Cytospin-A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cytospin-A

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q387_LEIMA

TriTrypDb:

LmjF.34.1170 , LMJSD75_340019600

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q387

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q387

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.579
CLV_NRD_NRD_1	300	302	PF00675	0.545
CLV_NRD_NRD_1	359	361	PF00675	0.536
CLV_NRD_NRD_1	408	410	PF00675	0.512
CLV_PCSK_KEX2_1	300	302	PF00082	0.545
CLV_PCSK_KEX2_1	359	361	PF00082	0.581
CLV_PCSK_KEX2_1	416	418	PF00082	0.565
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.548
CLV_PCSK_SKI1_1	136	140	PF00082	0.618
CLV_PCSK_SKI1_1	208	212	PF00082	0.628
CLV_PCSK_SKI1_1	315	319	PF00082	0.500
CLV_PCSK_SKI1_1	394	398	PF00082	0.533
CLV_PCSK_SKI1_1	416	420	PF00082	0.580
CLV_PCSK_SKI1_1	592	596	PF00082	0.777
CLV_Separin_Metazoa	245	249	PF03568	0.449
DEG_APCC_DBOX_1	103	111	PF00400	0.519
DEG_Nend_UBRbox_3	1	3	PF02207	0.613
DEG_SCF_FBW7_1	1	7	PF00400	0.651
DEG_SCF_FBW7_2	476	483	PF00400	0.541
DOC_CKS1_1	1	6	PF01111	0.653
DOC_CKS1_1	522	527	PF01111	0.515
DOC_CYCLIN_yClb5_NLxxxL_5	120	128	PF00134	0.376
DOC_PP2B_LxvP_1	278	281	PF13499	0.618
DOC_PP4_FxxP_1	522	525	PF00568	0.611
DOC_USP7_MATH_1	149	153	PF00917	0.480
DOC_USP7_MATH_1	249	253	PF00917	0.514
DOC_USP7_MATH_1	4	8	PF00917	0.582
DOC_USP7_MATH_1	456	460	PF00917	0.680
DOC_USP7_MATH_1	461	465	PF00917	0.707
DOC_USP7_MATH_1	536	540	PF00917	0.657
DOC_USP7_MATH_1	624	628	PF00917	0.763
DOC_USP7_MATH_1	631	635	PF00917	0.775
DOC_WW_Pin1_4	476	481	PF00397	0.639
DOC_WW_Pin1_4	490	495	PF00397	0.592
DOC_WW_Pin1_4	521	526	PF00397	0.785
DOC_WW_Pin1_4	549	554	PF00397	0.719
DOC_WW_Pin1_4	563	568	PF00397	0.575
DOC_WW_Pin1_4	608	613	PF00397	0.507
LIG_14-3-3_CanoR_1	141	145	PF00244	0.521
LIG_14-3-3_CanoR_1	197	206	PF00244	0.604
LIG_14-3-3_CanoR_1	214	219	PF00244	0.458
LIG_14-3-3_CanoR_1	343	347	PF00244	0.634
LIG_14-3-3_CanoR_1	354	358	PF00244	0.529
LIG_14-3-3_CanoR_1	581	586	PF00244	0.571
LIG_14-3-3_CanoR_1	592	598	PF00244	0.598
LIG_14-3-3_CanoR_1	66	76	PF00244	0.471
LIG_Actin_WH2_2	121	138	PF00022	0.470
LIG_Actin_WH2_2	240	257	PF00022	0.532
LIG_CaM_IQ_9	184	199	PF13499	0.514
LIG_Clathr_ClatBox_1	45	49	PF01394	0.515
LIG_CSL_BTD_1	621	624	PF09270	0.541
LIG_FHA_1	123	129	PF00498	0.505
LIG_FHA_1	173	179	PF00498	0.526
LIG_FHA_1	3	9	PF00498	0.636
LIG_FHA_1	308	314	PF00498	0.606
LIG_FHA_1	393	399	PF00498	0.545
LIG_FHA_1	41	47	PF00498	0.535
LIG_FHA_1	569	575	PF00498	0.630
LIG_FHA_1	659	665	PF00498	0.442
LIG_FHA_2	111	117	PF00498	0.640
LIG_FHA_2	255	261	PF00498	0.408
LIG_FHA_2	330	336	PF00498	0.465
LIG_FHA_2	387	393	PF00498	0.639
LIG_FHA_2	45	51	PF00498	0.530
LIG_FHA_2	627	633	PF00498	0.778
LIG_FHA_2	79	85	PF00498	0.366
LIG_LIR_Apic_2	521	525	PF02991	0.523
LIG_LIR_Apic_2	552	557	PF02991	0.721
LIG_LIR_Apic_2	603	608	PF02991	0.607
LIG_LIR_Gen_1	486	495	PF02991	0.555
LIG_LIR_Gen_1	513	522	PF02991	0.682
