Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q385_LEIMA

TriTrypDb:

LmjF.34.1180 , LMJLV39_340019800 , LMJSD75_340019800

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q385

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q385

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	191	193	PF00675	0.647
CLV_NRD_NRD_1	475	477	PF00675	0.571
CLV_NRD_NRD_1	51	53	PF00675	0.591
CLV_NRD_NRD_1	60	62	PF00675	0.482
CLV_PCSK_KEX2_1	18	20	PF00082	0.661
CLV_PCSK_KEX2_1	191	193	PF00082	0.625
CLV_PCSK_KEX2_1	272	274	PF00082	0.723
CLV_PCSK_KEX2_1	339	341	PF00082	0.613
CLV_PCSK_KEX2_1	475	477	PF00082	0.571
CLV_PCSK_KEX2_1	51	53	PF00082	0.591
CLV_PCSK_KEX2_1	60	62	PF00082	0.482
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.661
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.723
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.613
CLV_PCSK_SKI1_1	483	487	PF00082	0.607
CLV_PCSK_SKI1_1	52	56	PF00082	0.613
CLV_PCSK_SKI1_1	575	579	PF00082	0.489
CLV_PCSK_SKI1_1	60	64	PF00082	0.518
DEG_SCF_FBW7_1	139	145	PF00400	0.656
DEG_SCF_FBW7_1	230	237	PF00400	0.534
DEG_SCF_FBW7_2	378	385	PF00400	0.501
DOC_CKS1_1	139	144	PF01111	0.658
DOC_CKS1_1	231	236	PF01111	0.533
DOC_CKS1_1	345	350	PF01111	0.695
DOC_CKS1_1	379	384	PF01111	0.511
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.615
DOC_MAPK_gen_1	207	217	PF00069	0.571
DOC_MAPK_HePTP_8	154	166	PF00069	0.513
DOC_MAPK_MEF2A_6	157	166	PF00069	0.510
DOC_MAPK_MEF2A_6	210	217	PF00069	0.552
DOC_MAPK_MEF2A_6	413	422	PF00069	0.452
DOC_MAPK_MEF2A_6	452	460	PF00069	0.606
DOC_MAPK_MEF2A_6	514	522	PF00069	0.572
DOC_PP4_FxxP_1	150	153	PF00568	0.532
DOC_PP4_FxxP_1	376	379	PF00568	0.534
DOC_USP7_MATH_1	168	172	PF00917	0.577
DOC_USP7_MATH_1	201	205	PF00917	0.675
DOC_USP7_MATH_1	241	245	PF00917	0.608
DOC_USP7_MATH_1	288	292	PF00917	0.533
DOC_USP7_MATH_1	323	327	PF00917	0.562
DOC_USP7_MATH_1	346	350	PF00917	0.664
DOC_USP7_MATH_1	392	396	PF00917	0.615
DOC_USP7_MATH_1	40	44	PF00917	0.632
DOC_USP7_MATH_1	444	448	PF00917	0.521
DOC_USP7_MATH_1	523	527	PF00917	0.570
DOC_USP7_MATH_1	565	569	PF00917	0.592
DOC_USP7_MATH_1	73	77	PF00917	0.656
DOC_USP7_MATH_1	81	85	PF00917	0.770
DOC_USP7_MATH_1	92	96	PF00917	0.518
DOC_WW_Pin1_4	135	140	PF00397	0.653
DOC_WW_Pin1_4	142	147	PF00397	0.652
DOC_WW_Pin1_4	149	154	PF00397	0.631
DOC_WW_Pin1_4	230	235	PF00397	0.553
DOC_WW_Pin1_4	254	259	PF00397	0.583
DOC_WW_Pin1_4	340	345	PF00397	0.753
DOC_WW_Pin1_4	378	383	PF00397	0.516
DOC_WW_Pin1_4	452	457	PF00397	0.542
DOC_WW_Pin1_4	474	479	PF00397	0.529
LIG_14-3-3_CanoR_1	176	180	PF00244	0.572
