Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3B3_LEIMA

TriTrypDb:

LmjF.34.0920 , LMJLV39_340016200 , LMJSD75_340016000

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3B3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	608	612	PF00656	0.539
CLV_C14_Caspase3-7	634	638	PF00656	0.566
CLV_NRD_NRD_1	238	240	PF00675	0.682
CLV_NRD_NRD_1	277	279	PF00675	0.528
CLV_NRD_NRD_1	304	306	PF00675	0.638
CLV_NRD_NRD_1	313	315	PF00675	0.598
CLV_NRD_NRD_1	324	326	PF00675	0.555
CLV_NRD_NRD_1	33	35	PF00675	0.496
CLV_NRD_NRD_1	398	400	PF00675	0.507
CLV_NRD_NRD_1	417	419	PF00675	0.564
CLV_NRD_NRD_1	469	471	PF00675	0.521
CLV_NRD_NRD_1	629	631	PF00675	0.685
CLV_PCSK_FUR_1	275	279	PF00082	0.537
CLV_PCSK_KEX2_1	108	110	PF00082	0.418
CLV_PCSK_KEX2_1	238	240	PF00082	0.656
CLV_PCSK_KEX2_1	277	279	PF00082	0.528
CLV_PCSK_KEX2_1	303	305	PF00082	0.649
CLV_PCSK_KEX2_1	313	315	PF00082	0.594
CLV_PCSK_KEX2_1	324	326	PF00082	0.553
CLV_PCSK_KEX2_1	33	35	PF00082	0.496
CLV_PCSK_KEX2_1	398	400	PF00082	0.507
CLV_PCSK_KEX2_1	417	419	PF00082	0.564
CLV_PCSK_KEX2_1	469	471	PF00082	0.521
CLV_PCSK_KEX2_1	628	630	PF00082	0.693
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.418
CLV_PCSK_PC7_1	299	305	PF00082	0.544
CLV_PCSK_SKI1_1	108	112	PF00082	0.447
CLV_PCSK_SKI1_1	159	163	PF00082	0.423
CLV_PCSK_SKI1_1	325	329	PF00082	0.538
CLV_PCSK_SKI1_1	85	89	PF00082	0.391
CLV_Separin_Metazoa	23	27	PF03568	0.465
DEG_APCC_DBOX_1	154	162	PF00400	0.528
DEG_APCC_DBOX_1	468	476	PF00400	0.511
DEG_SPOP_SBC_1	175	179	PF00917	0.645
DEG_SPOP_SBC_1	210	214	PF00917	0.667
DEG_SPOP_SBC_1	360	364	PF00917	0.524
DEG_SPOP_SBC_1	505	509	PF00917	0.532
DOC_ANK_TNKS_1	335	342	PF00023	0.609
DOC_CYCLIN_RxL_1	105	114	PF00134	0.437
DOC_CYCLIN_RxL_1	155	164	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	660	666	PF00134	0.373
DOC_MAPK_gen_1	155	163	PF00069	0.451
DOC_MAPK_gen_1	33	42	PF00069	0.504
DOC_MIT_MIM_1	104	113	PF04212	0.435
DOC_PP1_RVXF_1	396	403	PF00149	0.512
DOC_PP2B_LxvP_1	660	663	PF13499	0.364
DOC_PP4_FxxP_1	353	356	PF00568	0.622
DOC_USP7_MATH_1	11	15	PF00917	0.548
DOC_USP7_MATH_1	166	170	PF00917	0.607
DOC_USP7_MATH_1	181	185	PF00917	0.520
DOC_USP7_MATH_1	210	214	PF00917	0.646
DOC_USP7_MATH_1	254	258	PF00917	0.587
DOC_USP7_MATH_1	262	266	PF00917	0.462
DOC_USP7_MATH_1	386	390	PF00917	0.638
DOC_USP7_MATH_1	505	509	PF00917	0.532
