D-isomer specific 2-hydroxyacid dehydrogenase-protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

d-isomer specific 2-hydroxyacid dehydrogenase- protein

Species:

Leishmania major

UniProt:

Q4Q362_LEIMA

TriTrypDb:

LmjF.34.1400 , LMJLV39_340022200 , LMJSD75_340022400

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q362

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q362

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0005488	binding	1	16
GO:0036094	small molecule binding	2	16
GO:0051287	NAD binding	4	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	24	30	PF00089	0.341
CLV_NRD_NRD_1	139	141	PF00675	0.264
CLV_NRD_NRD_1	151	153	PF00675	0.286
CLV_NRD_NRD_1	182	184	PF00675	0.318
CLV_NRD_NRD_1	26	28	PF00675	0.507
CLV_NRD_NRD_1	305	307	PF00675	0.446
CLV_NRD_NRD_1	321	323	PF00675	0.661
CLV_NRD_NRD_1	75	77	PF00675	0.339
CLV_PCSK_KEX2_1	151	153	PF00082	0.372
CLV_PCSK_KEX2_1	182	184	PF00082	0.254
CLV_PCSK_KEX2_1	26	28	PF00082	0.352
CLV_PCSK_KEX2_1	75	77	PF00082	0.339
CLV_PCSK_SKI1_1	223	227	PF00082	0.257
CLV_PCSK_SKI1_1	228	232	PF00082	0.251
CLV_PCSK_SKI1_1	75	79	PF00082	0.428
DOC_MAPK_gen_1	151	158	PF00069	0.510
DOC_MAPK_gen_1	187	196	PF00069	0.555
DOC_PP2B_PxIxI_1	2	8	PF00149	0.479
DOC_USP7_MATH_1	144	148	PF00917	0.526
DOC_USP7_MATH_1	315	319	PF00917	0.332
DOC_USP7_UBL2_3	137	141	PF12436	0.557
DOC_USP7_UBL2_3	187	191	PF12436	0.526
DOC_WW_Pin1_4	277	282	PF00397	0.454
LIG_14-3-3_CanoR_1	245	250	PF00244	0.454
LIG_14-3-3_CanoR_1	309	315	PF00244	0.437
LIG_BIR_II_1	1	5	PF00653	0.419
LIG_BRCT_BRCA1_1	236	240	PF00533	0.496
LIG_deltaCOP1_diTrp_1	139	145	PF00928	0.465
LIG_FHA_1	2	8	PF00498	0.395
LIG_FHA_1	319	325	PF00498	0.510
LIG_LIR_Gen_1	117	126	PF02991	0.479
LIG_LIR_Gen_1	143	150	PF02991	0.452
LIG_LIR_Gen_1	237	247	PF02991	0.476
LIG_LIR_Gen_1	38	45	PF02991	0.542
LIG_LIR_Nem_3	117	121	PF02991	0.490
LIG_LIR_Nem_3	139	145	PF02991	0.477
LIG_LIR_Nem_3	237	243	PF02991	0.454
LIG_LIR_Nem_3	38	43	PF02991	0.441
LIG_Pex14_2	226	230	PF04695	0.526
LIG_Pex14_2	310	314	PF04695	0.523
LIG_REV1ctd_RIR_1	223	232	PF16727	0.465
LIG_SH2_GRB2like	125	128	PF00017	0.389
LIG_SH2_STAP1	81	85	PF00017	0.447
LIG_SH2_STAT5	118	121	PF00017	0.374
LIG_SH2_STAT5	125	128	PF00017	0.296
LIG_SUMO_SIM_par_1	287	294	PF11976	0.518
LIG_SUMO_SIM_par_1	48	55	PF11976	0.513
LIG_TYR_ITIM	158	163	PF00017	0.454
LIG_UBA3_1	254	259	PF00899	0.526
LIG_WRC_WIRS_1	311	316	PF05994	0.422
MOD_CK1_1	291	297	PF00069	0.535
MOD_CK1_1	318	324	PF00069	0.629
MOD_CK2_1	202	208	PF00069	0.557
MOD_CK2_1	245	251	PF00069	0.454
MOD_CK2_1	310	316	PF00069	0.334
MOD_GlcNHglycan	14	17	PF01048	0.492
MOD_GlcNHglycan	183	186	PF01048	0.275
MOD_GlcNHglycan	236	239	PF01048	0.254
MOD_GlcNHglycan	28	31	PF01048	0.525
MOD_GlcNHglycan	295	298	PF01048	0.459
MOD_GlcNHglycan	54	57	PF01048	0.454
MOD_GlcNHglycan	83	86	PF01048	0.376
MOD_GlcNHglycan	98	102	PF01048	0.461
MOD_GSK3_1	35	42	PF00069	0.452
MOD_N-GLC_1	259	264	PF02516	0.205
MOD_NEK2_1	176	181	PF00069	0.454
MOD_NEK2_1	202	207	PF00069	0.545
MOD_NEK2_1	211	216	PF00069	0.486
MOD_NEK2_1	310	315	PF00069	0.462
MOD_NEK2_1	52	57	PF00069	0.475
MOD_NEK2_1	79	84	PF00069	0.472
MOD_NEK2_2	39	44	PF00069	0.483
MOD_OFUCOSY	33	39	PF10250	0.470
MOD_PK_1	245	251	PF00069	0.582
MOD_PKA_1	26	32	PF00069	0.358
MOD_PKA_2	181	187	PF00069	0.518
MOD_PKA_2	26	32	PF00069	0.496
MOD_Plk_1	202	208	PF00069	0.557
MOD_Plk_1	35	41	PF00069	0.528
MOD_Plk_4	211	217	PF00069	0.542
MOD_ProDKin_1	277	283	PF00069	0.454
MOD_SUMO_for_1	136	139	PF00179	0.405
MOD_SUMO_for_1	95	98	PF00179	0.446
MOD_SUMO_rev_2	184	189	PF00179	0.557
TRG_ENDOCYTIC_2	118	121	PF00928	0.391
TRG_ENDOCYTIC_2	160	163	PF00928	0.454
TRG_ER_diArg_1	150	152	PF00400	0.511
TRG_ER_diArg_1	181	183	PF00400	0.518
TRG_ER_diArg_1	26	28	PF00400	0.352
TRG_ER_diArg_1	75	77	PF00400	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM0	Leptomonas seymouri	57%	97%
A0A1X0PAE4	Trypanosomatidae	51%	90%
A0A1X0PAT7	Trypanosomatidae	48%	94%
A0A2Z4HPZ6	Hormonema carpetanum	26%	82%