LIG_14-3-3_CanoR_1	191	195	PF00244	0.532
LIG_14-3-3_CanoR_1	314	319	PF00244	0.569
LIG_14-3-3_CanoR_1	553	557	PF00244	0.517
LIG_14-3-3_CanoR_1	66	72	PF00244	0.674
LIG_14-3-3_CanoR_1	7	16	PF00244	0.611
LIG_BIR_III_2	341	345	PF00653	0.636
LIG_BRCT_BRCA1_1	354	358	PF00533	0.533
LIG_CaM_IQ_9	53	68	PF13499	0.585
LIG_deltaCOP1_diTrp_1	361	372	PF00928	0.600
LIG_eIF4E_1	182	188	PF01652	0.641
LIG_FHA_1	235	241	PF00498	0.580
LIG_FHA_1	315	321	PF00498	0.593
LIG_FHA_1	366	372	PF00498	0.553
LIG_FHA_1	535	541	PF00498	0.412
LIG_FHA_2	306	312	PF00498	0.656
LIG_FHA_2	556	562	PF00498	0.490
LIG_FHA_2	581	587	PF00498	0.481
LIG_GSK3_LRP6_1	142	147	PF00069	0.626
LIG_LIR_Apic_2	331	336	PF02991	0.577
LIG_LIR_Gen_1	414	424	PF02991	0.457
LIG_LIR_LC3C_4	537	541	PF02991	0.451
LIG_LIR_Nem_3	369	375	PF02991	0.703
LIG_LIR_Nem_3	414	420	PF02991	0.491
LIG_NRBOX	583	589	PF00104	0.526
LIG_Pex14_2	372	376	PF04695	0.593
LIG_PTAP_UEV_1	202	207	PF05743	0.536
LIG_Rb_LxCxE_1	43	59	PF01857	0.499
LIG_SH2_CRK	322	326	PF00017	0.543
LIG_SH2_NCK_1	322	326	PF00017	0.546
LIG_SH2_SRC	106	109	PF00017	0.569
LIG_SH2_STAT5	488	491	PF00017	0.376
LIG_SH3_1	136	142	PF00018	0.667
LIG_SH3_3	136	142	PF00018	0.631
LIG_SH3_3	197	203	PF00018	0.586
LIG_SH3_3	23	29	PF00018	0.625
LIG_SH3_3	368	374	PF00018	0.555
LIG_SH3_3	376	382	PF00018	0.530
LIG_SUMO_SIM_anti_2	537	542	PF11976	0.453
LIG_SUMO_SIM_par_1	152	158	PF11976	0.461
LIG_TRAF2_1	274	277	PF00917	0.668
LIG_TRAF2_1	470	473	PF00917	0.525
LIG_TRFH_1	254	258	PF08558	0.654
LIG_TYR_ITIM	180	185	PF00017	0.482
LIG_TYR_ITIM	320	325	PF00017	0.547
LIG_WRC_WIRS_1	419	424	PF05994	0.427
MOD_CDK_SPK_2	135	140	PF00069	0.648
MOD_CK1_1	10	16	PF00069	0.626
MOD_CK1_1	138	144	PF00069	0.668
MOD_CK1_1	169	175	PF00069	0.538
MOD_CK1_1	239	245	PF00069	0.634
MOD_CK1_1	249	255	PF00069	0.584
MOD_CK1_1	290	296	PF00069	0.707
MOD_CK1_1	307	313	PF00069	0.473
MOD_CK1_1	349	355	PF00069	0.657
MOD_CK1_1	399	405	PF00069	0.609
MOD_CK1_1	434	440	PF00069	0.542
MOD_CK1_1	555	561	PF00069	0.571
MOD_CK1_1	564	570	PF00069	0.659
MOD_CK2_1	190	196	PF00069	0.619
MOD_CK2_1	305	311	PF00069	0.647
MOD_CK2_1	392	398	PF00069	0.566
MOD_CK2_1	555	561	PF00069	0.485
MOD_Cter_Amidation	337	340	PF01082	0.601
MOD_DYRK1A_RPxSP_1	452	456	PF00069	0.548
MOD_GlcNHglycan	168	171	PF01048	0.564
MOD_GlcNHglycan	172	175	PF01048	0.519
MOD_GlcNHglycan	203	206	PF01048	0.606
MOD_GlcNHglycan	241	244	PF01048	0.686
MOD_GlcNHglycan	246	252	PF01048	0.594
MOD_GlcNHglycan	258	261	PF01048	0.493
MOD_GlcNHglycan	290	293	PF01048	0.701
MOD_GlcNHglycan	33	36	PF01048	0.661
