Ran gtpase-activating protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q373_LEIMA

TriTrypDb:

LmjF.34.1290 , LMJLV39_340021100 , LMJSD75_340021100

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

Q4Q373

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q373

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.573
CLV_NRD_NRD_1	30	32	PF00675	0.517
CLV_NRD_NRD_1	580	582	PF00675	0.753
CLV_NRD_NRD_1	623	625	PF00675	0.793
CLV_NRD_NRD_1	7	9	PF00675	0.534
CLV_NRD_NRD_1	711	713	PF00675	0.733
CLV_PCSK_FUR_1	4	8	PF00082	0.556
CLV_PCSK_KEX2_1	121	123	PF00082	0.532
CLV_PCSK_KEX2_1	30	32	PF00082	0.517
CLV_PCSK_KEX2_1	409	411	PF00082	0.633
CLV_PCSK_KEX2_1	6	8	PF00082	0.514
CLV_PCSK_KEX2_1	623	625	PF00082	0.793
CLV_PCSK_KEX2_1	71	73	PF00082	0.593
CLV_PCSK_KEX2_1	711	713	PF00082	0.694
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.633
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.620
CLV_PCSK_PC7_1	2	8	PF00082	0.621
CLV_PCSK_PC7_1	405	411	PF00082	0.630
CLV_PCSK_SKI1_1	230	234	PF00082	0.540
CLV_PCSK_SKI1_1	488	492	PF00082	0.551
CLV_PCSK_SKI1_1	638	642	PF00082	0.786
CLV_PCSK_SKI1_1	7	11	PF00082	0.505
DEG_APCC_DBOX_1	6	14	PF00400	0.524
DEG_APCC_DBOX_1	611	619	PF00400	0.717
DEG_Nend_UBRbox_1	1	4	PF02207	0.580
DOC_CDC14_PxL_1	349	357	PF14671	0.476
DOC_CKS1_1	226	231	PF01111	0.517
DOC_CKS1_1	34	39	PF01111	0.623
DOC_CYCLIN_RxL_1	160	169	PF00134	0.453
DOC_CYCLIN_RxL_1	264	273	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.441
DOC_MAPK_DCC_7	278	287	PF00069	0.664
DOC_MAPK_MEF2A_6	443	450	PF00069	0.516
DOC_PP1_RVXF_1	228	235	PF00149	0.546
DOC_PP2B_LxvP_1	542	545	PF13499	0.676
DOC_USP7_MATH_1	111	115	PF00917	0.544
DOC_USP7_MATH_1	149	153	PF00917	0.680
DOC_USP7_MATH_1	19	23	PF00917	0.616
DOC_USP7_MATH_1	301	305	PF00917	0.580
DOC_USP7_MATH_1	323	327	PF00917	0.484
DOC_USP7_MATH_1	42	46	PF00917	0.492
DOC_USP7_MATH_1	519	523	PF00917	0.693
DOC_USP7_MATH_1	567	571	PF00917	0.724
DOC_USP7_MATH_1	648	652	PF00917	0.761
DOC_USP7_MATH_1	702	706	PF00917	0.743
DOC_WW_Pin1_4	130	135	PF00397	0.539
DOC_WW_Pin1_4	225	230	PF00397	0.517
DOC_WW_Pin1_4	246	251	PF00397	0.512
DOC_WW_Pin1_4	33	38	PF00397	0.626
DOC_WW_Pin1_4	563	568	PF00397	0.724
DOC_WW_Pin1_4	573	578	PF00397	0.610
DOC_WW_Pin1_4	587	592	PF00397	0.531
DOC_WW_Pin1_4	650	655	PF00397	0.653
LIG_14-3-3_CanoR_1	121	130	PF00244	0.554
LIG_14-3-3_CanoR_1	197	206	PF00244	0.628
LIG_14-3-3_CanoR_1	334	342	PF00244	0.474
LIG_14-3-3_CanoR_1	405	412	PF00244	0.650
LIG_14-3-3_CanoR_1	458	466	PF00244	0.414
LIG_14-3-3_CanoR_1	488	495	PF00244	0.529
LIG_14-3-3_CanoR_1	579	589	PF00244	0.680
LIG_14-3-3_CanoR_1	623	627	PF00244	0.656
LIG_14-3-3_CanoR_1	672	679	PF00244	0.731
LIG_AP_GAE_1	89	95	PF02883	0.321
LIG_FHA_1	131	137	PF00498	0.607
LIG_FHA_1	226	232	PF00498	0.510
LIG_FHA_1	252	258	PF00498	0.471
LIG_FHA_1	328	334	PF00498	0.431
LIG_FHA_1	34	40	PF00498	0.561
LIG_FHA_1	377	383	PF00498	0.417
LIG_FHA_1	470	476	PF00498	0.499
LIG_FHA_1	588	594	PF00498	0.730
LIG_FHA_1	674	680	PF00498	0.751
LIG_FHA_2	101	107	PF00498	0.480
LIG_FHA_2	419	425	PF00498	0.649
LIG_FHA_2	487	493	PF00498	0.502
LIG_FHA_2	606	612	PF00498	0.697
LIG_LIR_Gen_1	179	188	PF02991	0.543
LIG_LIR_Gen_1	408	418	PF02991	0.498
LIG_LIR_Gen_1	492	503	PF02991	0.363
LIG_LIR_Gen_1	89	100	PF02991	0.494
LIG_LIR_Nem_3	179	183	PF02991	0.539
LIG_LIR_Nem_3	408	414	PF02991	0.495
LIG_LIR_Nem_3	492	498	PF02991	0.360
LIG_LIR_Nem_3	537	542	PF02991	0.719
LIG_LIR_Nem_3	573	578	PF02991	0.689
LIG_PCNA_yPIPBox_3	452	464	PF02747	0.484
LIG_PCNA_yPIPBox_3	484	494	PF02747	0.567
LIG_Pex14_1	29	33	PF04695	0.496
LIG_PTB_Apo_2	104	111	PF02174	0.486
LIG_SH2_CRK	495	499	PF00017	0.408
LIG_SH2_CRK	539	543	PF00017	0.726
LIG_SH2_CRK	575	579	PF00017	0.687
LIG_SH2_NCK_1	420	424	PF00017	0.605
LIG_SH2_NCK_1	495	499	PF00017	0.559
LIG_SH2_STAP1	703	707	PF00017	0.680
LIG_SH2_STAT3	703	706	PF00017	0.757
LIG_SH2_STAT5	224	227	PF00017	0.503
LIG_SH2_STAT5	270	273	PF00017	0.415
LIG_SH2_STAT5	33	36	PF00017	0.561
LIG_SH2_STAT5	357	360	PF00017	0.472
LIG_SH2_STAT5	420	423	PF00017	0.695
LIG_SH2_STAT5	495	498	PF00017	0.470
LIG_SH3_1	443	449	PF00018	0.516
LIG_SH3_3	284	290	PF00018	0.675
LIG_SH3_3	443	449	PF00018	0.489
LIG_SH3_3	591	597	PF00018	0.752
LIG_SH3_3	62	68	PF00018	0.539
LIG_SUMO_SIM_par_1	163	169	PF11976	0.532
LIG_SUMO_SIM_par_1	384	389	PF11976	0.432
LIG_SUMO_SIM_par_1	54	59	PF11976	0.543
LIG_SxIP_EBH_1	579	591	PF03271	0.563
LIG_TRAF2_1	439	442	PF00917	0.591
LIG_TYR_ITIM	355	360	PF00017	0.287
LIG_TYR_ITIM	493	498	PF00017	0.391
LIG_UBA3_1	447	456	PF00899	0.489
