R3H-assoc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

R3H-associated N-terminal domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q357_LEIMA

TriTrypDb:

LmjF.34.1450 , LMJLV39_340022800 , LMJSD75_340022900

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q357

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q357

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	473	477	PF00656	0.669
CLV_C14_Caspase3-7	77	81	PF00656	0.632
CLV_NRD_NRD_1	101	103	PF00675	0.449
CLV_NRD_NRD_1	132	134	PF00675	0.360
CLV_NRD_NRD_1	159	161	PF00675	0.337
CLV_NRD_NRD_1	318	320	PF00675	0.601
CLV_NRD_NRD_1	497	499	PF00675	0.559
CLV_NRD_NRD_1	501	503	PF00675	0.552
CLV_PCSK_FUR_1	99	103	PF00082	0.564
CLV_PCSK_KEX2_1	101	103	PF00082	0.449
CLV_PCSK_KEX2_1	158	160	PF00082	0.176
CLV_PCSK_KEX2_1	318	320	PF00082	0.638
CLV_PCSK_KEX2_1	337	339	PF00082	0.491
CLV_PCSK_KEX2_1	50	52	PF00082	0.559
CLV_PCSK_KEX2_1	86	88	PF00082	0.479
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.176
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.465
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.543
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.591
CLV_PCSK_SKI1_1	102	106	PF00082	0.464
CLV_PCSK_SKI1_1	150	154	PF00082	0.350
DEG_APCC_DBOX_1	328	336	PF00400	0.369
DEG_Nend_UBRbox_4	1	3	PF02207	0.480
DEG_SCF_FBW7_1	488	494	PF00400	0.651
DOC_CKS1_1	10	15	PF01111	0.677
DOC_CKS1_1	352	357	PF01111	0.561
DOC_CKS1_1	488	493	PF01111	0.691
DOC_CYCLIN_yCln2_LP_2	394	400	PF00134	0.593
DOC_MAPK_DCC_7	323	332	PF00069	0.469
DOC_MAPK_MEF2A_6	323	332	PF00069	0.479
DOC_MAPK_MEF2A_6	387	396	PF00069	0.473
DOC_PP2B_LxvP_1	394	397	PF13499	0.706
DOC_PP2B_LxvP_1	444	447	PF13499	0.546
DOC_PP4_FxxP_1	454	457	PF00568	0.561
DOC_PP4_FxxP_1	489	492	PF00568	0.569
DOC_USP7_MATH_1	167	171	PF00917	0.390
DOC_USP7_MATH_1	241	245	PF00917	0.406
DOC_USP7_MATH_1	510	514	PF00917	0.655
DOC_USP7_UBL2_3	263	267	PF12436	0.509
DOC_USP7_UBL2_3	499	503	PF12436	0.502
DOC_WW_Pin1_4	219	224	PF00397	0.405
DOC_WW_Pin1_4	265	270	PF00397	0.575
DOC_WW_Pin1_4	351	356	PF00397	0.586
DOC_WW_Pin1_4	357	362	PF00397	0.593
DOC_WW_Pin1_4	387	392	PF00397	0.652
DOC_WW_Pin1_4	480	485	PF00397	0.699
DOC_WW_Pin1_4	487	492	PF00397	0.693
DOC_WW_Pin1_4	9	14	PF00397	0.710
LIG_14-3-3_CanoR_1	101	109	PF00244	0.592
LIG_14-3-3_CanoR_1	159	163	PF00244	0.362
LIG_14-3-3_CanoR_1	348	357	PF00244	0.693
LIG_14-3-3_CanoR_1	460	466	PF00244	0.704
