Shwachman-Bodian-Diamond protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Shwachman-Bodian-Diamond syndrome (SBDS) protein/SBDS protein C-terminal domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q394_LEIMA

TriTrypDb:

LmjF.34.1110 , LMJLV39_340018700 , LMJSD75_340018800

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q394

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q394

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0022613	ribonucleoprotein complex biogenesis	4	7
GO:0042254	ribosome biogenesis	5	7
GO:0044085	cellular component biogenesis	3	7
GO:0071840	cellular component organization or biogenesis	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.570
CLV_C14_Caspase3-7	370	374	PF00656	0.748
CLV_NRD_NRD_1	12	14	PF00675	0.490
CLV_NRD_NRD_1	292	294	PF00675	0.781
CLV_NRD_NRD_1	355	357	PF00675	0.682
CLV_NRD_NRD_1	442	444	PF00675	0.761
CLV_NRD_NRD_1	464	466	PF00675	0.812
CLV_NRD_NRD_1	497	499	PF00675	0.607
CLV_PCSK_KEX2_1	12	14	PF00082	0.490
CLV_PCSK_KEX2_1	292	294	PF00082	0.812
CLV_PCSK_KEX2_1	343	345	PF00082	0.758
CLV_PCSK_KEX2_1	355	357	PF00082	0.610
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.711
CLV_PCSK_SKI1_1	155	159	PF00082	0.277
CLV_PCSK_SKI1_1	241	245	PF00082	0.429
CLV_PCSK_SKI1_1	466	470	PF00082	0.780
CLV_PCSK_SKI1_1	88	92	PF00082	0.284
DEG_SPOP_SBC_1	297	301	PF00917	0.653
DOC_CYCLIN_yClb5_NLxxxL_5	227	236	PF00134	0.485
DOC_MAPK_gen_1	12	19	PF00069	0.454
DOC_MAPK_gen_1	154	160	PF00069	0.477
DOC_MAPK_gen_1	21	31	PF00069	0.477
DOC_MAPK_MEF2A_6	24	31	PF00069	0.477
DOC_USP7_MATH_1	139	143	PF00917	0.507
DOC_USP7_MATH_1	243	247	PF00917	0.627
DOC_USP7_MATH_1	296	300	PF00917	0.737
DOC_USP7_MATH_1	434	438	PF00917	0.668
DOC_USP7_UBL2_3	24	28	PF12436	0.517
DOC_USP7_UBL2_3	462	466	PF12436	0.828
DOC_USP7_UBL2_3	499	503	PF12436	0.771
LIG_14-3-3_CanoR_1	180	189	PF00244	0.503
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BRCT_BRCA1_1	216	220	PF00533	0.471
LIG_deltaCOP1_diTrp_1	516	522	PF00928	0.693
LIG_FHA_2	181	187	PF00498	0.507
LIG_FHA_2	80	86	PF00498	0.535
LIG_LIR_Gen_1	56	67	PF02991	0.477
LIG_LIR_Nem_3	108	114	PF02991	0.386
LIG_LIR_Nem_3	56	62	PF02991	0.477
LIG_NRBOX	159	165	PF00104	0.535
LIG_SH2_STAT3	435	438	PF00017	0.650
LIG_SH2_STAT5	66	69	PF00017	0.535
LIG_SH3_3	127	133	PF00018	0.499
LIG_SUMO_SIM_anti_2	113	119	PF11976	0.477
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.315
LIG_TRAF2_1	282	285	PF00917	0.598
LIG_TRAF2_1	490	493	PF00917	0.678
LIG_TRAF2_1	99	102	PF00917	0.495
LIG_UBA3_1	232	241	PF00899	0.421
MOD_CK1_1	246	252	PF00069	0.615
MOD_CK1_1	299	305	PF00069	0.747
MOD_CK1_1	363	369	PF00069	0.682
MOD_CK1_1	40	46	PF00069	0.587
MOD_CK2_1	180	186	PF00069	0.503
MOD_CK2_1	299	305	PF00069	0.586
MOD_CK2_1	335	341	PF00069	0.729
MOD_CK2_1	40	46	PF00069	0.615
MOD_CK2_1	487	493	PF00069	0.601
MOD_CK2_1	66	72	PF00069	0.477
MOD_CK2_1	79	85	PF00069	0.477
MOD_Cter_Amidation	341	344	PF01082	0.681
MOD_Cter_Amidation	420	423	PF01082	0.660
MOD_Cter_Amidation	441	444	PF01082	0.676
MOD_Cter_Amidation	460	463	PF01082	0.702
MOD_GlcNHglycan	1	4	PF01048	0.620
MOD_GlcNHglycan	216	219	PF01048	0.577
MOD_GlcNHglycan	245	248	PF01048	0.668
MOD_GlcNHglycan	301	304	PF01048	0.669
MOD_GlcNHglycan	42	45	PF01048	0.409
MOD_GlcNHglycan	427	430	PF01048	0.746
MOD_GSK3_1	202	209	PF00069	0.530
MOD_GSK3_1	210	217	PF00069	0.649
MOD_GSK3_1	284	291	PF00069	0.664
MOD_GSK3_1	315	322	PF00069	0.664
MOD_N-GLC_1	329	334	PF02516	0.724
MOD_N-GLC_1	363	368	PF02516	0.679
MOD_N-GLC_1	425	430	PF02516	0.729
MOD_NEK2_1	149	154	PF00069	0.499
MOD_NEK2_1	288	293	PF00069	0.612
MOD_PIKK_1	116	122	PF00454	0.474
MOD_PIKK_1	124	130	PF00454	0.482
MOD_PIKK_1	434	440	PF00454	0.721
MOD_PIKK_1	7	13	PF00454	0.497
MOD_PKA_1	12	18	PF00069	0.464
MOD_PKA_2	12	18	PF00069	0.464
MOD_PKA_2	179	185	PF00069	0.523
MOD_PKA_2	20	26	PF00069	0.480
MOD_PKA_2	360	366	PF00069	0.645
MOD_PKA_2	416	422	PF00069	0.676
MOD_Plk_1	149	155	PF00069	0.499
MOD_Plk_1	284	290	PF00069	0.592
MOD_Plk_4	72	78	PF00069	0.470
MOD_SUMO_for_1	27	30	PF00179	0.517
TRG_NES_CRM1_1	138	150	PF08389	0.477
TRG_NES_CRM1_1	389	400	PF08389	0.596
TRG_NLS_MonoCore_2	421	426	PF00514	0.676
TRG_NLS_MonoExtC_3	461	466	PF00514	0.733
TRG_NLS_MonoExtN_4	420	427	PF00514	0.651
TRG_NLS_MonoExtN_4	460	466	PF00514	0.817

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFC9	Leishmania donovani	92%	100%
A0A422NGQ3	Trypanosoma rangeli	44%	100%
A4HAM9	Leishmania braziliensis	73%	100%
A4I9S1	Leishmania infantum	93%	100%
E9B4T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%