Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q354_LEIMA

TriTrypDb:

LmjF.34.1480 , LMJLV39_340023100 , LMJSD75_340023200

Length:

1006

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q354

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q354

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.622
CLV_C14_Caspase3-7	312	316	PF00656	0.632
CLV_C14_Caspase3-7	495	499	PF00656	0.725
CLV_C14_Caspase3-7	772	776	PF00656	0.818
CLV_C14_Caspase3-7	810	814	PF00656	0.642
CLV_C14_Caspase3-7	989	993	PF00656	0.594
CLV_NRD_NRD_1	303	305	PF00675	0.810
CLV_NRD_NRD_1	476	478	PF00675	0.738
CLV_NRD_NRD_1	528	530	PF00675	0.758
CLV_NRD_NRD_1	568	570	PF00675	0.747
CLV_NRD_NRD_1	648	650	PF00675	0.827
CLV_NRD_NRD_1	673	675	PF00675	0.708
CLV_NRD_NRD_1	68	70	PF00675	0.773
CLV_NRD_NRD_1	827	829	PF00675	0.644
CLV_NRD_NRD_1	838	840	PF00675	0.594
CLV_NRD_NRD_1	852	854	PF00675	0.564
CLV_NRD_NRD_1	9	11	PF00675	0.803
CLV_NRD_NRD_1	979	981	PF00675	0.662
CLV_PCSK_FUR_1	825	829	PF00082	0.644
CLV_PCSK_FUR_1	977	981	PF00082	0.665
CLV_PCSK_KEX2_1	303	305	PF00082	0.849
CLV_PCSK_KEX2_1	476	478	PF00082	0.738
CLV_PCSK_KEX2_1	528	530	PF00082	0.758
CLV_PCSK_KEX2_1	568	570	PF00082	0.778
CLV_PCSK_KEX2_1	580	582	PF00082	0.714
CLV_PCSK_KEX2_1	648	650	PF00082	0.826
CLV_PCSK_KEX2_1	827	829	PF00082	0.671
CLV_PCSK_KEX2_1	852	854	PF00082	0.806
CLV_PCSK_KEX2_1	977	979	PF00082	0.666
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.804
CLV_PCSK_SKI1_1	404	408	PF00082	0.737
CLV_PCSK_SKI1_1	461	465	PF00082	0.671
CLV_PCSK_SKI1_1	553	557	PF00082	0.764
CLV_PCSK_SKI1_1	707	711	PF00082	0.729
CLV_PCSK_SKI1_1	81	85	PF00082	0.769
CLV_PCSK_SKI1_1	828	832	PF00082	0.608
CLV_PCSK_SKI1_1	969	973	PF00082	0.493
CLV_PCSK_SKI1_1	997	1001	PF00082	0.616
CLV_Separin_Metazoa	614	618	PF03568	0.608
DEG_APCC_DBOX_1	552	560	PF00400	0.769
DEG_APCC_DBOX_1	661	669	PF00400	0.721
DEG_APCC_DBOX_1	702	710	PF00400	0.729
DEG_APCC_DBOX_1	977	985	PF00400	0.491
DEG_Kelch_actinfilin_1	12	16	PF01344	0.753
DOC_CYCLIN_RxL_1	372	386	PF00134	0.819
DOC_MAPK_gen_1	10	17	PF00069	0.812
DOC_MAPK_MEF2A_6	10	17	PF00069	0.754
DOC_MAPK_MEF2A_6	903	911	PF00069	0.607
DOC_PP1_RVXF_1	277	283	PF00149	0.761
DOC_PP1_RVXF_1	376	383	PF00149	0.824
DOC_PP2B_LxvP_1	798	801	PF13499	0.570
DOC_PP4_FxxP_1	438	441	PF00568	0.656
DOC_USP7_MATH_1	156	160	PF00917	0.740
DOC_USP7_MATH_1	183	187	PF00917	0.721
DOC_USP7_MATH_1	251	255	PF00917	0.752
DOC_USP7_MATH_1	265	269	PF00917	0.671
DOC_USP7_MATH_1	3	7	PF00917	0.618
DOC_USP7_MATH_1	417	421	PF00917	0.720
DOC_USP7_MATH_1	442	446	PF00917	0.794
DOC_USP7_MATH_1	543	547	PF00917	0.806
