N2227 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Carnosine N-methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q3A3_LEIMA

TriTrypDb:

LmjF.34.1020 , LMJLV39_340017100 , LMJSD75_340017100

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0010494	cytoplasmic stress granule	5	2
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3A3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.438
CLV_C14_Caspase3-7	39	43	PF00656	0.512
CLV_NRD_NRD_1	108	110	PF00675	0.491
CLV_PCSK_KEX2_1	94	96	PF00082	0.475
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.475
CLV_PCSK_SKI1_1	116	120	PF00082	0.445
CLV_PCSK_SKI1_1	202	206	PF00082	0.279
CLV_PCSK_SKI1_1	421	425	PF00082	0.213
CLV_PCSK_SKI1_1	429	433	PF00082	0.213
CLV_PCSK_SKI1_1	95	99	PF00082	0.485
DOC_CKS1_1	169	174	PF01111	0.479
DOC_CKS1_1	22	27	PF01111	0.658
DOC_CYCLIN_RxL_1	110	122	PF00134	0.288
DOC_MAPK_DCC_7	165	175	PF00069	0.289
DOC_MAPK_gen_1	215	225	PF00069	0.439
DOC_MAPK_MEF2A_6	116	123	PF00069	0.390
DOC_MAPK_MEF2A_6	218	225	PF00069	0.414
DOC_MAPK_MEF2A_6	232	239	PF00069	0.418
DOC_PP1_RVXF_1	307	314	PF00149	0.439
DOC_PP1_RVXF_1	398	404	PF00149	0.455
DOC_PP2B_LxvP_1	361	364	PF13499	0.424
DOC_PP2B_LxvP_1	56	59	PF13499	0.632
DOC_USP7_MATH_1	213	217	PF00917	0.483
DOC_USP7_UBL2_3	125	129	PF12436	0.442
DOC_WW_Pin1_4	168	173	PF00397	0.429
DOC_WW_Pin1_4	21	26	PF00397	0.770
LIG_14-3-3_CanoR_1	232	236	PF00244	0.417
LIG_APCC_ABBA_1	272	277	PF00400	0.413
LIG_BIR_II_1	1	5	PF00653	0.695
LIG_BIR_III_2	42	46	PF00653	0.482
LIG_BRCT_BRCA1_1	137	141	PF00533	0.288
LIG_Clathr_ClatBox_1	118	122	PF01394	0.500
LIG_deltaCOP1_diTrp_1	153	163	PF00928	0.355
LIG_FHA_1	277	283	PF00498	0.424
LIG_FHA_1	333	339	PF00498	0.513
LIG_FHA_2	169	175	PF00498	0.441
LIG_GBD_Chelix_1	397	405	PF00786	0.255
LIG_GSK3_LRP6_1	168	173	PF00069	0.479
LIG_LIR_Apic_2	324	330	PF02991	0.464
LIG_LIR_Gen_1	138	147	PF02991	0.336
LIG_LIR_Gen_1	248	259	PF02991	0.413
LIG_LIR_Gen_1	287	297	PF02991	0.426
LIG_LIR_Gen_1	322	330	PF02991	0.413
LIG_LIR_Gen_1	335	344	PF02991	0.413
LIG_LIR_Gen_1	353	362	PF02991	0.349
LIG_LIR_Nem_3	106	111	PF02991	0.441
LIG_LIR_Nem_3	138	144	PF02991	0.363
LIG_LIR_Nem_3	149	155	PF02991	0.364
LIG_LIR_Nem_3	198	204	PF02991	0.426
LIG_LIR_Nem_3	248	254	PF02991	0.413
LIG_LIR_Nem_3	287	292	PF02991	0.445
LIG_LIR_Nem_3	312	316	PF02991	0.439
LIG_LIR_Nem_3	322	326	PF02991	0.385
LIG_LIR_Nem_3	335	339	PF02991	0.413
LIG_LIR_Nem_3	353	357	PF02991	0.349
LIG_MLH1_MIPbox_1	137	141	PF16413	0.280
LIG_MYND_1	21	25	PF01753	0.597
LIG_PCNA_yPIPBox_3	420	429	PF02747	0.455
LIG_Pex14_2	152	156	PF04695	0.324
LIG_Pex14_2	185	189	PF04695	0.413
LIG_PTB_Apo_2	259	266	PF02174	0.513
LIG_SH2_CRK	201	205	PF00017	0.455
LIG_SH2_CRK	251	255	PF00017	0.413
LIG_SH2_CRK	327	331	PF00017	0.501
LIG_SH2_CRK	359	363	PF00017	0.424
LIG_SH2_GRB2like	416	419	PF00017	0.424
LIG_SH2_SRC	37	40	PF00017	0.534
