Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q356_LEIMA

TriTrypDb:

LmjF.34.1460 , LMJLV39_340022900 , LMJSD75_340023000

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q356

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q356

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	668	672	PF00656	0.552
CLV_C14_Caspase3-7	700	704	PF00656	0.592
CLV_NRD_NRD_1	107	109	PF00675	0.462
CLV_NRD_NRD_1	13	15	PF00675	0.713
CLV_NRD_NRD_1	137	139	PF00675	0.543
CLV_NRD_NRD_1	248	250	PF00675	0.507
CLV_NRD_NRD_1	479	481	PF00675	0.489
CLV_NRD_NRD_1	521	523	PF00675	0.480
CLV_NRD_NRD_1	534	536	PF00675	0.335
CLV_NRD_NRD_1	552	554	PF00675	0.382
CLV_NRD_NRD_1	658	660	PF00675	0.586
CLV_NRD_NRD_1	68	70	PF00675	0.447
CLV_NRD_NRD_1	685	687	PF00675	0.478
CLV_NRD_NRD_1	82	84	PF00675	0.430
CLV_PCSK_KEX2_1	107	109	PF00082	0.559
CLV_PCSK_KEX2_1	13	15	PF00082	0.740
CLV_PCSK_KEX2_1	137	139	PF00082	0.521
CLV_PCSK_KEX2_1	144	146	PF00082	0.594
CLV_PCSK_KEX2_1	248	250	PF00082	0.532
CLV_PCSK_KEX2_1	311	313	PF00082	0.475
CLV_PCSK_KEX2_1	335	337	PF00082	0.493
CLV_PCSK_KEX2_1	479	481	PF00082	0.490
CLV_PCSK_KEX2_1	497	499	PF00082	0.714
CLV_PCSK_KEX2_1	521	523	PF00082	0.501
CLV_PCSK_KEX2_1	534	536	PF00082	0.321
CLV_PCSK_KEX2_1	563	565	PF00082	0.376
CLV_PCSK_KEX2_1	68	70	PF00082	0.447
CLV_PCSK_KEX2_1	685	687	PF00082	0.467
CLV_PCSK_KEX2_1	82	84	PF00082	0.419
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.587
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.475
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.493
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.710
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.376
CLV_PCSK_SKI1_1	107	111	PF00082	0.493
CLV_PCSK_SKI1_1	137	141	PF00082	0.516
CLV_PCSK_SKI1_1	186	190	PF00082	0.417
CLV_PCSK_SKI1_1	311	315	PF00082	0.496
CLV_PCSK_SKI1_1	376	380	PF00082	0.465
CLV_PCSK_SKI1_1	429	433	PF00082	0.521
CLV_PCSK_SKI1_1	554	558	PF00082	0.383
CLV_PCSK_SKI1_1	56	60	PF00082	0.379
CLV_PCSK_SKI1_1	69	73	PF00082	0.519
DEG_APCC_DBOX_1	185	193	PF00400	0.413
DEG_SCF_FBW7_2	593	600	PF00400	0.524
DEG_SPOP_SBC_1	43	47	PF00917	0.699
DOC_CKS1_1	594	599	PF01111	0.511
DOC_CYCLIN_RxL_1	104	112	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	674	680	PF00134	0.615
DOC_MAPK_gen_1	563	569	PF00069	0.435
DOC_MAPK_MEF2A_6	180	189	PF00069	0.458
DOC_MAPK_MEF2A_6	563	571	PF00069	0.340
DOC_MAPK_MEF2A_6	620	628	PF00069	0.511
DOC_PP1_RVXF_1	310	317	PF00149	0.484
DOC_PP2B_LxvP_1	404	407	PF13499	0.341
