Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of Unknown Function (DUF1042), putative

Species:

Leishmania major

UniProt:

Q4Q393_LEIMA

TriTrypDb:

LmjF.34.1120 , LMJLV39_340018800 , LMJSD75_340018900

Length:

265

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0005930	axoneme	2	2
GO:0035869	ciliary transition zone	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q393

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q393

Function

Biological processes
Term	Name	Level	Count
GO:0033043	regulation of organelle organization	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051493	regulation of cytoskeleton organization	6	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.401
CLV_NRD_NRD_1	118	120	PF00675	0.409
CLV_NRD_NRD_1	78	80	PF00675	0.201
CLV_PCSK_FUR_1	25	29	PF00082	0.214
CLV_PCSK_KEX2_1	118	120	PF00082	0.409
CLV_PCSK_KEX2_1	27	29	PF00082	0.225
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.201
CLV_PCSK_SKI1_1	238	242	PF00082	0.483
CLV_PCSK_SKI1_1	45	49	PF00082	0.214
CLV_Separin_Metazoa	121	125	PF03568	0.335
CLV_Separin_Metazoa	244	248	PF03568	0.390
DOC_ANK_TNKS_1	31	38	PF00023	0.496
DOC_CKS1_1	202	207	PF01111	0.533
DOC_CYCLIN_RxL_1	76	84	PF00134	0.401
DOC_MAPK_FxFP_2	46	49	PF00069	0.414
DOC_MAPK_gen_1	103	112	PF00069	0.500
DOC_MAPK_gen_1	238	248	PF00069	0.366
DOC_MAPK_MEF2A_6	103	112	PF00069	0.513
DOC_PP1_RVXF_1	77	84	PF00149	0.401
DOC_PP4_FxxP_1	46	49	PF00568	0.414
DOC_PP4_FxxP_1	83	86	PF00568	0.414
DOC_USP7_MATH_1	139	143	PF00917	0.700
DOC_USP7_MATH_1	178	182	PF00917	0.583
DOC_USP7_MATH_1	59	63	PF00917	0.401
DOC_USP7_UBL2_3	76	80	PF12436	0.496
DOC_WW_Pin1_4	137	142	PF00397	0.655
DOC_WW_Pin1_4	168	173	PF00397	0.568
DOC_WW_Pin1_4	201	206	PF00397	0.717
LIG_14-3-3_CanoR_1	183	193	PF00244	0.577
LIG_14-3-3_CanoR_1	195	199	PF00244	0.469
LIG_Actin_WH2_2	108	126	PF00022	0.463
LIG_BIR_II_1	1	5	PF00653	0.489
LIG_BRCT_BRCA1_1	2	6	PF00533	0.451
LIG_FHA_1	202	208	PF00498	0.645
LIG_FHA_1	213	219	PF00498	0.529
LIG_FHA_1	229	235	PF00498	0.372
LIG_FHA_2	14	20	PF00498	0.496
LIG_FHA_2	222	228	PF00498	0.399
LIG_FHA_2	5	11	PF00498	0.363
LIG_LIR_Gen_1	13	23	PF02991	0.266
LIG_LIR_Gen_1	68	78	PF02991	0.401
LIG_LIR_Nem_3	13	18	PF02991	0.266
LIG_LIR_Nem_3	68	73	PF02991	0.401
LIG_PDZ_Class_2	260	265	PF00595	0.504
LIG_SH2_SRC	57	60	PF00017	0.457
LIG_SH2_STAT3	223	226	PF00017	0.516
LIG_SH2_STAT5	15	18	PF00017	0.401
LIG_SH2_STAT5	223	226	PF00017	0.516
LIG_SH2_STAT5	57	60	PF00017	0.434
LIG_SH2_STAT5	82	85	PF00017	0.514
LIG_SH3_2	190	195	PF14604	0.549
LIG_SH3_3	138	144	PF00018	0.738
LIG_SH3_3	166	172	PF00018	0.687
LIG_SH3_3	187	193	PF00018	0.596
LIG_SH3_3	200	206	PF00018	0.566
LIG_SH3_CIN85_PxpxPR_1	190	195	PF14604	0.549
LIG_SUMO_SIM_anti_2	230	237	PF11976	0.406
LIG_SUMO_SIM_par_1	230	237	PF11976	0.441
LIG_TRAF2_1	224	227	PF00917	0.504
LIG_TRAF2_1	86	89	PF00917	0.432
LIG_WW_3	192	196	PF00397	0.548
MOD_CK1_1	158	164	PF00069	0.592
MOD_CK1_1	182	188	PF00069	0.690
MOD_CK2_1	221	227	PF00069	0.348
MOD_CK2_1	36	42	PF00069	0.496
MOD_DYRK1A_RPxSP_1	168	172	PF00069	0.565
MOD_GlcNHglycan	157	160	PF01048	0.618
MOD_GlcNHglycan	165	168	PF01048	0.665
MOD_GlcNHglycan	186	189	PF01048	0.621
MOD_GSK3_1	163	170	PF00069	0.623
MOD_GSK3_1	178	185	PF00069	0.667
MOD_NEK2_1	228	233	PF00069	0.374
MOD_PIKK_1	139	145	PF00454	0.612
MOD_PIKK_1	194	200	PF00454	0.746
MOD_PIKK_1	212	218	PF00454	0.546
MOD_PKA_2	163	169	PF00069	0.598
MOD_PKA_2	182	188	PF00069	0.577
MOD_PKA_2	194	200	PF00069	0.651
MOD_PKA_2	228	234	PF00069	0.371
MOD_Plk_1	221	227	PF00069	0.374
MOD_Plk_2-3	13	19	PF00069	0.368
MOD_Plk_2-3	36	42	PF00069	0.496
MOD_Plk_4	13	19	PF00069	0.388
MOD_ProDKin_1	137	143	PF00069	0.659
MOD_ProDKin_1	168	174	PF00069	0.568
MOD_ProDKin_1	201	207	PF00069	0.715
MOD_SUMO_for_1	240	243	PF00179	0.441
MOD_SUMO_for_1	248	251	PF00179	0.253
MOD_SUMO_rev_2	244	253	PF00179	0.374
TRG_DiLeu_BaEn_3	88	94	PF01217	0.496
TRG_ENDOCYTIC_2	15	18	PF00928	0.401
TRG_ENDOCYTIC_2	82	85	PF00928	0.514
TRG_NES_CRM1_1	237	251	PF08389	0.501
TRG_Pf-PMV_PEXEL_1	79	84	PF00026	0.201

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G9	Leptomonas seymouri	64%	100%
A0A0S4JXH9	Bodo saltans	46%	100%
A0A1X0P9A7	Trypanosomatidae	52%	95%
A0A3S5H7W3	Leishmania donovani	95%	100%
A0A422NGQ0	Trypanosoma rangeli	53%	100%
A4HAN0	Leishmania braziliensis	77%	100%
A4I9S2	Leishmania infantum	94%	100%
C9ZMW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	96%
E9B4T3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q0IH24	Xenopus laevis	38%	100%
Q58DA1	Bos taurus	37%	100%
Q99JL1	Mus musculus	35%	100%
Q9Y4P9	Homo sapiens	36%	100%