Amastin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania major

UniProt:

Q4Q3A7_LEIMA

TriTrypDb:

LmjF.34.0980 , LMJLV39_340016700 , LMJSD75_340016700

Length:

193

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 9, no: 171
NetGPI	no	yes: 0, no: 180

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	160
GO:0110165	cellular anatomical entity	1	160

Expansion

Sequence features

Q4Q3A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3A7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.217
CLV_C14_Caspase3-7	98	102	PF00656	0.204
CLV_PCSK_SKI1_1	153	157	PF00082	0.416
DOC_CKS1_1	22	27	PF01111	0.388
DOC_MAPK_gen_1	51	58	PF00069	0.218
DOC_MAPK_MEF2A_6	109	117	PF00069	0.548
DOC_SPAK_OSR1_1	76	80	PF12202	0.213
DOC_WW_Pin1_4	21	26	PF00397	0.397
DOC_WW_Pin1_4	59	64	PF00397	0.212
LIG_FHA_1	175	181	PF00498	0.280
LIG_FHA_2	154	160	PF00498	0.241
LIG_LIR_Gen_1	182	191	PF02991	0.411
LIG_LIR_Nem_3	182	186	PF02991	0.403
LIG_NRBOX	113	119	PF00104	0.204
LIG_PDZ_Class_2	188	193	PF00595	0.365
LIG_Pex14_2	183	187	PF04695	0.504
LIG_SH2_CRK	29	33	PF00017	0.202
LIG_SH2_STAT5	134	137	PF00017	0.275
LIG_SH2_STAT5	43	46	PF00017	0.301
LIG_SH3_3	19	25	PF00018	0.353
LIG_Sin3_3	86	93	PF02671	0.208
LIG_SUMO_SIM_par_1	121	126	PF11976	0.288
LIG_SUMO_SIM_par_1	54	60	PF11976	0.207
LIG_Vh1_VBS_1	89	107	PF01044	0.338
LIG_WRC_WIRS_1	180	185	PF05994	0.281
LIG_WRC_WIRS_1	96	101	PF05994	0.209
MOD_GlcNHglycan	4	7	PF01048	0.366
MOD_GSK3_1	91	98	PF00069	0.317
MOD_N-GLC_1	153	158	PF02516	0.460
MOD_N-GLC_1	32	37	PF02516	0.418
MOD_NEK2_1	123	128	PF00069	0.538
MOD_NEK2_1	174	179	PF00069	0.290
MOD_NEK2_1	32	37	PF00069	0.314
MOD_NEK2_1	57	62	PF00069	0.372
MOD_NEK2_1	91	96	PF00069	0.312
MOD_NMyristoyl	1	7	PF02799	0.473
MOD_PIKK_1	147	153	PF00454	0.206
MOD_Plk_1	32	38	PF00069	0.283
MOD_Plk_4	179	185	PF00069	0.313
MOD_Plk_4	32	38	PF00069	0.419
MOD_Plk_4	43	49	PF00069	0.325
MOD_Plk_4	91	97	PF00069	0.323
MOD_ProDKin_1	21	27	PF00069	0.397
MOD_ProDKin_1	59	65	PF00069	0.212
TRG_ENDOCYTIC_2	29	32	PF00928	0.202

