Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q374_LEIMA

TriTrypDb:

LmjF.34.1280 , LMJLV39_340021000 , LMJSD75_340021000

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q374

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q374

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.735
CLV_C14_Caspase3-7	289	293	PF00656	0.637
CLV_C14_Caspase3-7	338	342	PF00656	0.508
CLV_NRD_NRD_1	148	150	PF00675	0.579
CLV_NRD_NRD_1	208	210	PF00675	0.548
CLV_PCSK_KEX2_1	173	175	PF00082	0.556
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.556
CLV_PCSK_SKI1_1	173	177	PF00082	0.559
CLV_PCSK_SKI1_1	327	331	PF00082	0.535
CLV_PCSK_SKI1_1	78	82	PF00082	0.544
DEG_Nend_Nbox_1	1	3	PF02207	0.537
DOC_CKS1_1	176	181	PF01111	0.472
DOC_MAPK_HePTP_8	324	336	PF00069	0.503
DOC_MAPK_MEF2A_6	277	285	PF00069	0.550
DOC_MAPK_MEF2A_6	327	336	PF00069	0.500
DOC_PP1_RVXF_1	255	261	PF00149	0.448
DOC_PP2B_LxvP_1	35	38	PF13499	0.609
DOC_PP4_FxxP_1	97	100	PF00568	0.735
DOC_USP7_MATH_1	109	113	PF00917	0.534
DOC_USP7_MATH_1	236	240	PF00917	0.678
DOC_USP7_MATH_1	29	33	PF00917	0.644
DOC_USP7_MATH_1	93	97	PF00917	0.759
DOC_WW_Pin1_4	175	180	PF00397	0.472
DOC_WW_Pin1_4	230	235	PF00397	0.783
DOC_WW_Pin1_4	62	67	PF00397	0.567
LIG_14-3-3_CanoR_1	118	127	PF00244	0.528
LIG_14-3-3_CanoR_1	257	265	PF00244	0.452
LIG_14-3-3_CanoR_1	331	337	PF00244	0.483
LIG_Actin_WH2_2	243	261	PF00022	0.422
LIG_BIR_III_4	52	56	PF00653	0.557
LIG_BRCT_BRCA1_1	113	117	PF00533	0.493
LIG_deltaCOP1_diTrp_1	104	113	PF00928	0.562
LIG_deltaCOP1_diTrp_1	202	207	PF00928	0.475
LIG_FHA_1	12	18	PF00498	0.573
LIG_FHA_1	143	149	PF00498	0.582
LIG_FHA_1	176	182	PF00498	0.471
LIG_FHA_1	192	198	PF00498	0.543
LIG_FHA_1	280	286	PF00498	0.550
LIG_FHA_2	120	126	PF00498	0.500
LIG_FHA_2	287	293	PF00498	0.611
LIG_FHA_2	299	305	PF00498	0.697
LIG_FHA_2	333	339	PF00498	0.420
LIG_LIR_Apic_2	96	100	PF02991	0.740
LIG_LIR_Gen_1	308	319	PF02991	0.549
LIG_LIR_Nem_3	104	110	PF02991	0.525
LIG_LIR_Nem_3	201	207	PF02991	0.467
LIG_LIR_Nem_3	308	314	PF02991	0.574
LIG_PDZ_Class_3	341	346	PF00595	0.490
LIG_Pex14_1	113	117	PF04695	0.419
LIG_Pex14_1	182	186	PF04695	0.536
LIG_PTAP_UEV_1	83	88	PF05743	0.609
LIG_SH2_PTP2	333	336	PF00017	0.443
LIG_SH2_SRC	7	10	PF00017	0.570
LIG_SH2_STAP1	186	190	PF00017	0.454
LIG_SH2_STAP1	252	256	PF00017	0.479
LIG_SH2_STAT5	137	140	PF00017	0.478
LIG_SH2_STAT5	333	336	PF00017	0.461
LIG_SH2_STAT5	49	52	PF00017	0.482
LIG_SH3_2	34	39	PF14604	0.598
