Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q395_LEIMA

TriTrypDb:

LmjF.34.1100 , LMJLV39_340018600 , LMJSD75_340018700

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q395

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q395

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.563
CLV_NRD_NRD_1	234	236	PF00675	0.505
CLV_NRD_NRD_1	252	254	PF00675	0.493
CLV_NRD_NRD_1	296	298	PF00675	0.430
CLV_NRD_NRD_1	312	314	PF00675	0.535
CLV_NRD_NRD_1	39	41	PF00675	0.524
CLV_PCSK_KEX2_1	234	236	PF00082	0.505
CLV_PCSK_KEX2_1	252	254	PF00082	0.493
CLV_PCSK_KEX2_1	296	298	PF00082	0.430
CLV_PCSK_KEX2_1	312	314	PF00082	0.535
CLV_PCSK_KEX2_1	39	41	PF00082	0.524
CLV_PCSK_SKI1_1	312	316	PF00082	0.526
CLV_PCSK_SKI1_1	317	321	PF00082	0.692
CLV_PCSK_SKI1_1	332	336	PF00082	0.345
CLV_PCSK_SKI1_1	364	368	PF00082	0.447
CLV_PCSK_SKI1_1	39	43	PF00082	0.522
DEG_APCC_DBOX_1	296	304	PF00400	0.494
DEG_APCC_DBOX_1	363	371	PF00400	0.489
DEG_APCC_DBOX_1	38	46	PF00400	0.528
DEG_SCF_FBW7_2	257	263	PF00400	0.540
DOC_CKS1_1	257	262	PF01111	0.538
DOC_CKS1_1	326	331	PF01111	0.418
DOC_CKS1_1	53	58	PF01111	0.584
DOC_CYCLIN_RxL_1	329	336	PF00134	0.493
DOC_CYCLIN_RxL_1	37	46	PF00134	0.533
DOC_MAPK_gen_1	296	302	PF00069	0.615
DOC_MAPK_gen_1	312	320	PF00069	0.436
DOC_MAPK_gen_1	360	367	PF00069	0.473
DOC_MAPK_gen_1	39	45	PF00069	0.520
DOC_MAPK_HePTP_8	314	326	PF00069	0.569
DOC_MAPK_MEF2A_6	201	208	PF00069	0.434
DOC_MAPK_MEF2A_6	317	326	PF00069	0.569
DOC_MAPK_MEF2A_6	376	384	PF00069	0.488
DOC_MAPK_MEF2A_6	78	85	PF00069	0.589
DOC_PP2B_LxvP_1	29	32	PF13499	0.584
DOC_USP7_MATH_1	138	142	PF00917	0.501
DOC_USP7_MATH_1	49	53	PF00917	0.629
DOC_USP7_MATH_1	60	64	PF00917	0.566
DOC_USP7_MATH_1	65	69	PF00917	0.511
DOC_WW_Pin1_4	102	107	PF00397	0.661
DOC_WW_Pin1_4	134	139	PF00397	0.496
DOC_WW_Pin1_4	246	251	PF00397	0.620
DOC_WW_Pin1_4	256	261	PF00397	0.573
DOC_WW_Pin1_4	325	330	PF00397	0.432
DOC_WW_Pin1_4	52	57	PF00397	0.606
LIG_14-3-3_CanoR_1	201	207	PF00244	0.502
LIG_14-3-3_CanoR_1	312	320	PF00244	0.583
LIG_14-3-3_CanoR_1	40	46	PF00244	0.517
LIG_BRCT_BRCA1_1	204	208	PF00533	0.473
LIG_BRCT_BRCA1_1	380	384	PF00533	0.491
LIG_deltaCOP1_diTrp_1	5	11	PF00928	0.479
LIG_FHA_1	197	203	PF00498	0.623
LIG_FHA_1	313	319	PF00498	0.482
LIG_FHA_1	326	332	PF00498	0.453
LIG_FHA_2	207	213	PF00498	0.556
LIG_FHA_2	240	246	PF00498	0.677
LIG_FHA_2	288	294	PF00498	0.375
LIG_FHA_2	340	346	PF00498	0.480
LIG_FHA_2	7	13	PF00498	0.462
LIG_GBD_Chelix_1	330	338	PF00786	0.501
LIG_LIR_Nem_3	333	338	PF02991	0.432
LIG_LIR_Nem_3	340	346	PF02991	0.414
LIG_LIR_Nem_3	35	41	PF02991	0.523
LIG_LIR_Nem_3	373	378	PF02991	0.436
LIG_LIR_Nem_3	5	10	PF02991	0.483
LIG_LIR_Nem_3	72	77	PF02991	0.539
LIG_MAD2	40	48	PF02301	0.531
LIG_NRBOX	165	171	PF00104	0.465
LIG_PCNA_yPIPBox_3	364	378	PF02747	0.496
LIG_Pex14_2	335	339	PF04695	0.424
LIG_Pex14_2	353	357	PF04695	0.394
LIG_SH2_CRK	38	42	PF00017	0.541
LIG_SH2_STAP1	129	133	PF00017	0.588
LIG_SH2_STAP1	173	177	PF00017	0.424
LIG_SH2_STAT5	133	136	PF00017	0.629
LIG_SH3_1	305	311	PF00018	0.535
