Inositol 5-phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol 5-phosphatase-like protein

Species:

Leishmania major

UniProt:

Q4Q381_LEIMA

TriTrypDb:

LmjF.34.1220 , LMJLV39_340020200 , LMJSD75_340020200

Length:

764

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q381

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q381

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0006066	alcohol metabolic process	3	2
GO:0006629	lipid metabolic process	3	8
GO:0006644	phospholipid metabolic process	4	8
GO:0006650	glycerophospholipid metabolic process	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	8
GO:0016311	dephosphorylation	5	8
GO:0019637	organophosphate metabolic process	3	8
GO:0019751	polyol metabolic process	4	2
GO:0030258	lipid modification	4	8
GO:0043647	inositol phosphate metabolic process	4	2
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044255	cellular lipid metabolic process	3	8
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046164	alcohol catabolic process	4	2
GO:0046174	polyol catabolic process	5	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046486	glycerolipid metabolic process	4	8
GO:0046488	phosphatidylinositol metabolic process	6	8
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	2
GO:0046839	phospholipid dephosphorylation	5	8
GO:0046855	obsolete inositol phosphate dephosphorylation	5	2
GO:0046856	phosphatidylinositol dephosphorylation	6	8
GO:0071545	inositol phosphate catabolic process	5	2
GO:0071704	organic substance metabolic process	2	8
GO:1901575	organic substance catabolic process	3	2
GO:1901615	organic hydroxy compound metabolic process	3	2
GO:1901616	organic hydroxy compound catabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	8	2
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	7	2
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	7	2
GO:0042578	phosphoric ester hydrolase activity	4	8
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	2
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	8	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.395
CLV_NRD_NRD_1	121	123	PF00675	0.656
CLV_NRD_NRD_1	210	212	PF00675	0.808
CLV_NRD_NRD_1	378	380	PF00675	0.632
CLV_NRD_NRD_1	532	534	PF00675	0.630
CLV_NRD_NRD_1	535	537	PF00675	0.600
CLV_NRD_NRD_1	59	61	PF00675	0.751
CLV_NRD_NRD_1	689	691	PF00675	0.642
CLV_NRD_NRD_1	81	83	PF00675	0.692
CLV_PCSK_FUR_1	533	537	PF00082	0.602
CLV_PCSK_KEX2_1	120	122	PF00082	0.657
CLV_PCSK_KEX2_1	180	182	PF00082	0.618
CLV_PCSK_KEX2_1	227	229	PF00082	0.774
CLV_PCSK_KEX2_1	360	362	PF00082	0.525
CLV_PCSK_KEX2_1	377	379	PF00082	0.609