DOC_PP2B_LxvP_1	469	472	PF13499	0.400
DOC_PP2B_LxvP_1	674	677	PF13499	0.505
DOC_USP7_MATH_1	116	120	PF00917	0.729
DOC_USP7_MATH_1	150	154	PF00917	0.637
DOC_USP7_MATH_1	200	204	PF00917	0.516
DOC_USP7_MATH_1	273	277	PF00917	0.690
DOC_USP7_MATH_1	30	34	PF00917	0.681
DOC_USP7_MATH_1	488	492	PF00917	0.644
DOC_USP7_UBL2_3	140	144	PF12436	0.305
DOC_WW_Pin1_4	15	20	PF00397	0.679
DOC_WW_Pin1_4	233	238	PF00397	0.638
DOC_WW_Pin1_4	408	413	PF00397	0.483
DOC_WW_Pin1_4	44	49	PF00397	0.675
DOC_WW_Pin1_4	447	452	PF00397	0.527
DOC_WW_Pin1_4	481	486	PF00397	0.474
DOC_WW_Pin1_4	593	598	PF00397	0.490
LIG_14-3-3_CanoR_1	108	114	PF00244	0.410
LIG_14-3-3_CanoR_1	13	19	PF00244	0.675
LIG_14-3-3_CanoR_1	248	252	PF00244	0.461
LIG_14-3-3_CanoR_1	336	344	PF00244	0.401
LIG_14-3-3_CanoR_1	376	381	PF00244	0.425
LIG_14-3-3_CanoR_1	479	485	PF00244	0.556
LIG_14-3-3_CanoR_1	572	578	PF00244	0.379
LIG_14-3-3_CanoR_1	68	78	PF00244	0.402
LIG_APCC_ABBA_1	624	629	PF00400	0.511
LIG_deltaCOP1_diTrp_1	287	293	PF00928	0.360
LIG_deltaCOP1_diTrp_1	307	316	PF00928	0.204
LIG_eIF4E_1	86	92	PF01652	0.517
LIG_FHA_1	131	137	PF00498	0.386
LIG_FHA_1	193	199	PF00498	0.530
LIG_FHA_1	234	240	PF00498	0.649
LIG_FHA_1	286	292	PF00498	0.451
LIG_FHA_1	377	383	PF00498	0.500
LIG_FHA_1	426	432	PF00498	0.534
LIG_FHA_1	52	58	PF00498	0.578
LIG_FHA_1	636	642	PF00498	0.535
LIG_FHA_1	74	80	PF00498	0.432
LIG_FHA_2	179	185	PF00498	0.522
LIG_FHA_2	557	563	PF00498	0.516
LIG_GBD_Chelix_1	57	65	PF00786	0.449
LIG_LIR_Apic_2	452	458	PF02991	0.483
LIG_LIR_Gen_1	168	178	PF02991	0.363
LIG_LIR_Gen_1	203	212	PF02991	0.377
LIG_LIR_Gen_1	287	297	PF02991	0.403
LIG_LIR_Gen_1	456	467	PF02991	0.392
LIG_LIR_Gen_1	546	557	PF02991	0.409
LIG_LIR_Gen_1	639	646	PF02991	0.457
LIG_LIR_Gen_1	72	80	PF02991	0.420
LIG_LIR_Nem_3	141	146	PF02991	0.509
LIG_LIR_Nem_3	168	173	PF02991	0.358
LIG_LIR_Nem_3	201	207	PF02991	0.379
LIG_LIR_Nem_3	287	292	PF02991	0.345
LIG_LIR_Nem_3	307	313	PF02991	0.208
LIG_LIR_Nem_3	456	462	PF02991	0.380
LIG_LIR_Nem_3	546	552	PF02991	0.391
LIG_LIR_Nem_3	639	645	PF02991	0.435
LIG_LIR_Nem_3	648	654	PF02991	0.516
LIG_LIR_Nem_3	72	78	PF02991	0.502
LIG_LYPXL_SIV_4	346	354	PF13949	0.345
LIG_NRBOX	105	111	PF00104	0.455
LIG_NRBOX	608	614	PF00104	0.450
LIG_Pex14_1	289	293	PF04695	0.356
LIG_Pex14_2	209	213	PF04695	0.451
LIG_RPA_C_Fungi	681	693	PF08784	0.493
LIG_SH2_CRK	170	174	PF00017	0.381
LIG_SH2_CRK	651	655	PF00017	0.638
LIG_SH2_CRK	75	79	PF00017	0.419
LIG_SH2_GRB2like	369	372	PF00017	0.498
