Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

selenoprotein, putative

Species:

Leishmania major

UniProt:

Q4Q3B0_LEIMA

TriTrypDb:

LmjF.34.0950 , LMJLV39_340016500 , LMJSD75_340016300 , LMJSD75_340016400

Length:

901

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3B0

Function

Biological processes
Term	Name	Level	Count
GO:0006518	peptide metabolic process	4	2
GO:0006575	cellular modified amino acid metabolic process	3	2
GO:0006749	glutathione metabolic process	4	2
GO:0006790	sulfur compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0043603	amide metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0070813	hydrogen sulfide metabolic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3	2
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	4	2
GO:0050313	sulfur dioxygenase activity	5	2
GO:0051213	dioxygenase activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.628
CLV_C14_Caspase3-7	301	305	PF00656	0.284
CLV_C14_Caspase3-7	506	510	PF00656	0.400
CLV_C14_Caspase3-7	604	608	PF00656	0.432
CLV_C14_Caspase3-7	683	687	PF00656	0.426
CLV_NRD_NRD_1	192	194	PF00675	0.457
CLV_NRD_NRD_1	523	525	PF00675	0.595
CLV_NRD_NRD_1	590	592	PF00675	0.543
CLV_NRD_NRD_1	62	64	PF00675	0.439
CLV_NRD_NRD_1	634	636	PF00675	0.471
CLV_NRD_NRD_1	665	667	PF00675	0.417
CLV_NRD_NRD_1	807	809	PF00675	0.278
CLV_PCSK_FUR_1	60	64	PF00082	0.543
CLV_PCSK_KEX2_1	192	194	PF00082	0.457
CLV_PCSK_KEX2_1	523	525	PF00082	0.543
CLV_PCSK_KEX2_1	590	592	PF00082	0.543
CLV_PCSK_KEX2_1	62	64	PF00082	0.439
CLV_PCSK_KEX2_1	634	636	PF00082	0.471
CLV_PCSK_KEX2_1	665	667	PF00082	0.410
CLV_PCSK_KEX2_1	807	809	PF00082	0.278
CLV_PCSK_SKI1_1	417	421	PF00082	0.337
CLV_PCSK_SKI1_1	440	444	PF00082	0.623
CLV_PCSK_SKI1_1	523	527	PF00082	0.464
CLV_PCSK_SKI1_1	543	547	PF00082	0.383
CLV_PCSK_SKI1_1	55	59	PF00082	0.540
CLV_PCSK_SKI1_1	727	731	PF00082	0.477
CLV_PCSK_SKI1_1	73	77	PF00082	0.349
CLV_PCSK_SKI1_1	756	760	PF00082	0.460
DEG_APCC_DBOX_1	330	338	PF00400	0.348
DEG_APCC_DBOX_1	542	550	PF00400	0.475
DEG_APCC_DBOX_1	885	893	PF00400	0.378
DEG_COP1_1	385	392	PF00400	0.585
DEG_Nend_Nbox_1	1	3	PF02207	0.622
DOC_CDC14_PxL_1	36	44	PF14671	0.507
DOC_CKS1_1	389	394	PF01111	0.500
DOC_CKS1_1	761	766	PF01111	0.501
DOC_CYCLIN_RxL_1	412	421	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	688	694	PF00134	0.417
DOC_MAPK_gen_1	331	339	PF00069	0.390