LIG_LIR_Gen_1	84	93	PF02991	0.470
LIG_LIR_Nem_3	486	490	PF02991	0.566
LIG_LIR_Nem_3	513	518	PF02991	0.649
LIG_LIR_Nem_3	531	537	PF02991	0.493
LIG_LIR_Nem_3	84	89	PF02991	0.474
LIG_NRBOX	92	98	PF00104	0.517
LIG_PCNA_yPIPBox_3	354	365	PF02747	0.513
LIG_PCNA_yPIPBox_3	85	97	PF02747	0.454
LIG_SH2_CRK	487	491	PF00017	0.641
LIG_SH2_CRK	515	519	PF00017	0.754
LIG_SH2_CRK	534	538	PF00017	0.469
LIG_SH2_CRK	545	549	PF00017	0.596
LIG_SH2_CRK	554	558	PF00017	0.537
LIG_SH2_CRK	605	609	PF00017	0.725
LIG_SH2_GRB2like	24	27	PF00017	0.498
LIG_SH2_NCK_1	534	538	PF00017	0.516
LIG_SH2_SRC	534	537	PF00017	0.521
LIG_SH2_STAP1	24	28	PF00017	0.427
LIG_SH2_STAT5	570	573	PF00017	0.632
LIG_SH3_3	464	470	PF00018	0.645
LIG_SH3_3	499	505	PF00018	0.747
LIG_SH3_3	610	616	PF00018	0.757
LIG_SH3_3	636	642	PF00018	0.461
LIG_SH3_4	615	622	PF00018	0.635
LIG_SUMO_SIM_anti_2	314	320	PF11976	0.668
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.545
LIG_SUMO_SIM_par_1	174	181	PF11976	0.375
LIG_SUMO_SIM_par_1	395	401	PF11976	0.485
LIG_SUMO_SIM_par_1	41	50	PF11976	0.507
LIG_TRAF2_1	145	148	PF00917	0.462
LIG_TRAF2_1	180	183	PF00917	0.471
LIG_TRAF2_1	389	392	PF00917	0.507
LIG_TYR_ITIM	532	537	PF00017	0.523
LIG_UBA3_1	396	400	PF00899	0.547
MOD_CDK_SPK_2	563	568	PF00069	0.536
MOD_CDK_SPxxK_3	608	615	PF00069	0.517
MOD_CK1_1	13	19	PF00069	0.554
MOD_CK1_1	143	149	PF00069	0.617
MOD_CK1_1	311	317	PF00069	0.539
MOD_CK1_1	323	329	PF00069	0.637
MOD_CK1_1	454	460	PF00069	0.715
MOD_CK1_1	510	516	PF00069	0.638
MOD_CK1_1	576	582	PF00069	0.641
MOD_CK2_1	110	116	PF00069	0.543
MOD_CK2_1	149	155	PF00069	0.415
MOD_CK2_1	177	183	PF00069	0.563
MOD_CK2_1	197	203	PF00069	0.555
MOD_CK2_1	32	38	PF00069	0.510
MOD_CK2_1	329	335	PF00069	0.586
MOD_CK2_1	363	369	PF00069	0.617
MOD_CK2_1	386	392	PF00069	0.514
MOD_CK2_1	454	460	PF00069	0.666
MOD_CK2_1	624	630	PF00069	0.633
MOD_CK2_1	89	95	PF00069	0.497
MOD_GlcNHglycan	152	155	PF01048	0.596
MOD_GlcNHglycan	199	202	PF01048	0.491
MOD_GlcNHglycan	208	211	PF01048	0.482
MOD_GlcNHglycan	267	270	PF01048	0.567
MOD_GlcNHglycan	447	450	PF01048	0.728
MOD_GlcNHglycan	455	459	PF01048	0.778
MOD_GlcNHglycan	476	479	PF01048	0.778
MOD_GlcNHglycan	578	581	PF01048	0.696
MOD_GlcNHglycan	626	629	PF01048	0.727
MOD_GSK3_1	10	17	PF00069	0.510
MOD_GSK3_1	136	143	PF00069	0.534
MOD_GSK3_1	178	185	PF00069	0.438
MOD_GSK3_1	307	314	PF00069	0.652
MOD_GSK3_1	40	47	PF00069	0.581
MOD_GSK3_1	450	457	PF00069	0.632
MOD_GSK3_1	507	514	PF00069	0.636
MOD_GSK3_1	576	583	PF00069	0.686
MOD_N-GLC_1	122	127	PF02516	0.606
MOD_N-GLC_1	308	313	PF02516	0.623
MOD_N-GLC_1	350	355	PF02516	0.382
MOD_N-GLC_1	392	397	PF02516	0.576
MOD_N-GLC_1	421	426	PF02516	0.470
MOD_N-GLC_1	445	450	PF02516	0.695
MOD_N-GLC_1	511	516	PF02516	0.635
MOD_N-GLC_1	54	59	PF02516	0.479
MOD_N-GLC_1	576	581	PF02516	0.538
MOD_N-GLC_1	89	94	PF02516	0.590
MOD_NEK2_1	110	115	PF00069	0.590
MOD_NEK2_1	177	182	PF00069	0.516
MOD_NEK2_1	254	259	PF00069	0.480
MOD_NEK2_1	40	45	PF00069	0.529