LIG_SH2_STAP1	170	174	PF00017	0.456
LIG_SH2_STAP1	205	209	PF00017	0.406
LIG_SH2_STAP1	610	614	PF00017	0.344
LIG_SH2_STAP1	75	79	PF00017	0.292
LIG_SH2_STAT3	67	70	PF00017	0.413
LIG_SH2_STAT5	162	165	PF00017	0.512
LIG_SH2_STAT5	369	372	PF00017	0.498
LIG_SH2_STAT5	455	458	PF00017	0.504
LIG_SH2_STAT5	574	577	PF00017	0.479
LIG_SH2_STAT5	665	668	PF00017	0.463
LIG_SH2_STAT5	75	78	PF00017	0.454
LIG_SH3_2	322	327	PF14604	0.471
LIG_SH3_3	319	325	PF00018	0.416
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.342
LIG_TRAF2_1	120	123	PF00917	0.519
LIG_TYR_ITIM	608	613	PF00017	0.495
LIG_TYR_ITSM	647	654	PF00017	0.554
LIG_UBA3_1	305	311	PF00899	0.482
LIG_UBA3_1	420	429	PF00899	0.364
LIG_UBA3_1	548	555	PF00899	0.420
MOD_CK1_1	17	23	PF00069	0.671
MOD_CK1_1	33	39	PF00069	0.626
MOD_CK1_1	408	414	PF00069	0.541
MOD_CK1_1	42	48	PF00069	0.691
MOD_CK1_1	427	433	PF00069	0.519
MOD_CK1_1	470	476	PF00069	0.403
MOD_CK1_1	492	498	PF00069	0.720
MOD_CK1_1	73	79	PF00069	0.443
MOD_CK1_1	94	100	PF00069	0.433
MOD_CK2_1	109	115	PF00069	0.519
MOD_CK2_1	178	184	PF00069	0.505
MOD_CK2_1	200	206	PF00069	0.470
MOD_CK2_1	47	53	PF00069	0.702
MOD_CK2_1	556	562	PF00069	0.523
MOD_CK2_1	57	63	PF00069	0.481
MOD_Cter_Amidation	519	522	PF01082	0.460
MOD_GlcNHglycan	118	121	PF01048	0.587
MOD_GlcNHglycan	146	149	PF01048	0.497
MOD_GlcNHglycan	175	178	PF01048	0.381
MOD_GlcNHglycan	275	278	PF01048	0.730
MOD_GlcNHglycan	337	340	PF01048	0.658
MOD_GlcNHglycan	38	41	PF01048	0.775
MOD_GlcNHglycan	472	475	PF01048	0.370
MOD_GlcNHglycan	513	516	PF01048	0.767
MOD_GlcNHglycan	583	586	PF01048	0.370
MOD_GSK3_1	13	20	PF00069	0.698
MOD_GSK3_1	144	151	PF00069	0.532
MOD_GSK3_1	169	176	PF00069	0.381
MOD_GSK3_1	218	225	PF00069	0.642
MOD_GSK3_1	29	36	PF00069	0.729
MOD_GSK3_1	292	299	PF00069	0.480
MOD_GSK3_1	376	383	PF00069	0.483
MOD_GSK3_1	39	46	PF00069	0.752
MOD_GSK3_1	402	409	PF00069	0.497
MOD_GSK3_1	47	54	PF00069	0.686
MOD_GSK3_1	488	495	PF00069	0.687
MOD_GSK3_1	646	653	PF00069	0.514
MOD_GSK3_1	69	76	PF00069	0.441
MOD_GSK3_1	90	97	PF00069	0.529
MOD_NEK2_1	109	114	PF00069	0.460
MOD_NEK2_1	139	144	PF00069	0.533
MOD_NEK2_1	173	178	PF00069	0.389
MOD_NEK2_1	247	252	PF00069	0.514
MOD_NEK2_1	267	272	PF00069	0.500
MOD_NEK2_1	292	297	PF00069	0.441
MOD_NEK2_1	380	385	PF00069	0.488
MOD_NEK2_1	424	429	PF00069	0.362
MOD_NEK2_1	556	561	PF00069	0.495
MOD_NEK2_1	57	62	PF00069	0.558
MOD_NEK2_1	573	578	PF00069	0.320
MOD_NEK2_1	645	650	PF00069	0.553
MOD_NEK2_1	697	702	PF00069	0.573
MOD_NEK2_1	90	95	PF00069	0.505
