PCI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3808), putative

Species:

Leishmania major

UniProt:

Q4Q352_LEIMA

TriTrypDb:

LmjF.34.1500 , LMJLV39_340023400 , LMJSD75_340023500

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	2

Expansion

Sequence features

Q4Q352

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q352

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.526
CLV_C14_Caspase3-7	479	483	PF00656	0.444
CLV_C14_Caspase3-7	614	618	PF00656	0.292
CLV_NRD_NRD_1	529	531	PF00675	0.316
CLV_NRD_NRD_1	607	609	PF00675	0.478
CLV_PCSK_KEX2_1	439	441	PF00082	0.309
CLV_PCSK_KEX2_1	548	550	PF00082	0.297
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.309
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.333
CLV_PCSK_SKI1_1	291	295	PF00082	0.362
CLV_PCSK_SKI1_1	302	306	PF00082	0.307
CLV_PCSK_SKI1_1	531	535	PF00082	0.315
CLV_PCSK_SKI1_1	56	60	PF00082	0.397
CLV_PCSK_SKI1_1	611	615	PF00082	0.333
CLV_PCSK_SKI1_1	697	701	PF00082	0.449
CLV_PCSK_SKI1_1	797	801	PF00082	0.597
DEG_APCC_DBOX_1	301	309	PF00400	0.536
DOC_CKS1_1	721	726	PF01111	0.519
DOC_CYCLIN_yCln2_LP_2	570	576	PF00134	0.596
DOC_MAPK_gen_1	373	381	PF00069	0.595
DOC_MAPK_gen_1	386	396	PF00069	0.498
DOC_MAPK_gen_1	439	447	PF00069	0.536
DOC_MAPK_gen_1	548	555	PF00069	0.624
DOC_MAPK_gen_1	608	615	PF00069	0.414
DOC_MAPK_gen_1	707	716	PF00069	0.452
DOC_MAPK_MEF2A_6	375	383	PF00069	0.486
DOC_MAPK_MEF2A_6	389	398	PF00069	0.444
DOC_USP7_MATH_1	205	209	PF00917	0.496
DOC_USP7_MATH_1	347	351	PF00917	0.454
DOC_USP7_MATH_1	406	410	PF00917	0.461
DOC_USP7_MATH_1	5	9	PF00917	0.614
DOC_USP7_MATH_1	647	651	PF00917	0.646
DOC_USP7_MATH_1	652	656	PF00917	0.670
DOC_USP7_MATH_1	673	677	PF00917	0.592
DOC_USP7_MATH_1	680	684	PF00917	0.677
DOC_USP7_MATH_1	756	760	PF00917	0.429
DOC_USP7_MATH_1	88	92	PF00917	0.475
DOC_USP7_UBL2_3	223	227	PF12436	0.453
DOC_USP7_UBL2_3	778	782	PF12436	0.526
DOC_WW_Pin1_4	246	251	PF00397	0.552
DOC_WW_Pin1_4	329	334	PF00397	0.473
DOC_WW_Pin1_4	557	562	PF00397	0.487
DOC_WW_Pin1_4	56	61	PF00397	0.566
DOC_WW_Pin1_4	626	631	PF00397	0.503
DOC_WW_Pin1_4	667	672	PF00397	0.715
DOC_WW_Pin1_4	720	725	PF00397	0.477
LIG_14-3-3_CanoR_1	110	116	PF00244	0.523
LIG_14-3-3_CanoR_1	129	137	PF00244	0.406
LIG_14-3-3_CanoR_1	170	175	PF00244	0.510
