Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q382_LEIMA

TriTrypDb:

LmjF.34.1210 , LMJLV39_340020100 , LMJSD75_340020100

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q382

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q382

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.452
CLV_MEL_PAP_1	61	67	PF00089	0.462
CLV_NRD_NRD_1	102	104	PF00675	0.400
CLV_NRD_NRD_1	292	294	PF00675	0.375
CLV_NRD_NRD_1	325	327	PF00675	0.463
CLV_NRD_NRD_1	33	35	PF00675	0.608
CLV_NRD_NRD_1	460	462	PF00675	0.432
CLV_NRD_NRD_1	87	89	PF00675	0.535
CLV_PCSK_KEX2_1	213	215	PF00082	0.519
CLV_PCSK_KEX2_1	292	294	PF00082	0.375
CLV_PCSK_KEX2_1	325	327	PF00082	0.463
CLV_PCSK_KEX2_1	33	35	PF00082	0.496
CLV_PCSK_KEX2_1	387	389	PF00082	0.424
CLV_PCSK_KEX2_1	460	462	PF00082	0.432
CLV_PCSK_KEX2_1	87	89	PF00082	0.471
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.519
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.392
CLV_PCSK_PC7_1	383	389	PF00082	0.510
CLV_PCSK_SKI1_1	103	107	PF00082	0.501
CLV_PCSK_SKI1_1	296	300	PF00082	0.425
CLV_PCSK_SKI1_1	339	343	PF00082	0.495
CLV_PCSK_SKI1_1	406	410	PF00082	0.562
CLV_PCSK_SKI1_1	5	9	PF00082	0.682
DEG_SPOP_SBC_1	302	306	PF00917	0.596
DOC_CYCLIN_yClb5_NLxxxL_5	219	226	PF00134	0.480
DOC_MAPK_gen_1	292	299	PF00069	0.378
DOC_MAPK_HePTP_8	322	338	PF00069	0.493
DOC_MAPK_HePTP_8	61	73	PF00069	0.559
DOC_MAPK_MEF2A_6	41	48	PF00069	0.432
DOC_MAPK_MEF2A_6	64	73	PF00069	0.562
DOC_PP2B_LxvP_1	240	243	PF13499	0.541
DOC_PP2B_LxvP_1	246	249	PF13499	0.550
DOC_PP2B_LxvP_1	40	43	PF13499	0.398
DOC_PP2B_PxIxI_1	16	22	PF00149	0.538
DOC_USP7_MATH_1	249	253	PF00917	0.648
DOC_USP7_MATH_1	254	258	PF00917	0.679
DOC_USP7_MATH_1	261	265	PF00917	0.713
DOC_USP7_MATH_1	274	278	PF00917	0.752
DOC_USP7_MATH_1	411	415	PF00917	0.585
DOC_USP7_MATH_1	433	437	PF00917	0.776
DOC_WW_Pin1_4	154	159	PF00397	0.616
DOC_WW_Pin1_4	275	280	PF00397	0.566
DOC_WW_Pin1_4	429	434	PF00397	0.818
DOC_WW_Pin1_4	442	447	PF00397	0.576
LIG_14-3-3_CanoR_1	130	138	PF00244	0.478
LIG_14-3-3_CanoR_1	169	175	PF00244	0.696
LIG_14-3-3_CanoR_1	23	31	PF00244	0.688
LIG_14-3-3_CanoR_1	235	241	PF00244	0.566
LIG_14-3-3_CanoR_1	388	395	PF00244	0.370
LIG_14-3-3_CanoR_1	64	68	PF00244	0.524
LIG_BIR_II_1	1	5	PF00653	0.499
LIG_eIF4E_1	402	408	PF01652	0.477
LIG_FHA_1	16	22	PF00498	0.657
LIG_FHA_1	23	29	PF00498	0.651
LIG_FHA_1	419	425	PF00498	0.681
LIG_FHA_1	447	453	PF00498	0.554
LIG_FHA_1	56	62	PF00498	0.510
LIG_FHA_2	202	208	PF00498	0.487
LIG_FHA_2	265	271	PF00498	0.760
LIG_FHA_2	346	352	PF00498	0.567
LIG_FHA_2	369	375	PF00498	0.519
LIG_FHA_2	6	12	PF00498	0.484
LIG_LIR_Gen_1	390	398	PF02991	0.531
LIG_LIR_Nem_3	329	334	PF02991	0.496
LIG_LIR_Nem_3	390	395	PF02991	0.386
LIG_SH2_GRB2like	402	405	PF00017	0.346
LIG_SH2_SRC	402	405	PF00017	0.346
