Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q3A4_LEIMA

TriTrypDb:

LmjF.34.1010 , LMJLV39_340017000 , LMJSD75_340017000

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3A4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	474	478	PF00656	0.508
CLV_C14_Caspase3-7	71	75	PF00656	0.568
CLV_NRD_NRD_1	223	225	PF00675	0.576
CLV_NRD_NRD_1	356	358	PF00675	0.492
CLV_NRD_NRD_1	428	430	PF00675	0.505
CLV_NRD_NRD_1	5	7	PF00675	0.464
CLV_PCSK_KEX2_1	223	225	PF00082	0.608
CLV_PCSK_KEX2_1	358	360	PF00082	0.521
CLV_PCSK_KEX2_1	375	377	PF00082	0.520
CLV_PCSK_KEX2_1	419	421	PF00082	0.670
CLV_PCSK_KEX2_1	428	430	PF00082	0.569
CLV_PCSK_KEX2_1	5	7	PF00082	0.473
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.521
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.520
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.670
CLV_PCSK_SKI1_1	298	302	PF00082	0.468
CLV_PCSK_SKI1_1	428	432	PF00082	0.541
CLV_PCSK_SKI1_1	555	559	PF00082	0.448
DEG_APCC_DBOX_1	554	562	PF00400	0.466
DEG_SPOP_SBC_1	157	161	PF00917	0.535
DEG_SPOP_SBC_1	187	191	PF00917	0.522
DEG_SPOP_SBC_1	422	426	PF00917	0.586
DOC_CYCLIN_yCln2_LP_2	332	338	PF00134	0.498
DOC_MAPK_MEF2A_6	325	332	PF00069	0.482
DOC_MAPK_MEF2A_6	56	63	PF00069	0.411
DOC_USP7_MATH_1	157	161	PF00917	0.794
DOC_USP7_MATH_1	176	180	PF00917	0.673
DOC_USP7_MATH_1	200	204	PF00917	0.542
DOC_USP7_MATH_1	254	258	PF00917	0.442
DOC_USP7_MATH_1	35	39	PF00917	0.588
DOC_USP7_MATH_1	423	427	PF00917	0.577
DOC_USP7_MATH_1	508	512	PF00917	0.423
DOC_USP7_MATH_1	94	98	PF00917	0.685
DOC_USP7_UBL2_3	317	321	PF12436	0.541
DOC_USP7_UBL2_3	371	375	PF12436	0.678
DOC_WW_Pin1_4	201	206	PF00397	0.571
DOC_WW_Pin1_4	247	252	PF00397	0.552
DOC_WW_Pin1_4	403	408	PF00397	0.778
DOC_WW_Pin1_4	414	419	PF00397	0.711
LIG_14-3-3_CanoR_1	113	121	PF00244	0.601
LIG_14-3-3_CanoR_1	164	172	PF00244	0.630
LIG_14-3-3_CanoR_1	247	251	PF00244	0.536
LIG_14-3-3_CanoR_1	429	435	PF00244	0.541
LIG_14-3-3_CanoR_1	518	527	PF00244	0.397
LIG_14-3-3_CanoR_1	555	565	PF00244	0.437
LIG_14-3-3_CanoR_1	56	60	PF00244	0.514
LIG_14-3-3_CanoR_1	569	573	PF00244	0.378
LIG_BRCT_BRCA1_1	426	430	PF00533	0.548
LIG_Clathr_ClatBox_1	307	311	PF01394	0.469
LIG_FHA_1	125	131	PF00498	0.496
LIG_FHA_1	153	159	PF00498	0.640
LIG_FHA_1	175	181	PF00498	0.607
LIG_FHA_1	243	249	PF00498	0.527
LIG_FHA_1	471	477	PF00498	0.665