DOC_MAPK_gen_1	520	528	PF00069	0.466
DOC_MAPK_gen_1	634	640	PF00069	0.325
DOC_MAPK_gen_1	893	900	PF00069	0.466
DOC_MAPK_MEF2A_6	847	854	PF00069	0.226
DOC_MAPK_NFAT4_5	847	855	PF00069	0.226
DOC_PP1_RVXF_1	725	732	PF00149	0.352
DOC_PP2B_LxvP_1	526	529	PF13499	0.547
DOC_PP4_FxxP_1	112	115	PF00568	0.687
DOC_PP4_FxxP_1	582	585	PF00568	0.434
DOC_SPAK_OSR1_1	278	282	PF12202	0.287
DOC_USP7_MATH_1	126	130	PF00917	0.560
DOC_USP7_MATH_1	157	161	PF00917	0.518
DOC_USP7_MATH_1	441	445	PF00917	0.649
DOC_USP7_MATH_1	577	581	PF00917	0.585
DOC_USP7_MATH_1	692	696	PF00917	0.690
DOC_USP7_MATH_1	794	798	PF00917	0.444
DOC_USP7_MATH_2	213	219	PF00917	0.522
DOC_WW_Pin1_4	1	6	PF00397	0.582
DOC_WW_Pin1_4	209	214	PF00397	0.539
DOC_WW_Pin1_4	27	32	PF00397	0.615
DOC_WW_Pin1_4	326	331	PF00397	0.533
DOC_WW_Pin1_4	340	345	PF00397	0.257
DOC_WW_Pin1_4	388	393	PF00397	0.558
DOC_WW_Pin1_4	422	427	PF00397	0.386
DOC_WW_Pin1_4	459	464	PF00397	0.591
DOC_WW_Pin1_4	668	673	PF00397	0.365
DOC_WW_Pin1_4	760	765	PF00397	0.441
DOC_WW_Pin1_4	861	866	PF00397	0.421
LIG_14-3-3_CanoR_1	235	240	PF00244	0.331
LIG_14-3-3_CanoR_1	278	284	PF00244	0.406
LIG_14-3-3_CanoR_1	333	338	PF00244	0.448
LIG_14-3-3_CanoR_1	554	561	PF00244	0.440
LIG_14-3-3_CanoR_1	570	574	PF00244	0.464
LIG_14-3-3_CanoR_1	591	597	PF00244	0.577
LIG_14-3-3_CanoR_1	665	672	PF00244	0.495
LIG_14-3-3_CanoR_1	73	79	PF00244	0.452
LIG_AP2alpha_2	243	245	PF02296	0.428
LIG_BIR_III_2	369	373	PF00653	0.337
LIG_EVH1_1	528	532	PF00568	0.511
LIG_FHA_1	122	128	PF00498	0.577
LIG_FHA_1	146	152	PF00498	0.743
LIG_FHA_1	159	165	PF00498	0.688
LIG_FHA_1	172	178	PF00498	0.651
LIG_FHA_1	321	327	PF00498	0.437
LIG_FHA_1	334	340	PF00498	0.239
LIG_FHA_1	360	366	PF00498	0.335
LIG_FHA_1	384	390	PF00498	0.573
LIG_FHA_1	482	488	PF00498	0.369
LIG_FHA_1	534	540	PF00498	0.414
LIG_FHA_1	56	62	PF00498	0.399
LIG_FHA_1	701	707	PF00498	0.577
LIG_FHA_1	753	759	PF00498	0.388
LIG_FHA_1	817	823	PF00498	0.425
LIG_FHA_1	867	873	PF00498	0.307
LIG_FHA_2	320	326	PF00498	0.504
LIG_FHA_2	511	517	PF00498	0.423
LIG_FHA_2	678	684	PF00498	0.354
LIG_FHA_2	740	746	PF00498	0.494
LIG_FHA_2	761	767	PF00498	0.368
LIG_FHA_2	80	86	PF00498	0.457
LIG_HP1_1	649	653	PF01393	0.366
LIG_LIR_Apic_2	421	426	PF02991	0.371
LIG_LIR_Apic_2	580	585	PF02991	0.634
LIG_LIR_Gen_1	597	605	PF02991	0.445
LIG_LIR_Gen_1	610	619	PF02991	0.447
LIG_LIR_Gen_1	742	752	PF02991	0.417
LIG_LIR_Nem_3	124	128	PF02991	0.530