MOD_NEK2_1	445	450	PF00069	0.551
MOD_NEK2_1	474	479	PF00069	0.570
MOD_NEK2_1	489	494	PF00069	0.560
MOD_NEK2_1	511	516	PF00069	0.720
MOD_NEK2_1	78	83	PF00069	0.527
MOD_PIKK_1	136	142	PF00454	0.511
MOD_PIKK_1	161	167	PF00454	0.580
MOD_PIKK_1	17	23	PF00454	0.501
MOD_PIKK_1	178	184	PF00454	0.444
MOD_PIKK_1	249	255	PF00454	0.655
MOD_PIKK_1	270	276	PF00454	0.612
MOD_PIKK_1	320	326	PF00454	0.489
MOD_PIKK_1	536	542	PF00454	0.612
MOD_PIKK_1	95	101	PF00454	0.513
MOD_PK_1	633	639	PF00069	0.446
MOD_PKA_1	150	156	PF00069	0.475
MOD_PKA_2	10	16	PF00069	0.441
MOD_PKA_2	140	146	PF00069	0.528
MOD_PKA_2	226	232	PF00069	0.593
MOD_PKA_2	254	260	PF00069	0.421
MOD_PKA_2	342	348	PF00069	0.604
MOD_PKA_2	353	359	PF00069	0.540
MOD_PKA_2	483	489	PF00069	0.742
MOD_PKA_2	580	586	PF00069	0.665
MOD_PKA_2	624	630	PF00069	0.731
MOD_PKA_2	79	85	PF00069	0.543
MOD_PKB_1	159	167	PF00069	0.388
MOD_Plk_1	14	20	PF00069	0.504
MOD_Plk_1	249	255	PF00069	0.526
MOD_Plk_1	308	314	PF00069	0.480
MOD_Plk_1	386	392	PF00069	0.554
MOD_Plk_1	421	427	PF00069	0.502
MOD_Plk_1	511	517	PF00069	0.634
MOD_Plk_1	54	60	PF00069	0.481
MOD_Plk_1	89	95	PF00069	0.519
MOD_Plk_2-3	32	38	PF00069	0.500
MOD_Plk_2-3	401	407	PF00069	0.514
MOD_Plk_4	14	20	PF00069	0.472
MOD_Plk_4	172	178	PF00069	0.374
MOD_Plk_4	308	314	PF00069	0.491
MOD_Plk_4	342	348	PF00069	0.575
MOD_Plk_4	4	10	PF00069	0.612
MOD_Plk_4	421	427	PF00069	0.471
MOD_ProDKin_1	476	482	PF00069	0.639
MOD_ProDKin_1	490	496	PF00069	0.592
MOD_ProDKin_1	521	527	PF00069	0.785
MOD_ProDKin_1	549	555	PF00069	0.723
MOD_ProDKin_1	563	569	PF00069	0.574
MOD_ProDKin_1	608	614	PF00069	0.513
MOD_SUMO_for_1	169	172	PF00179	0.434
MOD_SUMO_for_1	242	245	PF00179	0.430
MOD_SUMO_for_1	29	32	PF00179	0.526
MOD_SUMO_for_1	418	421	PF00179	0.526
MOD_SUMO_for_1	497	500	PF00179	0.617
MOD_SUMO_for_1	58	61	PF00179	0.485
MOD_SUMO_rev_2	106	113	PF00179	0.555
MOD_SUMO_rev_2	122	131	PF00179	0.476
MOD_SUMO_rev_2	143	152	PF00179	0.476
MOD_SUMO_rev_2	403	411	PF00179	0.481
MOD_SUMO_rev_2	412	418	PF00179	0.452
TRG_DiLeu_BaEn_1	172	177	PF01217	0.373
TRG_DiLeu_BaEn_1	335	340	PF01217	0.568
TRG_DiLeu_BaEn_1	392	397	PF01217	0.543
TRG_DiLeu_BaEn_1	41	46	PF01217	0.519
TRG_DiLeu_BaEn_1	421	426	PF01217	0.470
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.369
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.427
TRG_ENDOCYTIC_2	487	490	PF00928	0.619
TRG_ENDOCYTIC_2	515	518	PF00928	0.754
TRG_ENDOCYTIC_2	534	537	PF00928	0.475
TRG_ER_diArg_1	300	303	PF00400	0.549
TRG_ER_diArg_1	359	361	PF00400	0.615
TRG_NES_CRM1_1	235	250	PF08389	0.461
TRG_NES_CRM1_1	56	71	PF08389	0.508
TRG_NLS_MonoExtC_3	415	421	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H0	Leptomonas seymouri	45%	100%
A0A1X0P9M9	Trypanosomatidae	25%	100%
A0A3S7X7R3	Leishmania donovani	87%	100%
A4HAN5	Leishmania braziliensis	57%	100%
A4I9S8	Leishmania infantum	87%	100%
E9B4T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5B3B6	Trypanosoma cruzi	27%	100%