DOC_USP7_MATH_1	561	565	PF00917	0.535
DOC_USP7_MATH_1	642	646	PF00917	0.656
DOC_USP7_MATH_1	686	690	PF00917	0.638
DOC_USP7_MATH_1	764	768	PF00917	0.812
DOC_USP7_MATH_1	855	859	PF00917	0.737
DOC_USP7_MATH_1	875	879	PF00917	0.631
DOC_USP7_UBL2_3	742	746	PF12436	0.710
DOC_USP7_UBL2_3	997	1001	PF12436	0.484
DOC_WW_Pin1_4	108	113	PF00397	0.592
DOC_WW_Pin1_4	115	120	PF00397	0.718
DOC_WW_Pin1_4	128	133	PF00397	0.546
DOC_WW_Pin1_4	162	167	PF00397	0.848
DOC_WW_Pin1_4	177	182	PF00397	0.576
DOC_WW_Pin1_4	206	211	PF00397	0.654
DOC_WW_Pin1_4	221	226	PF00397	0.720
DOC_WW_Pin1_4	234	239	PF00397	0.651
DOC_WW_Pin1_4	283	288	PF00397	0.793
DOC_WW_Pin1_4	295	300	PF00397	0.637
DOC_WW_Pin1_4	306	311	PF00397	0.657
DOC_WW_Pin1_4	331	336	PF00397	0.793
DOC_WW_Pin1_4	36	41	PF00397	0.784
DOC_WW_Pin1_4	4	9	PF00397	0.789
DOC_WW_Pin1_4	433	438	PF00397	0.706
DOC_WW_Pin1_4	451	456	PF00397	0.592
DOC_WW_Pin1_4	498	503	PF00397	0.753
DOC_WW_Pin1_4	50	55	PF00397	0.614
DOC_WW_Pin1_4	684	689	PF00397	0.640
DOC_WW_Pin1_4	781	786	PF00397	0.635
DOC_WW_Pin1_4	92	97	PF00397	0.840
DOC_WW_Pin1_4	945	950	PF00397	0.730
LIG_14-3-3_CanoR_1	22	27	PF00244	0.629
LIG_14-3-3_CanoR_1	271	280	PF00244	0.842
LIG_14-3-3_CanoR_1	493	502	PF00244	0.638
LIG_14-3-3_CanoR_1	621	626	PF00244	0.820
LIG_14-3-3_CanoR_1	648	654	PF00244	0.677
LIG_14-3-3_CanoR_1	662	666	PF00244	0.496
LIG_14-3-3_CanoR_1	69	73	PF00244	0.762
LIG_14-3-3_CanoR_1	827	836	PF00244	0.743
LIG_14-3-3_CanoR_1	853	863	PF00244	0.828
LIG_14-3-3_CanoR_1	874	884	PF00244	0.757
LIG_14-3-3_CanoR_1	956	961	PF00244	0.603
LIG_14-3-3_CanoR_1	985	991	PF00244	0.648
LIG_APCC_ABBA_1	202	207	PF00400	0.621
LIG_BIR_III_2	592	596	PF00653	0.749
LIG_BRCT_BRCA1_1	173	177	PF00533	0.846
LIG_BRCT_BRCA1_1	258	262	PF00533	0.812
LIG_BRCT_BRCA1_1	366	370	PF00533	0.693
LIG_BRCT_BRCA1_1	409	413	PF00533	0.575
LIG_BRCT_BRCA1_1	686	690	PF00533	0.797
LIG_BRCT_BRCA1_2	258	264	PF00533	0.811
LIG_Clathr_ClatBox_1	665	669	PF01394	0.710
LIG_Clathr_ClatBox_1	970	974	PF01394	0.600
LIG_DCNL_PONY_1	1	4	PF03556	0.801
LIG_FHA_1	207	213	PF00498	0.628
LIG_FHA_1	608	614	PF00498	0.739
LIG_FHA_1	78	84	PF00498	0.763
LIG_FHA_1	862	868	PF00498	0.786
LIG_FHA_1	879	885	PF00498	0.616
LIG_FHA_1	948	954	PF00498	0.740
LIG_FHA_1	98	104	PF00498	0.583
LIG_FHA_2	30	36	PF00498	0.762
LIG_FHA_2	384	390	PF00498	0.737
LIG_FHA_2	493	499	PF00498	0.632
LIG_FHA_2	728	734	PF00498	0.718
LIG_FHA_2	956	962	PF00498	0.610
LIG_LIR_Apic_2	436	441	PF02991	0.691
LIG_LIR_Gen_1	189	198	PF02991	0.621
LIG_LIR_Gen_1	31	41	PF02991	0.810
LIG_LIR_Nem_3	31	36	PF02991	0.815
LIG_LIR_Nem_3	64	68	PF02991	0.726
LIG_MYND_1	539	543	PF01753	0.564
