C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3'-5' exonuclease, putative

Species:

Leishmania major

UniProt:

Q4Q379_LEIMA

TriTrypDb:

LmjF.34.1240 , LMJLV39_340020400 , LMJSD75_340020400

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q379

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q379

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	2
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	2
GO:0000469	cleavage involved in rRNA processing	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0031123	RNA 3'-end processing	7	2
GO:0031125	rRNA 3'-end processing	9	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043628	regulatory ncRNA 3'-end processing	8	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0090501	RNA phosphodiester bond hydrolysis	6	2
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	9
GO:0004527	exonuclease activity	5	9
GO:0005488	binding	1	10
GO:0008408	3'-5' exonuclease activity	6	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0000175	3'-5'-RNA exonuclease activity	7	2
GO:0004532	RNA exonuclease activity	5	2
GO:0004540	RNA nuclease activity	4	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.577
CLV_NRD_NRD_1	204	206	PF00675	0.536
CLV_NRD_NRD_1	268	270	PF00675	0.601
CLV_NRD_NRD_1	344	346	PF00675	0.329
CLV_NRD_NRD_1	422	424	PF00675	0.503
CLV_PCSK_KEX2_1	204	206	PF00082	0.567
CLV_PCSK_KEX2_1	380	382	PF00082	0.420
CLV_PCSK_KEX2_1	422	424	PF00082	0.518
CLV_PCSK_KEX2_1	492	494	PF00082	0.387
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.629
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.436
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.387
CLV_PCSK_SKI1_1	125	129	PF00082	0.306
CLV_PCSK_SKI1_1	262	266	PF00082	0.378
CLV_PCSK_SKI1_1	269	273	PF00082	0.322
CLV_PCSK_SKI1_1	332	336	PF00082	0.385
CLV_PCSK_SKI1_1	353	357	PF00082	0.424
CLV_PCSK_SKI1_1	407	411	PF00082	0.363
CLV_PCSK_SKI1_1	414	418	PF00082	0.428
CLV_PCSK_SKI1_1	56	60	PF00082	0.265
DOC_CYCLIN_RxL_1	401	413	PF00134	0.387
DOC_MAPK_gen_1	269	276	PF00069	0.446
DOC_MAPK_gen_1	471	480	PF00069	0.386
DOC_MAPK_gen_1	77	86	PF00069	0.491
DOC_MAPK_MEF2A_6	269	278	PF00069	0.366
DOC_MAPK_MEF2A_6	281	288	PF00069	0.330
DOC_MAPK_MEF2A_6	471	480	PF00069	0.386
DOC_PP4_FxxP_1	347	350	PF00568	0.467
DOC_PP4_MxPP_1	348	351	PF00568	0.387
DOC_USP7_MATH_1	148	152	PF00917	0.431
DOC_USP7_MATH_1	33	37	PF00917	0.505
DOC_USP7_MATH_1	386	390	PF00917	0.481
DOC_USP7_UBL2_3	110	114	PF12436	0.442
DOC_USP7_UBL2_3	397	401	PF12436	0.413
DOC_USP7_UBL2_3	431	435	PF12436	0.443
DOC_WW_Pin1_4	337	342	PF00397	0.428
DOC_WW_Pin1_4	533	538	PF00397	0.622
LIG_14-3-3_CanoR_1	181	188	PF00244	0.421
LIG_14-3-3_CanoR_1	471	477	PF00244	0.439
LIG_Actin_WH2_2	146	163	PF00022	0.490
LIG_APCC_ABBA_1	371	376	PF00400	0.365
LIG_APCC_ABBAyCdc20_2	435	441	PF00400	0.368
LIG_BRCT_BRCA1_1	35	39	PF00533	0.440
LIG_BRCT_BRCA1_1	435	439	PF00533	0.405
LIG_BRCT_BRCA1_1	95	99	PF00533	0.459
LIG_FHA_1	329	335	PF00498	0.415
LIG_FHA_1	368	374	PF00498	0.421
LIG_FHA_1	473	479	PF00498	0.392
LIG_FHA_1	499	505	PF00498	0.315
LIG_FHA_2	382	388	PF00498	0.482
LIG_FHA_2	435	441	PF00498	0.416
LIG_IRF3_LxIS_1	39	44	PF10401	0.477
LIG_LIR_Apic_2	130	135	PF02991	0.505
LIG_LIR_Gen_1	171	179	PF02991	0.296
LIG_LIR_Gen_1	403	412	PF02991	0.362
LIG_LIR_Gen_1	436	446	PF02991	0.495
LIG_LIR_Nem_3	171	176	PF02991	0.309
