Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q367_LEIMA

TriTrypDb:

LmjF.34.1350 , LMJLV39_340021700 , LMJSD75_340021700

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q367

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q367

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	472	476	PF00656	0.694
CLV_C14_Caspase3-7	562	566	PF00656	0.648
CLV_NRD_NRD_1	483	485	PF00675	0.523
CLV_PCSK_KEX2_1	34	36	PF00082	0.520
CLV_PCSK_KEX2_1	519	521	PF00082	0.571
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.520
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.571
CLV_PCSK_SKI1_1	107	111	PF00082	0.605
CLV_PCSK_SKI1_1	193	197	PF00082	0.564
CLV_PCSK_SKI1_1	379	383	PF00082	0.483
CLV_PCSK_SKI1_1	491	495	PF00082	0.641
CLV_PCSK_SKI1_1	51	55	PF00082	0.599
DEG_SCF_FBW7_1	290	297	PF00400	0.705
DEG_SPOP_SBC_1	116	120	PF00917	0.703
DOC_CKS1_1	140	145	PF01111	0.716
DOC_CKS1_1	246	251	PF01111	0.645
DOC_CKS1_1	279	284	PF01111	0.713
DOC_CKS1_1	291	296	PF01111	0.710
DOC_CKS1_1	322	327	PF01111	0.767
DOC_CKS1_1	498	503	PF01111	0.604
DOC_CKS1_1	83	88	PF01111	0.629
DOC_MAPK_MEF2A_6	261	268	PF00069	0.690
DOC_PP2B_LxvP_1	541	544	PF13499	0.686
DOC_USP7_MATH_1	116	120	PF00917	0.721
DOC_USP7_MATH_1	232	236	PF00917	0.710
DOC_USP7_MATH_1	239	243	PF00917	0.712
DOC_USP7_MATH_1	24	28	PF00917	0.485
DOC_USP7_MATH_1	250	254	PF00917	0.591
DOC_USP7_MATH_1	272	276	PF00917	0.720
DOC_USP7_MATH_1	280	284	PF00917	0.669
DOC_USP7_MATH_1	294	298	PF00917	0.770
DOC_USP7_MATH_1	315	319	PF00917	0.724
DOC_USP7_MATH_1	45	49	PF00917	0.485
DOC_USP7_MATH_1	546	550	PF00917	0.620
DOC_USP7_UBL2_3	60	64	PF12436	0.507
DOC_WW_Pin1_4	139	144	PF00397	0.773
DOC_WW_Pin1_4	241	246	PF00397	0.679
DOC_WW_Pin1_4	259	264	PF00397	0.674
DOC_WW_Pin1_4	268	273	PF00397	0.650
DOC_WW_Pin1_4	278	283	PF00397	0.584
DOC_WW_Pin1_4	284	289	PF00397	0.777
DOC_WW_Pin1_4	290	295	PF00397	0.688
DOC_WW_Pin1_4	299	304	PF00397	0.580
DOC_WW_Pin1_4	311	316	PF00397	0.630
DOC_WW_Pin1_4	318	323	PF00397	0.545
DOC_WW_Pin1_4	36	41	PF00397	0.541
DOC_WW_Pin1_4	406	411	PF00397	0.736
DOC_WW_Pin1_4	413	418	PF00397	0.550
DOC_WW_Pin1_4	497	502	PF00397	0.617
DOC_WW_Pin1_4	82	87	PF00397	0.655
LIG_14-3-3_CanoR_1	152	160	PF00244	0.562
LIG_14-3-3_CanoR_1	364	372	PF00244	0.538
LIG_14-3-3_CanoR_1	405	410	PF00244	0.722
LIG_14-3-3_CanoR_1	491	501	PF00244	0.539
LIG_14-3-3_CanoR_1	545	553	PF00244	0.534
LIG_APCC_ABBA_1	195	200	PF00400	0.451
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_BIR_III_3	1	5	PF00653	0.665
LIG_CtBP_PxDLS_1	148	152	PF00389	0.591