LIG_FHA_1	56	62	PF00498	0.399
LIG_FHA_1	8	14	PF00498	0.531
LIG_FHA_2	135	141	PF00498	0.747
LIG_FHA_2	157	163	PF00498	0.567
LIG_FHA_2	189	195	PF00498	0.652
LIG_FHA_2	274	280	PF00498	0.517
LIG_FHA_2	489	495	PF00498	0.504
LIG_FHA_2	521	527	PF00498	0.454
LIG_FHA_2	548	554	PF00498	0.438
LIG_GBD_Chelix_1	221	229	PF00786	0.436
LIG_LIR_Apic_2	74	80	PF02991	0.595
LIG_LIR_Gen_1	302	313	PF02991	0.394
LIG_LIR_Gen_1	559	570	PF02991	0.459
LIG_LIR_Gen_1	577	587	PF02991	0.386
LIG_LIR_Nem_3	577	582	PF02991	0.370
LIG_LYPXL_yS_3	327	330	PF13949	0.474
LIG_PCNA_PIPBox_1	573	582	PF02747	0.432
LIG_PCNA_yPIPBox_3	569	580	PF02747	0.425
LIG_SH2_CRK	503	507	PF00017	0.401
LIG_SH2_STAP1	503	507	PF00017	0.430
LIG_SH2_STAP1	520	524	PF00017	0.436
LIG_SH2_STAP1	542	546	PF00017	0.367
LIG_SH2_STAT3	570	573	PF00017	0.427
LIG_SH2_STAT5	12	15	PF00017	0.560
LIG_SH2_STAT5	275	278	PF00017	0.527
LIG_SH2_STAT5	305	308	PF00017	0.491
LIG_SH2_STAT5	347	350	PF00017	0.519
LIG_SH2_STAT5	403	406	PF00017	0.547
LIG_SH2_STAT5	579	582	PF00017	0.370
LIG_SH3_2	99	104	PF14604	0.519
LIG_SH3_3	225	231	PF00018	0.458
LIG_SH3_3	245	251	PF00018	0.355
LIG_SH3_3	289	295	PF00018	0.556
LIG_SH3_3	36	42	PF00018	0.480
LIG_SH3_3	404	410	PF00018	0.799
LIG_SH3_3	93	99	PF00018	0.723
LIG_SUMO_SIM_anti_2	493	500	PF11976	0.538
LIG_SUMO_SIM_anti_2	58	63	PF11976	0.394
LIG_TRAF2_1	192	195	PF00917	0.651
LIG_TRAF2_1	491	494	PF00917	0.544
LIG_TRAF2_1	523	526	PF00917	0.547
LIG_TRAF2_1	550	553	PF00917	0.413
MOD_CDC14_SPxK_1	417	420	PF00782	0.678
MOD_CDK_SPK_2	414	419	PF00069	0.634
MOD_CDK_SPxK_1	414	420	PF00069	0.683
MOD_CK1_1	112	118	PF00069	0.572
MOD_CK1_1	152	158	PF00069	0.676
MOD_CK1_1	179	185	PF00069	0.690
MOD_CK1_1	186	192	PF00069	0.705
MOD_CK1_1	250	256	PF00069	0.702
MOD_CK1_1	379	385	PF00069	0.702
MOD_CK1_1	406	412	PF00069	0.530
MOD_CK1_1	471	477	PF00069	0.579
MOD_CK2_1	134	140	PF00069	0.742
MOD_CK2_1	188	194	PF00069	0.619
MOD_CK2_1	265	271	PF00069	0.574
MOD_CK2_1	430	436	PF00069	0.561
MOD_CK2_1	488	494	PF00069	0.641
MOD_CK2_1	508	514	PF00069	0.510
MOD_CK2_1	520	526	PF00069	0.381
MOD_CK2_1	547	553	PF00069	0.440
MOD_Cter_Amidation	3	6	PF01082	0.487
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.504
MOD_GlcNHglycan	149	152	PF01048	0.839
MOD_GlcNHglycan	252	255	PF01048	0.579
MOD_GlcNHglycan	362	366	PF01048	0.595
MOD_GlcNHglycan	387	390	PF01048	0.646
