Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q390_LEIMA

TriTrypDb:

LmjF.34.1150 , LMJLV39_340019100 , LMJSD75_340019200

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q390

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q390

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.612
CLV_NRD_NRD_1	382	384	PF00675	0.467
CLV_PCSK_KEX2_1	381	383	PF00082	0.458
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.460
CLV_PCSK_SKI1_1	192	196	PF00082	0.611
CLV_PCSK_SKI1_1	201	205	PF00082	0.556
CLV_PCSK_SKI1_1	265	269	PF00082	0.733
CLV_PCSK_SKI1_1	30	34	PF00082	0.692
CLV_PCSK_SKI1_1	53	57	PF00082	0.517
DEG_APCC_DBOX_1	191	199	PF00400	0.608
DEG_SPOP_SBC_1	126	130	PF00917	0.553
DOC_CYCLIN_RxL_1	189	199	PF00134	0.609
DOC_MAPK_HePTP_8	90	102	PF00069	0.553
DOC_MAPK_MEF2A_6	251	260	PF00069	0.557
DOC_MAPK_MEF2A_6	84	92	PF00069	0.533
DOC_MAPK_MEF2A_6	93	102	PF00069	0.536
DOC_PP2B_PxIxI_1	97	103	PF00149	0.554
DOC_PP4_FxxP_1	74	77	PF00568	0.604
DOC_USP7_MATH_1	113	117	PF00917	0.537
DOC_USP7_MATH_1	126	130	PF00917	0.490
DOC_USP7_MATH_1	176	180	PF00917	0.658
DOC_USP7_MATH_1	213	217	PF00917	0.648
DOC_USP7_MATH_1	306	310	PF00917	0.590
DOC_USP7_MATH_1	48	52	PF00917	0.768
DOC_WW_Pin1_4	203	208	PF00397	0.598
DOC_WW_Pin1_4	209	214	PF00397	0.588
DOC_WW_Pin1_4	219	224	PF00397	0.573
DOC_WW_Pin1_4	44	49	PF00397	0.641
LIG_14-3-3_CanoR_1	124	133	PF00244	0.532
LIG_14-3-3_CanoR_1	174	184	PF00244	0.610
LIG_14-3-3_CanoR_1	295	302	PF00244	0.601
LIG_14-3-3_CanoR_1	53	58	PF00244	0.521
LIG_14-3-3_CanoR_1	7	13	PF00244	0.593
LIG_14-3-3_CterR_2	382	385	PF00244	0.628
LIG_Actin_WH2_2	187	203	PF00022	0.642
LIG_Actin_WH2_2	340	355	PF00022	0.483
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_BIR_III_2	45	49	PF00653	0.596
LIG_BRCT_BRCA1_1	129	133	PF00533	0.547
LIG_deltaCOP1_diTrp_1	280	283	PF00928	0.477
LIG_FHA_1	147	153	PF00498	0.545
LIG_FHA_1	179	185	PF00498	0.652
LIG_FHA_1	77	83	PF00498	0.607
LIG_FHA_1	97	103	PF00498	0.554
LIG_FHA_2	286	292	PF00498	0.524
LIG_FHA_2	357	363	PF00498	0.577
LIG_FHA_2	366	372	PF00498	0.576
LIG_FHA_2	54	60	PF00498	0.486
LIG_FHA_2	89	95	PF00498	0.560
LIG_LIR_Apic_2	280	284	PF02991	0.483
LIG_LIR_Apic_2	71	77	PF02991	0.597
LIG_LIR_Gen_1	101	111	PF02991	0.573
LIG_LIR_Gen_1	362	372	PF02991	0.540
LIG_LIR_Nem_3	101	107	PF02991	0.584
LIG_LIR_Nem_3	2	8	PF02991	0.628
LIG_LIR_Nem_3	280	286	PF02991	0.479
LIG_LIR_Nem_3	362	367	PF02991	0.563
LIG_SH2_CRK	104	108	PF00017	0.543
LIG_SH3_2	210	215	PF14604	0.583
LIG_SH3_3	204	210	PF00018	0.585
LIG_SH3_3	217	223	PF00018	0.616
LIG_SH3_3	335	341	PF00018	0.574
LIG_SUMO_SIM_anti_2	334	340	PF11976	0.581