DOC_USP7_MATH_1	529	533	PF00917	0.569
DOC_USP7_MATH_1	582	586	PF00917	0.541
DOC_USP7_UBL2_3	133	137	PF12436	0.361
DOC_WW_Pin1_4	248	253	PF00397	0.656
DOC_WW_Pin1_4	260	265	PF00397	0.499
DOC_WW_Pin1_4	307	312	PF00397	0.630
DOC_WW_Pin1_4	346	351	PF00397	0.603
DOC_WW_Pin1_4	361	366	PF00397	0.627
DOC_WW_Pin1_4	438	443	PF00397	0.640
DOC_WW_Pin1_4	578	583	PF00397	0.563
DOC_WW_Pin1_4	613	618	PF00397	0.618
DOC_WW_Pin1_4	622	627	PF00397	0.511
LIG_14-3-3_CanoR_1	165	175	PF00244	0.600
LIG_14-3-3_CanoR_1	176	181	PF00244	0.532
LIG_14-3-3_CanoR_1	385	393	PF00244	0.554
LIG_14-3-3_CanoR_1	595	602	PF00244	0.485
LIG_Actin_WH2_2	550	568	PF00022	0.446
LIG_BIR_II_1	1	5	PF00653	0.462
LIG_BRCT_BRCA1_1	128	132	PF00533	0.433
LIG_Clathr_ClatBox_1	110	114	PF01394	0.439
LIG_deltaCOP1_diTrp_1	457	465	PF00928	0.543
LIG_FHA_1	214	220	PF00498	0.595
LIG_FHA_1	326	332	PF00498	0.559
LIG_FHA_1	364	370	PF00498	0.571
LIG_FHA_1	496	502	PF00498	0.470
LIG_FHA_1	507	513	PF00498	0.409
LIG_FHA_1	54	60	PF00498	0.369
LIG_FHA_1	568	574	PF00498	0.579
LIG_FHA_1	651	657	PF00498	0.548
LIG_FHA_1	665	671	PF00498	0.312
LIG_FHA_1	676	682	PF00498	0.524
LIG_FHA_1	76	82	PF00498	0.426
LIG_FHA_2	186	192	PF00498	0.558
LIG_FHA_2	678	684	PF00498	0.500
LIG_HCF-1_HBM_1	191	194	PF13415	0.502
LIG_LIR_Gen_1	3	11	PF02991	0.533
LIG_LIR_Gen_1	36	47	PF02991	0.448
LIG_LIR_Gen_1	683	692	PF02991	0.389
LIG_LIR_Nem_3	104	110	PF02991	0.560
LIG_LIR_Nem_3	3	7	PF02991	0.542
LIG_LIR_Nem_3	36	42	PF02991	0.487
LIG_LIR_Nem_3	456	462	PF02991	0.553
LIG_LIR_Nem_3	683	688	PF02991	0.383
LIG_PDZ_Class_2	687	692	PF00595	0.385
LIG_SH2_CRK	77	81	PF00017	0.429
LIG_SH2_NCK_1	575	579	PF00017	0.534
LIG_SH2_SRC	354	357	PF00017	0.544
LIG_SH2_STAP1	167	171	PF00017	0.565
LIG_SH2_STAP1	60	64	PF00017	0.418
LIG_SH2_STAP1	77	81	PF00017	0.329
LIG_SH2_STAT5	354	357	PF00017	0.544
LIG_SH2_STAT5	575	578	PF00017	0.551
LIG_SH2_STAT5	606	609	PF00017	0.583
LIG_SH2_STAT5	77	80	PF00017	0.426
LIG_SH3_3	439	445	PF00018	0.570
LIG_SH3_3	499	505	PF00018	0.469
LIG_SUMO_SIM_anti_2	498	503	PF11976	0.399
LIG_SUMO_SIM_par_1	213	226	PF11976	0.527
LIG_SUMO_SIM_par_1	497	503	PF11976	0.441
LIG_SUMO_SIM_par_1	78	84	PF11976	0.429
LIG_TRAF2_1	478	481	PF00917	0.581
LIG_ULM_U2AF65_1	398	403	PF00076	0.501
LIG_WRC_WIRS_1	1	6	PF05994	0.553
MOD_CDC14_SPxK_1	310	313	PF00782	0.598
MOD_CDC14_SPxK_1	625	628	PF00782	0.633
