Putative tyrosine phosphatase isoform

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphatase and tensin homolog, putative

Species:

Leishmania major

UniProt:

Q4Q359_LEIMA

TriTrypDb:

LmjF.34.1430 , LMJLV39_340022500 , LMJSD75_340022600

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q359

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q359

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016311	dephosphorylation	5	9
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004721	phosphoprotein phosphatase activity	3	8
GO:0004725	protein tyrosine phosphatase activity	4	7
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	8	4
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016791	phosphatase activity	5	9
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity	7	4
GO:0042578	phosphoric ester hydrolase activity	4	9
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	4
GO:0140096	catalytic activity, acting on a protein	2	8
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.532
CLV_NRD_NRD_1	197	199	PF00675	0.337
CLV_NRD_NRD_1	242	244	PF00675	0.404
CLV_NRD_NRD_1	382	384	PF00675	0.342
CLV_NRD_NRD_1	398	400	PF00675	0.378
CLV_NRD_NRD_1	416	418	PF00675	0.332
CLV_NRD_NRD_1	540	542	PF00675	0.313
CLV_PCSK_KEX2_1	197	199	PF00082	0.336
CLV_PCSK_KEX2_1	242	244	PF00082	0.443
CLV_PCSK_KEX2_1	382	384	PF00082	0.318
CLV_PCSK_KEX2_1	398	400	PF00082	0.367
CLV_PCSK_KEX2_1	416	418	PF00082	0.332
CLV_PCSK_KEX2_1	540	542	PF00082	0.328
CLV_PCSK_SKI1_1	424	428	PF00082	0.513
CLV_PCSK_SKI1_1	445	449	PF00082	0.460
DEG_Nend_UBRbox_3	1	3	PF02207	0.759
DEG_SCF_FBW7_2	353	359	PF00400	0.496
DOC_CDC14_PxL_1	389	397	PF14671	0.551
DOC_CKS1_1	353	358	PF01111	0.463
DOC_CKS1_1	63	68	PF01111	0.570
DOC_CYCLIN_yCln2_LP_2	518	524	PF00134	0.496
DOC_MAPK_gen_1	25	33	PF00069	0.622
DOC_MAPK_gen_1	382	389	PF00069	0.517
DOC_MAPK_HePTP_8	395	410	PF00069	0.576
DOC_PP1_RVXF_1	137	143	PF00149	0.529
DOC_PP1_RVXF_1	422	429	PF00149	0.691
DOC_PP2B_LxvP_1	518	521	PF13499	0.496
DOC_PP2B_LxvP_1	91	94	PF13499	0.409
DOC_PP4_FxxP_1	63	66	PF00568	0.694
DOC_PP4_MxPP_1	8	11	PF00568	0.562
DOC_USP7_MATH_1	265	269	PF00917	0.608
DOC_USP7_MATH_1	464	468	PF00917	0.689
DOC_WW_Pin1_4	106	111	PF00397	0.426
DOC_WW_Pin1_4	157	162	PF00397	0.504
DOC_WW_Pin1_4	352	357	PF00397	0.463
DOC_WW_Pin1_4	6	11	PF00397	0.705
DOC_WW_Pin1_4	62	67	PF00397	0.690
LIG_14-3-3_CanoR_1	179	183	PF00244	0.351
LIG_14-3-3_CanoR_1	247	255	PF00244	0.540
LIG_14-3-3_CanoR_1	259	263	PF00244	0.600
LIG_14-3-3_CanoR_1	266	271	PF00244	0.605
LIG_14-3-3_CanoR_1	336	341	PF00244	0.500
LIG_14-3-3_CanoR_1	424	429	PF00244	0.710
LIG_14-3-3_CanoR_1	62	66	PF00244	0.646
LIG_BIR_III_4	567	571	PF00653	0.621
LIG_BRCT_BRCA1_1	108	112	PF00533	0.330
LIG_BRCT_BRCA1_1	116	120	PF00533	0.229
LIG_eIF4E_1	86	92	PF01652	0.409
LIG_EVH1_2	520	524	PF00568	0.496
LIG_FHA_1	211	217	PF00498	0.567
LIG_FHA_1	248	254	PF00498	0.430
LIG_FHA_1	26	32	PF00498	0.451
LIG_FHA_1	267	273	PF00498	0.642
LIG_FHA_1	40	46	PF00498	0.624
LIG_FHA_1	405	411	PF00498	0.612
LIG_FHA_1	468	474	PF00498	0.620
LIG_FHA_1	486	492	PF00498	0.553
LIG_FHA_1	533	539	PF00498	0.525
LIG_FHA_1	7	13	PF00498	0.692
LIG_FHA_2	116	122	PF00498	0.404
LIG_FHA_2	13	19	PF00498	0.622
LIG_FHA_2	526	532	PF00498	0.485
LIG_FHA_2	548	554	PF00498	0.485
LIG_FHA_2	63	69	PF00498	0.654
LIG_IRF3_LxIS_1	280	285	PF10401	0.513
LIG_LIR_Apic_2	227	233	PF02991	0.520
LIG_LIR_Apic_2	60	66	PF02991	0.697
LIG_LIR_Gen_1	109	120	PF02991	0.320
LIG_LIR_Gen_1	143	153	PF02991	0.421
LIG_LIR_Gen_1	28	38	PF02991	0.615
LIG_LIR_Gen_1	3	13	PF02991	0.573
LIG_LIR_Gen_1	402	412	PF02991	0.580
LIG_LIR_Gen_1	49	58	PF02991	0.591
LIG_LIR_Gen_1	95	104	PF02991	0.441
LIG_LIR_Nem_3	109	115	PF02991	0.322
LIG_LIR_Nem_3	143	149	PF02991	0.421
LIG_LIR_Nem_3	28	33	PF02991	0.587
LIG_LIR_Nem_3	359	364	PF02991	0.539
LIG_LIR_Nem_3	402	408	PF02991	0.575
LIG_LIR_Nem_3	478	482	PF02991	0.544
LIG_LIR_Nem_3	49	55	PF02991	0.693
LIG_LIR_Nem_3	503	509	PF02991	0.530
LIG_LIR_Nem_3	95	101	PF02991	0.441
LIG_NRBOX	164	170	PF00104	0.463
LIG_NRBOX	95	101	PF00104	0.431
LIG_REV1ctd_RIR_1	506	514	PF16727	0.530
LIG_RPA_C_Fungi	339	351	PF08784	0.463
LIG_SH2_CRK	116	120	PF00017	0.463
LIG_SH2_CRK	245	249	PF00017	0.506
LIG_SH2_NCK_1	116	120	PF00017	0.229
LIG_SH2_PTP2	52	55	PF00017	0.638
LIG_SH2_SRC	30	33	PF00017	0.556
LIG_SH2_SRC	456	459	PF00017	0.638
LIG_SH2_STAP1	116	120	PF00017	0.409
LIG_SH2_STAP1	130	134	PF00017	0.572
LIG_SH2_STAT3	324	327	PF00017	0.463
LIG_SH2_STAT5	200	203	PF00017	0.453
LIG_SH2_STAT5	211	214	PF00017	0.364
LIG_SH2_STAT5	23	26	PF00017	0.426
LIG_SH2_STAT5	293	296	PF00017	0.409
LIG_SH2_STAT5	30	33	PF00017	0.475
LIG_SH2_STAT5	321	324	PF00017	0.327
LIG_SH2_STAT5	361	364	PF00017	0.384
LIG_SH2_STAT5	420	423	PF00017	0.412
LIG_SH2_STAT5	472	475	PF00017	0.535
LIG_SH2_STAT5	52	55	PF00017	0.584
LIG_SH2_STAT5	572	575	PF00017	0.714
LIG_SH2_STAT5	86	89	PF00017	0.413
LIG_SH3_2	378	383	PF14604	0.504
LIG_SH3_3	350	356	PF00018	0.315
LIG_SH3_3	375	381	PF00018	0.510
LIG_SH3_3	429	435	PF00018	0.532
LIG_SH3_3	514	520	PF00018	0.409
LIG_SH3_3	52	58	PF00018	0.640
LIG_SH3_3	7	13	PF00018	0.618
LIG_SUMO_SIM_anti_2	121	126	PF11976	0.357
LIG_SUMO_SIM_par_1	249	258	PF11976	0.455