CLV_PCSK_KEX2_1	44	46	PF00082	0.669
CLV_PCSK_KEX2_1	534	536	PF00082	0.606
CLV_PCSK_KEX2_1	61	63	PF00082	0.695
CLV_PCSK_KEX2_1	679	681	PF00082	0.768
CLV_PCSK_KEX2_1	689	691	PF00082	0.595
CLV_PCSK_KEX2_1	81	83	PF00082	0.509
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.724
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.618
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.765
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.525
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.600
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.669
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.606
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.695
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.622
CLV_PCSK_SKI1_1	360	364	PF00082	0.516
CLV_PCSK_SKI1_1	412	416	PF00082	0.742
CLV_PCSK_SKI1_1	44	48	PF00082	0.729
CLV_PCSK_SKI1_1	543	547	PF00082	0.521
CLV_PCSK_SKI1_1	605	609	PF00082	0.645
CLV_PCSK_SKI1_1	635	639	PF00082	0.649
CLV_PCSK_SKI1_1	692	696	PF00082	0.792
CLV_PCSK_SKI1_1	70	74	PF00082	0.720
CLV_PCSK_SKI1_1	754	758	PF00082	0.653
CLV_PCSK_SKI1_1	85	89	PF00082	0.615
DEG_APCC_DBOX_1	129	137	PF00400	0.472
DEG_APCC_DBOX_1	634	642	PF00400	0.448
DEG_Kelch_Keap1_1	697	702	PF01344	0.558
DEG_Nend_UBRbox_3	1	3	PF02207	0.774
DEG_SPOP_SBC_1	620	624	PF00917	0.598
DOC_CYCLIN_RxL_1	632	640	PF00134	0.447
DOC_CYCLIN_RxL_1	689	699	PF00134	0.555
DOC_CYCLIN_RxL_1	81	92	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.443
DOC_MAPK_gen_1	305	312	PF00069	0.333
DOC_MAPK_gen_1	44	53	PF00069	0.508
DOC_MAPK_gen_1	734	744	PF00069	0.393
DOC_MAPK_gen_1	81	90	PF00069	0.541
DOC_MAPK_HePTP_8	345	357	PF00069	0.432
DOC_MAPK_MEF2A_6	25	33	PF00069	0.413
DOC_MAPK_MEF2A_6	348	357	PF00069	0.404
DOC_MAPK_MEF2A_6	44	53	PF00069	0.533
DOC_MAPK_MEF2A_6	81	90	PF00069	0.506
DOC_MIT_MIM_1	465	473	PF04212	0.355
DOC_PP1_RVXF_1	386	393	PF00149	0.366
DOC_PP1_RVXF_1	541	547	PF00149	0.319
DOC_PP2B_LxvP_1	141	144	PF13499	0.426
DOC_PP2B_LxvP_1	584	587	PF13499	0.445
DOC_PP2B_LxvP_1	704	707	PF13499	0.589
DOC_PP4_FxxP_1	392	395	PF00568	0.385
DOC_PP4_FxxP_1	573	576	PF00568	0.602
DOC_PP4_FxxP_1	659	662	PF00568	0.596
DOC_SPAK_OSR1_1	739	743	PF12202	0.399
DOC_USP7_MATH_1	213	217	PF00917	0.490
DOC_USP7_MATH_1	295	299	PF00917	0.427
DOC_USP7_MATH_1	567	571	PF00917	0.610
DOC_USP7_MATH_1	587	591	PF00917	0.555
DOC_USP7_MATH_1	620	624	PF00917	0.574
DOC_USP7_MATH_1	65	69	PF00917	0.536
DOC_USP7_MATH_1	750	754	PF00917	0.453
DOC_USP7_UBL2_3	116	120	PF12436	0.391
DOC_USP7_UBL2_3	373	377	PF12436	0.465
DOC_WW_Pin1_4	105	110	PF00397	0.532
