Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q370_LEIMA

TriTrypDb:

LmjF.34.1320 , LMJLV39_340021400 , LMJSD75_340021400

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q370

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q370

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	436	440	PF00656	0.750
CLV_C14_Caspase3-7	576	580	PF00656	0.777
CLV_C14_Caspase3-7	592	596	PF00656	0.718
CLV_NRD_NRD_1	163	165	PF00675	0.696
CLV_NRD_NRD_1	193	195	PF00675	0.747
CLV_NRD_NRD_1	236	238	PF00675	0.645
CLV_NRD_NRD_1	465	467	PF00675	0.670
CLV_NRD_NRD_1	510	512	PF00675	0.587
CLV_NRD_NRD_1	568	570	PF00675	0.694
CLV_NRD_NRD_1	58	60	PF00675	0.696
CLV_NRD_NRD_1	649	651	PF00675	0.591
CLV_NRD_NRD_1	714	716	PF00675	0.659
CLV_NRD_NRD_1	753	755	PF00675	0.761
CLV_NRD_NRD_1	90	92	PF00675	0.755
CLV_PCSK_FUR_1	161	165	PF00082	0.754
CLV_PCSK_FUR_1	462	466	PF00082	0.712
CLV_PCSK_KEX2_1	160	162	PF00082	0.762
CLV_PCSK_KEX2_1	163	165	PF00082	0.745
CLV_PCSK_KEX2_1	235	237	PF00082	0.669
CLV_PCSK_KEX2_1	464	466	PF00082	0.671
CLV_PCSK_KEX2_1	510	512	PF00082	0.587
CLV_PCSK_KEX2_1	568	570	PF00082	0.771
CLV_PCSK_KEX2_1	58	60	PF00082	0.753
CLV_PCSK_KEX2_1	649	651	PF00082	0.603
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.745
CLV_PCSK_SKI1_1	157	161	PF00082	0.800
CLV_PCSK_SKI1_1	389	393	PF00082	0.685
CLV_PCSK_SKI1_1	49	53	PF00082	0.524
CLV_PCSK_SKI1_1	637	641	PF00082	0.510
DEG_Nend_UBRbox_1	1	4	PF02207	0.612
DEG_SCF_FBW7_2	289	296	PF00400	0.753
DEG_SPOP_SBC_1	125	129	PF00917	0.761
DEG_SPOP_SBC_1	224	228	PF00917	0.712
DOC_CKS1_1	177	182	PF01111	0.553
DOC_CKS1_1	484	489	PF01111	0.722
DOC_CYCLIN_RxL_1	634	641	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	207	213	PF00134	0.671
DOC_CYCLIN_yCln2_LP_2	418	421	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	630	636	PF00134	0.621
DOC_MAPK_MEF2A_6	686	695	PF00069	0.594
DOC_PP1_RVXF_1	528	534	PF00149	0.522
DOC_PP2B_LxvP_1	207	210	PF13499	0.792
DOC_PP2B_LxvP_1	418	421	PF13499	0.508
DOC_PP2B_LxvP_1	424	427	PF13499	0.553
DOC_PP2B_LxvP_1	482	485	PF13499	0.569
DOC_PP4_FxxP_1	277	280	PF00568	0.654
DOC_PP4_FxxP_1	475	478	PF00568	0.675
DOC_PP4_FxxP_1	533	536	PF00568	0.597
DOC_PP4_FxxP_1	601	604	PF00568	0.740
DOC_USP7_MATH_1	118	122	PF00917	0.786
DOC_USP7_MATH_1	125	129	PF00917	0.755
DOC_USP7_MATH_1	169	173	PF00917	0.763
DOC_USP7_MATH_1	224	228	PF00917	0.731
DOC_USP7_MATH_1	247	251	PF00917	0.753
DOC_USP7_MATH_1	355	359	PF00917	0.703
DOC_USP7_MATH_1	362	366	PF00917	0.771
DOC_USP7_MATH_1	432	436	PF00917	0.729
DOC_USP7_MATH_1	442	446	PF00917	0.799
DOC_USP7_MATH_1	471	475	PF00917	0.634
DOC_USP7_MATH_1	544	548	PF00917	0.679
DOC_USP7_MATH_1	604	608	PF00917	0.774
DOC_USP7_MATH_1	659	663	PF00917	0.691
DOC_USP7_MATH_1	735	739	PF00917	0.800
DOC_USP7_MATH_1	80	84	PF00917	0.713
DOC_USP7_UBL2_3	331	335	PF12436	0.718
DOC_WW_Pin1_4	17	22	PF00397	0.693
DOC_WW_Pin1_4	176	181	PF00397	0.748
DOC_WW_Pin1_4	184	189	PF00397	0.775
DOC_WW_Pin1_4	209	214	PF00397	0.665
DOC_WW_Pin1_4	269	274	PF00397	0.787
DOC_WW_Pin1_4	276	281	PF00397	0.656
DOC_WW_Pin1_4	289	294	PF00397	0.538
DOC_WW_Pin1_4	480	485	PF00397	0.693
DOC_WW_Pin1_4	490	495	PF00397	0.507
DOC_WW_Pin1_4	629	634	PF00397	0.642
DOC_WW_Pin1_4	755	760	PF00397	0.592
LIG_14-3-3_CanoR_1	235	244	PF00244	0.653
LIG_14-3-3_CanoR_1	26	32	PF00244	0.708
LIG_14-3-3_CanoR_1	470	476	PF00244	0.702
LIG_14-3-3_CanoR_1	686	694	PF00244	0.594
LIG_14-3-3_CanoR_1	715	725	PF00244	0.743
LIG_14-3-3_CanoR_1	754	758	PF00244	0.652
LIG_BIR_III_4	743	747	PF00653	0.567
LIG_BRCT_BRCA1_1	273	277	PF00533	0.661
LIG_BRCT_BRCA1_1	314	318	PF00533	0.582
LIG_BRCT_BRCA1_1	44	48	PF00533	0.739
LIG_CaM_IQ_9	449	464	PF13499	0.730
LIG_CaM_IQ_9	498	513	PF13499	0.587
LIG_eIF4E_1	61	67	PF01652	0.561
LIG_eIF4E_1	634	640	PF01652	0.624
LIG_FHA_1	256	262	PF00498	0.685
LIG_FHA_1	266	272	PF00498	0.696
LIG_FHA_1	305	311	PF00498	0.587
LIG_FHA_1	378	384	PF00498	0.718
LIG_FHA_1	403	409	PF00498	0.581
LIG_FHA_1	484	490	PF00498	0.752
LIG_FHA_1	580	586	PF00498	0.712
LIG_FHA_1	608	614	PF00498	0.669
LIG_FHA_1	61	67	PF00498	0.711
LIG_FHA_1	690	696	PF00498	0.606
LIG_FHA_2	364	370	PF00498	0.794
LIG_FHA_2	428	434	PF00498	0.691
LIG_FHA_2	450	456	PF00498	0.823
LIG_IBAR_NPY_1	674	676	PF08397	0.528
LIG_LIR_Apic_2	274	280	PF02991	0.657
LIG_LIR_Apic_2	474	478	PF02991	0.559
LIG_LIR_Gen_1	30	39	PF02991	0.738
LIG_LIR_Gen_1	344	351	PF02991	0.591
LIG_LIR_Gen_1	388	398	PF02991	0.632
LIG_LIR_Gen_1	407	415	PF02991	0.635
LIG_LIR_Nem_3	30	34	PF02991	0.695
LIG_LIR_Nem_3	344	348	PF02991	0.584
LIG_LIR_Nem_3	388	394	PF02991	0.632
LIG_LIR_Nem_3	407	412	PF02991	0.639
LIG_LIR_Nem_3	45	51	PF02991	0.707
LIG_LIR_Nem_3	670	676	PF02991	0.771
LIG_MYND_1	490	494	PF01753	0.619
LIG_SH2_CRK	345	349	PF00017	0.589
LIG_SH2_CRK	525	529	PF00017	0.547
LIG_SH2_CRK	774	778	PF00017	0.641
LIG_SH2_STAP1	285	289	PF00017	0.748
LIG_SH2_STAP1	609	613	PF00017	0.790
LIG_SH2_STAP1	676	680	PF00017	0.752
LIG_SH2_STAP1	687	691	PF00017	0.624
LIG_SH2_STAT5	285	288	PF00017	0.706
LIG_SH2_STAT5	333	336	PF00017	0.579
LIG_SH2_STAT5	519	522	PF00017	0.656
LIG_SH2_STAT5	609	612	PF00017	0.553
LIG_SH2_STAT5	634	637	PF00017	0.686
LIG_SH2_STAT5	774	777	PF00017	0.605
LIG_SH3_1	679	685	PF00018	0.658
LIG_SH3_3	105	111	PF00018	0.722
LIG_SH3_3	174	180	PF00018	0.688
LIG_SH3_3	182	188	PF00018	0.735
LIG_SH3_3	203	209	PF00018	0.723