LIG_SUMO_SIM_par_1	146	154	PF11976	0.580
LIG_TYR_ITIM	102	107	PF00017	0.526
LIG_WRC_WIRS_1	1	6	PF05994	0.559
LIG_WRC_WIRS_1	361	366	PF05994	0.566
MOD_CDC14_SPxK_1	212	215	PF00782	0.587
MOD_CDK_SPxK_1	209	215	PF00069	0.582
MOD_CK1_1	129	135	PF00069	0.601
MOD_CK1_1	178	184	PF00069	0.715
MOD_CK1_1	206	212	PF00069	0.598
MOD_CK1_1	222	228	PF00069	0.581
MOD_CK1_1	301	307	PF00069	0.588
MOD_CK1_1	355	361	PF00069	0.537
MOD_CK1_1	47	53	PF00069	0.588
MOD_CK2_1	113	119	PF00069	0.541
MOD_CK2_1	163	169	PF00069	0.621
MOD_CK2_1	285	291	PF00069	0.511
MOD_CK2_1	356	362	PF00069	0.550
MOD_CK2_1	365	371	PF00069	0.535
MOD_CK2_1	53	59	PF00069	0.504
MOD_CK2_1	88	94	PF00069	0.544
MOD_GlcNHglycan	146	149	PF01048	0.754
MOD_GlcNHglycan	153	156	PF01048	0.707
MOD_GlcNHglycan	217	220	PF01048	0.655
MOD_GlcNHglycan	234	237	PF01048	0.501
MOD_GlcNHglycan	308	311	PF01048	0.600
MOD_GlcNHglycan	368	371	PF01048	0.517
MOD_GlcNHglycan	49	53	PF01048	0.670
MOD_GSK3_1	125	132	PF00069	0.578
MOD_GSK3_1	15	22	PF00069	0.535
MOD_GSK3_1	176	183	PF00069	0.632
MOD_GSK3_1	209	216	PF00069	0.621
MOD_GSK3_1	221	228	PF00069	0.668
MOD_GSK3_1	261	268	PF00069	0.559
MOD_GSK3_1	297	304	PF00069	0.514
MOD_GSK3_1	351	358	PF00069	0.504
MOD_GSK3_1	362	369	PF00069	0.549
MOD_GSK3_1	40	47	PF00069	0.627
MOD_GSK3_1	88	95	PF00069	0.555
MOD_N-GLC_1	19	24	PF02516	0.657
MOD_NEK2_1	127	132	PF00069	0.595
MOD_NEK2_1	151	156	PF00069	0.609
MOD_NEK2_1	175	180	PF00069	0.583
MOD_NEK2_1	256	261	PF00069	0.459
MOD_NEK2_1	352	357	PF00069	0.570
MOD_PIKK_1	132	138	PF00454	0.536
MOD_PIKK_1	15	21	PF00454	0.592
MOD_PIKK_1	184	190	PF00454	0.595
MOD_PIKK_1	295	301	PF00454	0.661
MOD_PIKK_1	339	345	PF00454	0.395
MOD_PIKK_1	76	82	PF00454	0.592
MOD_PKA_2	176	182	PF00069	0.621
MOD_PKA_2	286	292	PF00069	0.509
MOD_PKA_2	92	98	PF00069	0.532
MOD_PKB_1	295	303	PF00069	0.536
MOD_Plk_1	25	31	PF00069	0.626
MOD_Plk_1	265	271	PF00069	0.654
MOD_Plk_1	333	339	PF00069	0.592
MOD_Plk_4	146	152	PF00069	0.583
MOD_Plk_4	333	339	PF00069	0.592
MOD_ProDKin_1	203	209	PF00069	0.600
MOD_ProDKin_1	219	225	PF00069	0.573
MOD_ProDKin_1	44	50	PF00069	0.640
TRG_DiLeu_BaEn_1	110	115	PF01217	0.544
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.513
TRG_ENDOCYTIC_2	104	107	PF00928	0.557
TRG_ER_diArg_1	294	297	PF00400	0.592
TRG_ER_diArg_1	382	384	PF00400	0.468
TRG_NES_CRM1_1	80	94	PF08389	0.529
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWJ1	Leptomonas seymouri	52%	79%
A0A3Q8IH36	Leishmania donovani	95%	100%
A4HAN3	Leishmania braziliensis	78%	100%
A4I9S5	Leishmania infantum	95%	100%
E9B4T6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%