DOC_WW_Pin1_4	222	227	PF00397	0.525
DOC_WW_Pin1_4	472	477	PF00397	0.477
DOC_WW_Pin1_4	53	58	PF00397	0.528
DOC_WW_Pin1_4	563	568	PF00397	0.629
LIG_14-3-3_CanoR_1	128	137	PF00244	0.470
LIG_14-3-3_CanoR_1	228	236	PF00244	0.430
LIG_14-3-3_CanoR_1	333	337	PF00244	0.343
LIG_14-3-3_CanoR_1	432	437	PF00244	0.543
LIG_14-3-3_CanoR_1	442	446	PF00244	0.516
LIG_14-3-3_CanoR_1	616	625	PF00244	0.560
LIG_14-3-3_CanoR_1	729	736	PF00244	0.338
LIG_AP2alpha_1	257	261	PF02296	0.362
LIG_BRCT_BRCA1_1	365	369	PF00533	0.364
LIG_BRCT_BRCA1_1	569	573	PF00533	0.626
LIG_Clathr_ClatBox_1	87	91	PF01394	0.506
LIG_deltaCOP1_diTrp_1	247	257	PF00928	0.406
LIG_deltaCOP1_diTrp_1	511	516	PF00928	0.404
LIG_deltaCOP1_diTrp_1	537	546	PF00928	0.317
LIG_eIF4E_1	358	364	PF01652	0.330
LIG_FHA_1	149	155	PF00498	0.316
LIG_FHA_1	174	180	PF00498	0.399
LIG_FHA_1	337	343	PF00498	0.445
LIG_FHA_1	449	455	PF00498	0.381
LIG_FHA_1	590	596	PF00498	0.530
LIG_FHA_1	670	676	PF00498	0.527
LIG_FHA_1	712	718	PF00498	0.454
LIG_FHA_2	227	233	PF00498	0.540
LIG_FHA_2	445	451	PF00498	0.463
LIG_FHA_2	555	561	PF00498	0.587
LIG_FHA_2	624	630	PF00498	0.593
LIG_HCF-1_HBM_1	456	459	PF13415	0.395
LIG_LIR_Apic_2	389	395	PF02991	0.372
LIG_LIR_Apic_2	570	576	PF02991	0.613
LIG_LIR_Apic_2	656	662	PF02991	0.574
LIG_LIR_Gen_1	247	258	PF02991	0.433
LIG_LIR_Gen_1	428	436	PF02991	0.509
LIG_LIR_Gen_1	456	466	PF02991	0.319
LIG_LIR_Gen_1	486	491	PF02991	0.356
LIG_LIR_Gen_1	511	520	PF02991	0.397
LIG_LIR_Gen_1	593	602	PF02991	0.544
LIG_LIR_Gen_1	721	728	PF02991	0.344
LIG_LIR_Nem_3	247	253	PF02991	0.349
LIG_LIR_Nem_3	254	260	PF02991	0.288
LIG_LIR_Nem_3	301	307	PF02991	0.400
LIG_LIR_Nem_3	39	43	PF02991	0.625
LIG_LIR_Nem_3	428	433	PF02991	0.479
LIG_LIR_Nem_3	456	462	PF02991	0.308
LIG_LIR_Nem_3	486	490	PF02991	0.360
LIG_LIR_Nem_3	504	509	PF02991	0.255
LIG_LIR_Nem_3	511	516	PF02991	0.404
LIG_LIR_Nem_3	593	599	PF02991	0.546
LIG_LIR_Nem_3	708	713	PF02991	0.523
LIG_LIR_Nem_3	721	725	PF02991	0.283
LIG_Pex14_1	36	40	PF04695	0.282
LIG_Pex14_1	430	434	PF04695	0.507
LIG_Pex14_2	257	261	PF04695	0.362
LIG_Pex14_2	441	445	PF04695	0.562
LIG_Pex14_2	509	513	PF04695	0.405
LIG_SH2_CRK	304	308	PF00017	0.336
LIG_SH2_CRK	487	491	PF00017	0.379
LIG_SH2_CRK	722	726	PF00017	0.412
LIG_SH2_GRB2like	487	490	PF00017	0.454
LIG_SH2_NCK_1	722	726	PF00017	0.382
LIG_SH2_SRC	182	185	PF00017	0.315
LIG_SH2_STAP1	162	166	PF00017	0.407
LIG_SH2_STAP1	487	491	PF00017	0.379
LIG_SH2_STAT5	328	331	PF00017	0.362
LIG_SH2_STAT5	459	462	PF00017	0.308
LIG_SH2_STAT5	722	725	PF00017	0.379
LIG_SH3_3	15	21	PF00018	0.720
LIG_SH3_3	196	202	PF00018	0.578
LIG_SUMO_SIM_par_1	261	267	PF11976	0.313
