ATP-dependent DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3B8_LEIMA

TriTrypDb:

LmjF.34.0870 , LMJLV39_340015600 , LMJSD75_340015400

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3B8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.472
CLV_C14_Caspase3-7	499	503	PF00656	0.608
CLV_NRD_NRD_1	125	127	PF00675	0.542
CLV_NRD_NRD_1	241	243	PF00675	0.588
CLV_NRD_NRD_1	350	352	PF00675	0.682
CLV_NRD_NRD_1	404	406	PF00675	0.445
CLV_NRD_NRD_1	433	435	PF00675	0.496
CLV_PCSK_KEX2_1	125	127	PF00082	0.466
CLV_PCSK_KEX2_1	241	243	PF00082	0.588
CLV_PCSK_KEX2_1	350	352	PF00082	0.682
CLV_PCSK_KEX2_1	403	405	PF00082	0.443
CLV_PCSK_KEX2_1	432	434	PF00082	0.489
CLV_PCSK_SKI1_1	103	107	PF00082	0.629
CLV_PCSK_SKI1_1	141	145	PF00082	0.385
CLV_PCSK_SKI1_1	201	205	PF00082	0.541
CLV_PCSK_SKI1_1	434	438	PF00082	0.464
CLV_PCSK_SKI1_1	547	551	PF00082	0.538
DEG_SPOP_SBC_1	47	51	PF00917	0.610
DOC_ANK_TNKS_1	298	305	PF00023	0.537
DOC_CKS1_1	202	207	PF01111	0.538
DOC_CKS1_1	480	485	PF01111	0.645
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.586
DOC_MAPK_FxFP_2	111	114	PF00069	0.404
DOC_MAPK_gen_1	438	446	PF00069	0.570
DOC_PP1_RVXF_1	114	120	PF00149	0.450
DOC_PP2B_LxvP_1	32	35	PF13499	0.605
DOC_PP4_FxxP_1	111	114	PF00568	0.525
DOC_USP7_MATH_1	165	169	PF00917	0.544
DOC_USP7_MATH_1	22	26	PF00917	0.555
DOC_USP7_MATH_1	252	256	PF00917	0.651
DOC_USP7_MATH_1	37	41	PF00917	0.651
DOC_USP7_MATH_1	375	379	PF00917	0.501
DOC_USP7_MATH_1	45	49	PF00917	0.574
DOC_USP7_MATH_1	450	454	PF00917	0.621
DOC_USP7_UBL2_3	547	551	PF12436	0.538
DOC_WW_Pin1_4	156	161	PF00397	0.553
DOC_WW_Pin1_4	201	206	PF00397	0.540
DOC_WW_Pin1_4	255	260	PF00397	0.672
DOC_WW_Pin1_4	298	303	PF00397	0.483
DOC_WW_Pin1_4	404	409	PF00397	0.469
DOC_WW_Pin1_4	479	484	PF00397	0.648
LIG_14-3-3_CanoR_1	154	159	PF00244	0.517
LIG_14-3-3_CanoR_1	297	302	PF00244	0.502
LIG_14-3-3_CanoR_1	353	361	PF00244	0.630
LIG_Actin_WH2_2	533	549	PF00022	0.621
LIG_BIR_III_4	236	240	PF00653	0.641
LIG_deltaCOP1_diTrp_1	394	400	PF00928	0.406
LIG_deltaCOP1_diTrp_1	412	416	PF00928	0.441
LIG_FHA_1	148	154	PF00498	0.412
LIG_FHA_1	202	208	PF00498	0.595
LIG_FHA_1	361	367	PF00498	0.473
LIG_FHA_1	479	485	PF00498	0.695
LIG_FHA_1	532	538	PF00498	0.519
LIG_FHA_2	244	250	PF00498	0.598
LIG_FHA_2	473	479	PF00498	0.711
LIG_FHA_2	509	515	PF00498	0.705
LIG_LIR_Apic_2	108	114	PF02991	0.413
LIG_LIR_Apic_2	25	31	PF02991	0.653
LIG_LIR_Apic_2	33	39	PF02991	0.636
LIG_LIR_Apic_2	370	375	PF02991	0.524
LIG_LIR_Nem_3	171	175	PF02991	0.528
LIG_LIR_Nem_3	422	428	PF02991	0.468