LIG_SH3_2	308	313	PF14604	0.550
LIG_SH3_3	111	117	PF00018	0.550
LIG_SH3_3	254	260	PF00018	0.546
LIG_SH3_3	305	311	PF00018	0.535
LIG_SH3_3	323	329	PF00018	0.527
LIG_SH3_3	42	48	PF00018	0.528
LIG_SH3_3	92	98	PF00018	0.629
LIG_SUMO_SIM_par_1	41	46	PF11976	0.516
LIG_TRAF2_1	269	272	PF00917	0.653
LIG_TRAF2_1	290	293	PF00917	0.539
MOD_CDC14_SPxK_1	249	252	PF00782	0.602
MOD_CDK_SPxK_1	246	252	PF00069	0.598
MOD_CDK_SPxxK_3	246	253	PF00069	0.551
MOD_CDK_SPxxK_3	325	332	PF00069	0.502
MOD_CK1_1	102	108	PF00069	0.636
MOD_CK1_1	121	127	PF00069	0.608
MOD_CK1_1	132	138	PF00069	0.729
MOD_CK1_1	196	202	PF00069	0.566
MOD_CK1_1	333	339	PF00069	0.494
MOD_CK1_1	52	58	PF00069	0.630
MOD_CK1_1	63	69	PF00069	0.591
MOD_CK2_1	206	212	PF00069	0.495
MOD_CK2_1	239	245	PF00069	0.544
MOD_CK2_1	287	293	PF00069	0.385
MOD_CK2_1	339	345	PF00069	0.478
MOD_CK2_1	6	12	PF00069	0.463
MOD_CK2_1	85	91	PF00069	0.587
MOD_GlcNHglycan	144	147	PF01048	0.654
MOD_GlcNHglycan	190	193	PF01048	0.646
MOD_GlcNHglycan	239	242	PF01048	0.484
MOD_GlcNHglycan	45	48	PF01048	0.517
MOD_GlcNHglycan	62	65	PF01048	0.549
MOD_GlcNHglycan	68	71	PF01048	0.607
MOD_GSK3_1	102	109	PF00069	0.657
MOD_GSK3_1	118	125	PF00069	0.585
MOD_GSK3_1	127	134	PF00069	0.571
MOD_GSK3_1	138	145	PF00069	0.553
MOD_GSK3_1	202	209	PF00069	0.431
MOD_GSK3_1	237	244	PF00069	0.527
MOD_GSK3_1	259	266	PF00069	0.627
MOD_GSK3_1	378	385	PF00069	0.532
MOD_GSK3_1	51	58	PF00069	0.657
MOD_GSK3_1	59	66	PF00069	0.592
MOD_GSK3_1	81	88	PF00069	0.644
MOD_LATS_1	120	126	PF00433	0.608
MOD_NEK2_1	100	105	PF00069	0.638
MOD_NEK2_1	330	335	PF00069	0.553
MOD_NEK2_1	338	343	PF00069	0.415
MOD_NEK2_1	370	375	PF00069	0.417
MOD_NEK2_1	378	383	PF00069	0.471
MOD_NEK2_1	43	48	PF00069	0.535
MOD_PIKK_1	234	240	PF00454	0.593
MOD_PK_1	122	128	PF00069	0.604
MOD_PKA_1	234	240	PF00069	0.538
MOD_PKA_1	312	318	PF00069	0.629
MOD_PKA_2	121	127	PF00069	0.705
MOD_PKA_2	185	191	PF00069	0.615
MOD_PKA_2	234	240	PF00069	0.538
MOD_PKA_2	312	318	PF00069	0.652
MOD_Plk_1	122	128	PF00069	0.679
MOD_Plk_1	339	345	PF00069	0.478
MOD_Plk_2-3	222	228	PF00069	0.474
MOD_Plk_4	108	114	PF00069	0.592
MOD_Plk_4	157	163	PF00069	0.483
MOD_Plk_4	330	336	PF00069	0.573
MOD_Plk_4	339	345	PF00069	0.402
MOD_Plk_4	370	376	PF00069	0.496
MOD_Plk_4	378	384	PF00069	0.461
MOD_Plk_4	6	12	PF00069	0.506
MOD_Plk_4	81	87	PF00069	0.591
MOD_ProDKin_1	102	108	PF00069	0.662
MOD_ProDKin_1	134	140	PF00069	0.493
MOD_ProDKin_1	246	252	PF00069	0.623
MOD_ProDKin_1	256	262	PF00069	0.573
MOD_ProDKin_1	325	331	PF00069	0.428
MOD_ProDKin_1	52	58	PF00069	0.608
MOD_SUMO_rev_2	88	96	PF00179	0.667
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.423
TRG_ENDOCYTIC_2	38	41	PF00928	0.539
TRG_ER_diArg_1	233	235	PF00400	0.497
TRG_ER_diArg_1	311	313	PF00400	0.480
TRG_ER_diArg_1	38	40	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P9L5	Trypanosomatidae	24%	94%
A0A3Q8II07	Leishmania donovani	89%	99%
A4HAM8	Leishmania braziliensis	68%	96%
A4I9S0	Leishmania infantum	90%	69%
E9B4T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%