MOD_NEK2_2	200	205	PF00069	0.470
MOD_PIKK_1	118	124	PF00454	0.634
MOD_PIKK_1	296	302	PF00454	0.409
MOD_PIKK_1	646	652	PF00454	0.617
MOD_PIKK_1	95	101	PF00454	0.399
MOD_PKA_1	13	19	PF00069	0.734
MOD_PKA_1	144	150	PF00069	0.355
MOD_PKA_1	335	341	PF00069	0.451
MOD_PKA_1	479	485	PF00069	0.541
MOD_PKA_2	13	19	PF00069	0.741
MOD_PKA_2	144	150	PF00069	0.397
MOD_PKA_2	192	198	PF00069	0.458
MOD_PKA_2	218	224	PF00069	0.602
MOD_PKA_2	247	253	PF00069	0.417
MOD_PKA_2	335	341	PF00069	0.451
MOD_PKA_2	479	485	PF00069	0.541
MOD_Plk_1	200	206	PF00069	0.470
MOD_Plk_1	219	225	PF00069	0.565
MOD_Plk_1	508	514	PF00069	0.625
MOD_Plk_4	169	175	PF00069	0.447
MOD_Plk_4	200	206	PF00069	0.371
MOD_Plk_4	489	495	PF00069	0.735
MOD_Plk_4	528	534	PF00069	0.343
MOD_Plk_4	544	550	PF00069	0.431
MOD_Plk_4	70	76	PF00069	0.395
MOD_ProDKin_1	15	21	PF00069	0.675
MOD_ProDKin_1	233	239	PF00069	0.628
MOD_ProDKin_1	408	414	PF00069	0.476
MOD_ProDKin_1	44	50	PF00069	0.667
MOD_ProDKin_1	447	453	PF00069	0.521
MOD_ProDKin_1	481	487	PF00069	0.480
MOD_ProDKin_1	593	599	PF00069	0.498
TRG_DiLeu_BaEn_1	562	567	PF01217	0.432
TRG_DiLeu_BaEn_2	522	528	PF01217	0.481
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.446
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.504
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.401
TRG_ENDOCYTIC_2	170	173	PF00928	0.335
TRG_ENDOCYTIC_2	205	208	PF00928	0.330
TRG_ENDOCYTIC_2	574	577	PF00928	0.507
TRG_ENDOCYTIC_2	610	613	PF00928	0.375
TRG_ENDOCYTIC_2	651	654	PF00928	0.637
TRG_ENDOCYTIC_2	75	78	PF00928	0.486
TRG_ER_diArg_1	106	108	PF00400	0.460
TRG_ER_diArg_1	136	138	PF00400	0.551
TRG_ER_diArg_1	247	249	PF00400	0.491
TRG_ER_diArg_1	478	480	PF00400	0.525
TRG_ER_diArg_1	533	535	PF00400	0.337
TRG_ER_diArg_1	67	69	PF00400	0.440
TRG_ER_diArg_1	684	686	PF00400	0.471
TRG_ER_diArg_1	690	693	PF00400	0.486
TRG_ER_diArg_1	82	84	PF00400	0.427
TRG_NES_CRM1_1	546	562	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	564	568	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	659	664	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA97	Leptomonas seymouri	56%	100%
A0A0S4IIE1	Bodo saltans	33%	100%
A0A1X0P9G0	Trypanosomatidae	37%	100%
A0A3R7MA99	Trypanosoma rangeli	39%	100%
A0A3S7X7S0	Leishmania donovani	93%	100%
A4H7S8	Leishmania braziliensis	77%	95%
A4I9V8	Leishmania infantum	93%	100%
C9ZMS3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B4X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BT29	Trypanosoma cruzi	38%	100%