LIG_LIR_Nem_3	195	200	PF02991	0.393
LIG_LIR_Nem_3	350	356	PF02991	0.291
LIG_LIR_Nem_3	421	427	PF02991	0.333
LIG_LIR_Nem_3	516	521	PF02991	0.399
LIG_LIR_Nem_3	595	599	PF02991	0.523
LIG_LIR_Nem_3	610	614	PF02991	0.434
LIG_LIR_Nem_3	625	629	PF02991	0.550
LIG_LIR_Nem_3	705	711	PF02991	0.410
LIG_LIR_Nem_3	742	747	PF02991	0.415
LIG_LIR_Nem_3	864	870	PF02991	0.425
LIG_LYPXL_S_1	38	42	PF13949	0.506
LIG_LYPXL_yS_3	125	128	PF13949	0.526
LIG_LYPXL_yS_3	39	42	PF13949	0.638
LIG_MAD2	756	764	PF02301	0.421
LIG_NRBOX	541	547	PF00104	0.467
LIG_PCNA_yPIPBox_3	62	76	PF02747	0.499
LIG_Pex14_2	420	424	PF04695	0.424
LIG_SH2_CRK	200	204	PF00017	0.416
LIG_SH2_CRK	480	484	PF00017	0.362
LIG_SH2_CRK	611	615	PF00017	0.440
LIG_SH2_CRK	68	72	PF00017	0.414
LIG_SH2_CRK	846	850	PF00017	0.294
LIG_SH2_GRB2like	229	232	PF00017	0.476
LIG_SH2_GRB2like	599	602	PF00017	0.378
LIG_SH2_NCK_1	246	250	PF00017	0.484
LIG_SH2_NCK_1	480	484	PF00017	0.362
LIG_SH2_PTP2	599	602	PF00017	0.345
LIG_SH2_SRC	292	295	PF00017	0.436
LIG_SH2_STAP1	272	276	PF00017	0.344
LIG_SH2_STAP1	9	13	PF00017	0.525
LIG_SH2_STAT3	132	135	PF00017	0.589
LIG_SH2_STAT3	9	12	PF00017	0.627
LIG_SH2_STAT5	229	232	PF00017	0.387
LIG_SH2_STAT5	246	249	PF00017	0.450
LIG_SH2_STAT5	292	295	PF00017	0.377
LIG_SH2_STAT5	352	355	PF00017	0.402
LIG_SH2_STAT5	418	421	PF00017	0.332
LIG_SH2_STAT5	423	426	PF00017	0.288
LIG_SH2_STAT5	599	602	PF00017	0.345
LIG_SH2_STAT5	813	816	PF00017	0.479
LIG_SH2_STAT5	841	844	PF00017	0.313
LIG_SH3_1	130	136	PF00018	0.449
LIG_SH3_3	130	136	PF00018	0.449
LIG_SH3_3	166	172	PF00018	0.440
LIG_SH3_3	313	319	PF00018	0.424
LIG_SH3_3	334	340	PF00018	0.384
LIG_SH3_3	34	40	PF00018	0.555
LIG_SH3_3	386	392	PF00018	0.705
LIG_SH3_3	428	434	PF00018	0.485
LIG_SH3_3	469	475	PF00018	0.373
LIG_SH3_3	526	532	PF00018	0.402
LIG_SH3_3	617	623	PF00018	0.298
LIG_SH3_3	640	646	PF00018	0.329
LIG_SH3_3	718	724	PF00018	0.439
LIG_SH3_3	758	764	PF00018	0.451
LIG_SUMO_SIM_par_1	39	44	PF11976	0.417
LIG_SUMO_SIM_par_1	470	476	PF11976	0.412
LIG_SUMO_SIM_par_1	601	607	PF11976	0.311
LIG_SUMO_SIM_par_1	757	763	PF11976	0.364
LIG_SUMO_SIM_par_1	848	853	PF11976	0.225
LIG_TRAF2_1	452	455	PF00917	0.704
LIG_TRAF2_1	655	658	PF00917	0.454
LIG_WRC_WIRS_1	593	598	PF05994	0.557
MOD_CDK_SPK_2	326	331	PF00069	0.441
MOD_CDK_SPxK_1	27	33	PF00069	0.614
MOD_CDK_SPxxK_3	326	333	PF00069	0.426
MOD_CDK_SPxxK_3	668	675	PF00069	0.436
