti_2	23	28	PF11976	0.306
LIG_SUMO_SIM_par_1	23	28	PF11976	0.281
LIG_TYR_ITIM	121	126	PF00017	0.281
LIG_UBA3_1	24	30	PF00899	0.438
MOD_Cter_Amidation	47	50	PF01082	0.281
MOD_GlcNHglycan	15	18	PF01048	0.500
MOD_GlcNHglycan	198	201	PF01048	0.467
MOD_LATS_1	90	96	PF00433	0.306
MOD_N-GLC_2	159	161	PF02516	0.495
MOD_NEK2_1	98	103	PF00069	0.254
MOD_PKA_1	49	55	PF00069	0.281
MOD_PKA_1	79	85	PF00069	0.281
MOD_PKA_2	107	113	PF00069	0.303
MOD_PKA_2	13	19	PF00069	0.588
MOD_PKB_1	77	85	PF00069	0.281
MOD_Plk_4	116	122	PF00069	0.366
MOD_Plk_4	152	158	PF00069	0.506
TRG_ENDOCYTIC_2	123	126	PF00928	0.281
TRG_ENDOCYTIC_2	154	157	PF00928	0.499
TRG_ENDOCYTIC_2	168	171	PF00928	0.497
TRG_ER_diArg_1	76	79	PF00400	0.281
TRG_NLS_Bipartite_1	6	22	PF00514	0.562
TRG_NLS_MonoCore_2	76	81	PF00514	0.281
TRG_NLS_MonoExtC_3	17	22	PF00514	0.511
TRG_NLS_MonoExtN_4	15	22	PF00514	0.496
TRG_NLS_MonoExtN_4	77	82	PF00514	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JFU0	Bodo saltans	77%	100%
A0A0S4KJ25	Bodo saltans	76%	93%
A0A1X0P9I5	Trypanosomatidae	82%	100%
A0A3Q8IN17	Leishmania donovani	99%	100%
A0A3S5IQR0	Trypanosoma rangeli	80%	100%
A0A422NS83	Trypanosoma rangeli	81%	100%
A4H7Z1	Leishmania braziliensis	92%	100%
A4HAJ9	Leishmania braziliensis	92%	100%
A4HWB9	Leishmania infantum	99%	100%
C9ZNV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	100%
E9AQ19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O42848	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
O42991	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
O43004	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
O49885	Lupinus luteus	44%	100%
O65055	Picea mariana	44%	100%
P0DJ15	Tetrahymena thermophila (strain SB210)	41%	100%
P19253	Mus musculus	48%	100%
P26784	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	100%
P26785	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	100%
P35427	Rattus norvegicus	49%	100%
P40429	Homo sapiens	49%	100%
P93099	Cyanophora paradoxa	42%	100%
Q27389	Caenorhabditis elegans	42%	100%
Q3SZ90	Bos taurus	49%	100%
Q4QFG2	Leishmania major	99%	100%
Q4R8Z2	Macaca fascicularis	48%	100%
Q553M7	Dictyostelium discoideum	47%	100%
Q5AB87	Candida albicans (strain SC5314 / ATCC MYA-2876)	46%	100%
Q5RA38	Pongo abelii	48%	100%
Q8MUR4	Choristoneura parallela	46%	100%
Q8ZYQ1	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	33%	100%
Q91487	Salmo trutta	46%	100%
Q962U0	Spodoptera frugiperda	46%	100%
Q9FKC0	Arabidopsis thaliana	41%	100%
Q9LRX8	Arabidopsis thaliana	39%	100%
Q9P720	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	45%	100%
Q9SFU1	Arabidopsis thaliana	42%	100%
Q9SVR0	Arabidopsis thaliana	42%	100%
Q9VNE9	Drosophila melanogaster	46%	100%
Q9XSU0	Canis lupus familiaris	48%	100%
Q9YB50	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	33%	100%
V5BAB2	Trypanosoma cruzi	81%	79%
V5DCT1	Trypanosoma cruzi	82%	100%