EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania major

UniProt:

Q4Q3A2_LEIMA

TriTrypDb:

LmjF.34.1030 , LMJLV39_340017200 , LMJSD75_340017200

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q3A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3A2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005509	calcium ion binding	5	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.512
CLV_MEL_PAP_1	205	211	PF00089	0.524
CLV_NRD_NRD_1	240	242	PF00675	0.449
CLV_PCSK_KEX2_1	240	242	PF00082	0.449
CLV_PCSK_SKI1_1	152	156	PF00082	0.776
DEG_SPOP_SBC_1	63	67	PF00917	0.727
DOC_MAPK_JIP1_4	76	82	PF00069	0.714
DOC_PP1_RVXF_1	206	212	PF00149	0.524
DOC_USP7_MATH_1	154	158	PF00917	0.497
DOC_USP7_MATH_1	27	31	PF00917	0.799
DOC_USP7_MATH_1	40	44	PF00917	0.584
DOC_USP7_MATH_1	63	67	PF00917	0.672
DOC_USP7_MATH_1	71	75	PF00917	0.582
LIG_14-3-3_CanoR_1	233	237	PF00244	0.524
LIG_14-3-3_CanoR_1	240	246	PF00244	0.411
LIG_14-3-3_CanoR_1	7	15	PF00244	0.737
LIG_BIR_III_4	180	184	PF00653	0.449
LIG_CaM_IQ_9	125	141	PF13499	0.775
LIG_deltaCOP1_diTrp_1	119	128	PF00928	0.722
LIG_FHA_1	167	173	PF00498	0.496
LIG_FHA_1	192	198	PF00498	0.526
LIG_FHA_1	63	69	PF00498	0.755
LIG_FHA_2	14	20	PF00498	0.729
LIG_FHA_2	213	219	PF00498	0.434
LIG_LIR_Gen_1	119	128	PF02991	0.722
LIG_LIR_Gen_1	176	186	PF02991	0.524
LIG_LIR_Nem_3	119	125	PF02991	0.712
LIG_LIR_Nem_3	127	131	PF02991	0.621
LIG_LIR_Nem_3	157	162	PF02991	0.680
LIG_LIR_Nem_3	17	23	PF02991	0.508
LIG_LIR_Nem_3	176	182	PF02991	0.721
LIG_LIR_Nem_3	184	189	PF02991	0.394
LIG_LIR_Nem_3	237	242	PF02991	0.524
LIG_LIR_Nem_3	9	15	PF02991	0.680
LIG_LYPXL_S_1	11	15	PF13949	0.665
LIG_LYPXL_yS_3	12	15	PF13949	0.660
LIG_Pex14_2	155	159	PF04695	0.694
LIG_SH2_CRK	20	24	PF00017	0.747
LIG_SH2_SRC	189	192	PF00017	0.449
LIG_SH2_STAT5	162	165	PF00017	0.755
LIG_SH2_STAT5	196	199	PF00017	0.524
LIG_SH3_3	21	27	PF00018	0.771
LIG_SUMO_SIM_anti_2	215	225	PF11976	0.517
LIG_TRAF2_1	215	218	PF00917	0.524
LIG_WRC_WIRS_1	125	130	PF05994	0.735
MOD_CK1_1	107	113	PF00069	0.581
MOD_CK1_1	28	34	PF00069	0.810
MOD_CK1_1	78	84	PF00069	0.714
MOD_CK2_1	13	19	PF00069	0.735
MOD_CK2_1	212	218	PF00069	0.454
MOD_GlcNHglycan	101	104	PF01048	0.755
MOD_GlcNHglycan	110	113	PF01048	0.606
MOD_GlcNHglycan	152	155	PF01048	0.771
MOD_GlcNHglycan	173	176	PF01048	0.600
MOD_GlcNHglycan	25	30	PF01048	0.791
MOD_GlcNHglycan	38	41	PF01048	0.588
MOD_GlcNHglycan	42	45	PF01048	0.518
MOD_GlcNHglycan	73	76	PF01048	0.701
MOD_GlcNHglycan	8	11	PF01048	0.737
MOD_GlcNHglycan	95	98	PF01048	0.754
MOD_GSK3_1	104	111	PF00069	0.576
MOD_GSK3_1	150	157	PF00069	0.567
MOD_GSK3_1	36	43	PF00069	0.632
MOD_GSK3_1	57	64	PF00069	0.768
MOD_GSK3_1	71	78	PF00069	0.535
MOD_N-GLC_1	107	112	PF02516	0.600
MOD_N-GLC_1	155	160	PF02516	0.614
MOD_N-GLC_1	78	83	PF02516	0.713
MOD_NEK2_1	124	129	PF00069	0.731
MOD_NEK2_1	131	136	PF00069	0.677
MOD_NEK2_1	163	168	PF00069	0.538
MOD_PIKK_1	166	172	PF00454	0.538
MOD_PKA_2	232	238	PF00069	0.524
MOD_PKA_2	6	12	PF00069	0.742
MOD_PKA_2	75	81	PF00069	0.712
MOD_Plk_1	155	161	PF00069	0.768
MOD_Plk_1	78	84	PF00069	0.714
MOD_SUMO_rev_2	17	23	PF00179	0.669
TRG_DiLeu_BaEn_1	19	24	PF01217	0.744
TRG_DiLeu_BaEn_1	218	223	PF01217	0.524
TRG_ENDOCYTIC_2	12	15	PF00928	0.686
TRG_ENDOCYTIC_2	20	23	PF00928	0.584
TRG_ER_diArg_1	239	241	PF00400	0.449
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.762

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X7M0	Leishmania donovani	91%	100%
A4HAL6	Leishmania braziliensis	63%	100%
A4I9Q9	Leishmania infantum	91%	100%
E9B4S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%