LIG_WRC_WIRS_1	177	182	PF05994	0.539
LIG_WRC_WIRS_1	231	236	PF05994	0.392
MOD_CDC14_SPxK_1	566	569	PF00782	0.719
MOD_CDC14_SPxK_1	576	579	PF00782	0.597
MOD_CDK_SPK_2	225	230	PF00069	0.571
MOD_CDK_SPxK_1	563	569	PF00069	0.718
MOD_CDK_SPxK_1	573	579	PF00069	0.603
MOD_CK1_1	138	144	PF00069	0.638
MOD_CK1_1	154	160	PF00069	0.543
MOD_CK1_1	326	332	PF00069	0.433
MOD_CK1_1	359	365	PF00069	0.326
MOD_CK1_1	389	395	PF00069	0.457
MOD_CK1_1	413	419	PF00069	0.613
MOD_CK1_1	432	438	PF00069	0.704
MOD_CK1_1	486	492	PF00069	0.421
MOD_CK1_1	534	540	PF00069	0.644
MOD_CK1_1	547	553	PF00069	0.645
MOD_CK1_1	561	567	PF00069	0.655
MOD_CK1_1	592	598	PF00069	0.763
MOD_CK1_1	607	613	PF00069	0.519
MOD_CK1_1	629	635	PF00069	0.756
MOD_CK1_1	685	691	PF00069	0.807
MOD_CK2_1	100	106	PF00069	0.479
MOD_CK2_1	418	424	PF00069	0.578
MOD_CK2_1	436	442	PF00069	0.609
MOD_CK2_1	486	492	PF00069	0.508
MOD_CK2_1	567	573	PF00069	0.750
MOD_CK2_1	625	631	PF00069	0.801
MOD_GlcNHglycan	137	140	PF01048	0.738
MOD_GlcNHglycan	199	202	PF01048	0.615
MOD_GlcNHglycan	213	216	PF01048	0.374
MOD_GlcNHglycan	263	266	PF01048	0.530
MOD_GlcNHglycan	431	434	PF01048	0.707
MOD_GlcNHglycan	438	441	PF01048	0.502
MOD_GlcNHglycan	521	524	PF01048	0.675
MOD_GlcNHglycan	549	552	PF01048	0.686
MOD_GlcNHglycan	58	61	PF01048	0.583
MOD_GlcNHglycan	650	653	PF01048	0.742
MOD_GlcNHglycan	690	693	PF01048	0.809
MOD_GlcNHglycan	96	99	PF01048	0.535
MOD_GSK3_1	19	26	PF00069	0.539
MOD_GSK3_1	322	329	PF00069	0.436
MOD_GSK3_1	359	366	PF00069	0.488
MOD_GSK3_1	410	417	PF00069	0.576
MOD_GSK3_1	428	435	PF00069	0.391
MOD_GSK3_1	482	489	PF00069	0.471
MOD_GSK3_1	493	500	PF00069	0.416
MOD_GSK3_1	530	537	PF00069	0.682
MOD_GSK3_1	561	568	PF00069	0.725
MOD_GSK3_1	622	629	PF00069	0.719
MOD_GSK3_1	648	655	PF00069	0.692
MOD_GSK3_1	688	695	PF00069	0.786
MOD_GSK3_1	697	704	PF00069	0.717
MOD_N-GLC_1	130	135	PF02516	0.524
MOD_N-GLC_1	326	331	PF02516	0.421
MOD_N-GLC_1	456	461	PF02516	0.403
MOD_N-GLC_1	468	473	PF02516	0.429
MOD_N-GLC_1	486	491	PF02516	0.506
MOD_N-GLC_1	605	610	PF02516	0.672
MOD_NEK2_1	100	105	PF00069	0.449
MOD_NEK2_1	13	18	PF00069	0.525
MOD_NEK2_1	356	361	PF00069	0.472
MOD_NEK2_1	386	391	PF00069	0.388
MOD_NEK2_1	404	409	PF00069	0.542
MOD_NEK2_1	414	419	PF00069	0.600
