LeishMANIAdb
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D-isomer specific 2-hydroxyacid dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
D-isomer specific 2-hydroxyacid dehydrogenase-like protein
Gene product:
d-isomer specific 2-hydroxyacid dehydrogenase- like protein
Species:
Leishmania major
UniProt:
Q4Q361_LEIMA
TriTrypDb:
LmjF.34.1410 , LMJLV39_340022300 , LMJSD75_340022400 *
Length:
335

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 6
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q361
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q361

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 16
GO:0005488 binding 1 16
GO:0036094 small molecule binding 2 16
GO:0051287 NAD binding 4 16
GO:0097159 organic cyclic compound binding 2 16
GO:1901265 nucleoside phosphate binding 3 16
GO:1901363 heterocyclic compound binding 2 16
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 284 288 PF00656 0.450
CLV_MEL_PAP_1 24 30 PF00089 0.313
CLV_NRD_NRD_1 139 141 PF00675 0.276
CLV_NRD_NRD_1 151 153 PF00675 0.298
CLV_NRD_NRD_1 182 184 PF00675 0.346
CLV_NRD_NRD_1 223 225 PF00675 0.266
CLV_NRD_NRD_1 26 28 PF00675 0.476
CLV_NRD_NRD_1 322 324 PF00675 0.621
CLV_NRD_NRD_1 75 77 PF00675 0.336
CLV_PCSK_KEX2_1 151 153 PF00082 0.399
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PBM0 Leptomonas seymouri 55% 99%
A0A1X0PAE4 Trypanosomatidae 51% 93%
A0A1X0PAT7 Trypanosomatidae 49% 97%
A0A2Z4HPZ6 Hormonema carpetanum 26% 84%
A0A381MVV1 Leishmania infantum 92% 100%
A0A3Q8IN76 Leishmania donovani 92% 100%
A0A3S5H7W5 Leishmania donovani 92% 100%
A0A3S7X7S4 Leishmania donovani 82% 100%
A0A422MS54 Trypanosoma rangeli 49% 100%
A1A9T1 Escherichia coli O1:K1 / APEC 28% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS