Alkaline phosphatase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q353_LEIMA

TriTrypDb:

LmjF.34.1490 , LMJLV39_340023200 , LMJSD75_340023300

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q353

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q353

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.463
CLV_NRD_NRD_1	193	195	PF00675	0.645
CLV_NRD_NRD_1	266	268	PF00675	0.562
CLV_NRD_NRD_1	33	35	PF00675	0.447
CLV_NRD_NRD_1	63	65	PF00675	0.575
CLV_PCSK_KEX2_1	266	268	PF00082	0.613
CLV_PCSK_KEX2_1	33	35	PF00082	0.447
CLV_PCSK_KEX2_1	349	351	PF00082	0.572
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.572
CLV_PCSK_SKI1_1	138	142	PF00082	0.480
CLV_PCSK_SKI1_1	195	199	PF00082	0.643
CLV_PCSK_SKI1_1	24	28	PF00082	0.471
CLV_PCSK_SKI1_1	259	263	PF00082	0.526
CLV_PCSK_SKI1_1	34	38	PF00082	0.369
DOC_MAPK_gen_1	30	38	PF00069	0.641
DOC_MAPK_gen_1	64	72	PF00069	0.331
DOC_MAPK_gen_1	86	95	PF00069	0.431
DOC_MAPK_HePTP_8	106	118	PF00069	0.336
DOC_MAPK_MEF2A_6	109	118	PF00069	0.339
DOC_MAPK_MEF2A_6	64	72	PF00069	0.318
DOC_PP1_SILK_1	134	139	PF00149	0.269
DOC_USP7_MATH_1	150	154	PF00917	0.371
DOC_USP7_MATH_1	84	88	PF00917	0.387
DOC_USP7_UBL2_3	141	145	PF12436	0.380
DOC_USP7_UBL2_3	322	326	PF12436	0.337
DOC_WW_Pin1_4	161	166	PF00397	0.453
DOC_WW_Pin1_4	74	79	PF00397	0.406
DOC_WW_Pin1_4	87	92	PF00397	0.494
LIG_14-3-3_CanoR_1	138	148	PF00244	0.411
LIG_14-3-3_CanoR_1	33	37	PF00244	0.591
LIG_14-3-3_CanoR_1	57	61	PF00244	0.480
LIG_Actin_WH2_2	20	35	PF00022	0.713
LIG_Clathr_ClatBox_1	211	215	PF01394	0.375
LIG_eIF4E_1	206	212	PF01652	0.383
LIG_FHA_1	131	137	PF00498	0.381
LIG_FHA_1	312	318	PF00498	0.347
LIG_FHA_1	33	39	PF00498	0.495
LIG_FHA_1	330	336	PF00498	0.296
LIG_FHA_2	17	23	PF00498	0.756
LIG_FHA_2	196	202	PF00498	0.457
LIG_FHA_2	231	237	PF00498	0.357
LIG_FHA_2	266	272	PF00498	0.425
LIG_FHA_2	296	302	PF00498	0.388
LIG_FHA_2	338	344	PF00498	0.440
LIG_FHA_2	57	63	PF00498	0.471
LIG_GBD_Chelix_1	41	49	PF00786	0.360
LIG_LIR_Gen_1	273	279	PF02991	0.337
LIG_LIR_Gen_1	90	99	PF02991	0.438
LIG_LIR_Nem_3	153	158	PF02991	0.520
LIG_LIR_Nem_3	223	229	PF02991	0.367
LIG_LIR_Nem_3	273	278	PF02991	0.400
LIG_LIR_Nem_3	90	95	PF02991	0.434
LIG_SH2_STAT5	189	192	PF00017	0.368
LIG_SH2_STAT5	196	199	PF00017	0.362
LIG_SH2_STAT5	226	229	PF00017	0.365
LIG_SH2_STAT5	297	300	PF00017	0.364
LIG_SH3_1	6	12	PF00018	0.765
LIG_SH3_3	146	152	PF00018	0.374
LIG_SH3_3	234	240	PF00018	0.416
LIG_SH3_3	5	11	PF00018	0.726
LIG_SUMO_SIM_par_1	275	282	PF11976	0.329
LIG_SUMO_SIM_par_1	292	298	PF11976	0.251