LIG_PCNA_yPIPBox_3	418	432	PF02747	0.467
LIG_SH2_CRK	36	40	PF00017	0.585
LIG_SH2_NCK_1	36	40	PF00017	0.643
LIG_SH2_NCK_1	372	376	PF00017	0.538
LIG_SH2_PTP2	28	31	PF00017	0.518
LIG_SH2_SRC	428	431	PF00017	0.468
LIG_SH2_STAT3	341	344	PF00017	0.553
LIG_SH2_STAT5	158	161	PF00017	0.537
LIG_SH2_STAT5	28	31	PF00017	0.518
LIG_SH2_STAT5	291	294	PF00017	0.423
LIG_SH2_STAT5	428	431	PF00017	0.544
LIG_SH3_3	16	22	PF00018	0.597
LIG_SH3_3	161	167	PF00018	0.536
LIG_SH3_3	374	380	PF00018	0.548
LIG_SH3_3	527	533	PF00018	0.609
LIG_TRAF2_1	460	463	PF00917	0.592
LIG_TRAF2_1	485	488	PF00917	0.598
LIG_UBA3_1	169	176	PF00899	0.532
LIG_UBA3_1	539	547	PF00899	0.549
LIG_WRC_WIRS_1	86	91	PF05994	0.401
LIG_WW_3	380	384	PF00397	0.566
MOD_CDK_SPxK_1	156	162	PF00069	0.539
MOD_CK1_1	168	174	PF00069	0.548
MOD_CK1_1	255	261	PF00069	0.608
MOD_CK1_1	407	413	PF00069	0.469
MOD_CK1_1	48	54	PF00069	0.618
MOD_CK2_1	243	249	PF00069	0.705
MOD_CK2_1	508	514	PF00069	0.705
MOD_CMANNOS	397	400	PF00535	0.404
MOD_CMANNOS	413	416	PF00535	0.516
MOD_Cter_Amidation	239	242	PF01082	0.590
MOD_GlcNHglycan	10	13	PF01048	0.539
MOD_GlcNHglycan	197	200	PF01048	0.620
MOD_GlcNHglycan	254	257	PF01048	0.554
MOD_GlcNHglycan	32	35	PF01048	0.598
MOD_GlcNHglycan	39	42	PF01048	0.558
MOD_GlcNHglycan	409	412	PF01048	0.473
MOD_GSK3_1	154	161	PF00069	0.578
MOD_GSK3_1	255	262	PF00069	0.614
MOD_GSK3_1	336	343	PF00069	0.566
MOD_GSK3_1	39	46	PF00069	0.688
MOD_GSK3_1	47	54	PF00069	0.717
MOD_N-GLC_1	84	89	PF02516	0.421
MOD_NEK2_1	8	13	PF00069	0.540
MOD_NEK2_2	360	365	PF00069	0.576
MOD_OFUCOSY	272	278	PF10250	0.420
MOD_PIKK_1	105	111	PF00454	0.393
MOD_PIKK_1	340	346	PF00454	0.630
MOD_PKA_2	211	217	PF00069	0.611
MOD_PKA_2	79	85	PF00069	0.437
MOD_Plk_1	508	514	PF00069	0.633
MOD_Plk_1	84	90	PF00069	0.459
MOD_Plk_4	165	171	PF00069	0.530
MOD_Plk_4	336	342	PF00069	0.542
MOD_Plk_4	39	45	PF00069	0.653
MOD_ProDKin_1	156	162	PF00069	0.555
MOD_ProDKin_1	201	207	PF00069	0.539
MOD_ProDKin_1	255	261	PF00069	0.665
MOD_ProDKin_1	298	304	PF00069	0.495
MOD_ProDKin_1	404	410	PF00069	0.472
MOD_ProDKin_1	479	485	PF00069	0.647
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.426
TRG_ER_diArg_1	153	156	PF00400	0.469
TRG_ER_diArg_1	403	405	PF00400	0.445
TRG_ER_diArg_1	432	434	PF00400	0.488
TRG_ER_diArg_1	89	92	PF00400	0.405
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2A7	Leptomonas seymouri	54%	100%
A0A3S7X7L7	Leishmania donovani	89%	100%
A4HAK0	Leishmania braziliensis	76%	100%
A4I9P4	Leishmania infantum	89%	100%
E9B4Q8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%