A0A381MVV1	Leishmania infantum	84%	97%
A0A3Q8IN76	Leishmania donovani	84%	97%
A0A3S5H7W5	Leishmania donovani	84%	97%
A0A3S7X7S4	Leishmania donovani	88%	100%
A0A422MS54	Trypanosoma rangeli	49%	100%
A1JT62	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	33%	100%
A1S7K2	Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)	26%	87%
A3QFC7	Shewanella loihica (strain ATCC BAA-1088 / PV-4)	26%	87%
A4H7T3	Leishmania braziliensis	68%	97%
A7MFZ8	Cronobacter sakazakii (strain ATCC BAA-894)	28%	100%
A8G7S7	Serratia proteamaculans (strain 568)	30%	100%
B1L765	Korarchaeum cryptofilum (strain OPF8)	27%	98%
B2VCD1	Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99)	32%	100%
B6YWH0	Thermococcus onnurineus (strain NA1)	27%	98%
C6DJ88	Pectobacterium carotovorum subsp. carotovorum (strain PC1)	30%	100%
E9B4W4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B4W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	97%
G9EZR6	Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679)	27%	98%
J7SHB8	Clostridium sporogenes (strain ATCC 15579)	27%	98%
O32264	Bacillus subtilis (strain 168)	28%	100%
O88712	Mus musculus	23%	74%
P0C1E8	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	28%	100%
P0C1E9	Corynebacterium melassecola	28%	100%
P36234	Hyphomicrobium methylovorum	26%	100%
P56545	Homo sapiens	24%	73%
P56546	Mus musculus	24%	73%
P63940	Staphylococcus aureus (strain Mu50 / ATCC 700699)	27%	99%
P72357	Staphylococcus aureus	27%	99%
P99116	Staphylococcus aureus (strain N315)	27%	99%
Q03134	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	89%
Q0VCQ1	Bos taurus	23%	73%
Q13363	Homo sapiens	23%	74%
Q1QE21	Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5)	25%	84%
Q1QWN6	Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)	27%	100%
Q1QXV7	Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)	24%	85%
Q2FEI9	Staphylococcus aureus (strain USA300)	27%	100%
Q2FVW4	Staphylococcus aureus (strain NCTC 8325 / PS 47)	27%	100%
Q2YYT9	Staphylococcus aureus (strain bovine RF122 / ET3-1)	27%	100%
Q49ZM5	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	30%	100%
Q4FV16	Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4)	29%	86%
Q4Q361	Leishmania major	89%	100%
Q5HD29	Staphylococcus aureus (strain COL)	27%	99%
Q5HDQ4	Staphylococcus aureus (strain COL)	27%	100%
Q5HLA0	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	27%	99%
Q5HLU4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	30%	100%
Q5LIR8	Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)	22%	94%
Q64ZV5	Bacteroides fragilis (strain YCH46)	24%	94%
Q6DB24	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	31%	100%
Q6G6F1	Staphylococcus aureus (strain MSSA476)	27%	99%
Q6G716	Staphylococcus aureus (strain MSSA476)	27%	100%
Q6GDS2	Staphylococcus aureus (strain MRSA252)	27%	99%
Q6GEC9	Staphylococcus aureus (strain MRSA252)	28%	100%
Q7A417	Staphylococcus aureus (strain N315)	27%	100%
Q7N571	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	26%	100%
Q8CN22	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	27%	99%
Q8CNB8	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	30%	100%
Q8E0N5	Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)	31%	99%
Q8E6A9	Streptococcus agalactiae serotype III (strain NEM316)	30%	99%
Q8NUT2	Staphylococcus aureus (strain MW2)	27%	99%
Q8NV80	Staphylococcus aureus (strain MW2)	27%	100%
Q8U3Y2	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	27%	97%
Q91Z53	Mus musculus	32%	99%
Q99RW8	Staphylococcus aureus (strain Mu50 / ATCC 700699)	27%	100%
Q9C4M5	Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)	27%	98%
Q9CA90	Arabidopsis thaliana	27%	100%
Q9EQH5	Rattus norvegicus	24%	73%
Q9UBQ7	Homo sapiens	32%	99%
Q9W758	Xenopus laevis	23%	75%
Q9X1C1	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	29%	100%
Q9YAW4	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	27%	97%
Q9Z2F5	Rattus norvegicus	23%	76%
V5B3E2	Trypanosoma cruzi	47%	100%
V5BIV9	Trypanosoma cruzi	47%	93%