Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q371_LEIMA

TriTrypDb:

LmjF.34.1310 , LMJLV39_340021300 , LMJSD75_340021300

Length:

857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q371

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q371

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.461
CLV_C14_Caspase3-7	548	552	PF00656	0.384
CLV_C14_Caspase3-7	82	86	PF00656	0.564
CLV_NRD_NRD_1	141	143	PF00675	0.551
CLV_NRD_NRD_1	235	237	PF00675	0.661
CLV_NRD_NRD_1	578	580	PF00675	0.427
CLV_NRD_NRD_1	603	605	PF00675	0.542
CLV_NRD_NRD_1	631	633	PF00675	0.559
CLV_NRD_NRD_1	658	660	PF00675	0.697
CLV_NRD_NRD_1	707	709	PF00675	0.714
CLV_NRD_NRD_1	741	743	PF00675	0.623
CLV_NRD_NRD_1	75	77	PF00675	0.443
CLV_NRD_NRD_1	789	791	PF00675	0.698
CLV_PCSK_FUR_1	601	605	PF00082	0.535
CLV_PCSK_KEX2_1	235	237	PF00082	0.728
CLV_PCSK_KEX2_1	304	306	PF00082	0.563
CLV_PCSK_KEX2_1	603	605	PF00082	0.542
CLV_PCSK_KEX2_1	631	633	PF00082	0.559
CLV_PCSK_KEX2_1	658	660	PF00082	0.654
CLV_PCSK_KEX2_1	741	743	PF00082	0.623
CLV_PCSK_KEX2_1	815	817	PF00082	0.703
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.642
CLV_PCSK_PC1ET2_1	815	817	PF00082	0.703
CLV_PCSK_SKI1_1	117	121	PF00082	0.493
CLV_PCSK_SKI1_1	357	361	PF00082	0.470
CLV_PCSK_SKI1_1	52	56	PF00082	0.504
CLV_PCSK_SKI1_1	550	554	PF00082	0.383
CLV_PCSK_SKI1_1	850	854	PF00082	0.566
DEG_APCC_DBOX_1	213	221	PF00400	0.585
DEG_APCC_KENBOX_2	440	444	PF00400	0.569
DEG_SPOP_SBC_1	727	731	PF00917	0.562
DOC_ANK_TNKS_1	644	651	PF00023	0.605
DOC_CYCLIN_yCln2_LP_2	509	515	PF00134	0.562
DOC_MAPK_gen_1	214	222	PF00069	0.448
DOC_MAPK_gen_1	831	838	PF00069	0.652
DOC_MAPK_gen_1	848	856	PF00069	0.451
DOC_MAPK_MEF2A_6	187	196	PF00069	0.520
DOC_MAPK_MEF2A_6	216	224	PF00069	0.446
DOC_MAPK_MEF2A_6	697	705	PF00069	0.569
DOC_MIT_MIM_1	596	605	PF04212	0.540
DOC_PP1_RVXF_1	475	481	PF00149	0.525
DOC_PP1_RVXF_1	74	81	PF00149	0.527
DOC_PP2B_LxvP_1	509	512	PF13499	0.619
DOC_PP2B_LxvP_1	782	785	PF13499	0.676
DOC_USP7_MATH_1	251	255	PF00917	0.654
DOC_USP7_MATH_1	30	34	PF00917	0.516
DOC_USP7_MATH_1	355	359	PF00917	0.602
DOC_USP7_MATH_1	492	496	PF00917	0.634
DOC_USP7_MATH_1	561	565	PF00917	0.468
DOC_USP7_MATH_1	677	681	PF00917	0.655
DOC_USP7_MATH_1	687	691	PF00917	0.588
DOC_USP7_MATH_1	748	752	PF00917	0.554
DOC_WW_Pin1_4	181	186	PF00397	0.590
DOC_WW_Pin1_4	238	243	PF00397	0.622
DOC_WW_Pin1_4	280	285	PF00397	0.789
DOC_WW_Pin1_4	643	648	PF00397	0.570
DOC_WW_Pin1_4	691	696	PF00397	0.730
DOC_WW_Pin1_4	740	745	PF00397	0.598
DOC_WW_Pin1_4	758	763	PF00397	0.590
LIG_14-3-3_CanoR_1	133	141	PF00244	0.510
LIG_14-3-3_CanoR_1	219	225	PF00244	0.602
LIG_14-3-3_CanoR_1	522	526	PF00244	0.466
LIG_14-3-3_CanoR_1	531	535	PF00244	0.551
LIG_14-3-3_CanoR_1	570	578	PF00244	0.496
LIG_14-3-3_CanoR_1	672	677	PF00244	0.535
LIG_14-3-3_CanoR_1	97	102	PF00244	0.507
LIG_APCC_ABBA_1	764	769	PF00400	0.552
LIG_BIR_II_1	1	5	PF00653	0.496
LIG_BIR_III_4	329	333	PF00653	0.526
LIG_CaM_IQ_9	333	349	PF13499	0.546
LIG_CaM_IQ_9	572	588	PF13499	0.549
LIG_deltaCOP1_diTrp_1	471	480	PF00928	0.482
LIG_DLG_GKlike_1	97	104	PF00625	0.487
LIG_EH1_1	92	100	PF00400	0.493
LIG_EVH1_1	782	786	PF00568	0.628
LIG_FHA_1	143	149	PF00498	0.551
LIG_FHA_1	538	544	PF00498	0.468
LIG_FHA_1	569	575	PF00498	0.492
LIG_FHA_1	718	724	PF00498	0.514
LIG_FHA_1	741	747	PF00498	0.748
LIG_FHA_2	437	443	PF00498	0.564
LIG_FHA_2	525	531	PF00498	0.482
LIG_FHA_2	543	549	PF00498	0.324
LIG_FHA_2	806	812	PF00498	0.634
LIG_GBD_Chelix_1	391	399	PF00786	0.499
LIG_LIR_Gen_1	100	105	PF02991	0.516
LIG_LIR_Gen_1	433	438	PF02991	0.474
LIG_LIR_Gen_1	610	620	PF02991	0.483
LIG_LIR_Gen_1	851	857	PF02991	0.594
LIG_LIR_Nem_3	100	104	PF02991	0.519
LIG_LIR_Nem_3	433	437	PF02991	0.488
LIG_LIR_Nem_3	610	615	PF02991	0.491
LIG_LIR_Nem_3	851	856	PF02991	0.542
LIG_PCNA_yPIPBox_3	408	418	PF02747	0.514
LIG_REV1ctd_RIR_1	639	646	PF16727	0.548
LIG_SH2_CRK	434	438	PF00017	0.472
LIG_SH2_PTP2	101	104	PF00017	0.514
LIG_SH2_SRC	88	91	PF00017	0.541
LIG_SH2_STAP1	434	438	PF00017	0.466
LIG_SH2_STAP1	619	623	PF00017	0.559
LIG_SH2_STAT5	101	104	PF00017	0.597
LIG_SH2_STAT5	320	323	PF00017	0.594
LIG_SH2_STAT5	57	60	PF00017	0.573
LIG_SH2_STAT5	634	637	PF00017	0.535
LIG_SH2_STAT5	702	705	PF00017	0.601
LIG_SH2_STAT5	738	741	PF00017	0.604
LIG_SH2_STAT5	796	799	PF00017	0.564
LIG_SH2_STAT5	88	91	PF00017	0.542
LIG_SH3_1	692	698	PF00018	0.635
LIG_SH3_2	785	790	PF14604	0.585
LIG_SH3_3	196	202	PF00018	0.630
LIG_SH3_3	281	287	PF00018	0.682
LIG_SH3_3	505	511	PF00018	0.738
LIG_SH3_3	692	698	PF00018	0.662
LIG_SH3_3	756	762	PF00018	0.559
LIG_SH3_3	780	786	PF00018	0.613
LIG_TRAF2_1	564	567	PF00917	0.455
LIG_TRAF2_1	649	652	PF00917	0.564
LIG_TRAF2_1	72	75	PF00917	0.501
LIG_TYR_ITIM	99	104	PF00017	0.514
LIG_WRC_WIRS_1	525	530	PF05994	0.476
LIG_WW_1	510	513	PF00397	0.563
LIG_WW_3	787	791	PF00397	0.563