MOD_CDK_SPxxK_3	861	868	PF00069	0.418
MOD_CK1_1	145	151	PF00069	0.701
MOD_CK1_1	178	184	PF00069	0.660
MOD_CK1_1	234	240	PF00069	0.415
MOD_CK1_1	435	441	PF00069	0.691
MOD_CK1_1	444	450	PF00069	0.738
MOD_CK1_1	533	539	PF00069	0.427
MOD_CK1_1	586	592	PF00069	0.544
MOD_CK1_1	595	601	PF00069	0.308
MOD_CK1_1	625	631	PF00069	0.361
MOD_CK1_1	668	674	PF00069	0.452
MOD_CK1_1	816	822	PF00069	0.265
MOD_CK1_1	873	879	PF00069	0.362
MOD_CK2_1	209	215	PF00069	0.514
MOD_CK2_1	510	516	PF00069	0.429
MOD_CK2_1	739	745	PF00069	0.515
MOD_CK2_1	760	766	PF00069	0.363
MOD_CK2_1	79	85	PF00069	0.630
MOD_GlcNHglycan	15	18	PF01048	0.679
MOD_GlcNHglycan	177	180	PF01048	0.557
MOD_GlcNHglycan	217	220	PF01048	0.613
MOD_GlcNHglycan	247	250	PF01048	0.496
MOD_GlcNHglycan	296	299	PF01048	0.396
MOD_GlcNHglycan	312	315	PF01048	0.249
MOD_GlcNHglycan	379	382	PF01048	0.528
MOD_GlcNHglycan	400	403	PF01048	0.619
MOD_GlcNHglycan	437	440	PF01048	0.663
MOD_GlcNHglycan	443	446	PF01048	0.696
MOD_GlcNHglycan	561	564	PF01048	0.441
MOD_GlcNHglycan	574	578	PF01048	0.579
MOD_GlcNHglycan	579	582	PF01048	0.568
MOD_GlcNHglycan	667	670	PF01048	0.435
MOD_GlcNHglycan	860	864	PF01048	0.475
MOD_GlcNHglycan	875	878	PF01048	0.302
MOD_GlcNHglycan	91	95	PF01048	0.660
MOD_GSK3_1	117	124	PF00069	0.568
MOD_GSK3_1	171	178	PF00069	0.683
MOD_GSK3_1	205	212	PF00069	0.563
MOD_GSK3_1	23	30	PF00069	0.623
MOD_GSK3_1	231	238	PF00069	0.384
MOD_GSK3_1	530	537	PF00069	0.570
MOD_GSK3_1	569	576	PF00069	0.501
MOD_GSK3_1	661	668	PF00069	0.517
MOD_GSK3_1	74	81	PF00069	0.583
MOD_GSK3_1	768	775	PF00069	0.356
MOD_GSK3_1	792	799	PF00069	0.505
MOD_GSK3_1	866	873	PF00069	0.277
MOD_N-GLC_1	121	126	PF02516	0.593
MOD_N-GLC_1	209	214	PF02516	0.615
MOD_N-GLC_1	481	486	PF02516	0.350
MOD_N-GLC_1	586	591	PF02516	0.544
MOD_N-GLC_1	739	744	PF02516	0.448
MOD_N-GLC_1	768	773	PF02516	0.360
MOD_N-GLC_1	873	878	PF02516	0.396
MOD_NEK2_1	205	210	PF00069	0.497
MOD_NEK2_1	245	250	PF00069	0.480
MOD_NEK2_1	279	284	PF00069	0.308
MOD_NEK2_1	302	307	PF00069	0.494
MOD_NEK2_1	377	382	PF00069	0.544
MOD_NEK2_1	427	432	PF00069	0.590
MOD_NEK2_1	501	506	PF00069	0.392
MOD_NEK2_1	534	539	PF00069	0.381
MOD_NEK2_1	78	83	PF00069	0.499
MOD_NEK2_1	8	13	PF00069	0.513
MOD_NEK2_1	870	875	PF00069	0.490
MOD_NEK2_2	813	818	PF00069	0.285
MOD_NEK2_2	866	871	PF00069	0.426
MOD_OFUCOSY	138	144	PF10250	0.523
MOD_PIKK_1	482	488	PF00454	0.408