LIG_SUMO_SIM_par_1	27	32	PF11976	0.410
LIG_SUMO_SIM_par_1	743	748	PF11976	0.437
LIG_TRAF2_1	264	267	PF00917	0.305
LIG_TRAF2_1	557	560	PF00917	0.588
LIG_TRAF2_1	598	601	PF00917	0.569
LIG_TYR_ITIM	302	307	PF00017	0.338
LIG_TYR_ITIM	720	725	PF00017	0.365
LIG_UBA3_1	317	324	PF00899	0.375
LIG_WRC_WIRS_1	37	42	PF05994	0.282
LIG_WRC_WIRS_1	405	410	PF05994	0.436
LIG_WRC_WIRS_1	433	438	PF05994	0.548
LIG_WW_1	159	162	PF00397	0.464
LIG_WW_1	517	520	PF00397	0.326
MOD_CDC14_SPxK_1	225	228	PF00782	0.541
MOD_CDK_SPK_2	222	227	PF00069	0.550
MOD_CDK_SPxK_1	222	228	PF00069	0.549
MOD_CDK_SPxxK_3	472	479	PF00069	0.468
MOD_CDK_SPxxK_3	53	60	PF00069	0.563
MOD_CK1_1	216	222	PF00069	0.547
MOD_CK1_1	298	304	PF00069	0.395
MOD_CK1_1	444	450	PF00069	0.457
MOD_CK1_1	563	569	PF00069	0.586
MOD_CK1_1	590	596	PF00069	0.575
MOD_CK1_1	619	625	PF00069	0.502
MOD_CK1_1	697	703	PF00069	0.589
MOD_CK1_1	95	101	PF00069	0.547
MOD_CK2_1	226	232	PF00069	0.529
MOD_CK2_1	261	267	PF00069	0.292
MOD_CK2_1	395	401	PF00069	0.444
MOD_CK2_1	407	413	PF00069	0.395
MOD_CK2_1	444	450	PF00069	0.477
MOD_CK2_1	554	560	PF00069	0.577
MOD_CK2_1	595	601	PF00069	0.575
MOD_CK2_1	696	702	PF00069	0.593
MOD_Cter_Amidation	358	361	PF01082	0.551
MOD_GlcNHglycan	102	105	PF01048	0.732
MOD_GlcNHglycan	213	216	PF01048	0.815
MOD_GlcNHglycan	365	368	PF01048	0.563
MOD_GlcNHglycan	409	412	PF01048	0.644
MOD_GlcNHglycan	427	430	PF01048	0.691
MOD_GlcNHglycan	438	441	PF01048	0.768
MOD_GlcNHglycan	501	504	PF01048	0.588
MOD_GlcNHglycan	560	565	PF01048	0.826
MOD_GlcNHglycan	568	572	PF01048	0.788
MOD_GlcNHglycan	592	595	PF01048	0.774
MOD_GlcNHglycan	609	612	PF01048	0.707
MOD_GlcNHglycan	618	621	PF01048	0.757
MOD_GlcNHglycan	653	656	PF01048	0.747
MOD_GlcNHglycan	699	702	PF01048	0.793
MOD_GSK3_1	200	207	PF00069	0.596
MOD_GSK3_1	213	220	PF00069	0.550
MOD_GSK3_1	222	229	PF00069	0.519
MOD_GSK3_1	276	283	PF00069	0.478
MOD_GSK3_1	332	339	PF00069	0.348
MOD_GSK3_1	395	402	PF00069	0.474
MOD_GSK3_1	415	422	PF00069	0.538
MOD_GSK3_1	432	439	PF00069	0.456
MOD_GSK3_1	440	447	PF00069	0.520
MOD_GSK3_1	512	519	PF00069	0.364
MOD_GSK3_1	550	557	PF00069	0.570
MOD_GSK3_1	559	566	PF00069	0.590
MOD_GSK3_1	612	619	PF00069	0.478
MOD_GSK3_1	620	627	PF00069	0.450
MOD_GSK3_1	720	727	PF00069	0.412
MOD_GSK3_1	89	96	PF00069	0.493
MOD_N-GLC_1	415	420	PF02516	0.731
MOD_N-GLC_1	550	555	PF02516	0.712
MOD_N-GLC_2	148	150	PF02516	0.616
MOD_NEK2_1	1	6	PF00069	0.769
MOD_NEK2_1	110	115	PF00069	0.548
MOD_NEK2_1	261	266	PF00069	0.363
MOD_NEK2_1	270	275	PF00069	0.465
MOD_NEK2_1	276	281	PF00069	0.470
MOD_NEK2_1	334	339	PF00069	0.352