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	27%	100%
A0A0N0P547	Leptomonas seymouri	36%	100%
A0A0N1HWY5	Leptomonas seymouri	45%	99%
A0A0N1PDH0	Leptomonas seymouri	30%	96%
A0A1X0P988	Trypanosomatidae	31%	100%
A0A381MTA7	Leishmania infantum	32%	100%
A0A381MTB8	Leishmania infantum	29%	100%
A0A381MTC7	Leishmania infantum	26%	94%
A0A381MTN2	Leishmania infantum	28%	99%
A0A381MVY0	Leishmania infantum	33%	100%
A0A3Q8ID16	Leishmania donovani	21%	100%
A0A3Q8IE85	Leishmania donovani	32%	100%
A0A3Q8IEC2	Leishmania donovani	28%	100%
A0A3Q8IEI1	Leishmania donovani	30%	100%
A0A3Q8IF65	Leishmania donovani	25%	98%
A0A3Q8IFB9	Leishmania donovani	29%	95%
A0A3Q8IFH7	Leishmania donovani	26%	94%
A0A3Q8IH65	Leishmania donovani	27%	100%
A0A3Q8IHN2	Leishmania donovani	29%	100%
A0A3Q8IHW7	Leishmania donovani	30%	100%
A0A3Q8IHZ6	Leishmania donovani	29%	91%
A0A3Q8IIH1	Leishmania donovani	31%	99%
A0A3Q8IL03	Leishmania donovani	28%	100%
A0A3Q8IUK8	Leishmania donovani	30%	100%
A0A3Q8IUR5	Leishmania donovani	28%	99%
A0A3S5H662	Leishmania donovani	27%	96%
A0A3S5H663	Leishmania donovani	27%	96%
A0A3S5H665	Leishmania donovani	27%	96%
A0A3S5H666	Leishmania donovani	30%	100%
A0A3S5H667	Leishmania donovani	27%	95%
A0A3S5H7L2	Leishmania donovani	29%	94%
A0A3S5H7V9	Leishmania donovani	25%	97%
A0A3S5H7W2	Leishmania donovani	86%	100%
A0A3S5H7W6	Leishmania donovani	34%	97%
A0A3S7WQA0	Leishmania donovani	27%	95%
A0A3S7WQA8	Leishmania donovani	31%	100%
A0A3S7WQC1	Leishmania donovani	28%	100%
A0A3S7X2E6	Leishmania donovani	29%	100%
A0A3S7X453	Leishmania donovani	25%	98%
A0A3S7X472	Leishmania donovani	27%	97%
A0A3S7X7E5	Leishmania donovani	33%	77%
A0A3S7X7M4	Leishmania donovani	29%	91%
A0A3S7X7U1	Leishmania donovani	29%	92%
A0A3S7X7U4	Leishmania donovani	29%	75%
A0A3S7X7W2	Leishmania donovani	25%	92%
A0A3S7X7Y0	Leishmania donovani	30%	99%
A4H595	Leishmania braziliensis	28%	84%
A4H596	Leishmania braziliensis	29%	89%
A4H597	Leishmania braziliensis	28%	84%
A4H5D1	Leishmania braziliensis	33%	99%
A4H5D2	Leishmania braziliensis	29%	100%
A4H5G0	Leishmania braziliensis	28%	100%
A4H5G4	Leishmania braziliensis	32%	92%
A4H5G6	Leishmania braziliensis	28%	87%
A4H5G7	Leishmania braziliensis	27%	89%
A4H5G9	Leishmania braziliensis	34%	100%
A4H5H0	Leishmania braziliensis	35%	100%
A4H5H1	Leishmania braziliensis	31%	100%
A4H5H2	Leishmania braziliensis	29%	100%
A4H5H3	Leishmania braziliensis	30%	93%
A4H6C8	Leishmania braziliensis	28%	97%
A4H7D7	Leishmania braziliensis	30%	99%
A4H9E8	Leishmania braziliensis	26%	92%
A4H9E9	Leishmania braziliensis	27%	99%
A4HAJ4	Leishmania braziliensis	29%	91%
A4HAJ5	Leishmania braziliensis	30%	87%
A4HAJ6	Leishmania braziliensis	28%	84%
A4HAL1	Leishmania braziliensis	24%	100%
A4HAL2	Leishmania braziliensis	63%	100%
A4HAM2	Leishmania braziliensis	29%	100%
A4HAM4	Leishmania braziliensis	29%	100%
A4HAR1	Leishmania braziliensis	28%	100%
A4HAZ8	Leishmania braziliensis	29%	100%
A4HB00	Leishmania braziliensis	28%	100%
A4HB02	Leishmania braziliensis	32%	100%
A4HB47	Leishmania braziliensis	26%	95%
A4HBJ0	Leishmania braziliensis	30%	100%
A4HBJ1	Leishmania braziliensis	29%	100%
A4HBJ2	Leishmania braziliensis	30%	93%
A4HTM3	Leishmania infantum	30%	100%
A4HTM4	Leishmania infantum	31%	100%
A4HTM5	Leishmania infantum	30%	100%
A4I0W5	Leishmania infantum	21%	100%
A4I4J2	Leishmania infantum	31%	94%
A4I4J3	Leishmania infantum	28%	75%
A4I6E5	Leishmania infantum	28%	97%
A4I9Q4	Leishmania infantum	30%	100%
A4I9R4	Leishmania infantum	86%	100%
A4I9R5	Leishmania infantum	29%	95%
A4I9R7	Leishmania infantum	29%	98%
A4I9W8	Leishmania infantum	28%	75%
A4I9X0	Leishmania infantum	25%	92%
A4IA59	Leishmania infantum	28%	74%
A4IAL7	Leishmania infantum	30%	100%
A4IAM1	Leishmania infantum	30%	100%
A4IAM2	Leishmania infantum	29%	100%
E8NHC3	Leishmania infantum	28%	96%
E8NHD3	Leishmania infantum	29%	94%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	92%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	93%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	91%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	91%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	99%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	91%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	99%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	91%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	91%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	94%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	92%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	99%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	99%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	91%
E9AG81	Leishmania infantum	27%	95%
E9AG82	Leishmania infantum	27%	95%
E9AG83	Leishmania infantum	29%	96%
E9AG85	Leishmania infantum	27%	95%
E9AHI9	Leishmania infantum	29%	100%
E9AHT2	Leishmania infantum	29%	91%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	93%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	99%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	99%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	75%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	92%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	99%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	91%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	97%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	97%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	98%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	95%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	94%
Q4Q1U9	Leishmania major	28%	100%
Q4Q305	Leishmania major	32%	99%
Q4Q309	Leishmania major	29%	100%
Q4Q313	Leishmania major	32%	99%
Q4Q317	Leishmania major	32%	100%
Q4Q325	Leishmania major	31%	100%
Q4Q327	Leishmania major	30%	100%
Q4Q329	Leishmania major	30%	99%
Q4Q333	Leishmania major	32%	99%
Q4Q335	Leishmania major	33%	99%
Q4Q337	Leishmania major	27%	100%
Q4Q339	Leishmania major	32%	99%
Q4Q341	Leishmania major	33%	92%
Q4Q397	Leishmania major	30%	100%
Q4Q3A8	Leishmania major	30%	95%
Q4Q3A9	Leishmania major	30%	97%
Q4Q3F7	Leishmania major	33%	91%
Q4Q6L8	Leishmania major	27%	98%
Q4QI84	Leishmania major	30%	100%
Q4QI85	Leishmania major	31%	100%
Q4QI86	Leishmania major	34%	100%
Q4QI87	Leishmania major	32%	100%
Q4QI88	Leishmania major	32%	100%
Q4QI92	Leishmania major	30%	97%
Q4QI93	Leishmania major	30%	97%
Q4QI95	Leishmania major	30%	97%
Q4QI97	Leishmania major	30%	97%
Q4QIA0	Leishmania major	29%	95%
Q4QIA1	Leishmania major	28%	95%