LIG_FHA_1	140	146	PF00498	0.715
LIG_FHA_1	169	175	PF00498	0.473
LIG_FHA_1	279	285	PF00498	0.710
LIG_FHA_1	351	357	PF00498	0.613
LIG_FHA_1	493	499	PF00498	0.586
LIG_FHA_1	565	571	PF00498	0.728
LIG_FHA_1	83	89	PF00498	0.584
LIG_FHA_2	124	130	PF00498	0.703
LIG_FHA_2	355	361	PF00498	0.682
LIG_FHA_2	414	420	PF00498	0.563
LIG_FHA_2	470	476	PF00498	0.688
LIG_FHA_2	498	504	PF00498	0.487
LIG_FHA_2	52	58	PF00498	0.593
LIG_FHA_2	530	536	PF00498	0.652
LIG_FHA_2	546	552	PF00498	0.511
LIG_LIR_Apic_2	183	187	PF02991	0.506
LIG_LIR_Nem_3	522	527	PF02991	0.589
LIG_NRBOX	69	75	PF00104	0.652
LIG_PALB2_WD40_1	186	194	PF16756	0.456
LIG_SH2_CRK	184	188	PF00017	0.476
LIG_SH2_STAT3	460	463	PF00017	0.474
LIG_SH2_STAT3	81	84	PF00017	0.668
LIG_SH2_STAT5	167	170	PF00017	0.469
LIG_SH2_STAT5	371	374	PF00017	0.531
LIG_SH2_STAT5	376	379	PF00017	0.486
LIG_SH2_STAT5	525	528	PF00017	0.590
LIG_SH2_STAT5	66	69	PF00017	0.585
LIG_SH2_STAT5	81	84	PF00017	0.473
LIG_SH3_3	134	140	PF00018	0.602
LIG_SH3_3	243	249	PF00018	0.779
LIG_SH3_3	257	263	PF00018	0.554
LIG_SH3_3	279	285	PF00018	0.732
LIG_SH3_3	319	325	PF00018	0.668
LIG_SH3_3	353	359	PF00018	0.597
LIG_SUMO_SIM_anti_2	512	519	PF11976	0.593
LIG_TRAF2_1	4	7	PF00917	0.520
LIG_TRAF2_1	500	503	PF00917	0.488
LIG_UBA3_1	515	519	PF00899	0.552
LIG_WRPW_2	63	66	PF00400	0.565
MOD_CDK_SPK_2	268	273	PF00069	0.669
MOD_CDK_SPxxK_3	245	252	PF00069	0.646
MOD_CDK_SPxxK_3	413	420	PF00069	0.665
MOD_CK1_1	103	109	PF00069	0.681
MOD_CK1_1	118	124	PF00069	0.645
MOD_CK1_1	241	247	PF00069	0.675
MOD_CK1_1	27	33	PF00069	0.523
MOD_CK1_1	271	277	PF00069	0.699
MOD_CK1_1	311	317	PF00069	0.656
MOD_CK1_1	318	324	PF00069	0.684
MOD_CK1_1	395	401	PF00069	0.761
MOD_CK1_1	480	486	PF00069	0.602
MOD_CK1_1	529	535	PF00069	0.702
MOD_CK2_1	413	419	PF00069	0.550
MOD_CK2_1	497	503	PF00069	0.502
MOD_CK2_1	51	57	PF00069	0.597
MOD_CK2_1	545	551	PF00069	0.688
MOD_GlcNHglycan	241	244	PF01048	0.684
MOD_GlcNHglycan	26	29	PF01048	0.490
MOD_GlcNHglycan	296	299	PF01048	0.718
MOD_GlcNHglycan	310	313	PF01048	0.657
MOD_GlcNHglycan	317	320	PF01048	0.693
MOD_GlcNHglycan	331	334	PF01048	0.636
MOD_GlcNHglycan	397	400	PF01048	0.754
MOD_GlcNHglycan	413	416	PF01048	0.477
MOD_GlcNHglycan	440	443	PF01048	0.530
MOD_GlcNHglycan	447	450	PF01048	0.490
MOD_GlcNHglycan	477	482	PF01048	0.634
MOD_GlcNHglycan	528	531	PF01048	0.699
MOD_GlcNHglycan	538	541	PF01048	0.584
MOD_GlcNHglycan	548	551	PF01048	0.415
MOD_GSK3_1	103	110	PF00069	0.671
MOD_GSK3_1	112	119	PF00069	0.671
MOD_GSK3_1	120	127	PF00069	0.722
