UPF0235 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

UPF0235 protein

Gene product:

Uncharacterised ACR, YggU family COG1872, putative

Species:

Leishmania major

UniProt:

Q4Q389_LEIMA

TriTrypDb:

LmjF.34.1155 , LMJLV39_340019200 , LMJSD75_340019300

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q389

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q389

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	181	185	PF00082	0.516
CLV_PCSK_SKI1_1	22	26	PF00082	0.447
CLV_PCSK_SKI1_1	79	83	PF00082	0.590
CLV_Separin_Metazoa	65	69	PF03568	0.444
DEG_APCC_DBOX_1	190	198	PF00400	0.532
DEG_SCF_FBW7_1	41	47	PF00400	0.444
DEG_SPOP_SBC_1	132	136	PF00917	0.586
DOC_CKS1_1	41	46	PF01111	0.436
DOC_CYCLIN_RxL_1	19	26	PF00134	0.439
DOC_MAPK_gen_1	179	187	PF00069	0.446
DOC_MAPK_MEF2A_6	179	187	PF00069	0.470
DOC_PP4_FxxP_1	38	41	PF00568	0.444
DOC_USP7_MATH_1	102	106	PF00917	0.622
DOC_USP7_MATH_1	108	112	PF00917	0.673
DOC_USP7_MATH_1	132	136	PF00917	0.704
DOC_USP7_MATH_1	137	141	PF00917	0.681
DOC_USP7_MATH_1	146	150	PF00917	0.775
DOC_USP7_MATH_1	152	156	PF00917	0.650
DOC_USP7_MATH_1	29	33	PF00917	0.383
DOC_USP7_UBL2_3	120	124	PF12436	0.669
DOC_WW_Pin1_4	154	159	PF00397	0.732
DOC_WW_Pin1_4	40	45	PF00397	0.444
LIG_14-3-3_CanoR_1	34	42	PF00244	0.344
LIG_14-3-3_CanoR_1	79	88	PF00244	0.492
LIG_FHA_1	180	186	PF00498	0.504
LIG_FHA_1	193	199	PF00498	0.498
LIG_FHA_1	41	47	PF00498	0.485
LIG_FHA_2	175	181	PF00498	0.491
LIG_FHA_2	45	51	PF00498	0.407
LIG_LIR_Apic_2	36	41	PF02991	0.444
LIG_LIR_Gen_1	92	102	PF02991	0.541
LIG_LIR_Nem_3	92	97	PF02991	0.520
LIG_PCNA_yPIPBox_3	63	76	PF02747	0.378
LIG_SH2_CRK	94	98	PF00017	0.546
LIG_SH2_STAP1	94	98	PF00017	0.536
LIG_SH2_STAT5	23	26	PF00017	0.485
LIG_SH2_STAT5	69	72	PF00017	0.457
LIG_SH2_STAT5	88	91	PF00017	0.324
LIG_SH3_3	182	188	PF00018	0.452
LIG_SH3_3	38	44	PF00018	0.425
LIG_SUMO_SIM_anti_2	169	174	PF11976	0.571
LIG_SUMO_SIM_anti_2	182	187	PF11976	0.524
LIG_TYR_ITSM	90	97	PF00017	0.546
MOD_CK1_1	111	117	PF00069	0.524
MOD_CK1_1	135	141	PF00069	0.736
MOD_CK1_1	93	99	PF00069	0.566
MOD_CK2_1	174	180	PF00069	0.530
MOD_Cter_Amidation	122	125	PF01082	0.692
MOD_GlcNHglycan	104	107	PF01048	0.608
MOD_GlcNHglycan	110	113	PF01048	0.694
MOD_GlcNHglycan	115	118	PF01048	0.706
MOD_GlcNHglycan	121	124	PF01048	0.687
MOD_GlcNHglycan	135	138	PF01048	0.445
MOD_GlcNHglycan	143	146	PF01048	0.758
MOD_GlcNHglycan	31	34	PF01048	0.413
MOD_GlcNHglycan	35	38	PF01048	0.388
MOD_GSK3_1	104	111	PF00069	0.487
MOD_GSK3_1	131	138	PF00069	0.716
MOD_GSK3_1	141	148	PF00069	0.683
MOD_GSK3_1	175	182	PF00069	0.490
MOD_GSK3_1	29	36	PF00069	0.374
MOD_GSK3_1	40	47	PF00069	0.353
MOD_GSK3_1	89	96	PF00069	0.555
MOD_NEK2_1	1	6	PF00069	0.610
MOD_NEK2_2	23	28	PF00069	0.408
MOD_PIKK_1	146	152	PF00454	0.696
MOD_PKA_2	33	39	PF00069	0.344
MOD_Plk_1	168	174	PF00069	0.567
MOD_Plk_1	179	185	PF00069	0.260
MOD_Plk_4	168	174	PF00069	0.467
MOD_Plk_4	179	185	PF00069	0.260
MOD_Plk_4	93	99	PF00069	0.583
MOD_ProDKin_1	154	160	PF00069	0.728
MOD_ProDKin_1	40	46	PF00069	0.444
MOD_SUMO_rev_2	114	122	PF00179	0.665
TRG_DiLeu_BaEn_1	180	185	PF01217	0.467
TRG_ENDOCYTIC_2	94	97	PF00928	0.542
TRG_NLS_MonoExtN_4	121	128	PF00514	0.653
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK74	Leptomonas seymouri	53%	100%
A0A1X0P9D1	Trypanosomatidae	32%	100%
A0A3Q8IKV6	Leishmania donovani	94%	100%
A0A422NGS4	Trypanosoma rangeli	32%	100%
A4I9S6	Leishmania infantum	93%	100%
C9ZMV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AI65	Leishmania braziliensis	75%	100%
E9B4T7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%