LIG_14-3-3_CanoR_1	204	210	PF00244	0.496
LIG_14-3-3_CanoR_1	277	281	PF00244	0.451
LIG_14-3-3_CanoR_1	389	395	PF00244	0.589
LIG_14-3-3_CanoR_1	530	536	PF00244	0.536
LIG_14-3-3_CanoR_1	681	685	PF00244	0.658
LIG_14-3-3_CanoR_1	689	694	PF00244	0.271
LIG_14-3-3_CanoR_1	729	734	PF00244	0.367
LIG_14-3-3_CanoR_1	90	100	PF00244	0.525
LIG_Actin_WH2_2	290	308	PF00022	0.536
LIG_BIR_II_1	1	5	PF00653	0.734
LIG_BRCT_BRCA1_1	145	149	PF00533	0.519
LIG_BRCT_BRCA1_2	145	151	PF00533	0.496
LIG_DLG_GKlike_1	260	268	PF00625	0.393
LIG_DLG_GKlike_1	729	737	PF00625	0.408
LIG_FHA_1	133	139	PF00498	0.427
LIG_FHA_1	270	276	PF00498	0.538
LIG_FHA_1	364	370	PF00498	0.502
LIG_FHA_1	389	395	PF00498	0.509
LIG_FHA_1	655	661	PF00498	0.505
LIG_FHA_2	266	272	PF00498	0.543
LIG_FHA_2	612	618	PF00498	0.379
LIG_HCF-1_HBM_1	217	220	PF13415	0.461
LIG_IRF3_LxIS_1	394	399	PF10401	0.444
LIG_LIR_Gen_1	146	153	PF02991	0.503
LIG_LIR_Gen_1	211	220	PF02991	0.495
LIG_LIR_Gen_1	504	515	PF02991	0.542
LIG_LIR_Nem_3	146	152	PF02991	0.543
LIG_LIR_Nem_3	207	212	PF02991	0.471
LIG_LIR_Nem_3	355	360	PF02991	0.511
LIG_LIR_Nem_3	422	426	PF02991	0.442
LIG_LIR_Nem_3	427	432	PF02991	0.442
LIG_LIR_Nem_3	504	510	PF02991	0.542
LIG_LIR_Nem_3	686	691	PF02991	0.362
LIG_LIR_Nem_3	743	749	PF02991	0.369
LIG_PCNA_yPIPBox_3	182	196	PF02747	0.557
LIG_PCNA_yPIPBox_3	622	635	PF02747	0.418
LIG_Pex14_1	731	735	PF04695	0.404
LIG_Pex14_2	149	153	PF04695	0.496
LIG_Pex14_2	184	188	PF04695	0.479
LIG_REV1ctd_RIR_1	75	85	PF16727	0.473
LIG_RPA_C_Fungi	44	56	PF08784	0.445
LIG_SH2_CRK	209	213	PF00017	0.331
LIG_SH2_CRK	343	347	PF00017	0.410
LIG_SH2_CRK	432	436	PF00017	0.306
LIG_SH2_CRK	688	692	PF00017	0.394
LIG_SH2_NCK_1	735	739	PF00017	0.367
LIG_SH2_NCK_1	742	746	PF00017	0.320
LIG_SH2_SRC	357	360	PF00017	0.410
LIG_SH2_SRC	432	435	PF00017	0.306
LIG_SH2_SRC	459	462	PF00017	0.309
LIG_SH2_STAP1	426	430	PF00017	0.322
LIG_SH2_STAP1	592	596	PF00017	0.433
LIG_SH2_STAP1	72	76	PF00017	0.306
LIG_SH2_STAP1	735	739	PF00017	0.394
LIG_SH2_STAP1	742	746	PF00017	0.361
LIG_SH2_STAT5	357	360	PF00017	0.410
LIG_SH2_STAT5	619	622	PF00017	0.469
LIG_SH2_STAT5	634	637	PF00017	0.517
LIG_SH2_STAT5	746	749	PF00017	0.435
LIG_SH3_3	244	250	PF00018	0.355
LIG_SH3_3	570	576	PF00018	0.514
LIG_SH3_3	584	590	PF00018	0.450
