Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q365_LEIMA

TriTrypDb:

LmjF.34.1370 , LMJLV39_340021900 , LMJSD75_340021900

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q365

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q365

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.531
CLV_C14_Caspase3-7	200	204	PF00656	0.434
CLV_C14_Caspase3-7	271	275	PF00656	0.429
CLV_NRD_NRD_1	260	262	PF00675	0.470
CLV_NRD_NRD_1	287	289	PF00675	0.513
CLV_NRD_NRD_1	301	303	PF00675	0.425
CLV_NRD_NRD_1	314	316	PF00675	0.385
CLV_NRD_NRD_1	320	322	PF00675	0.427
CLV_NRD_NRD_1	53	55	PF00675	0.425
CLV_PCSK_FUR_1	299	303	PF00082	0.378
CLV_PCSK_KEX2_1	287	289	PF00082	0.515
CLV_PCSK_KEX2_1	299	301	PF00082	0.382
CLV_PCSK_KEX2_1	313	315	PF00082	0.460
CLV_PCSK_KEX2_1	319	321	PF00082	0.368
CLV_PCSK_KEX2_1	36	38	PF00082	0.569
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.525
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.569
CLV_PCSK_PC7_1	315	321	PF00082	0.456
CLV_PCSK_SKI1_1	262	266	PF00082	0.459
CLV_PCSK_SKI1_1	27	31	PF00082	0.607
CLV_PCSK_SKI1_1	315	319	PF00082	0.449
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DOC_ANK_TNKS_1	198	205	PF00023	0.364
DOC_ANK_TNKS_1	286	293	PF00023	0.363
DOC_CYCLIN_yClb1_LxF_4	74	80	PF00134	0.429
DOC_MAPK_gen_1	61	68	PF00069	0.450
DOC_MAPK_MEF2A_6	86	93	PF00069	0.509
DOC_USP7_MATH_1	102	106	PF00917	0.590
DOC_USP7_MATH_1	147	151	PF00917	0.522
DOC_USP7_MATH_1	8	12	PF00917	0.624
DOC_USP7_UBL2_3	319	323	PF12436	0.588
DOC_WW_Pin1_4	145	150	PF00397	0.684
DOC_WW_Pin1_4	37	42	PF00397	0.556
DOC_WW_Pin1_4	95	100	PF00397	0.643
LIG_14-3-3_CanoR_1	189	197	PF00244	0.460
LIG_14-3-3_CanoR_1	261	265	PF00244	0.583
LIG_14-3-3_CanoR_1	302	308	PF00244	0.376
LIG_APCC_ABBA_1	166	171	PF00400	0.427
LIG_eIF4E_1	160	166	PF01652	0.433
LIG_FHA_1	125	131	PF00498	0.724
LIG_FHA_1	80	86	PF00498	0.492
LIG_FHA_2	127	133	PF00498	0.604
LIG_FHA_2	210	216	PF00498	0.462
LIG_FHA_2	261	267	PF00498	0.510
LIG_FHA_2	38	44	PF00498	0.459
LIG_LIR_Gen_1	78	89	PF02991	0.535
LIG_LIR_Nem_3	119	124	PF02991	0.519
LIG_LIR_Nem_3	45	51	PF02991	0.470
LIG_PCNA_yPIPBox_3	211	224	PF02747	0.495
LIG_Pex14_2	117	121	PF04695	0.549
LIG_SH2_STAP1	161	165	PF00017	0.408
LIG_SH2_STAP1	81	85	PF00017	0.447
LIG_SH2_STAT5	81	84	PF00017	0.443
LIG_SH3_3	1	7	PF00018	0.627
LIG_SUMO_SIM_par_1	88	95	PF11976	0.577
LIG_UBA3_1	120	125	PF00899	0.545
MOD_CK1_1	126	132	PF00069	0.755
MOD_CK1_1	16	22	PF00069	0.738
MOD_CK1_1	95	101	PF00069	0.684
MOD_CK2_1	130	136	PF00069	0.626
MOD_CK2_1	138	144	PF00069	0.577
MOD_CK2_1	202	208	PF00069	0.518
MOD_CK2_1	209	215	PF00069	0.431
MOD_CK2_1	223	229	PF00069	0.538
MOD_CK2_1	260	266	PF00069	0.508
MOD_CK2_1	37	43	PF00069	0.517
MOD_CK2_1	67	73	PF00069	0.545
MOD_CK2_1	95	101	PF00069	0.501
MOD_Cter_Amidation	311	314	PF01082	0.474
MOD_GlcNHglycan	106	109	PF01048	0.662
MOD_GlcNHglycan	135	139	PF01048	0.622
MOD_GlcNHglycan	149	152	PF01048	0.677
MOD_GlcNHglycan	162	165	PF01048	0.405
MOD_GlcNHglycan	69	72	PF01048	0.502
MOD_GSK3_1	124	131	PF00069	0.624
MOD_GSK3_1	134	141	PF00069	0.612
MOD_GSK3_1	237	244	PF00069	0.444
MOD_GSK3_1	67	74	PF00069	0.506
MOD_N-GLC_1	303	308	PF02516	0.443
MOD_NEK2_1	124	129	PF00069	0.624
MOD_NEK2_1	223	228	PF00069	0.516
MOD_NEK2_1	79	84	PF00069	0.478
MOD_PIKK_1	92	98	PF00454	0.589
MOD_PKA_2	260	266	PF00069	0.628
MOD_Plk_1	193	199	PF00069	0.575
MOD_Plk_1	303	309	PF00069	0.443
MOD_Plk_4	260	266	PF00069	0.532
MOD_ProDKin_1	145	151	PF00069	0.679
MOD_ProDKin_1	37	43	PF00069	0.552
MOD_ProDKin_1	95	101	PF00069	0.648
MOD_SUMO_for_1	279	282	PF00179	0.439
MOD_SUMO_for_1	29	32	PF00179	0.606
MOD_SUMO_rev_2	119	127	PF00179	0.531
MOD_SUMO_rev_2	43	51	PF00179	0.407
TRG_DiLeu_BaEn_4	215	221	PF01217	0.516
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.550
TRG_ENDOCYTIC_2	81	84	PF00928	0.473
TRG_ER_diArg_1	286	288	PF00400	0.515
TRG_ER_diArg_1	299	302	PF00400	0.600
TRG_ER_diArg_1	313	315	PF00400	0.411
TRG_NLS_Bipartite_1	301	323	PF00514	0.392
TRG_NLS_MonoCore_2	318	323	PF00514	0.581
TRG_NLS_MonoExtC_3	318	323	PF00514	0.581
TRG_NLS_MonoExtN_4	35	40	PF00514	0.566
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R6	Leptomonas seymouri	49%	100%
A0A3Q8IIE4	Leishmania donovani	89%	100%
A4HAQ3	Leishmania braziliensis	68%	100%
A4I9V0	Leishmania infantum	90%	100%
E9B4W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%