MOD_GSK3_1	241	248	PF00069	0.695
MOD_GSK3_1	264	271	PF00069	0.725
MOD_GSK3_1	274	281	PF00069	0.602
MOD_GSK3_1	290	297	PF00069	0.838
MOD_GSK3_1	311	318	PF00069	0.671
MOD_GSK3_1	329	336	PF00069	0.605
MOD_GSK3_1	337	344	PF00069	0.749
MOD_GSK3_1	350	357	PF00069	0.704
MOD_GSK3_1	389	396	PF00069	0.647
MOD_GSK3_1	397	404	PF00069	0.731
MOD_GSK3_1	51	58	PF00069	0.621
MOD_GSK3_1	526	533	PF00069	0.591
MOD_N-GLC_1	107	112	PF02516	0.571
MOD_N-GLC_1	124	129	PF02516	0.744
MOD_N-GLC_1	308	313	PF02516	0.716
MOD_N-GLC_1	406	411	PF02516	0.715
MOD_NEK2_1	151	156	PF00069	0.579
MOD_NEK2_1	168	173	PF00069	0.641
MOD_NEK2_1	210	215	PF00069	0.694
MOD_NEK2_1	266	271	PF00069	0.690
MOD_NEK2_1	308	313	PF00069	0.716
MOD_NEK2_1	489	494	PF00069	0.682
MOD_NEK2_1	564	569	PF00069	0.555
MOD_NEK2_2	45	50	PF00069	0.477
MOD_PIKK_1	210	216	PF00454	0.685
MOD_PIKK_1	337	343	PF00454	0.765
MOD_PIKK_1	436	442	PF00454	0.536
MOD_PK_1	55	61	PF00069	0.590
MOD_PKA_1	519	525	PF00069	0.579
MOD_PKA_2	103	109	PF00069	0.697
MOD_PKA_2	112	118	PF00069	0.642
MOD_PKA_2	151	157	PF00069	0.572
MOD_PKA_2	329	335	PF00069	0.704
MOD_PKA_2	519	525	PF00069	0.579
MOD_PKA_2	546	552	PF00069	0.609
MOD_Plk_1	210	216	PF00069	0.563
MOD_Plk_1	382	388	PF00069	0.515
MOD_Plk_1	564	570	PF00069	0.608
MOD_Plk_2-3	91	97	PF00069	0.807
MOD_Plk_4	333	339	PF00069	0.724
MOD_Plk_4	494	500	PF00069	0.541
MOD_Plk_4	77	83	PF00069	0.619
MOD_ProDKin_1	139	145	PF00069	0.773
MOD_ProDKin_1	241	247	PF00069	0.681
MOD_ProDKin_1	259	265	PF00069	0.677
MOD_ProDKin_1	268	274	PF00069	0.650
MOD_ProDKin_1	278	284	PF00069	0.586
MOD_ProDKin_1	290	296	PF00069	0.750
MOD_ProDKin_1	299	305	PF00069	0.639
MOD_ProDKin_1	311	317	PF00069	0.630
MOD_ProDKin_1	318	324	PF00069	0.546
MOD_ProDKin_1	36	42	PF00069	0.543
MOD_ProDKin_1	406	412	PF00069	0.733
MOD_ProDKin_1	413	419	PF00069	0.545
MOD_ProDKin_1	497	503	PF00069	0.612
MOD_ProDKin_1	82	88	PF00069	0.659
MOD_SUMO_for_1	372	375	PF00179	0.639
TRG_DiLeu_BaEn_1	513	518	PF01217	0.592
TRG_DiLeu_BaEn_1	7	12	PF01217	0.490
TRG_DiLeu_BaEn_4	513	519	PF01217	0.597
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.629
TRG_ER_diArg_1	158	161	PF00400	0.511
TRG_ER_diArg_1	252	255	PF00400	0.717
TRG_ER_diArg_1	544	547	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	491	496	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C9	Leptomonas seymouri	53%	98%
A0A3S7X7T6	Leishmania donovani	95%	100%
A4HAQ2	Leishmania braziliensis	78%	100%
A4I9U8	Leishmania infantum	94%	99%
E9B4V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%