LIG_PALB2_WD40_1	476	484	PF16756	0.695
LIG_PCNA_TLS_4	185	192	PF02747	0.686
LIG_RPA_C_Fungi	669	681	PF08784	0.630
LIG_RPA_C_Fungi	811	823	PF08784	0.627
LIG_SH2_GRB2like	396	399	PF00017	0.598
LIG_SH2_NCK_1	818	822	PF00017	0.659
LIG_SH2_SRC	818	821	PF00017	0.663
LIG_SH2_STAP1	582	586	PF00017	0.731
LIG_SH2_STAP1	818	822	PF00017	0.659
LIG_SH2_STAT3	582	585	PF00017	0.805
LIG_SH2_STAT5	187	190	PF00017	0.686
LIG_SH2_STAT5	396	399	PF00017	0.750
LIG_SH2_STAT5	637	640	PF00017	0.848
LIG_SH3_1	160	166	PF00018	0.734
LIG_SH3_2	134	139	PF14604	0.627
LIG_SH3_3	111	117	PF00018	0.835
LIG_SH3_3	131	137	PF00018	0.675
LIG_SH3_3	160	166	PF00018	0.734
LIG_SH3_3	284	290	PF00018	0.826
LIG_SH3_3	317	323	PF00018	0.686
LIG_SH3_3	436	442	PF00018	0.724
LIG_SH3_3	449	455	PF00018	0.584
LIG_SH3_3	460	466	PF00018	0.607
LIG_SH3_3	486	492	PF00018	0.706
LIG_SH3_3	510	516	PF00018	0.782
LIG_SH3_3	519	525	PF00018	0.703
LIG_SH3_3	536	542	PF00018	0.566
LIG_SH3_3	682	688	PF00018	0.652
LIG_SH3_3	779	785	PF00018	0.769
LIG_SH3_3	867	873	PF00018	0.729
LIG_SH3_4	840	847	PF00018	0.766
LIG_SH3_4	997	1004	PF00018	0.492
LIG_SUMO_SIM_par_1	12	19	PF11976	0.815
LIG_TRAF2_1	386	389	PF00917	0.701
LIG_WRC_WIRS_1	465	470	PF05994	0.626
LIG_WRPW_2	1000	1003	PF00400	0.656
LIG_WW_3	594	598	PF00397	0.826
LIG_WW_3	871	875	PF00397	0.724
MOD_CDC14_SPxK_1	118	121	PF00782	0.765
MOD_CDC14_SPxK_1	133	136	PF00782	0.696
MOD_CDC14_SPxK_1	298	301	PF00782	0.752
MOD_CDK_SPxK_1	115	121	PF00069	0.765
MOD_CDK_SPxK_1	130	136	PF00069	0.693
MOD_CDK_SPxK_1	295	301	PF00069	0.758
MOD_CDK_SPxK_1	4	10	PF00069	0.791
MOD_CDK_SPxxK_3	206	213	PF00069	0.657
MOD_CDK_SPxxK_3	234	241	PF00069	0.643
MOD_CDK_SPxxK_3	4	11	PF00069	0.794
MOD_CK1_1	104	110	PF00069	0.770
MOD_CK1_1	130	136	PF00069	0.802
MOD_CK1_1	167	173	PF00069	0.856
MOD_CK1_1	249	255	PF00069	0.840
MOD_CK1_1	283	289	PF00069	0.794
MOD_CK1_1	309	315	PF00069	0.772
MOD_CK1_1	31	37	PF00069	0.771
MOD_CK1_1	361	367	PF00069	0.651
MOD_CK1_1	428	434	PF00069	0.614
MOD_CK1_1	467	473	PF00069	0.741
MOD_CK1_1	511	517	PF00069	0.620
MOD_CK1_1	55	61	PF00069	0.758
MOD_CK1_1	551	557	PF00069	0.624
MOD_CK1_1	564	570	PF00069	0.602
MOD_CK1_1	584	590	PF00069	0.632
MOD_CK1_1	631	637	PF00069	0.816
MOD_CK1_1	752	758	PF00069	0.611
MOD_CK1_1	767	773	PF00069	0.753
MOD_CK1_1	857	863	PF00069	0.720
MOD_CK1_1	878	884	PF00069	0.755
MOD_CK1_1	895	901	PF00069	0.735
MOD_CK1_1	95	101	PF00069	0.793
MOD_CK2_1	103	109	PF00069	0.754
MOD_CK2_1	183	189	PF00069	0.685
MOD_CK2_1	29	35	PF00069	0.815
MOD_CK2_1	383	389	PF00069	0.735
MOD_CK2_1	494	500	PF00069	0.600
MOD_CK2_1	532	538	PF00069	0.618
MOD_CK2_1	727	733	PF00069	0.753