LIG_SH3_3	157	163	PF00018	0.542
LIG_SH3_3	31	37	PF00018	0.639
LIG_SH3_3	312	318	PF00018	0.428
LIG_SH3_3	81	87	PF00018	0.620
LIG_SH3_CIN85_PxpxPR_1	34	39	PF14604	0.598
LIG_SUMO_SIM_anti_2	244	251	PF11976	0.565
LIG_SUMO_SIM_par_1	281	286	PF11976	0.566
LIG_SUMO_SIM_par_1	316	323	PF11976	0.572
LIG_TRAF2_1	164	167	PF00917	0.504
LIG_TRAF2_1	243	246	PF00917	0.667
LIG_TRAF2_1	301	304	PF00917	0.754
LIG_WRPW_2	330	333	PF00400	0.547
LIG_WW_3	36	40	PF00397	0.580
MOD_CK1_1	120	126	PF00069	0.523
MOD_CK1_1	237	243	PF00069	0.687
MOD_CK1_1	267	273	PF00069	0.691
MOD_CK2_1	120	126	PF00069	0.464
MOD_CK2_1	161	167	PF00069	0.501
MOD_CK2_1	298	304	PF00069	0.748
MOD_CK2_1	317	323	PF00069	0.496
MOD_CK2_1	332	338	PF00069	0.333
MOD_CK2_1	56	62	PF00069	0.414
MOD_Cter_Amidation	207	210	PF01082	0.529
MOD_GlcNHglycan	11	14	PF01048	0.369
MOD_GlcNHglycan	142	145	PF01048	0.638
MOD_GlcNHglycan	163	166	PF01048	0.557
MOD_GlcNHglycan	225	228	PF01048	0.652
MOD_GlcNHglycan	239	242	PF01048	0.586
MOD_GlcNHglycan	260	263	PF01048	0.459
MOD_GlcNHglycan	274	277	PF01048	0.598
MOD_GlcNHglycan	31	34	PF01048	0.411
MOD_GlcNHglycan	58	61	PF01048	0.506
MOD_GlcNHglycan	75	78	PF01048	0.453
MOD_GSK3_1	105	112	PF00069	0.514
MOD_GSK3_1	117	124	PF00069	0.558
MOD_GSK3_1	186	193	PF00069	0.398
MOD_GSK3_1	223	230	PF00069	0.715
MOD_GSK3_1	264	271	PF00069	0.645
MOD_GSK3_1	64	71	PF00069	0.525
MOD_GSK3_1	82	89	PF00069	0.520
MOD_NEK2_1	11	16	PF00069	0.486
MOD_NEK2_1	117	122	PF00069	0.458
MOD_NEK2_1	258	263	PF00069	0.509
MOD_PKA_2	117	123	PF00069	0.501
MOD_PKA_2	223	229	PF00069	0.652
MOD_PKA_2	258	264	PF00069	0.464
MOD_PKA_2	267	273	PF00069	0.641
MOD_Plk_4	332	338	PF00069	0.416
MOD_Plk_4	64	70	PF00069	0.682
MOD_ProDKin_1	175	181	PF00069	0.468
MOD_ProDKin_1	230	236	PF00069	0.778
MOD_ProDKin_1	62	68	PF00069	0.566
MOD_SUMO_rev_2	284	289	PF00179	0.518
TRG_DiLeu_BaEn_1	126	131	PF01217	0.429
TRG_DiLeu_BaEn_1	245	250	PF01217	0.578
TRG_DiLeu_BaEn_4	183	189	PF01217	0.428
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.480
TRG_ENDOCYTIC_2	333	336	PF00928	0.443
TRG_ER_diArg_1	256	259	PF00400	0.489
TRG_NES_CRM1_1	308	323	PF08389	0.523
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C8	Leptomonas seymouri	47%	100%
A0A3Q8IKX0	Leishmania donovani	95%	100%
A4HAP5	Leishmania braziliensis	76%	100%
A4I9U1	Leishmania infantum	95%	100%
C9ZMU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B4V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BIU6	Trypanosoma cruzi	33%	99%