MOD_NEK2_1	353	358	PF00069	0.410
MOD_NEK2_1	363	368	PF00069	0.327
MOD_NEK2_1	436	441	PF00069	0.473
MOD_NEK2_1	529	534	PF00069	0.398
MOD_NEK2_1	694	699	PF00069	0.583
MOD_NEK2_1	720	725	PF00069	0.365
MOD_NEK2_2	115	120	PF00069	0.499
MOD_NEK2_2	65	70	PF00069	0.535
MOD_NEK2_2	664	669	PF00069	0.444
MOD_NEK2_2	724	729	PF00069	0.455
MOD_OFUCOSY	661	668	PF10250	0.646
MOD_PIKK_1	277	283	PF00454	0.443
MOD_PIKK_1	555	561	PF00454	0.576
MOD_PKA_1	211	217	PF00069	0.571
MOD_PKA_1	227	233	PF00069	0.505
MOD_PKA_1	377	383	PF00069	0.419
MOD_PKA_2	227	233	PF00069	0.540
MOD_PKA_2	276	282	PF00069	0.454
MOD_PKA_2	332	338	PF00069	0.335
MOD_PKA_2	353	359	PF00069	0.336
MOD_PKA_2	377	383	PF00069	0.454
MOD_PKA_2	441	447	PF00069	0.510
MOD_PKA_2	523	529	PF00069	0.396
MOD_PKA_2	728	734	PF00069	0.341
MOD_PKB_1	209	217	PF00069	0.606
MOD_Plk_1	162	168	PF00069	0.451
MOD_Plk_1	298	304	PF00069	0.395
MOD_Plk_1	415	421	PF00069	0.539
MOD_Plk_1	550	556	PF00069	0.520
MOD_Plk_1	633	639	PF00069	0.560
MOD_Plk_1	65	71	PF00069	0.535
MOD_Plk_1	720	726	PF00069	0.370
MOD_Plk_4	162	168	PF00069	0.447
MOD_Plk_4	340	346	PF00069	0.474
MOD_Plk_4	353	359	PF00069	0.332
MOD_Plk_4	404	410	PF00069	0.491
MOD_Plk_4	580	586	PF00069	0.580
MOD_ProDKin_1	105	111	PF00069	0.528
MOD_ProDKin_1	222	228	PF00069	0.523
MOD_ProDKin_1	472	478	PF00069	0.470
MOD_ProDKin_1	53	59	PF00069	0.527
MOD_ProDKin_1	563	569	PF00069	0.629
MOD_SUMO_rev_2	178	188	PF00179	0.457
MOD_SUMO_rev_2	249	258	PF00179	0.426
MOD_SUMO_rev_2	298	307	PF00179	0.402
MOD_SUMO_rev_2	598	607	PF00179	0.577
TRG_DiLeu_BaEn_1	486	491	PF01217	0.355
TRG_DiLeu_BaEn_1	495	500	PF01217	0.341
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.465
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.507
TRG_ENDOCYTIC_2	304	307	PF00928	0.333
TRG_ENDOCYTIC_2	459	462	PF00928	0.293
TRG_ENDOCYTIC_2	487	490	PF00928	0.367
TRG_ENDOCYTIC_2	722	725	PF00928	0.334
TRG_ER_diArg_1	208	211	PF00400	0.610
TRG_ER_diArg_1	533	536	PF00400	0.447
TRG_ER_diArg_1	59	62	PF00400	0.565
TRG_ER_diArg_1	689	692	PF00400	0.558
TRG_ER_diArg_1	736	739	PF00400	0.389
TRG_ER_diArg_1	81	83	PF00400	0.505
TRG_ER_FFAT_2	439	451	PF00635	0.548
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	547	552	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	635	640	PF00026	0.791
TRG_Pf-PMV_PEXEL_1	692	696	PF00026	0.756

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ6	Leptomonas seymouri	57%	100%
A0A3Q8IFD8	Leishmania donovani	94%	100%
A0A422NU02	Trypanosoma rangeli	36%	99%
A4I9T4	Leishmania infantum	94%	100%
E9B4U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B3B9	Trypanosoma cruzi	38%	100%