MOD_CK2_1	767	773	PF00069	0.809
MOD_CK2_1	955	961	PF00069	0.642
MOD_Cter_Amidation	646	649	PF01082	0.626
MOD_GlcNHglycan	103	106	PF01048	0.699
MOD_GlcNHglycan	154	157	PF01048	0.783
MOD_GlcNHglycan	214	217	PF01048	0.787
MOD_GlcNHglycan	249	252	PF01048	0.757
MOD_GlcNHglycan	273	276	PF01048	0.744
MOD_GlcNHglycan	283	286	PF01048	0.763
MOD_GlcNHglycan	343	346	PF01048	0.729
MOD_GlcNHglycan	366	369	PF01048	0.711
MOD_GlcNHglycan	409	412	PF01048	0.714
MOD_GlcNHglycan	427	430	PF01048	0.549
MOD_GlcNHglycan	472	476	PF01048	0.661
MOD_GlcNHglycan	50	53	PF01048	0.812
MOD_GlcNHglycan	510	513	PF01048	0.702
MOD_GlcNHglycan	534	537	PF01048	0.727
MOD_GlcNHglycan	545	548	PF01048	0.790
MOD_GlcNHglycan	563	566	PF01048	0.514
MOD_GlcNHglycan	57	60	PF01048	0.740
MOD_GlcNHglycan	572	575	PF01048	0.636
MOD_GlcNHglycan	630	633	PF01048	0.732
MOD_GlcNHglycan	651	654	PF01048	0.771
MOD_GlcNHglycan	697	700	PF01048	0.757
MOD_GlcNHglycan	751	754	PF01048	0.686
MOD_GlcNHglycan	857	860	PF01048	0.702
MOD_GlcNHglycan	877	880	PF01048	0.670
MOD_GlcNHglycan	97	100	PF01048	0.734
MOD_GSK3_1	152	159	PF00069	0.789
MOD_GSK3_1	162	169	PF00069	0.725
MOD_GSK3_1	219	226	PF00069	0.733
MOD_GSK3_1	22	29	PF00069	0.804
MOD_GSK3_1	245	252	PF00069	0.841
MOD_GSK3_1	343	350	PF00069	0.731
MOD_GSK3_1	357	364	PF00069	0.617
MOD_GSK3_1	44	51	PF00069	0.679
MOD_GSK3_1	442	449	PF00069	0.811
MOD_GSK3_1	464	471	PF00069	0.789
MOD_GSK3_1	492	499	PF00069	0.722
MOD_GSK3_1	543	550	PF00069	0.607
MOD_GSK3_1	570	577	PF00069	0.759
MOD_GSK3_1	68	75	PF00069	0.803
MOD_GSK3_1	686	693	PF00069	0.683
MOD_GSK3_1	748	755	PF00069	0.598
MOD_GSK3_1	764	771	PF00069	0.746
MOD_GSK3_1	79	86	PF00069	0.677
MOD_GSK3_1	853	860	PF00069	0.728
MOD_GSK3_1	87	94	PF00069	0.570
MOD_GSK3_1	878	885	PF00069	0.715
MOD_GSK3_1	943	950	PF00069	0.731
MOD_GSK3_1	952	959	PF00069	0.594
MOD_GSK3_1	97	104	PF00069	0.640
MOD_GSK3_1	986	993	PF00069	0.592
MOD_N-GLC_1	252	257	PF02516	0.615
MOD_N-GLC_1	356	361	PF02516	0.647
MOD_N-GLC_1	543	548	PF02516	0.730
MOD_N-GLC_1	598	603	PF02516	0.834
MOD_NEK2_1	103	108	PF00069	0.792
MOD_NEK2_1	168	173	PF00069	0.838
MOD_NEK2_1	26	31	PF00069	0.654
MOD_NEK2_1	336	341	PF00069	0.749
MOD_NEK2_1	347	352	PF00069	0.621
MOD_NEK2_1	508	513	PF00069	0.821
MOD_NEK2_1	668	673	PF00069	0.630
MOD_NEK2_1	709	714	PF00069	0.595
MOD_NEK2_1	72	77	PF00069	0.821
MOD_NEK2_1	789	794	PF00069	0.783
MOD_NEK2_1	944	949	PF00069	0.729
MOD_NEK2_1	990	995	PF00069	0.485
MOD_NEK2_2	343	348	PF00069	0.688
MOD_PIKK_1	265	271	PF00454	0.800
MOD_PIKK_1	309	315	PF00454	0.776
MOD_PIKK_1	384	390	PF00454	0.740
MOD_PIKK_1	581	587	PF00454	0.806