LIG_SH2_SRC	61	64	PF00017	0.523
LIG_SH2_STAT3	93	96	PF00017	0.392
LIG_SH2_STAT5	130	133	PF00017	0.369
LIG_SH2_STAT5	259	262	PF00017	0.421
LIG_SH2_STAT5	354	357	PF00017	0.413
LIG_SH2_STAT5	416	419	PF00017	0.416
LIG_SH3_3	164	170	PF00018	0.267
LIG_SH3_3	19	25	PF00018	0.733
LIG_SH3_3	197	203	PF00018	0.424
LIG_SH3_3	220	226	PF00018	0.479
LIG_SH3_3	289	295	PF00018	0.424
LIG_SH3_3	60	66	PF00018	0.449
LIG_SH3_3	68	74	PF00018	0.538
LIG_SUMO_SIM_anti_2	353	359	PF11976	0.424
LIG_TRAF2_1	147	150	PF00917	0.440
LIG_TYR_ITIM	352	357	PF00017	0.413
LIG_UBA3_1	118	125	PF00899	0.483
LIG_WW_1	45	48	PF00397	0.539
MOD_CK1_1	14	20	PF00069	0.656
MOD_CK1_1	276	282	PF00069	0.513
MOD_CK1_1	49	55	PF00069	0.591
MOD_CK2_1	213	219	PF00069	0.463
MOD_CK2_1	387	393	PF00069	0.413
MOD_GlcNHglycan	1	4	PF01048	0.711
MOD_GlcNHglycan	13	16	PF01048	0.666
MOD_GlcNHglycan	137	140	PF01048	0.361
MOD_GlcNHglycan	188	192	PF01048	0.213
MOD_GlcNHglycan	380	383	PF01048	0.284
MOD_GlcNHglycan	51	54	PF01048	0.595
MOD_GSK3_1	10	17	PF00069	0.618
MOD_GSK3_1	334	341	PF00069	0.500
MOD_GSK3_1	383	390	PF00069	0.421
MOD_GSK3_1	407	414	PF00069	0.513
MOD_GSK3_1	79	86	PF00069	0.340
MOD_N-GLC_1	213	218	PF02516	0.200
MOD_NEK2_1	103	108	PF00069	0.222
MOD_NEK2_1	151	156	PF00069	0.408
MOD_NEK2_1	344	349	PF00069	0.418
MOD_NEK2_1	411	416	PF00069	0.413
MOD_NEK2_1	83	88	PF00069	0.326
MOD_PK_1	334	340	PF00069	0.477
MOD_PKA_2	103	109	PF00069	0.457
MOD_PKA_2	231	237	PF00069	0.459
MOD_PKA_2	441	447	PF00069	0.399
MOD_Plk_1	247	253	PF00069	0.413
MOD_Plk_1	383	389	PF00069	0.436
MOD_Plk_1	412	418	PF00069	0.413
MOD_Plk_2-3	383	389	PF00069	0.438
MOD_Plk_4	151	157	PF00069	0.391
MOD_Plk_4	158	164	PF00069	0.407
MOD_Plk_4	314	320	PF00069	0.413
MOD_Plk_4	407	413	PF00069	0.513
MOD_Plk_4	79	85	PF00069	0.427
MOD_ProDKin_1	168	174	PF00069	0.429
MOD_ProDKin_1	21	27	PF00069	0.771
MOD_SUMO_rev_2	448	456	PF00179	0.587
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.413
TRG_ENDOCYTIC_2	201	204	PF00928	0.413
TRG_ENDOCYTIC_2	251	254	PF00928	0.413
TRG_ENDOCYTIC_2	354	357	PF00928	0.413
TRG_ENDOCYTIC_2	359	362	PF00928	0.413
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M2	Leptomonas seymouri	86%	100%
A0A0S4IZ95	Bodo saltans	53%	100%
A0A1X0PA60	Trypanosomatidae	70%	100%
A0A3Q8IH25	Leishmania donovani	96%	100%
A0A3S5IQL4	Trypanosoma rangeli	73%	100%
A4HAL5	Leishmania braziliensis	88%	100%
A4I9R0	Leishmania infantum	97%	100%
C9ZMY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9B4S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F1N9S8	Gallus gallus	39%	100%
P53934	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q54ST2	Dictyostelium discoideum	36%	98%
Q5BJZ6	Rattus norvegicus	37%	100%
Q80UY1	Mus musculus	37%	100%
Q8N4J0	Homo sapiens	36%	100%
Q9Y7J3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
V5BEW2	Trypanosoma cruzi	67%	100%