HVA22-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

HVA22-like protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3B4_LEIMA

TriTrypDb:

LmjF.34.0910 , LMJLV39_340016100 , LMJSD75_340015900

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q3B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3B4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.622
CLV_NRD_NRD_1	49	51	PF00675	0.500
CLV_NRD_NRD_1	57	59	PF00675	0.478
CLV_NRD_NRD_1	81	83	PF00675	0.460
CLV_PCSK_KEX2_1	133	135	PF00082	0.632
CLV_PCSK_KEX2_1	140	142	PF00082	0.620
CLV_PCSK_KEX2_1	49	51	PF00082	0.499
CLV_PCSK_KEX2_1	57	59	PF00082	0.477
CLV_PCSK_KEX2_1	81	83	PF00082	0.460
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.623
CLV_PCSK_SKI1_1	140	144	PF00082	0.607
DEG_APCC_DBOX_1	80	88	PF00400	0.639
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DOC_CDC14_PxL_1	104	112	PF14671	0.410
DOC_CDC14_PxL_1	20	28	PF14671	0.572
DOC_CYCLIN_yCln2_LP_2	3	9	PF00134	0.621
DOC_MAPK_gen_1	81	89	PF00069	0.676
DOC_PP2B_LxvP_1	3	6	PF13499	0.618
DOC_PP4_FxxP_1	105	108	PF00568	0.328
LIG_BRCT_BRCA1_1	101	105	PF00533	0.363
LIG_CSL_BTD_1	105	108	PF09270	0.328
LIG_CtBP_PxDLS_1	30	34	PF00389	0.590
LIG_DCNL_PONY_1	1	4	PF03556	0.629
LIG_FHA_1	158	164	PF00498	0.394
LIG_FHA_2	150	156	PF00498	0.436
LIG_FHA_2	32	38	PF00498	0.645
LIG_LIR_Apic_2	102	108	PF02991	0.363
LIG_LIR_Apic_2	16	22	PF02991	0.628
LIG_LIR_Gen_1	118	129	PF02991	0.406
LIG_LIR_Gen_1	94	103	PF02991	0.328
LIG_LIR_Nem_3	102	107	PF02991	0.328
LIG_LIR_Nem_3	118	124	PF02991	0.353
LIG_LIR_Nem_3	94	98	PF02991	0.328
LIG_MLH1_MIPbox_1	101	105	PF16413	0.363
LIG_Pex14_1	99	103	PF04695	0.363
LIG_Pex14_2	9	13	PF04695	0.609
LIG_SH2_CRK	121	125	PF00017	0.409
LIG_SH2_STAP1	101	105	PF00017	0.328
LIG_SH2_STAT5	11	14	PF00017	0.625
LIG_SH2_STAT5	147	150	PF00017	0.448
LIG_SH2_STAT5	91	94	PF00017	0.328
LIG_SH3_3	69	75	PF00018	0.693
LIG_TRAF2_1	34	37	PF00917	0.643
LIG_WRC_WIRS_1	116	121	PF05994	0.406
MOD_CK1_1	157	163	PF00069	0.429
MOD_CK1_1	32	38	PF00069	0.690
MOD_CK2_1	149	155	PF00069	0.478
MOD_CK2_1	31	37	PF00069	0.640
MOD_CK2_1	73	79	PF00069	0.696
MOD_GSK3_1	145	152	PF00069	0.455
MOD_GSK3_1	25	32	PF00069	0.623
MOD_GSK3_1	73	80	PF00069	0.701
MOD_GSK3_1	9	16	PF00069	0.635
MOD_NEK2_1	143	148	PF00069	0.421
MOD_NEK2_1	154	159	PF00069	0.484
MOD_NEK2_1	25	30	PF00069	0.663
MOD_NEK2_1	66	71	PF00069	0.713
MOD_NEK2_1	77	82	PF00069	0.690
MOD_NEK2_1	9	14	PF00069	0.635
MOD_NEK2_2	52	57	PF00069	0.735
MOD_NEK2_2	99	104	PF00069	0.363
MOD_PIKK_1	145	151	PF00454	0.490
MOD_Plk_1	143	149	PF00069	0.418
MOD_Plk_1	154	160	PF00069	0.481
MOD_Plk_1	36	42	PF00069	0.651
MOD_Plk_4	115	121	PF00069	0.360
MOD_Plk_4	36	42	PF00069	0.651
MOD_Plk_4	73	79	PF00069	0.688
MOD_Plk_4	85	91	PF00069	0.492
MOD_Plk_4	99	105	PF00069	0.320
MOD_SUMO_rev_2	132	139	PF00179	0.400
MOD_SUMO_rev_2	62	72	PF00179	0.709
TRG_ENDOCYTIC_2	101	104	PF00928	0.329
TRG_ENDOCYTIC_2	121	124	PF00928	0.411
TRG_ER_diArg_1	139	141	PF00400	0.409
TRG_ER_diArg_1	48	50	PF00400	0.674
TRG_ER_diArg_1	56	58	PF00400	0.644
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JM59	Bodo saltans	54%	100%
A0A3Q8IUG3	Leishmania donovani	95%	100%
A4HAK4	Leishmania braziliensis	96%	100%
A4I9P8	Leishmania infantum	95%	100%
C6K3V2	Leptomonas seymouri	92%	100%
C9ZMZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9B4R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%