LIG_SUMO_SIM_par_1	34	39	PF11976	0.512
LIG_TRAF2_1	243	246	PF00917	0.420
LIG_UBA3_1	136	145	PF00899	0.384
MOD_CDK_SPxxK_3	87	94	PF00069	0.400
MOD_CK1_1	126	132	PF00069	0.439
MOD_CK1_1	230	236	PF00069	0.328
MOD_CK1_1	265	271	PF00069	0.393
MOD_CK1_1	77	83	PF00069	0.453
MOD_CK1_1	87	93	PF00069	0.426
MOD_CK2_1	16	22	PF00069	0.765
MOD_CK2_1	230	236	PF00069	0.366
MOD_CK2_1	265	271	PF00069	0.434
MOD_CK2_1	295	301	PF00069	0.401
MOD_CK2_1	337	343	PF00069	0.419
MOD_GlcNHglycan	121	124	PF01048	0.571
MOD_GlcNHglycan	125	128	PF01048	0.591
MOD_GlcNHglycan	175	179	PF01048	0.639
MOD_GlcNHglycan	186	189	PF01048	0.608
MOD_GlcNHglycan	220	223	PF01048	0.610
MOD_GlcNHglycan	254	257	PF01048	0.591
MOD_GSK3_1	117	124	PF00069	0.430
MOD_GSK3_1	126	133	PF00069	0.429
MOD_GSK3_1	150	157	PF00069	0.385
MOD_GSK3_1	262	269	PF00069	0.406
MOD_GSK3_1	32	39	PF00069	0.526
MOD_GSK3_1	325	332	PF00069	0.473
MOD_GSK3_1	52	59	PF00069	0.655
MOD_N-GLC_1	131	136	PF02516	0.647
MOD_N-GLC_1	218	223	PF02516	0.604
MOD_N-GLC_1	330	335	PF02516	0.590
MOD_N-GLC_1	87	92	PF02516	0.681
MOD_NEK2_1	119	124	PF00069	0.387
MOD_NEK2_1	130	135	PF00069	0.403
MOD_NEK2_1	227	232	PF00069	0.402
MOD_NEK2_1	252	257	PF00069	0.355
MOD_NEK2_1	262	267	PF00069	0.359
MOD_NEK2_1	32	37	PF00069	0.602
MOD_NEK2_1	325	330	PF00069	0.416
MOD_PIKK_1	139	145	PF00454	0.416
MOD_PKA_1	266	272	PF00069	0.382
MOD_PKA_2	265	271	PF00069	0.391
MOD_PKA_2	32	38	PF00069	0.555
MOD_PKA_2	56	62	PF00069	0.474
MOD_Plk_1	131	137	PF00069	0.458
MOD_Plk_1	330	336	PF00069	0.386
MOD_Plk_4	126	132	PF00069	0.410
MOD_Plk_4	144	150	PF00069	0.406
MOD_Plk_4	151	157	PF00069	0.482
MOD_Plk_4	47	53	PF00069	0.380
MOD_ProDKin_1	161	167	PF00069	0.454
MOD_ProDKin_1	74	80	PF00069	0.404
MOD_ProDKin_1	87	93	PF00069	0.489
MOD_SUMO_rev_2	177	187	PF00179	0.529
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.394
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.429
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.432
TRG_ENDOCYTIC_2	155	158	PF00928	0.388
TRG_ENDOCYTIC_2	226	229	PF00928	0.371
TRG_ER_diArg_1	32	34	PF00400	0.672
TRG_NLS_MonoCore_2	63	68	PF00514	0.352
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAP6	Leptomonas seymouri	65%	100%
A0A0S4IM03	Bodo saltans	31%	96%
A0A1X0PAG1	Trypanosomatidae	37%	98%
A0A3S7X7R9	Leishmania donovani	93%	100%
A0A422N0E3	Trypanosoma rangeli	39%	99%
A4H7S5	Leishmania braziliensis	81%	99%
A4I9W1	Leishmania infantum	93%	100%
C9ZMS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B4X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%