LIG_SUMO_SIM_par_1	279	285	PF11976	0.463
LIG_TRAF2_1	356	359	PF00917	0.361
LIG_TYR_ITIM	114	119	PF00017	0.424
LIG_TYR_ITSM	26	33	PF00017	0.527
LIG_WRC_WIRS_1	283	288	PF05994	0.409
MOD_CK1_1	467	473	PF00069	0.593
MOD_CK2_1	12	18	PF00069	0.554
MOD_CK2_1	525	531	PF00069	0.346
MOD_CK2_1	570	576	PF00069	0.642
MOD_CK2_1	62	68	PF00069	0.579
MOD_GlcNHglycan	329	332	PF01048	0.371
MOD_GlcNHglycan	466	469	PF01048	0.630
MOD_GSK3_1	247	254	PF00069	0.478
MOD_GSK3_1	336	343	PF00069	0.395
MOD_GSK3_1	462	469	PF00069	0.448
MOD_GSK3_1	525	532	PF00069	0.385
MOD_GSK3_1	62	69	PF00069	0.633
MOD_N-GLC_1	422	427	PF02516	0.619
MOD_N-GLC_2	73	75	PF02516	0.394
MOD_NEK2_1	114	119	PF00069	0.409
MOD_NEK2_1	151	156	PF00069	0.365
MOD_NEK2_1	282	287	PF00069	0.427
MOD_NEK2_1	340	345	PF00069	0.409
MOD_NEK2_1	404	409	PF00069	0.513
MOD_NEK2_1	547	552	PF00069	0.438
MOD_NEK2_1	61	66	PF00069	0.689
MOD_NEK2_1	81	86	PF00069	0.287
MOD_PIKK_1	354	360	PF00454	0.322
MOD_PIKK_1	439	445	PF00454	0.693
MOD_PKA_2	178	184	PF00069	0.365
MOD_PKA_2	223	229	PF00069	0.483
MOD_PKA_2	246	252	PF00069	0.484
MOD_PKA_2	258	264	PF00069	0.500
MOD_PKA_2	265	271	PF00069	0.516
MOD_PKA_2	61	67	PF00069	0.589
MOD_Plk_1	25	31	PF00069	0.460
MOD_Plk_1	422	428	PF00069	0.609
MOD_Plk_1	67	73	PF00069	0.625
MOD_Plk_4	115	121	PF00069	0.395
MOD_Plk_4	123	129	PF00069	0.421
MOD_Plk_4	313	319	PF00069	0.361
MOD_Plk_4	364	370	PF00069	0.294
MOD_Plk_4	404	410	PF00069	0.505
MOD_Plk_4	81	87	PF00069	0.389
MOD_Plk_4	92	98	PF00069	0.438
MOD_ProDKin_1	106	112	PF00069	0.538
MOD_ProDKin_1	157	163	PF00069	0.385
MOD_ProDKin_1	352	358	PF00069	0.315
MOD_ProDKin_1	6	12	PF00069	0.648
MOD_ProDKin_1	62	68	PF00069	0.633
TRG_DiLeu_BaEn_1	143	148	PF01217	0.477
TRG_DiLeu_BaEn_2	235	241	PF01217	0.440
TRG_ENDOCYTIC_2	116	119	PF00928	0.409
TRG_ENDOCYTIC_2	245	248	PF00928	0.487
TRG_ENDOCYTIC_2	30	33	PF00928	0.546
TRG_ENDOCYTIC_2	52	55	PF00928	0.590
TRG_ENDOCYTIC_2	79	82	PF00928	0.575
TRG_ER_diArg_1	241	243	PF00400	0.545
TRG_ER_diArg_1	27	30	PF00400	0.510
TRG_ER_diArg_1	341	344	PF00400	0.361
TRG_ER_diArg_1	381	383	PF00400	0.447
TRG_ER_diArg_1	397	399	PF00400	0.493
TRG_ER_diArg_1	416	418	PF00400	0.398
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N6	Leptomonas seymouri	70%	95%
A0A0S4J8D3	Bodo saltans	29%	100%
A0A1X0PAB6	Trypanosomatidae	41%	92%
A0A1X0PB63	Trypanosomatidae	31%	100%
A0A3S7X7V0	Leishmania donovani	95%	100%
A4H7T1	Leishmania braziliensis	84%	100%
A4I9V5	Leishmania infantum	95%	100%
E9B4W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P56180	Homo sapiens	30%	100%
Q6XPS3	Homo sapiens	31%	100%
V5BT25	Trypanosoma cruzi	41%	92%