LIG_SH3_3	665	671	PF00018	0.771
LIG_SH3_5	630	634	PF00018	0.455
LIG_SUMO_SIM_anti_2	25	32	PF11976	0.599
LIG_SUMO_SIM_par_1	468	473	PF11976	0.362
LIG_SUMO_SIM_par_1	610	617	PF11976	0.532
LIG_TRAF2_1	23	26	PF00917	0.629
LIG_TRAF2_1	239	242	PF00917	0.306
LIG_UBA3_1	690	697	PF00899	0.422
LIG_UBA3_1	760	766	PF00899	0.503
MOD_CDC14_SPxK_1	249	252	PF00782	0.379
MOD_CDK_SPxK_1	246	252	PF00069	0.379
MOD_CDK_SPxxK_3	720	727	PF00069	0.513
MOD_CK1_1	140	146	PF00069	0.414
MOD_CK1_1	208	214	PF00069	0.478
MOD_CK1_1	226	232	PF00069	0.386
MOD_CK1_1	4	10	PF00069	0.707
MOD_CK1_1	449	455	PF00069	0.289
MOD_CK1_1	508	514	PF00069	0.361
MOD_CK1_1	650	656	PF00069	0.632
MOD_CK1_1	659	665	PF00069	0.677
MOD_CK1_1	674	680	PF00069	0.549
MOD_CK1_1	91	97	PF00069	0.453
MOD_CK2_1	162	168	PF00069	0.410
MOD_CK2_1	265	271	PF00069	0.421
MOD_CK2_1	45	51	PF00069	0.464
MOD_CK2_1	508	514	PF00069	0.311
MOD_CK2_1	639	645	PF00069	0.633
MOD_CK2_1	65	71	PF00069	0.313
MOD_CK2_1	673	679	PF00069	0.691
MOD_CK2_1	680	686	PF00069	0.584
MOD_GlcNHglycan	130	133	PF01048	0.415
MOD_GlcNHglycan	164	167	PF01048	0.357
MOD_GlcNHglycan	192	195	PF01048	0.391
MOD_GlcNHglycan	3	6	PF01048	0.610
MOD_GlcNHglycan	349	352	PF01048	0.347
MOD_GlcNHglycan	7	10	PF01048	0.560
MOD_GlcNHglycan	769	772	PF01048	0.617
MOD_GSK3_1	1	8	PF00069	0.757
MOD_GSK3_1	128	135	PF00069	0.321
MOD_GSK3_1	136	143	PF00069	0.337
MOD_GSK3_1	204	211	PF00069	0.407
MOD_GSK3_1	226	233	PF00069	0.403
MOD_GSK3_1	242	249	PF00069	0.173
MOD_GSK3_1	260	267	PF00069	0.472
MOD_GSK3_1	390	397	PF00069	0.368
MOD_GSK3_1	505	512	PF00069	0.326
MOD_GSK3_1	553	560	PF00069	0.535
MOD_GSK3_1	639	646	PF00069	0.558
MOD_GSK3_1	647	654	PF00069	0.625
MOD_GSK3_1	655	662	PF00069	0.606
MOD_GSK3_1	667	674	PF00069	0.542
MOD_N-GLC_1	205	210	PF02516	0.313
MOD_N-GLC_1	449	454	PF02516	0.210
MOD_N-GLC_1	56	61	PF02516	0.388
MOD_N-GLC_1	655	660	PF02516	0.728
MOD_N-GLC_2	402	404	PF02516	0.355
MOD_NEK2_1	127	132	PF00069	0.305
MOD_NEK2_1	188	193	PF00069	0.346
MOD_NEK2_1	264	269	PF00069	0.410
MOD_NEK2_1	292	297	PF00069	0.410
MOD_NEK2_1	353	358	PF00069	0.346
MOD_NEK2_1	396	401	PF00069	0.385
MOD_NEK2_1	405	410	PF00069	0.307
MOD_NEK2_1	448	453	PF00069	0.349
MOD_NEK2_1	45	50	PF00069	0.463
MOD_NEK2_1	651	656	PF00069	0.693
MOD_PIKK_1	132	138	PF00454	0.313
MOD_PIKK_1	175	181	PF00454	0.446