LIG_SH3_3	435	441	PF00018	0.794
LIG_SH3_3	481	487	PF00018	0.736
LIG_SH3_3	596	602	PF00018	0.719
LIG_SH3_3	621	627	PF00018	0.723
LIG_SH3_3	679	685	PF00018	0.624
LIG_SH3_3	764	770	PF00018	0.709
LIG_SUMO_SIM_anti_2	688	696	PF11976	0.592
LIG_SUMO_SIM_par_1	307	313	PF11976	0.602
LIG_SUMO_SIM_par_1	691	696	PF11976	0.594
LIG_SUMO_SIM_par_1	703	710	PF11976	0.580
LIG_UBA3_1	498	506	PF00899	0.579
LIG_WRC_WIRS_1	28	33	PF05994	0.756
LIG_WW_2	487	490	PF00397	0.661
MOD_CDK_SPK_2	289	294	PF00069	0.770
MOD_CDK_SPxxK_3	490	497	PF00069	0.557
MOD_CDK_SPxxK_3	755	762	PF00069	0.572
MOD_CK1_1	184	190	PF00069	0.756
MOD_CK1_1	238	244	PF00069	0.770
MOD_CK1_1	317	323	PF00069	0.555
MOD_CK1_1	445	451	PF00069	0.769
MOD_CK1_1	480	486	PF00069	0.730
MOD_CK1_1	552	558	PF00069	0.566
MOD_CK1_1	575	581	PF00069	0.691
MOD_CK1_1	607	613	PF00069	0.711
MOD_CK1_1	632	638	PF00069	0.661
MOD_CK1_1	717	723	PF00069	0.734
MOD_CK1_1	738	744	PF00069	0.773
MOD_CK1_1	79	85	PF00069	0.711
MOD_CK2_1	124	130	PF00069	0.733
MOD_CK2_1	363	369	PF00069	0.719
MOD_CK2_1	449	455	PF00069	0.713
MOD_CK2_1	490	496	PF00069	0.541
MOD_CK2_1	664	670	PF00069	0.658
MOD_CK2_1	704	710	PF00069	0.578
MOD_CK2_1	718	724	PF00069	0.681
MOD_CK2_1	755	761	PF00069	0.690
MOD_Cter_Amidation	161	164	PF01082	0.717
MOD_Cter_Amidation	229	232	PF01082	0.775
MOD_Cter_Amidation	233	236	PF01082	0.697
MOD_Cter_Amidation	462	465	PF01082	0.748
MOD_Cter_Amidation	56	59	PF01082	0.733
MOD_GlcNHglycan	147	150	PF01048	0.708
MOD_GlcNHglycan	171	174	PF01048	0.742
MOD_GlcNHglycan	249	252	PF01048	0.659
MOD_GlcNHglycan	312	315	PF01048	0.608
MOD_GlcNHglycan	444	447	PF01048	0.823
MOD_GlcNHglycan	467	470	PF01048	0.751
MOD_GlcNHglycan	546	549	PF01048	0.577
MOD_GlcNHglycan	661	664	PF01048	0.665
MOD_GlcNHglycan	666	669	PF01048	0.646
MOD_GlcNHglycan	670	673	PF01048	0.634
MOD_GlcNHglycan	720	723	PF01048	0.695
MOD_GlcNHglycan	737	740	PF01048	0.485
MOD_GlcNHglycan	748	751	PF01048	0.569
MOD_GlcNHglycan	78	81	PF01048	0.705
MOD_GlcNHglycan	85	88	PF01048	0.696
MOD_GSK3_1	114	121	PF00069	0.761
MOD_GSK3_1	134	141	PF00069	0.675
MOD_GSK3_1	165	172	PF00069	0.811
MOD_GSK3_1	183	190	PF00069	0.726
MOD_GSK3_1	238	245	PF00069	0.701
MOD_GSK3_1	265	272	PF00069	0.768
MOD_GSK3_1	288	295	PF00069	0.668
MOD_GSK3_1	310	317	PF00069	0.608
MOD_GSK3_1	319	326	PF00069	0.610
MOD_GSK3_1	353	360	PF00069	0.632
MOD_GSK3_1	442	449	PF00069	0.708
MOD_GSK3_1	473	480	PF00069	0.777
MOD_GSK3_1	573	580	PF00069	0.700
MOD_GSK3_1	604	611	PF00069	0.727
MOD_GSK3_1	628	635	PF00069	0.670
MOD_GSK3_1	638	645	PF00069	0.451
MOD_GSK3_1	664	671	PF00069	0.658
MOD_GSK3_1	685	692	PF00069	0.574
MOD_GSK3_1	700	707	PF00069	0.573
MOD_GSK3_1	710	717	PF00069	0.631
