Dus domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrouridine synthase (Dus), putative

Species:

Leishmania major

UniProt:

Q4Q391_LEIMA

TriTrypDb:

LmjF.34.1140 , LMJLV39_340019000 , LMJSD75_340019100

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

Q4Q391

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q391

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003824	catalytic activity	1	15
GO:0005488	binding	1	15
GO:0016491	oxidoreductase activity	2	15
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	15
GO:0017150	tRNA dihydrouridine synthase activity	5	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0050660	flavin adenine dinucleotide binding	4	15
GO:0097159	organic cyclic compound binding	2	15
GO:0106413	dihydrouridine synthase activity	4	15
GO:0140098	catalytic activity, acting on RNA	3	15
GO:0140101	catalytic activity, acting on a tRNA	4	15
GO:0140640	catalytic activity, acting on a nucleic acid	2	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.550
CLV_NRD_NRD_1	257	259	PF00675	0.283
CLV_PCSK_KEX2_1	257	259	PF00082	0.288
CLV_PCSK_SKI1_1	108	112	PF00082	0.255
DEG_APCC_DBOX_1	461	469	PF00400	0.418
DEG_Kelch_actinfilin_1	223	227	PF01344	0.418
DOC_CYCLIN_yCln2_LP_2	301	307	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.448
DOC_MAPK_gen_1	295	305	PF00069	0.468
DOC_MAPK_MEF2A_6	298	307	PF00069	0.439
DOC_PP1_RVXF_1	256	263	PF00149	0.456
DOC_PP1_RVXF_1	390	397	PF00149	0.575
DOC_PP2B_LxvP_1	301	304	PF13499	0.494
DOC_PP2B_LxvP_1	397	400	PF13499	0.470
DOC_PP2B_LxvP_1	440	443	PF13499	0.483
DOC_USP7_MATH_1	158	162	PF00917	0.443
DOC_USP7_MATH_1	218	222	PF00917	0.549
DOC_USP7_MATH_1	269	273	PF00917	0.535
DOC_USP7_MATH_1	353	357	PF00917	0.611
DOC_USP7_MATH_1	400	404	PF00917	0.570
DOC_USP7_MATH_2	424	430	PF00917	0.322
DOC_USP7_UBL2_3	249	253	PF12436	0.551
DOC_WW_Pin1_4	133	138	PF00397	0.552
DOC_WW_Pin1_4	277	282	PF00397	0.442
DOC_WW_Pin1_4	370	375	PF00397	0.751
DOC_WW_Pin1_4	386	391	PF00397	0.526
DOC_WW_Pin1_4	420	425	PF00397	0.607
DOC_WW_Pin1_4	455	460	PF00397	0.384
DOC_WW_Pin1_4	55	60	PF00397	0.770
DOC_WW_Pin1_4	77	82	PF00397	0.544
LIG_14-3-3_CanoR_1	121	129	PF00244	0.535
LIG_14-3-3_CanoR_1	257	261	PF00244	0.460
LIG_14-3-3_CanoR_1	364	374	PF00244	0.526
LIG_14-3-3_CanoR_1	392	397	PF00244	0.603
LIG_14-3-3_CanoR_1	411	415	PF00244	0.561
LIG_14-3-3_CanoR_1	469	475	PF00244	0.389
LIG_Actin_WH2_2	241	259	PF00022	0.472
LIG_Actin_WH2_2	307	325	PF00022	0.535
LIG_APCC_ABBA_1	172	177	PF00400	0.468
LIG_APCC_ABBA_1	481	486	PF00400	0.323
LIG_BIR_II_1	1	5	PF00653	0.654
LIG_BRCT_BRCA1_1	258	262	PF00533	0.439
LIG_BRCT_BRCA1_1	384	388	PF00533	0.513
LIG_deltaCOP1_diTrp_1	3	12	PF00928	0.620
LIG_eIF4E_1	93	99	PF01652	0.440
LIG_FHA_1	123	129	PF00498	0.481
LIG_FHA_1	235	241	PF00498	0.456
LIG_FHA_1	436	442	PF00498	0.372
LIG_FHA_2	314	320	PF00498	0.475
LIG_FHA_2	411	417	PF00498	0.628
LIG_FHA_2	421	427	PF00498	0.411
LIG_FHA_2	56	62	PF00498	0.611
LIG_FHA_2	63	69	PF00498	0.595
LIG_KLC1_Yacidic_2	482	486	PF13176	0.278
LIG_LIR_Apic_2	359	365	PF02991	0.600
LIG_LIR_Gen_1	123	130	PF02991	0.433
LIG_LIR_Gen_1	272	281	PF02991	0.535
LIG_LIR_Gen_1	382	391	PF02991	0.420
LIG_LIR_LC3C_4	438	442	PF02991	0.294
LIG_LIR_Nem_3	143	147	PF02991	0.485
LIG_LIR_Nem_3	2	8	PF02991	0.641
LIG_LIR_Nem_3	272	276	PF02991	0.539
LIG_LIR_Nem_3	382	387	PF02991	0.584
LIG_LIR_Nem_3	86	92	PF02991	0.410
LIG_Pex14_1	89	93	PF04695	0.497
LIG_Pex14_2	384	388	PF04695	0.513
LIG_SH2_CRK	93	97	PF00017	0.413
LIG_SH2_NCK_1	412	416	PF00017	0.582