LIG_SH2_STAP1	139	143	PF00017	0.657
LIG_SH2_STAT5	49	52	PF00017	0.463
LIG_SH3_2	29	34	PF14604	0.565
LIG_SH3_3	26	32	PF00018	0.621
LIG_SH3_3	414	420	PF00018	0.608
LIG_SUMO_SIM_anti_2	333	338	PF11976	0.489
LIG_SUMO_SIM_par_1	17	22	PF11976	0.649
LIG_SUMO_SIM_par_1	277	283	PF11976	0.496
LIG_TRAF2_1	208	211	PF00917	0.514
LIG_TRAF2_1	98	101	PF00917	0.588
MOD_CDK_SPK_2	442	447	PF00069	0.611
MOD_CK1_1	12	18	PF00069	0.578
MOD_CK1_1	184	190	PF00069	0.641
MOD_CK1_1	252	258	PF00069	0.644
MOD_CK1_1	264	270	PF00069	0.578
MOD_CK1_1	304	310	PF00069	0.684
MOD_CK1_1	315	321	PF00069	0.531
MOD_CK2_1	201	207	PF00069	0.491
MOD_CK2_1	264	270	PF00069	0.614
MOD_CK2_1	311	317	PF00069	0.605
MOD_CK2_1	368	374	PF00069	0.524
MOD_GlcNHglycan	11	14	PF01048	0.543
MOD_GlcNHglycan	131	134	PF01048	0.520
MOD_GlcNHglycan	194	197	PF01048	0.490
MOD_GlcNHglycan	246	249	PF01048	0.623
MOD_GlcNHglycan	254	257	PF01048	0.657
MOD_GlcNHglycan	270	273	PF01048	0.503
MOD_GlcNHglycan	282	285	PF01048	0.578
MOD_GlcNHglycan	306	309	PF01048	0.659
MOD_GlcNHglycan	314	317	PF01048	0.562
MOD_GlcNHglycan	389	392	PF01048	0.397
MOD_GlcNHglycan	455	458	PF01048	0.453
MOD_GlcNHglycan	94	97	PF01048	0.449
MOD_GSK3_1	148	155	PF00069	0.666
MOD_GSK3_1	181	188	PF00069	0.629
MOD_GSK3_1	244	251	PF00069	0.642
MOD_GSK3_1	264	271	PF00069	0.448
MOD_GSK3_1	302	309	PF00069	0.690
MOD_GSK3_1	311	318	PF00069	0.610
MOD_GSK3_1	425	432	PF00069	0.773
MOD_GSK3_1	442	449	PF00069	0.665
MOD_GSK3_1	5	12	PF00069	0.559
MOD_LATS_1	423	429	PF00433	0.547
MOD_N-GLC_1	268	273	PF02516	0.659
MOD_NEK2_1	453	458	PF00069	0.457
MOD_NEK2_2	63	68	PF00069	0.451
MOD_PIKK_1	190	196	PF00454	0.528
MOD_PKA_1	387	393	PF00069	0.319
MOD_PKA_2	129	135	PF00069	0.471
MOD_PKA_2	15	21	PF00069	0.632
MOD_PKA_2	22	28	PF00069	0.593
MOD_PKA_2	387	393	PF00069	0.319
MOD_PKA_2	453	459	PF00069	0.460
MOD_PKA_2	63	69	PF00069	0.450
MOD_Plk_1	145	151	PF00069	0.621
MOD_Plk_1	316	322	PF00069	0.588
MOD_Plk_2-3	345	351	PF00069	0.622
MOD_Plk_2-3	374	380	PF00069	0.481
MOD_Plk_4	15	21	PF00069	0.649
MOD_Plk_4	236	242	PF00069	0.517
MOD_ProDKin_1	154	160	PF00069	0.618
MOD_ProDKin_1	275	281	PF00069	0.553
MOD_ProDKin_1	429	435	PF00069	0.820
MOD_ProDKin_1	442	448	PF00069	0.560
MOD_SUMO_for_1	202	205	PF00179	0.440
MOD_SUMO_rev_2	205	215	PF00179	0.520
TRG_ER_diArg_1	292	294	PF00400	0.375
TRG_ER_diArg_1	32	34	PF00400	0.522
TRG_ER_diArg_1	324	326	PF00400	0.460
TRG_ER_diArg_1	459	461	PF00400	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY58	Leptomonas seymouri	47%	85%
A0A3Q8II15	Leishmania donovani	89%	100%
A0A422MPI6	Trypanosoma rangeli	24%	100%
A4HBJ3	Leishmania braziliensis	64%	85%
A4I9T3	Leishmania infantum	90%	100%
C9ZMU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9B4U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	84%
V5BIT8	Trypanosoma cruzi	25%	100%