SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/SET domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q3A0_LEIMA

TriTrypDb:

LmjF.34.1050 , LMJLV39_340017400 , LMJSD75_340017400 , LMJSD75_340017500

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q3A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q3A0

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	2
GO:0034968	histone lysine methylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.711
CLV_C14_Caspase3-7	188	192	PF00656	0.456
CLV_NRD_NRD_1	101	103	PF00675	0.441
CLV_NRD_NRD_1	164	166	PF00675	0.332
CLV_NRD_NRD_1	403	405	PF00675	0.277
CLV_NRD_NRD_1	555	557	PF00675	0.426
CLV_NRD_NRD_1	664	666	PF00675	0.440
CLV_NRD_NRD_1	78	80	PF00675	0.425
CLV_PCSK_KEX2_1	100	102	PF00082	0.537
CLV_PCSK_KEX2_1	164	166	PF00082	0.332
CLV_PCSK_KEX2_1	555	557	PF00082	0.444
CLV_PCSK_KEX2_1	664	666	PF00082	0.399
CLV_PCSK_KEX2_1	78	80	PF00082	0.425
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.537
CLV_PCSK_SKI1_1	22	26	PF00082	0.633
CLV_PCSK_SKI1_1	229	233	PF00082	0.479
CLV_PCSK_SKI1_1	285	289	PF00082	0.215
CLV_PCSK_SKI1_1	290	294	PF00082	0.207
CLV_PCSK_SKI1_1	328	332	PF00082	0.366
CLV_PCSK_SKI1_1	408	412	PF00082	0.237
CLV_PCSK_SKI1_1	641	645	PF00082	0.364
CLV_Separin_Metazoa	661	665	PF03568	0.400
DEG_APCC_DBOX_1	508	516	PF00400	0.396
DEG_SPOP_SBC_1	430	434	PF00917	0.524
DOC_CDC14_PxL_1	333	341	PF14671	0.514
DOC_CKS1_1	688	693	PF01111	0.535
DOC_MAPK_gen_1	164	174	PF00069	0.466
DOC_MAPK_gen_1	404	412	PF00069	0.480
DOC_MAPK_HePTP_8	162	174	PF00069	0.441
DOC_MAPK_MEF2A_6	165	174	PF00069	0.465
DOC_PP1_RVXF_1	639	645	PF00149	0.368
DOC_PP4_FxxP_1	293	296	PF00568	0.457
DOC_PP4_FxxP_1	666	669	PF00568	0.386
DOC_USP7_MATH_1	425	429	PF00917	0.510
DOC_USP7_MATH_1	430	434	PF00917	0.529
DOC_USP7_MATH_1	472	476	PF00917	0.455
DOC_USP7_MATH_2	427	433	PF00917	0.424
DOC_USP7_UBL2_3	90	94	PF12436	0.406
DOC_WW_Pin1_4	192	197	PF00397	0.505
DOC_WW_Pin1_4	292	297	PF00397	0.457
DOC_WW_Pin1_4	342	347	PF00397	0.516
DOC_WW_Pin1_4	645	650	PF00397	0.393
DOC_WW_Pin1_4	687	692	PF00397	0.639
LIG_14-3-3_CanoR_1	131	135	PF00244	0.310
LIG_14-3-3_CanoR_1	164	170	PF00244	0.486
LIG_14-3-3_CanoR_1	241	248	PF00244	0.520
LIG_14-3-3_CanoR_1	511	516	PF00244	0.367
LIG_Actin_WH2_2	388	406	PF00022	0.435
LIG_APCC_ABBAyCdc20_2	131	137	PF00400	0.430
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_BRCT_BRCA1_1	288	292	PF00533	0.503
LIG_DLG_GKlike_1	165	172	PF00625	0.434
LIG_eIF4E_1	450	456	PF01652	0.477
LIG_FHA_1	110	116	PF00498	0.354
LIG_FHA_1	121	127	PF00498	0.362
LIG_FHA_1	257	263	PF00498	0.464
LIG_FHA_1	436	442	PF00498	0.455
LIG_FHA_1	566	572	PF00498	0.424
LIG_FHA_1	84	90	PF00498	0.472
LIG_FHA_2	350	356	PF00498	0.514
LIG_FHA_2	394	400	PF00498	0.514
LIG_FHA_2	512	518	PF00498	0.446
LIG_HCF-1_HBM_1	138	141	PF13415	0.401