MOD_GlcNHglycan	361	366	PF01048	0.626
MOD_GlcNHglycan	394	397	PF01048	0.661
MOD_GlcNHglycan	398	401	PF01048	0.623
MOD_GlcNHglycan	414	417	PF01048	0.426
MOD_GlcNHglycan	433	436	PF01048	0.327
MOD_GlcNHglycan	483	486	PF01048	0.570
MOD_GlcNHglycan	563	566	PF01048	0.615
MOD_GlcNHglycan	579	583	PF01048	0.487
MOD_GlcNHglycan	75	78	PF01048	0.770
MOD_GlcNHglycan	83	86	PF01048	0.615
MOD_GlcNHglycan	92	95	PF01048	0.486
MOD_GSK3_1	138	145	PF00069	0.718
MOD_GSK3_1	162	169	PF00069	0.524
MOD_GSK3_1	230	237	PF00069	0.645
MOD_GSK3_1	340	347	PF00069	0.667
MOD_GSK3_1	361	368	PF00069	0.592
MOD_GSK3_1	374	381	PF00069	0.487
MOD_GSK3_1	392	399	PF00069	0.711
MOD_GSK3_1	403	410	PF00069	0.619
MOD_GSK3_1	452	459	PF00069	0.579
MOD_GSK3_1	551	558	PF00069	0.529
MOD_GSK3_1	561	568	PF00069	0.744
MOD_N-GLC_1	392	397	PF02516	0.594
MOD_NEK2_1	155	160	PF00069	0.502
MOD_NEK2_1	162	167	PF00069	0.511
MOD_NEK2_1	265	270	PF00069	0.638
MOD_NEK2_1	411	416	PF00069	0.509
MOD_NEK2_1	418	423	PF00069	0.458
MOD_NEK2_1	458	463	PF00069	0.717
MOD_NEK2_1	551	556	PF00069	0.529
MOD_NEK2_1	578	583	PF00069	0.542
MOD_NEK2_2	190	195	PF00069	0.620
MOD_PIKK_1	434	440	PF00454	0.616
MOD_PKA_2	175	181	PF00069	0.564
MOD_PKA_2	190	196	PF00069	0.525
MOD_PKA_2	304	310	PF00069	0.545
MOD_PKA_2	552	558	PF00069	0.483
MOD_PKA_2	65	71	PF00069	0.670
MOD_Plk_1	127	133	PF00069	0.663
MOD_Plk_1	361	367	PF00069	0.604
MOD_Plk_1	5	11	PF00069	0.541
MOD_Plk_4	130	136	PF00069	0.674
MOD_Plk_4	213	219	PF00069	0.688
MOD_Plk_4	249	255	PF00069	0.654
MOD_Plk_4	354	360	PF00069	0.647
MOD_Plk_4	407	413	PF00069	0.557
MOD_Plk_4	418	424	PF00069	0.480
MOD_Plk_4	523	529	PF00069	0.564
MOD_Plk_4	534	540	PF00069	0.368
MOD_Plk_4	92	98	PF00069	0.627
MOD_ProDKin_1	135	141	PF00069	0.651
MOD_ProDKin_1	142	148	PF00069	0.648
MOD_ProDKin_1	149	155	PF00069	0.624
MOD_ProDKin_1	230	236	PF00069	0.556
MOD_ProDKin_1	254	260	PF00069	0.586
MOD_ProDKin_1	340	346	PF00069	0.752
MOD_ProDKin_1	378	384	PF00069	0.517
MOD_ProDKin_1	452	458	PF00069	0.539
MOD_ProDKin_1	474	480	PF00069	0.521
MOD_SUMO_rev_2	193	200	PF00179	0.624
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.617
TRG_ENDOCYTIC_2	182	185	PF00928	0.532
TRG_ENDOCYTIC_2	322	325	PF00928	0.545
TRG_ER_diArg_1	190	192	PF00400	0.613
TRG_ER_diArg_1	474	476	PF00400	0.550
TRG_ER_diArg_1	60	62	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6C8	Leptomonas seymouri	33%	89%
A0A3Q8IE95	Leishmania donovani	88%	100%
A4HAN7	Leishmania braziliensis	60%	91%
A4I9T0	Leishmania infantum	88%	100%
E9B4U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	90%