MOD_PIKK_1	668	674	PF00454	0.465
MOD_PIKK_1	727	733	PF00454	0.800
MOD_PIKK_1	828	834	PF00454	0.647
MOD_PIKK_1	97	103	PF00454	0.756
MOD_PK_1	273	279	PF00069	0.752
MOD_PK_1	621	627	PF00069	0.738
MOD_PKA_2	107	113	PF00069	0.863
MOD_PKA_2	127	133	PF00069	0.522
MOD_PKA_2	135	141	PF00069	0.765
MOD_PKA_2	171	177	PF00069	0.732
MOD_PKA_2	212	218	PF00069	0.747
MOD_PKA_2	446	452	PF00069	0.748
MOD_PKA_2	492	498	PF00069	0.629
MOD_PKA_2	620	626	PF00069	0.761
MOD_PKA_2	647	653	PF00069	0.823
MOD_PKA_2	661	667	PF00069	0.501
MOD_PKA_2	68	74	PF00069	0.817
MOD_PKA_2	882	888	PF00069	0.706
MOD_PKA_2	955	961	PF00069	0.612
MOD_PKA_2	990	996	PF00069	0.640
MOD_PKB_1	271	279	PF00069	0.765
MOD_Plk_1	764	770	PF00069	0.789
MOD_Plk_1	895	901	PF00069	0.595
MOD_Plk_4	343	349	PF00069	0.723
MOD_Plk_4	661	667	PF00069	0.727
MOD_Plk_4	752	758	PF00069	0.611
MOD_ProDKin_1	108	114	PF00069	0.588
MOD_ProDKin_1	115	121	PF00069	0.719
MOD_ProDKin_1	128	134	PF00069	0.543
MOD_ProDKin_1	162	168	PF00069	0.849
MOD_ProDKin_1	177	183	PF00069	0.571
MOD_ProDKin_1	206	212	PF00069	0.654
MOD_ProDKin_1	221	227	PF00069	0.719
MOD_ProDKin_1	234	240	PF00069	0.652
MOD_ProDKin_1	283	289	PF00069	0.794
MOD_ProDKin_1	295	301	PF00069	0.637
MOD_ProDKin_1	306	312	PF00069	0.659
MOD_ProDKin_1	331	337	PF00069	0.789
MOD_ProDKin_1	36	42	PF00069	0.782
MOD_ProDKin_1	4	10	PF00069	0.791
MOD_ProDKin_1	433	439	PF00069	0.706
MOD_ProDKin_1	451	457	PF00069	0.595
MOD_ProDKin_1	498	504	PF00069	0.754
MOD_ProDKin_1	50	56	PF00069	0.610
MOD_ProDKin_1	684	690	PF00069	0.646
MOD_ProDKin_1	781	787	PF00069	0.635
MOD_ProDKin_1	92	98	PF00069	0.842
MOD_ProDKin_1	945	951	PF00069	0.723
MOD_SUMO_for_1	971	974	PF00179	0.443
MOD_SUMO_rev_2	147	156	PF00179	0.782
MOD_SUMO_rev_2	333	342	PF00179	0.709
MOD_SUMO_rev_2	400	406	PF00179	0.702
MOD_SUMO_rev_2	704	712	PF00179	0.728
MOD_SUMO_rev_2	739	747	PF00179	0.668
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.783
TRG_DiLeu_BaLyEn_6	923	928	PF01217	0.587
TRG_DiLeu_BaLyEn_6	966	971	PF01217	0.606
TRG_ENDOCYTIC_2	33	36	PF00928	0.817
TRG_ER_diArg_1	270	273	PF00400	0.721
TRG_ER_diArg_1	302	304	PF00400	0.811
TRG_ER_diArg_1	527	529	PF00400	0.756
TRG_ER_diArg_1	648	651	PF00400	0.811
TRG_ER_diArg_1	851	853	PF00400	0.785
TRG_ER_diArg_1	977	980	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.732
TRG_Pf-PMV_PEXEL_1	834	838	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	969	974	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHG2	Leishmania donovani	86%	100%
A4H7S6	Leishmania braziliensis	52%	99%
A4I9W0	Leishmania infantum	86%	100%
E9B4X3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%