MOD_GSK3_1	105	112	PF00069	0.762
MOD_GSK3_1	122	129	PF00069	0.372
MOD_GSK3_1	147	154	PF00069	0.753
MOD_GSK3_1	175	182	PF00069	0.615
MOD_GSK3_1	183	190	PF00069	0.580
MOD_GSK3_1	242	249	PF00069	0.497
MOD_GSK3_1	250	257	PF00069	0.491
MOD_GSK3_1	261	268	PF00069	0.371
MOD_GSK3_1	361	368	PF00069	0.736
MOD_GSK3_1	376	383	PF00069	0.579
MOD_GSK3_1	402	409	PF00069	0.794
MOD_GSK3_1	414	421	PF00069	0.600
MOD_GSK3_1	464	471	PF00069	0.512
MOD_GSK3_1	472	479	PF00069	0.505
MOD_GSK3_1	547	554	PF00069	0.478
MOD_N-GLC_1	140	145	PF02516	0.555
MOD_N-GLC_1	385	390	PF02516	0.700
MOD_NEK2_1	180	185	PF00069	0.522
MOD_NEK2_1	243	248	PF00069	0.465
MOD_NEK2_1	265	270	PF00069	0.442
MOD_NEK2_1	287	292	PF00069	0.600
MOD_NEK2_1	430	435	PF00069	0.513
MOD_NEK2_1	468	473	PF00069	0.507
MOD_NEK2_1	568	573	PF00069	0.289
MOD_PIKK_1	124	130	PF00454	0.486
MOD_PIKK_1	466	472	PF00454	0.518
MOD_PIKK_1	534	540	PF00454	0.510
MOD_PIKK_1	547	553	PF00454	0.394
MOD_PKA_2	112	118	PF00069	0.595
MOD_PKA_2	232	238	PF00069	0.521
MOD_PKA_2	246	252	PF00069	0.508
MOD_PKA_2	379	385	PF00069	0.679
MOD_PKA_2	450	456	PF00069	0.481
MOD_PKA_2	55	61	PF00069	0.516
MOD_PKA_2	568	574	PF00069	0.381
MOD_PKB_1	376	384	PF00069	0.709
MOD_Plk_1	194	200	PF00069	0.626
MOD_Plk_2-3	140	146	PF00069	0.558
MOD_Plk_4	126	132	PF00069	0.630
MOD_Plk_4	176	182	PF00069	0.627
MOD_Plk_4	183	189	PF00069	0.604
MOD_Plk_4	508	514	PF00069	0.419
MOD_ProDKin_1	201	207	PF00069	0.568
MOD_ProDKin_1	247	253	PF00069	0.550
MOD_ProDKin_1	403	409	PF00069	0.779
MOD_ProDKin_1	414	420	PF00069	0.710
MOD_SUMO_rev_2	311	318	PF00179	0.455
TRG_DiLeu_BaEn_4	194	200	PF01217	0.654
TRG_ENDOCYTIC_2	305	308	PF00928	0.376
TRG_ENDOCYTIC_2	327	330	PF00928	0.474
TRG_ENDOCYTIC_2	45	48	PF00928	0.478
TRG_ENDOCYTIC_2	503	506	PF00928	0.391
TRG_ENDOCYTIC_2	562	565	PF00928	0.489
TRG_ENDOCYTIC_2	579	582	PF00928	0.370
TRG_ER_diArg_1	222	224	PF00400	0.592
TRG_ER_diArg_1	295	298	PF00400	0.510
TRG_ER_diArg_1	428	430	PF00400	0.505
TRG_NES_CRM1_1	342	355	PF08389	0.518
TRG_NLS_MonoExtC_3	356	361	PF00514	0.554
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P311	Leptomonas seymouri	43%	93%
A0A3S7X7P4	Leishmania donovani	90%	100%
A0A422N6A0	Trypanosoma rangeli	24%	100%
A4HAL4	Leishmania braziliensis	70%	95%
A4I9R1	Leishmania infantum	90%	95%
E9B4S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BJB9	Trypanosoma cruzi	22%	100%