LIG_LIR_Gen_1	171	182	PF02991	0.469
LIG_LIR_Gen_1	250	261	PF02991	0.508
LIG_LIR_Gen_1	504	512	PF02991	0.489
LIG_LIR_Gen_1	573	581	PF02991	0.404
LIG_LIR_Gen_1	65	74	PF02991	0.370
LIG_LIR_Nem_3	157	162	PF02991	0.391
LIG_LIR_Nem_3	171	177	PF02991	0.497
LIG_LIR_Nem_3	250	256	PF02991	0.524
LIG_LIR_Nem_3	31	36	PF02991	0.502
LIG_LIR_Nem_3	494	500	PF02991	0.458
LIG_LIR_Nem_3	517	522	PF02991	0.451
LIG_LIR_Nem_3	573	577	PF02991	0.382
LIG_LIR_Nem_3	65	70	PF02991	0.363
LIG_LYPXL_S_1	32	36	PF13949	0.387
LIG_LYPXL_yS_3	33	36	PF13949	0.392
LIG_LYPXL_yS_3	336	339	PF13949	0.514
LIG_MYND_1	346	350	PF01753	0.457
LIG_NRBOX	123	129	PF00104	0.320
LIG_NRBOX	54	60	PF00104	0.542
LIG_Rb_LxCxE_1	110	133	PF01857	0.441
LIG_SH2_CRK	253	257	PF00017	0.508
LIG_SH2_CRK	327	331	PF00017	0.514
LIG_SH2_CRK	497	501	PF00017	0.515
LIG_SH2_GRB2like	111	114	PF00017	0.442
LIG_SH2_NCK_1	253	257	PF00017	0.514
LIG_SH2_SRC	141	144	PF00017	0.465
LIG_SH2_SRC	253	256	PF00017	0.470
LIG_SH2_SRC	450	453	PF00017	0.407
LIG_SH2_SRC	574	577	PF00017	0.370
LIG_SH2_SRC	667	670	PF00017	0.338
LIG_SH2_SRC	679	682	PF00017	0.346
LIG_SH2_STAP1	253	257	PF00017	0.448
LIG_SH2_STAP1	563	567	PF00017	0.314
LIG_SH2_STAP1	574	578	PF00017	0.291
LIG_SH2_STAT3	268	271	PF00017	0.514
LIG_SH2_STAT5	111	114	PF00017	0.312
LIG_SH2_STAT5	135	138	PF00017	0.228
LIG_SH2_STAT5	268	271	PF00017	0.451
LIG_SH2_STAT5	391	394	PF00017	0.514
LIG_SH2_STAT5	465	468	PF00017	0.460
LIG_SH2_STAT5	544	547	PF00017	0.358
LIG_SH2_STAT5	603	606	PF00017	0.408
LIG_SH2_STAT5	679	682	PF00017	0.446
LIG_SH3_1	685	691	PF00018	0.506
LIG_SH3_3	529	535	PF00018	0.563
LIG_SH3_3	581	587	PF00018	0.437
LIG_SH3_3	685	691	PF00018	0.615
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.393
LIG_SUMO_SIM_anti_2	54	60	PF11976	0.389
LIG_SUMO_SIM_par_1	259	267	PF11976	0.508
LIG_SUMO_SIM_par_1	567	573	PF11976	0.385
LIG_TRAF2_1	185	188	PF00917	0.478
LIG_TYR_ITIM	325	330	PF00017	0.390
LIG_TYR_ITIM	495	500	PF00017	0.339
LIG_UBA3_1	55	63	PF00899	0.467
LIG_WRC_WIRS_1	465	470	PF05994	0.260
LIG_WW_3	215	219	PF00397	0.536
MOD_CDK_SPxxK_3	645	652	PF00069	0.386
MOD_CK1_1	195	201	PF00069	0.531
MOD_CK1_1	2	8	PF00069	0.609
MOD_CK1_1	208	214	PF00069	0.586
MOD_CK1_1	240	246	PF00069	0.329
MOD_CK1_1	264	270	PF00069	0.392
MOD_CK1_1	501	507	PF00069	0.438
MOD_CK2_1	165	171	PF00069	0.415
MOD_CK2_1	182	188	PF00069	0.476
MOD_CK2_1	393	399	PF00069	0.339
MOD_CK2_1	645	651	PF00069	0.398
MOD_Cter_Amidation	553	556	PF01082	0.429
MOD_GlcNHglycan	12	15	PF01048	0.701
MOD_GlcNHglycan	207	210	PF01048	0.526
MOD_GlcNHglycan	228	232	PF01048	0.469
MOD_GlcNHglycan	272	275	PF01048	0.293
MOD_GlcNHglycan	28	31	PF01048	0.583
MOD_GlcNHglycan	341	345	PF01048	0.362
MOD_GlcNHglycan	4	7	PF01048	0.677
MOD_GlcNHglycan	80	83	PF01048	0.472
MOD_GSK3_1	1	8	PF00069	0.721
MOD_GSK3_1	182	189	PF00069	0.464
MOD_GSK3_1	204	211	PF00069	0.485
MOD_GSK3_1	22	29	PF00069	0.634