MOD_CDK_SPK_2	248	253	PF00069	0.600
MOD_CDK_SPxK_1	307	313	PF00069	0.599
MOD_CDK_SPxK_1	622	628	PF00069	0.633
MOD_CDK_SPxxK_3	307	314	PF00069	0.635
MOD_CDK_SPxxK_3	622	629	PF00069	0.599
MOD_CK1_1	179	185	PF00069	0.584
MOD_CK1_1	209	215	PF00069	0.669
MOD_CK1_1	218	224	PF00069	0.570
MOD_CK1_1	225	231	PF00069	0.507
MOD_CK1_1	263	269	PF00069	0.580
MOD_CK1_1	3	9	PF00069	0.552
MOD_CK1_1	316	322	PF00069	0.812
MOD_CK1_1	332	338	PF00069	0.554
MOD_CK1_1	363	369	PF00069	0.686
MOD_CK1_1	375	381	PF00069	0.570
MOD_CK1_1	410	416	PF00069	0.561
MOD_CK1_1	438	444	PF00069	0.670
MOD_CK1_1	461	467	PF00069	0.487
MOD_CK1_1	484	490	PF00069	0.555
MOD_CK1_1	500	506	PF00069	0.425
MOD_CK1_1	532	538	PF00069	0.539
MOD_CK1_1	596	602	PF00069	0.703
MOD_CK2_1	677	683	PF00069	0.518
MOD_CMANNOS	494	497	PF00535	0.538
MOD_Cter_Amidation	322	325	PF01082	0.604
MOD_Cter_Amidation	396	399	PF01082	0.528
MOD_GlcNHglycan	13	16	PF01048	0.417
MOD_GlcNHglycan	184	187	PF01048	0.550
MOD_GlcNHglycan	208	211	PF01048	0.674
MOD_GlcNHglycan	245	248	PF01048	0.634
MOD_GlcNHglycan	256	259	PF01048	0.579
MOD_GlcNHglycan	306	310	PF01048	0.622
MOD_GlcNHglycan	374	377	PF01048	0.638
MOD_GlcNHglycan	381	384	PF01048	0.669
MOD_GlcNHglycan	395	398	PF01048	0.468
MOD_GlcNHglycan	437	440	PF01048	0.648
MOD_GlcNHglycan	486	489	PF01048	0.576
MOD_GlcNHglycan	529	532	PF01048	0.566
MOD_GlcNHglycan	534	537	PF01048	0.550
MOD_GlcNHglycan	541	544	PF01048	0.508
MOD_GlcNHglycan	548	551	PF01048	0.406
MOD_GlcNHglycan	584	587	PF01048	0.557
MOD_GlcNHglycan	607	610	PF01048	0.532
MOD_GlcNHglycan	8	11	PF01048	0.462
MOD_GSK3_1	161	168	PF00069	0.601
MOD_GSK3_1	175	182	PF00069	0.504
MOD_GSK3_1	206	213	PF00069	0.670
MOD_GSK3_1	214	221	PF00069	0.584
MOD_GSK3_1	222	229	PF00069	0.541
MOD_GSK3_1	256	263	PF00069	0.544
MOD_GSK3_1	305	312	PF00069	0.649
MOD_GSK3_1	313	320	PF00069	0.609
MOD_GSK3_1	325	332	PF00069	0.507
MOD_GSK3_1	341	348	PF00069	0.585
MOD_GSK3_1	359	366	PF00069	0.535
MOD_GSK3_1	371	378	PF00069	0.623
MOD_GSK3_1	384	391	PF00069	0.570
MOD_GSK3_1	407	414	PF00069	0.537
MOD_GSK3_1	484	491	PF00069	0.521
MOD_GSK3_1	500	507	PF00069	0.463
MOD_GSK3_1	573	580	PF00069	0.522
MOD_GSK3_1	589	596	PF00069	0.573
MOD_GSK3_1	618	625	PF00069	0.627
MOD_GSK3_1	650	657	PF00069	0.514
MOD_LATS_1	174	180	PF00433	0.599
MOD_N-GLC_1	182	187	PF02516	0.635
MOD_N-GLC_2	605	607	PF02516	0.610