MOD_PIKK_1	230	236	PF00454	0.306
MOD_PIKK_1	518	524	PF00454	0.340
MOD_PKA_1	439	445	PF00069	0.410
MOD_PKA_2	128	134	PF00069	0.321
MOD_PKA_2	276	282	PF00069	0.322
MOD_PKA_2	374	380	PF00069	0.331
MOD_PKA_2	388	394	PF00069	0.253
MOD_PKA_2	439	445	PF00069	0.410
MOD_PKA_2	643	649	PF00069	0.544
MOD_PKA_2	680	686	PF00069	0.497
MOD_PKA_2	91	97	PF00069	0.390
MOD_Plk_1	140	146	PF00069	0.395
MOD_Plk_1	205	211	PF00069	0.313
MOD_Plk_1	260	266	PF00069	0.388
MOD_Plk_1	394	400	PF00069	0.392
MOD_Plk_1	655	661	PF00069	0.511
MOD_Plk_1	750	756	PF00069	0.471
MOD_Plk_4	140	146	PF00069	0.410
MOD_Plk_4	208	214	PF00069	0.401
MOD_Plk_4	252	258	PF00069	0.282
MOD_Plk_4	292	298	PF00069	0.342
MOD_Plk_4	326	332	PF00069	0.332
MOD_Plk_4	353	359	PF00069	0.341
MOD_Plk_4	374	380	PF00069	0.279
MOD_Plk_4	560	566	PF00069	0.415
MOD_Plk_4	611	617	PF00069	0.354
MOD_Plk_4	695	701	PF00069	0.416
MOD_Plk_4	756	762	PF00069	0.491
MOD_ProDKin_1	246	252	PF00069	0.433
MOD_ProDKin_1	329	335	PF00069	0.322
MOD_ProDKin_1	557	563	PF00069	0.491
MOD_ProDKin_1	56	62	PF00069	0.567
MOD_ProDKin_1	626	632	PF00069	0.498
MOD_ProDKin_1	667	673	PF00069	0.716
MOD_ProDKin_1	720	726	PF00069	0.473
MOD_SUMO_for_1	31	34	PF00179	0.477
MOD_SUMO_for_1	369	372	PF00179	0.311
MOD_SUMO_for_1	501	504	PF00179	0.210
MOD_SUMO_rev_2	498	503	PF00179	0.352
TRG_DiLeu_BaEn_1	316	321	PF01217	0.355
TRG_DiLeu_BaEn_1	686	691	PF01217	0.498
TRG_DiLeu_BaEn_3	25	31	PF01217	0.425
TRG_DiLeu_LyEn_5	686	691	PF01217	0.364
TRG_ENDOCYTIC_2	209	212	PF00928	0.289
TRG_ENDOCYTIC_2	213	216	PF00928	0.292
TRG_ENDOCYTIC_2	343	346	PF00928	0.410
TRG_ENDOCYTIC_2	357	360	PF00928	0.410
TRG_ENDOCYTIC_2	432	435	PF00928	0.353
TRG_ENDOCYTIC_2	688	691	PF00928	0.398
TRG_ER_diArg_1	89	92	PF00400	0.410
TRG_NES_CRM1_1	20	34	PF08389	0.505
TRG_NES_CRM1_1	372	384	PF08389	0.306
TRG_NLS_MonoExtC_3	566	572	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I210	Leptomonas seymouri	59%	100%
A0A1X0PAU9	Trypanosomatidae	29%	100%
A0A3Q8IUJ9	Leishmania donovani	91%	100%
A0A3R7K1I3	Trypanosoma rangeli	28%	100%
A4H7S4	Leishmania braziliensis	73%	100%
A4I9W2	Leishmania infantum	91%	100%
C9ZMS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B4X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B3F2	Trypanosoma cruzi	27%	100%