MOD_GSK3_1	738	745	PF00069	0.811
MOD_GSK3_1	76	83	PF00069	0.709
MOD_NEK2_1	124	129	PF00069	0.779
MOD_NEK2_1	181	186	PF00069	0.692
MOD_NEK2_1	22	27	PF00069	0.564
MOD_NEK2_1	288	293	PF00069	0.776
MOD_NEK2_1	318	323	PF00069	0.590
MOD_NEK2_2	27	32	PF00069	0.714
MOD_NEK2_2	404	409	PF00069	0.626
MOD_NEK2_2	43	48	PF00069	0.743
MOD_PIKK_1	355	361	PF00454	0.702
MOD_PIKK_1	449	455	PF00454	0.697
MOD_PIKK_1	512	518	PF00454	0.528
MOD_PIKK_1	612	618	PF00454	0.724
MOD_PK_1	434	440	PF00069	0.708
MOD_PKA_1	235	241	PF00069	0.706
MOD_PKA_1	465	471	PF00069	0.749
MOD_PKA_1	715	721	PF00069	0.733
MOD_PKA_2	235	241	PF00069	0.706
MOD_PKA_2	302	308	PF00069	0.534
MOD_PKA_2	32	38	PF00069	0.682
MOD_PKA_2	465	471	PF00069	0.697
MOD_PKA_2	685	691	PF00069	0.594
MOD_PKA_2	714	720	PF00069	0.692
MOD_PKA_2	753	759	PF00069	0.612
MOD_PKA_2	83	89	PF00069	0.803
MOD_Plk_1	539	545	PF00069	0.545
MOD_Plk_1	594	600	PF00069	0.720
MOD_Plk_1	733	739	PF00069	0.758
MOD_Plk_2-3	704	710	PF00069	0.578
MOD_Plk_4	238	244	PF00069	0.717
MOD_Plk_4	272	278	PF00069	0.777
MOD_Plk_4	314	320	PF00069	0.552
MOD_Plk_4	404	410	PF00069	0.606
MOD_Plk_4	43	49	PF00069	0.719
MOD_Plk_4	552	558	PF00069	0.503
MOD_Plk_4	580	586	PF00069	0.745
MOD_Plk_4	604	610	PF00069	0.776
MOD_ProDKin_1	17	23	PF00069	0.694
MOD_ProDKin_1	176	182	PF00069	0.746
MOD_ProDKin_1	184	190	PF00069	0.776
MOD_ProDKin_1	209	215	PF00069	0.667
MOD_ProDKin_1	269	275	PF00069	0.787
MOD_ProDKin_1	276	282	PF00069	0.657
MOD_ProDKin_1	289	295	PF00069	0.528
MOD_ProDKin_1	480	486	PF00069	0.692
MOD_ProDKin_1	490	496	PF00069	0.502
MOD_ProDKin_1	629	635	PF00069	0.630
MOD_ProDKin_1	755	761	PF00069	0.594
MOD_SUMO_rev_2	451	458	PF00179	0.731
MOD_SUMO_rev_2	756	763	PF00179	0.570
TRG_DiLeu_BaEn_1	414	419	PF01217	0.621
TRG_DiLeu_BaEn_2	624	630	PF01217	0.719
TRG_DiLeu_BaLyEn_6	635	640	PF01217	0.535
TRG_ENDOCYTIC_2	285	288	PF00928	0.607
TRG_ENDOCYTIC_2	345	348	PF00928	0.675
TRG_ENDOCYTIC_2	525	528	PF00928	0.524
TRG_ENDOCYTIC_2	774	777	PF00928	0.605
TRG_ER_diArg_1	161	164	PF00400	0.763
TRG_ER_diArg_1	235	237	PF00400	0.636
TRG_ER_diArg_1	462	465	PF00400	0.659
TRG_ER_diArg_1	530	533	PF00400	0.497
TRG_ER_diArg_1	648	650	PF00400	0.587
TRG_NLS_MonoExtC_3	159	164	PF00514	0.700
TRG_NLS_MonoExtN_4	157	164	PF00514	0.744
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	497	502	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL05	Leptomonas seymouri	45%	100%
A0A1X0P9E8	Trypanosomatidae	30%	100%
A0A3S7X7P6	Leishmania donovani	91%	100%
A4HAP9	Leishmania braziliensis	73%	100%
A4I9U5	Leishmania infantum	91%	100%
E9B4V6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BT09	Trypanosoma cruzi	31%	100%