LIG_LIR_Nem_3	343	347	PF02991	0.401
LIG_LIR_Nem_3	357	363	PF02991	0.252
LIG_LIR_Nem_3	403	408	PF02991	0.407
LIG_LIR_Nem_3	436	442	PF02991	0.417
LIG_PCNA_yPIPBox_3	77	90	PF02747	0.442
LIG_Pex14_2	442	446	PF04695	0.471
LIG_Pex14_2	490	494	PF04695	0.326
LIG_Rb_pABgroove_1	272	280	PF01858	0.468
LIG_REV1ctd_RIR_1	43	51	PF16727	0.477
LIG_SH2_CRK	289	293	PF00017	0.403
LIG_SH2_CRK	405	409	PF00017	0.411
LIG_SH2_CRK	95	99	PF00017	0.544
LIG_SH2_NCK_1	383	387	PF00017	0.490
LIG_SH2_SRC	360	363	PF00017	0.449
LIG_SH2_STAP1	375	379	PF00017	0.389
LIG_SH2_STAP1	405	409	PF00017	0.294
LIG_SH2_STAP1	95	99	PF00017	0.477
LIG_SH2_STAT5	152	155	PF00017	0.363
LIG_SH2_STAT5	251	254	PF00017	0.387
LIG_SH2_STAT5	360	363	PF00017	0.440
LIG_SH2_STAT5	383	386	PF00017	0.408
LIG_SH2_STAT5	497	500	PF00017	0.417
MOD_CK1_1	163	169	PF00069	0.554
MOD_CK1_1	212	218	PF00069	0.683
MOD_CK2_1	127	133	PF00069	0.484
MOD_CK2_1	195	201	PF00069	0.551
MOD_CK2_1	381	387	PF00069	0.477
MOD_CK2_1	434	440	PF00069	0.524
MOD_CK2_1	441	447	PF00069	0.368
MOD_GlcNHglycan	167	171	PF01048	0.559
MOD_GlcNHglycan	214	217	PF01048	0.665
MOD_GlcNHglycan	225	228	PF01048	0.616
MOD_GlcNHglycan	244	247	PF01048	0.262
MOD_GlcNHglycan	443	446	PF01048	0.521
MOD_GlcNHglycan	71	74	PF01048	0.242
MOD_GlcNHglycan	95	98	PF01048	0.336
MOD_GSK3_1	317	324	PF00069	0.384
MOD_GSK3_1	506	513	PF00069	0.433
MOD_GSK3_1	69	76	PF00069	0.442
MOD_N-GLC_1	117	122	PF02516	0.277
MOD_N-GLC_1	367	372	PF02516	0.327
MOD_N-GLC_1	82	87	PF02516	0.242
MOD_NEK2_1	1	6	PF00069	0.527
MOD_NEK2_1	112	117	PF00069	0.465
MOD_NEK2_1	136	141	PF00069	0.442
MOD_NEK2_1	179	184	PF00069	0.482
MOD_NEK2_1	241	246	PF00069	0.475
MOD_NEK2_1	317	322	PF00069	0.461
MOD_NEK2_1	32	37	PF00069	0.475
MOD_NEK2_1	41	46	PF00069	0.450
MOD_NEK2_2	367	372	PF00069	0.327
MOD_NEK2_2	400	405	PF00069	0.296
MOD_NEK2_2	434	439	PF00069	0.440
MOD_PIKK_1	317	323	PF00454	0.333
MOD_PIKK_1	381	387	PF00454	0.500
MOD_PKA_2	180	186	PF00069	0.468
MOD_PKA_2	194	200	PF00069	0.406
MOD_Plk_1	117	123	PF00069	0.477
MOD_Plk_1	367	373	PF00069	0.335
MOD_Plk_1	387	393	PF00069	0.393
MOD_Plk_1	73	79	PF00069	0.477
MOD_Plk_1	82	88	PF00069	0.411
MOD_Plk_4	148	154	PF00069	0.487
MOD_Plk_4	388	394	PF00069	0.597
MOD_Plk_4	400	406	PF00069	0.208
MOD_Plk_4	434	440	PF00069	0.485
MOD_Plk_4	60	66	PF00069	0.490
MOD_Plk_4	85	91	PF00069	0.505
MOD_ProDKin_1	337	343	PF00069	0.434
MOD_SUMO_rev_2	183	193	PF00179	0.406
MOD_SUMO_rev_2	273	282	PF00179	0.443
MOD_SUMO_rev_2	389	399	PF00179	0.476
MOD_SUMO_rev_2	482	487	PF00179	0.306
MOD_SUMO_rev_2	500	509	PF00179	0.311
TRG_DiLeu_BaEn_3	387	393	PF01217	0.426
TRG_DiLeu_BaEn_3	424	430	PF01217	0.355
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.372
TRG_ENDOCYTIC_2	289	292	PF00928	0.435
TRG_ENDOCYTIC_2	360	363	PF00928	0.408
TRG_ENDOCYTIC_2	405	408	PF00928	0.338
TRG_ENDOCYTIC_2	95	98	PF00928	0.529
TRG_NES_CRM1_1	469	484	PF08389	0.273
TRG_NLS_Bipartite_1	191	209	PF00514	0.391
TRG_NLS_MonoExtN_4	204	209	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV0	Leptomonas seymouri	54%	96%
A0A0S4IZU9	Bodo saltans	31%	100%
A0A1X0NK05	Trypanosomatidae	26%	72%
A0A3S7X7Q1	Leishmania donovani	90%	98%
A0A422NPF9	Trypanosoma rangeli	25%	68%
A4HAP1	Leishmania braziliensis	73%	100%
A4I9T6	Leishmania infantum	90%	98%
E9B4U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
Q8VEG4	Mus musculus	25%	83%
Q9NVH0	Homo sapiens	25%	87%