MOD_NEK2_1	132	137	PF00069	0.363
MOD_NEK2_1	161	166	PF00069	0.544
MOD_NEK2_1	222	227	PF00069	0.580
MOD_NEK2_1	283	288	PF00069	0.487
MOD_NEK2_1	495	500	PF00069	0.538
MOD_NEK2_1	52	57	PF00069	0.425
MOD_NEK2_1	573	578	PF00069	0.545
MOD_NEK2_1	675	680	PF00069	0.481
MOD_NEK2_2	294	299	PF00069	0.524
MOD_NEK2_2	341	346	PF00069	0.542
MOD_PIKK_1	200	206	PF00454	0.619
MOD_PIKK_1	263	269	PF00454	0.592
MOD_PIKK_1	636	642	PF00454	0.626
MOD_PK_1	176	182	PF00069	0.596
MOD_PKA_1	313	319	PF00069	0.635
MOD_PKA_2	126	132	PF00069	0.463
MOD_PKA_2	175	181	PF00069	0.564
MOD_PKA_2	313	319	PF00069	0.641
MOD_PKA_2	345	351	PF00069	0.609
MOD_PKA_2	384	390	PF00069	0.565
MOD_PKA_2	484	490	PF00069	0.546
MOD_PKA_2	596	602	PF00069	0.595
MOD_PKB_1	239	247	PF00069	0.672
MOD_PKB_1	303	311	PF00069	0.605
MOD_PKB_1	593	601	PF00069	0.571
MOD_Plk_1	182	188	PF00069	0.634
MOD_Plk_1	35	41	PF00069	0.515
MOD_Plk_1	488	494	PF00069	0.448
MOD_Plk_1	505	511	PF00069	0.462
MOD_Plk_4	215	221	PF00069	0.528
MOD_Plk_4	35	41	PF00069	0.515
MOD_Plk_4	497	503	PF00069	0.499
MOD_Plk_4	506	512	PF00069	0.434
MOD_Plk_4	76	82	PF00069	0.443
MOD_ProDKin_1	248	254	PF00069	0.654
MOD_ProDKin_1	260	266	PF00069	0.495
MOD_ProDKin_1	307	313	PF00069	0.632
MOD_ProDKin_1	346	352	PF00069	0.597
MOD_ProDKin_1	361	367	PF00069	0.631
MOD_ProDKin_1	438	444	PF00069	0.636
MOD_ProDKin_1	578	584	PF00069	0.566
MOD_ProDKin_1	613	619	PF00069	0.624
MOD_ProDKin_1	622	628	PF00069	0.513
MOD_SUMO_for_1	87	90	PF00179	0.389
TRG_DiLeu_BaEn_4	101	107	PF01217	0.518
TRG_DiLeu_BaEn_4	89	95	PF01217	0.426
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.440
TRG_ENDOCYTIC_2	77	80	PF00928	0.426
TRG_ER_diArg_1	154	157	PF00400	0.453
TRG_ER_diArg_1	237	239	PF00400	0.662
TRG_ER_diArg_1	275	278	PF00400	0.532
TRG_ER_diArg_1	302	305	PF00400	0.636
TRG_ER_diArg_1	313	315	PF00400	0.541
TRG_ER_diArg_1	398	401	PF00400	0.504
TRG_ER_diArg_1	416	418	PF00400	0.561
TRG_ER_diArg_1	628	630	PF00400	0.693
TRG_ER_diArg_1	641	644	PF00400	0.516
TRG_ER_diArg_1	670	673	PF00400	0.438
TRG_Pf-PMV_PEXEL_1	109	114	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	633	637	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IE77	Leishmania donovani	90%	100%
A4HAK8	Leishmania braziliensis	67%	100%
A4I9P9	Leishmania infantum	90%	100%
C6K3V3	Leptomonas seymouri	39%	100%
E9B4R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%