MOD_PIKK_1	55	61	PF00454	0.529
MOD_PIKK_1	796	802	PF00454	0.494
MOD_PIKK_1	8	14	PF00454	0.624
MOD_PIKK_1	881	887	PF00454	0.490
MOD_PK_1	893	899	PF00069	0.458
MOD_PKA_1	665	671	PF00069	0.495
MOD_PKA_2	234	240	PF00069	0.379
MOD_PKA_2	383	389	PF00069	0.676
MOD_PKA_2	553	559	PF00069	0.460
MOD_PKA_2	569	575	PF00069	0.456
MOD_PKA_2	665	671	PF00069	0.495
MOD_PKB_1	331	339	PF00069	0.390
MOD_Plk_1	121	127	PF00069	0.553
MOD_Plk_1	274	280	PF00069	0.411
MOD_Plk_1	496	502	PF00069	0.399
MOD_Plk_1	534	540	PF00069	0.475
MOD_Plk_1	739	745	PF00069	0.522
MOD_Plk_1	831	837	PF00069	0.493
MOD_Plk_1	893	899	PF00069	0.458
MOD_Plk_4	235	241	PF00069	0.324
MOD_Plk_4	595	601	PF00069	0.463
MOD_Plk_4	850	856	PF00069	0.284
MOD_ProDKin_1	1	7	PF00069	0.582
MOD_ProDKin_1	209	215	PF00069	0.545
MOD_ProDKin_1	27	33	PF00069	0.614
MOD_ProDKin_1	326	332	PF00069	0.527
MOD_ProDKin_1	340	346	PF00069	0.253
MOD_ProDKin_1	388	394	PF00069	0.559
MOD_ProDKin_1	422	428	PF00069	0.386
MOD_ProDKin_1	459	465	PF00069	0.574
MOD_ProDKin_1	668	674	PF00069	0.362
MOD_ProDKin_1	760	766	PF00069	0.442
MOD_ProDKin_1	861	867	PF00069	0.416
MOD_SUMO_rev_2	743	750	PF00179	0.341
TRG_DiLeu_BaEn_1	464	469	PF01217	0.441
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.413
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.544
TRG_ENDOCYTIC_2	125	128	PF00928	0.526
TRG_ENDOCYTIC_2	200	203	PF00928	0.432
TRG_ENDOCYTIC_2	39	42	PF00928	0.638
TRG_ENDOCYTIC_2	480	483	PF00928	0.375
TRG_ENDOCYTIC_2	599	602	PF00928	0.485
TRG_ENDOCYTIC_2	611	614	PF00928	0.378
TRG_ENDOCYTIC_2	68	71	PF00928	0.422
TRG_ENDOCYTIC_2	744	747	PF00928	0.399
TRG_ENDOCYTIC_2	846	849	PF00928	0.297
TRG_ER_diArg_1	191	193	PF00400	0.462
TRG_ER_diArg_1	330	333	PF00400	0.430
TRG_ER_diArg_1	523	525	PF00400	0.550
TRG_ER_diArg_1	60	63	PF00400	0.419
TRG_ER_diArg_1	64	67	PF00400	0.422
TRG_ER_diArg_1	665	667	PF00400	0.390
TRG_ER_diArg_1	807	809	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	796	800	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	807	811	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P997	Trypanosomatidae	34%	100%
A0A3Q8IIB2	Leishmania donovani	92%	100%
A0A422N289	Trypanosoma rangeli	36%	100%
A4I9Q2	Leishmania infantum	92%	100%
C6K3V6	Leptomonas seymouri	54%	93%
C9ZMY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B4R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5AUV4	Trypanosoma cruzi	34%	100%