MOD_GSK3_1	360	367	PF00069	0.410
MOD_GSK3_1	380	387	PF00069	0.308
MOD_GSK3_1	421	428	PF00069	0.387
MOD_GSK3_1	431	438	PF00069	0.347
MOD_N-GLC_1	129	134	PF02516	0.341
MOD_N-GLC_1	430	435	PF02516	0.387
MOD_NEK2_1	1	6	PF00069	0.694
MOD_NEK2_1	109	114	PF00069	0.377
MOD_NEK2_1	270	275	PF00069	0.260
MOD_NEK2_1	364	369	PF00069	0.416
MOD_NEK2_1	420	425	PF00069	0.389
MOD_NEK2_1	435	440	PF00069	0.206
MOD_NEK2_1	493	498	PF00069	0.339
MOD_NEK2_1	73	78	PF00069	0.456
MOD_NEK2_1	83	88	PF00069	0.361
MOD_NEK2_2	498	503	PF00069	0.482
MOD_NEK2_2	524	529	PF00069	0.352
MOD_OFUCOSY	523	528	PF10250	0.371
MOD_PK_1	186	192	PF00069	0.319
MOD_PKA_1	78	84	PF00069	0.400
MOD_PKA_2	130	136	PF00069	0.314
MOD_PKA_2	240	246	PF00069	0.264
MOD_PKA_2	421	427	PF00069	0.264
MOD_PKA_2	78	84	PF00069	0.400
MOD_PKB_1	509	517	PF00069	0.430
MOD_Plk_1	129	135	PF00069	0.334
MOD_Plk_1	415	421	PF00069	0.399
MOD_Plk_1	430	436	PF00069	0.447
MOD_Plk_1	491	497	PF00069	0.294
MOD_Plk_1	637	643	PF00069	0.386
MOD_Plk_1	680	686	PF00069	0.507
MOD_Plk_1	83	89	PF00069	0.354
MOD_Plk_2-3	349	355	PF00069	0.369
MOD_Plk_4	130	136	PF00069	0.309
MOD_Plk_4	154	160	PF00069	0.444
MOD_Plk_4	380	386	PF00069	0.329
MOD_Plk_4	431	437	PF00069	0.416
MOD_Plk_4	565	571	PF00069	0.306
MOD_Plk_4	668	674	PF00069	0.427
MOD_ProDKin_1	192	198	PF00069	0.505
MOD_ProDKin_1	292	298	PF00069	0.310
MOD_ProDKin_1	342	348	PF00069	0.394
MOD_ProDKin_1	645	651	PF00069	0.392
MOD_ProDKin_1	687	693	PF00069	0.640
MOD_SUMO_for_1	684	687	PF00179	0.444
MOD_SUMO_rev_2	13	23	PF00179	0.702
MOD_SUMO_rev_2	648	654	PF00179	0.367
TRG_DiLeu_BaEn_1	54	59	PF01217	0.390
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.404
TRG_ENDOCYTIC_2	253	256	PF00928	0.384
TRG_ENDOCYTIC_2	327	330	PF00928	0.390
TRG_ENDOCYTIC_2	33	36	PF00928	0.468
TRG_ENDOCYTIC_2	336	339	PF00928	0.390
TRG_ENDOCYTIC_2	465	468	PF00928	0.390
TRG_ENDOCYTIC_2	497	500	PF00928	0.346
TRG_ENDOCYTIC_2	519	522	PF00928	0.440
TRG_ENDOCYTIC_2	574	577	PF00928	0.409
TRG_ENDOCYTIC_2	603	606	PF00928	0.480
TRG_ER_diArg_1	101	103	PF00400	0.527
TRG_ER_diArg_1	164	167	PF00400	0.423
TRG_ER_diArg_1	282	285	PF00400	0.223
TRG_ER_diArg_1	508	511	PF00400	0.363
TRG_ER_diArg_1	555	557	PF00400	0.426
TRG_ER_diArg_1	663	665	PF00400	0.402
TRG_ER_diArg_1	78	80	PF00400	0.425
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	555	560	PF00026	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKN8	Leptomonas seymouri	76%	99%
A0A0S4JQY2	Bodo saltans	41%	100%
A0A1X0P998	Trypanosomatidae	37%	100%
A0A3Q8IKU3	Leishmania donovani	97%	100%
A0A422N693	Trypanosoma rangeli	36%	100%
A4HAL8	Leishmania braziliensis	88%	100%
A4I9Q7	Leishmania infantum	97%	100%
C9ZMX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B4S7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q5F3V0	Gallus gallus	21%	94%
V5BJB7	Trypanosoma cruzi	36%	100%