LIG_APCC_ABBA_1	200	205	PF00400	0.405
LIG_APCC_ABBAyCdc20_2	199	205	PF00400	0.405
LIG_BRCT_BRCA1_1	270	274	PF00533	0.519
LIG_Clathr_ClatBox_1	194	198	PF01394	0.338
LIG_CtBP_PxDLS_1	269	273	PF00389	0.534
LIG_FHA_1	246	252	PF00498	0.405
LIG_FHA_1	352	358	PF00498	0.628
LIG_FHA_1	40	46	PF00498	0.564
LIG_FHA_1	439	445	PF00498	0.691
LIG_FHA_1	460	466	PF00498	0.633
LIG_FHA_1	488	494	PF00498	0.688
LIG_FHA_1	53	59	PF00498	0.348
LIG_FHA_2	103	109	PF00498	0.479
LIG_FHA_2	375	381	PF00498	0.628
LIG_FHA_2	92	98	PF00498	0.512
LIG_LIR_Apic_2	71	76	PF02991	0.548
LIG_LIR_Gen_1	174	183	PF02991	0.367
LIG_LIR_Gen_1	196	204	PF02991	0.391
LIG_LIR_Gen_1	255	262	PF02991	0.383
LIG_LIR_Gen_1	310	315	PF02991	0.526
LIG_LIR_Nem_3	174	178	PF02991	0.367
LIG_LIR_Nem_3	196	200	PF02991	0.394
LIG_LIR_Nem_3	224	230	PF02991	0.350
LIG_LIR_Nem_3	255	261	PF02991	0.367
LIG_LIR_Nem_3	278	283	PF02991	0.340
LIG_LIR_Nem_3	310	314	PF02991	0.522
LIG_LIR_Nem_3	37	43	PF02991	0.518
LIG_LIR_Nem_3	437	442	PF02991	0.698
LIG_LYPXL_yS_3	124	127	PF13949	0.272
LIG_MYND_1	484	488	PF01753	0.638
LIG_NRP_CendR_1	519	520	PF00754	0.559
LIG_PCNA_yPIPBox_3	131	144	PF02747	0.272
LIG_PTB_Apo_2	138	145	PF02174	0.290
LIG_SH2_CRK	280	284	PF00017	0.322
LIG_SH2_NCK_1	73	77	PF00017	0.562
LIG_SH2_PTP2	311	314	PF00017	0.519
LIG_SH2_STAP1	34	38	PF00017	0.428
LIG_SH2_STAT5	292	295	PF00017	0.439
LIG_SH2_STAT5	311	314	PF00017	0.604
LIG_SH2_STAT5	455	458	PF00017	0.709
LIG_SH3_3	211	217	PF00018	0.301
LIG_SH3_3	309	315	PF00018	0.386
LIG_SH3_3	322	328	PF00018	0.452
LIG_SH3_3	361	367	PF00018	0.685
LIG_SH3_3	385	391	PF00018	0.672
LIG_SH3_3	394	400	PF00018	0.667
LIG_SH3_3	485	491	PF00018	0.709
LIG_SH3_3	92	98	PF00018	0.562
LIG_SUMO_SIM_par_1	461	466	PF11976	0.633
LIG_TYR_ITIM	309	314	PF00017	0.516
LIG_UBA3_1	332	337	PF00899	0.431
LIG_WW_3	326	330	PF00397	0.328
MOD_CDK_SPxxK_3	219	226	PF00069	0.405
MOD_CK1_1	265	271	PF00069	0.586
MOD_CK1_1	350	356	PF00069	0.579
MOD_CK1_1	6	12	PF00069	0.683
MOD_CK1_1	74	80	PF00069	0.473
MOD_CK1_1	91	97	PF00069	0.510
MOD_CK2_1	102	108	PF00069	0.501
MOD_CK2_1	374	380	PF00069	0.608
MOD_Cter_Amidation	48	51	PF01082	0.549
MOD_GlcNHglycan	13	16	PF01048	0.546
MOD_GlcNHglycan	304	307	PF01048	0.598
MOD_GlcNHglycan	430	433	PF01048	0.712
MOD_GlcNHglycan	478	481	PF01048	0.718
MOD_GlcNHglycan	508	511	PF01048	0.715
MOD_GSK3_1	167	174	PF00069	0.431
MOD_GSK3_1	19	26	PF00069	0.578
MOD_GSK3_1	241	248	PF00069	0.400
MOD_GSK3_1	293	300	PF00069	0.478