MOD_CDC14_SPxK_1	184	187	PF00782	0.607
MOD_CDC14_SPxK_1	694	697	PF00782	0.605
MOD_CDK_SPxK_1	181	187	PF00069	0.605
MOD_CDK_SPxK_1	691	697	PF00069	0.615
MOD_CDK_SPxxK_3	283	290	PF00069	0.618
MOD_CDK_SPxxK_3	758	765	PF00069	0.549
MOD_CK1_1	173	179	PF00069	0.786
MOD_CK1_1	238	244	PF00069	0.697
MOD_CK1_1	24	30	PF00069	0.549
MOD_CK1_1	245	251	PF00069	0.668
MOD_CK1_1	275	281	PF00069	0.700
MOD_CK1_1	283	289	PF00069	0.633
MOD_CK1_1	436	442	PF00069	0.560
MOD_CK1_1	653	659	PF00069	0.730
MOD_CK1_1	704	710	PF00069	0.627
MOD_CK1_1	757	763	PF00069	0.739
MOD_CK1_1	773	779	PF00069	0.592
MOD_CK2_1	220	226	PF00069	0.541
MOD_CK2_1	255	261	PF00069	0.667
MOD_CK2_1	436	442	PF00069	0.556
MOD_CK2_1	492	498	PF00069	0.737
MOD_CK2_1	524	530	PF00069	0.536
MOD_CK2_1	561	567	PF00069	0.448
MOD_CK2_1	675	681	PF00069	0.704
MOD_CK2_1	683	689	PF00069	0.595
MOD_CK2_1	69	75	PF00069	0.569
MOD_CK2_1	800	806	PF00069	0.610
MOD_GlcNHglycan	15	18	PF01048	0.685
MOD_GlcNHglycan	157	160	PF01048	0.690
MOD_GlcNHglycan	166	169	PF01048	0.733
MOD_GlcNHglycan	172	175	PF01048	0.628
MOD_GlcNHglycan	237	240	PF01048	0.768
MOD_GlcNHglycan	253	256	PF01048	0.606
MOD_GlcNHglycan	271	277	PF01048	0.585
MOD_GlcNHglycan	386	389	PF01048	0.491
MOD_GlcNHglycan	420	423	PF01048	0.475
MOD_GlcNHglycan	44	47	PF01048	0.565
MOD_GlcNHglycan	445	448	PF01048	0.555
MOD_GlcNHglycan	589	592	PF01048	0.593
MOD_GlcNHglycan	652	656	PF01048	0.635
MOD_GlcNHglycan	685	688	PF01048	0.640
MOD_GlcNHglycan	71	74	PF01048	0.569
MOD_GlcNHglycan	750	753	PF01048	0.561
MOD_GlcNHglycan	756	759	PF01048	0.648
MOD_GlcNHglycan	769	773	PF01048	0.568
MOD_GSK3_1	132	139	PF00069	0.579
MOD_GSK3_1	220	227	PF00069	0.692
MOD_GSK3_1	237	244	PF00069	0.626
MOD_GSK3_1	251	258	PF00069	0.666
MOD_GSK3_1	272	279	PF00069	0.801
MOD_GSK3_1	286	293	PF00069	0.535
MOD_GSK3_1	30	37	PF00069	0.706
MOD_GSK3_1	432	439	PF00069	0.507
MOD_GSK3_1	538	545	PF00069	0.437
MOD_GSK3_1	587	594	PF00069	0.532
MOD_GSK3_1	650	657	PF00069	0.646
MOD_GSK3_1	683	690	PF00069	0.699
MOD_GSK3_1	754	761	PF00069	0.635
MOD_GSK3_1	773	780	PF00069	0.606
MOD_GSK3_1	792	799	PF00069	0.744
MOD_GSK3_1	800	807	PF00069	0.616
MOD_LATS_1	115	121	PF00433	0.457
MOD_N-GLC_1	251	256	PF02516	0.630
MOD_N-GLC_1	305	310	PF02516	0.581
MOD_N-GLC_1	34	39	PF02516	0.473
MOD_N-GLC_1	42	47	PF02516	0.522
MOD_NEK2_1	1	6	PF00069	0.554
MOD_NEK2_1	104	109	PF00069	0.513
MOD_NEK2_1	154	159	PF00069	0.604
MOD_NEK2_1	204	209	PF00069	0.661
MOD_NEK2_1	21	26	PF00069	0.515
MOD_NEK2_1	374	379	PF00069	0.495
MOD_NEK2_1	553	558	PF00069	0.516
MOD_NEK2_1	568	573	PF00069	0.436
MOD_NEK2_1	587	592	PF00069	0.397
MOD_NEK2_1	641	646	PF00069	0.612
MOD_NEK2_1	754	759	PF00069	0.639
MOD_NEK2_1	770	775	PF00069	0.513
MOD_PIKK_1	136	142	PF00454	0.514
MOD_PIKK_1	162	168	PF00454	0.523
MOD_PIKK_1	204	210	PF00454	0.626
MOD_PIKK_1	245	251	PF00454	0.684
MOD_PIKK_1	253	259	PF00454	0.654
MOD_PIKK_1	276	282	PF00454	0.666
MOD_PIKK_1	67	73	PF00454	0.520
MOD_PIKK_1	817	823	PF00454	0.609
MOD_PKA_1	142	148	PF00069	0.572
MOD_PKA_1	235	241	PF00069	0.769
MOD_PKA_2	10	16	PF00069	0.529
MOD_PKA_2	132	138	PF00069	0.496
MOD_PKA_2	204	210	PF00069	0.599
MOD_PKA_2	235	241	PF00069	0.684
MOD_PKA_2	374	380	PF00069	0.491
MOD_PKA_2	521	527	PF00069	0.460
MOD_PKA_2	530	536	PF00069	0.550
MOD_PKA_2	569	575	PF00069	0.488
MOD_Plk_1	305	311	PF00069	0.628
MOD_Plk_1	34	40	PF00069	0.501
MOD_Plk_1	432	438	PF00069	0.466
MOD_Plk_1	84	90	PF00069	0.584
MOD_Plk_4	34	40	PF00069	0.541
MOD_Plk_4	355	361	PF00069	0.518
MOD_Plk_4	413	419	PF00069	0.422
MOD_Plk_4	521	527	PF00069	0.450
MOD_Plk_4	701	707	PF00069	0.687
MOD_Plk_4	79	85	PF00069	0.532
MOD_Plk_4	792	798	PF00069	0.550
MOD_Plk_4	97	103	PF00069	0.377
MOD_ProDKin_1	181	187	PF00069	0.590
MOD_ProDKin_1	238	244	PF00069	0.623
MOD_ProDKin_1	280	286	PF00069	0.788
MOD_ProDKin_1	643	649	PF00069	0.573
MOD_ProDKin_1	691	697	PF00069	0.727
MOD_ProDKin_1	740	746	PF00069	0.599
MOD_ProDKin_1	758	764	PF00069	0.593
MOD_SUMO_for_1	19	22	PF00179	0.554
MOD_SUMO_rev_2	69	79	PF00179	0.440
TRG_DiLeu_BaEn_1	94	99	PF01217	0.491
TRG_DiLeu_BaEn_2	848	854	PF01217	0.552
TRG_ENDOCYTIC_2	101	104	PF00928	0.647
TRG_ENDOCYTIC_2	434	437	PF00928	0.474
TRG_ENDOCYTIC_2	702	705	PF00928	0.559
TRG_ER_diArg_1	235	237	PF00400	0.691
TRG_ER_diArg_1	474	477	PF00400	0.430
TRG_ER_diArg_1	600	603	PF00400	0.577
TRG_ER_diArg_1	630	632	PF00400	0.440
TRG_ER_diArg_1	658	660	PF00400	0.697
TRG_ER_diArg_1	713	716	PF00400	0.666
TRG_ER_diArg_1	8	11	PF00400	0.635
TRG_NES_CRM1_1	393	407	PF08389	0.543
TRG_NES_CRM1_1	94	106	PF08389	0.488
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	621	626	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC52	Leptomonas seymouri	40%	100%
A0A3S7X7P7	Leishmania donovani	90%	90%
A4HAP8	Leishmania braziliensis	65%	92%
A4I9U4	Leishmania infantum	90%	90%
E9B4V5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	77%