LIG_SH2_PTP2	456	459	PF00017	0.400
LIG_SH2_SRC	484	487	PF00017	0.394
LIG_SH2_STAP1	124	128	PF00017	0.450
LIG_SH2_STAP1	47	51	PF00017	0.670
LIG_SH2_STAP1	8	12	PF00017	0.565
LIG_SH2_STAT5	124	127	PF00017	0.439
LIG_SH2_STAT5	175	178	PF00017	0.451
LIG_SH2_STAT5	343	346	PF00017	0.547
LIG_SH2_STAT5	412	415	PF00017	0.583
LIG_SH2_STAT5	456	459	PF00017	0.372
LIG_SH2_STAT5	484	487	PF00017	0.366
LIG_SH2_STAT5	93	96	PF00017	0.481
LIG_SH3_3	131	137	PF00018	0.559
LIG_SH3_3	20	26	PF00018	0.519
LIG_SH3_3	239	245	PF00018	0.603
LIG_SH3_3	368	374	PF00018	0.775
LIG_SH3_3	384	390	PF00018	0.546
LIG_SH3_3	75	81	PF00018	0.551
LIG_SUMO_SIM_anti_2	470	476	PF11976	0.441
LIG_TRAF2_1	477	480	PF00917	0.409
LIG_TRAF2_1	66	69	PF00917	0.565
LIG_WW_3	364	368	PF00397	0.561
MOD_CDC14_SPxK_1	389	392	PF00782	0.465
MOD_CDK_SPK_2	420	425	PF00069	0.504
MOD_CDK_SPxK_1	386	392	PF00069	0.453
MOD_CDK_SPxxK_3	133	140	PF00069	0.535
MOD_CDK_SPxxK_3	455	462	PF00069	0.359
MOD_CK1_1	234	240	PF00069	0.539
MOD_CK1_1	272	278	PF00069	0.541
MOD_CK1_1	356	362	PF00069	0.696
MOD_CK1_1	470	476	PF00069	0.352
MOD_CK1_1	52	58	PF00069	0.774
MOD_CK1_1	80	86	PF00069	0.611
MOD_CK2_1	313	319	PF00069	0.475
MOD_CK2_1	400	406	PF00069	0.547
MOD_CK2_1	420	426	PF00069	0.541
MOD_CK2_1	455	461	PF00069	0.361
MOD_CK2_1	55	61	PF00069	0.589
MOD_CK2_1	62	68	PF00069	0.764
MOD_GlcNHglycan	160	163	PF01048	0.247
MOD_GlcNHglycan	237	240	PF01048	0.255
MOD_GlcNHglycan	330	333	PF01048	0.265
MOD_GlcNHglycan	486	489	PF01048	0.548
MOD_GlcNHglycan	65	68	PF01048	0.660
MOD_GSK3_1	129	136	PF00069	0.451
MOD_GSK3_1	231	238	PF00069	0.561
MOD_GSK3_1	279	286	PF00069	0.458
MOD_GSK3_1	309	316	PF00069	0.456
MOD_GSK3_1	353	360	PF00069	0.652
MOD_GSK3_1	382	389	PF00069	0.616
MOD_LATS_1	277	283	PF00433	0.494
MOD_N-GLC_1	299	304	PF02516	0.386
MOD_N-GLC_1	41	46	PF02516	0.553
MOD_N-GLC_1	470	475	PF02516	0.449
MOD_N-GLC_1	83	88	PF02516	0.484
MOD_NEK2_1	129	134	PF00069	0.401
MOD_NEK2_1	209	214	PF00069	0.458
MOD_NEK2_1	357	362	PF00069	0.733
MOD_NEK2_1	410	415	PF00069	0.589
MOD_NEK2_1	467	472	PF00069	0.366
MOD_NEK2_1	92	97	PF00069	0.487
MOD_PKA_2	104	110	PF00069	0.439
MOD_PKA_2	120	126	PF00069	0.471
MOD_PKA_2	256	262	PF00069	0.451
MOD_PKA_2	410	416	PF00069	0.563
MOD_Plk_1	299	305	PF00069	0.472
MOD_Plk_1	353	359	PF00069	0.654
MOD_Plk_1	47	53	PF00069	0.594
MOD_Plk_1	470	476	PF00069	0.377
MOD_Plk_4	129	135	PF00069	0.535
MOD_Plk_4	269	275	PF00069	0.535
MOD_Plk_4	353	359	PF00069	0.501
MOD_Plk_4	392	398	PF00069	0.624
MOD_Plk_4	470	476	PF00069	0.399
MOD_ProDKin_1	133	139	PF00069	0.552
MOD_ProDKin_1	277	283	PF00069	0.442
MOD_ProDKin_1	370	376	PF00069	0.748
MOD_ProDKin_1	386	392	PF00069	0.528
MOD_ProDKin_1	420	426	PF00069	0.604
MOD_ProDKin_1	455	461	PF00069	0.380
MOD_ProDKin_1	55	61	PF00069	0.772
MOD_ProDKin_1	77	83	PF00069	0.541
TRG_DiLeu_BaEn_1	292	297	PF01217	0.483
TRG_ENDOCYTIC_2	124	127	PF00928	0.442
TRG_ENDOCYTIC_2	93	96	PF00928	0.347
TRG_ER_diArg_1	256	258	PF00400	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT7	Leptomonas seymouri	60%	96%
A0A0S4JTG4	Bodo saltans	44%	100%
A0A3Q8IJ00	Leishmania donovani	25%	100%
A0A3Q8IN46	Leishmania donovani	92%	100%
A0A3R7KZP3	Trypanosoma rangeli	44%	100%
A4HAN2	Leishmania braziliensis	79%	96%
A4HNQ5	Leishmania braziliensis	24%	100%
A4I9S4	Leishmania infantum	92%	100%
A4ICU0	Leishmania infantum	25%	100%
C9ZMV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ASG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B4T5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DJT2	Trypanosoma cruzi	45%	100%