MOD_GSK3_1	310	317	PF00069	0.349
MOD_GSK3_1	347	354	PF00069	0.608
MOD_GSK3_1	434	441	PF00069	0.733
MOD_GSK3_1	476	483	PF00069	0.707
MOD_GSK3_1	487	494	PF00069	0.719
MOD_GSK3_1	506	513	PF00069	0.426
MOD_GSK3_1	54	61	PF00069	0.435
MOD_LATS_1	443	449	PF00433	0.566
MOD_N-GLC_1	302	307	PF02516	0.621
MOD_NEK2_1	302	307	PF00069	0.608
MOD_NEK2_1	459	464	PF00069	0.717
MOD_NEK2_1	493	498	PF00069	0.665
MOD_PIKK_1	245	251	PF00454	0.463
MOD_PIKK_1	348	354	PF00454	0.461
MOD_PIKK_1	493	499	PF00454	0.593
MOD_PIKK_1	6	12	PF00454	0.627
MOD_PKA_1	158	164	PF00069	0.176
MOD_PKA_2	158	164	PF00069	0.176
MOD_PKA_2	23	29	PF00069	0.572
MOD_PKA_2	347	353	PF00069	0.691
MOD_PKA_2	459	465	PF00069	0.634
MOD_Plk_1	167	173	PF00069	0.338
MOD_Plk_4	268	274	PF00069	0.528
MOD_Plk_4	297	303	PF00069	0.440
MOD_Plk_4	307	313	PF00069	0.445
MOD_Plk_4	434	440	PF00069	0.727
MOD_Plk_4	91	97	PF00069	0.586
MOD_ProDKin_1	219	225	PF00069	0.405
MOD_ProDKin_1	265	271	PF00069	0.566
MOD_ProDKin_1	351	357	PF00069	0.590
MOD_ProDKin_1	387	393	PF00069	0.652
MOD_ProDKin_1	480	486	PF00069	0.701
MOD_ProDKin_1	487	493	PF00069	0.684
MOD_ProDKin_1	9	15	PF00069	0.704
MOD_SUMO_rev_2	380	389	PF00179	0.480
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.315
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.460
TRG_ENDOCYTIC_2	124	127	PF00928	0.272
TRG_ENDOCYTIC_2	280	283	PF00928	0.327
TRG_ENDOCYTIC_2	291	294	PF00928	0.329
TRG_ENDOCYTIC_2	311	314	PF00928	0.264
TRG_ENDOCYTIC_2	455	458	PF00928	0.607
TRG_ER_diArg_1	118	121	PF00400	0.357
TRG_ER_diArg_1	135	138	PF00400	0.287
TRG_ER_diArg_1	199	202	PF00400	0.338
TRG_ER_diArg_1	98	101	PF00400	0.486
TRG_NES_CRM1_1	177	192	PF08389	0.350
TRG_NES_CRM1_1	193	205	PF08389	0.350
TRG_NES_CRM1_1	245	260	PF08389	0.358
TRG_NLS_Bipartite_1	122	137	PF00514	0.315
TRG_NLS_MonoExtC_3	497	502	PF00514	0.517
TRG_NLS_MonoExtN_4	130	137	PF00514	0.398
TRG_NLS_MonoExtN_4	155	162	PF00514	0.176
TRG_NLS_MonoExtN_4	498	503	PF00514	0.499
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	160	165	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P399	Leptomonas seymouri	70%	80%
A0A1X0P9H7	Trypanosomatidae	51%	100%
A0A3S7X7Q4	Leishmania donovani	94%	100%
A0A422N0N2	Trypanosoma rangeli	51%	100%
A4H7S9	Leishmania braziliensis	81%	77%
A4I9V7	Leishmania infantum	94%	100%
C9ZMS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B4X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DJW5	Trypanosoma cruzi	48%	100%