MOD_NEK2_1	510	515	PF00069	0.574
MOD_NEK2_1	530	535	PF00069	0.734
MOD_NEK2_1	630	635	PF00069	0.715
MOD_NEK2_1	666	671	PF00069	0.698
MOD_NEK2_1	673	678	PF00069	0.700
MOD_PIKK_1	151	157	PF00454	0.631
MOD_PIKK_1	458	464	PF00454	0.456
MOD_PIKK_1	630	636	PF00454	0.800
MOD_PIKK_1	652	658	PF00454	0.713
MOD_PIKK_1	673	679	PF00454	0.598
MOD_PIKK_1	702	708	PF00454	0.752
MOD_PKA_2	209	215	PF00069	0.524
MOD_PKA_2	404	410	PF00069	0.546
MOD_PKA_2	483	489	PF00069	0.484
MOD_PKA_2	547	553	PF00069	0.681
MOD_PKA_2	580	586	PF00069	0.642
MOD_PKA_2	622	628	PF00069	0.569
MOD_PKA_2	671	677	PF00069	0.721
MOD_Plk_1	100	106	PF00069	0.432
MOD_Plk_1	20	26	PF00069	0.342
MOD_Plk_1	301	307	PF00069	0.590
MOD_Plk_1	326	332	PF00069	0.450
MOD_Plk_1	386	392	PF00069	0.423
MOD_Plk_1	456	462	PF00069	0.404
MOD_Plk_1	486	492	PF00069	0.508
MOD_Plk_1	605	611	PF00069	0.804
MOD_Plk_1	666	672	PF00069	0.768
MOD_Plk_1	682	688	PF00069	0.678
MOD_Plk_4	100	106	PF00069	0.467
MOD_Plk_4	220	226	PF00069	0.447
MOD_Plk_4	230	236	PF00069	0.393
MOD_Plk_4	327	333	PF00069	0.458
MOD_Plk_4	410	416	PF00069	0.616
MOD_Plk_4	42	48	PF00069	0.439
MOD_Plk_4	549	555	PF00069	0.663
MOD_Plk_4	589	595	PF00069	0.807
MOD_Plk_4	657	663	PF00069	0.703
MOD_Plk_4	666	672	PF00069	0.490
MOD_ProDKin_1	130	136	PF00069	0.551
MOD_ProDKin_1	225	231	PF00069	0.510
MOD_ProDKin_1	246	252	PF00069	0.507
MOD_ProDKin_1	33	39	PF00069	0.618
MOD_ProDKin_1	563	569	PF00069	0.725
MOD_ProDKin_1	573	579	PF00069	0.611
MOD_ProDKin_1	587	593	PF00069	0.535
MOD_ProDKin_1	650	656	PF00069	0.653
MOD_SUMO_for_1	505	508	PF00179	0.444
TRG_DiLeu_BaLyEn_6	443	448	PF01217	0.435
TRG_ENDOCYTIC_2	357	360	PF00928	0.283
TRG_ENDOCYTIC_2	495	498	PF00928	0.400
TRG_ENDOCYTIC_2	539	542	PF00928	0.724
TRG_ENDOCYTIC_2	575	578	PF00928	0.685
TRG_ER_diArg_1	1	4	PF00400	0.612
TRG_ER_diArg_1	120	122	PF00400	0.569
TRG_ER_diArg_1	29	31	PF00400	0.492
TRG_ER_diArg_1	578	581	PF00400	0.755
TRG_ER_diArg_1	6	8	PF00400	0.545
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7T2	Leptomonas seymouri	52%	94%
A0A3Q8IHF2	Leishmania donovani	92%	99%
A0A3R7MW53	Trypanosoma rangeli	28%	100%
A4HAP6	Leishmania braziliensis	70%	100%
A4I9U2	Leishmania infantum	93%	99%
E9B4V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5B3D0	Trypanosoma cruzi	28%	100%