P25-alpha family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p25-alpha, putative

Species:

Leishmania major

UniProt:

Q4Q349_LEIMA

TriTrypDb:

LmjF.34.1530 , LMJLV39_340023700 , LMJSD75_340023700

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 14

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q349

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q349

Function

Biological processes
Term	Name	Level	Count
GO:0031334	positive regulation of protein-containing complex assembly	6	3
GO:0032271	regulation of protein polymerization	6	3
GO:0032273	positive regulation of protein polymerization	7	3
GO:0043254	regulation of protein-containing complex assembly	5	3
GO:0044087	regulation of cellular component biogenesis	4	3
GO:0044089	positive regulation of cellular component biogenesis	5	3
GO:0048518	positive regulation of biological process	3	3
GO:0048522	positive regulation of cellular process	4	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0051128	regulation of cellular component organization	4	3
GO:0051130	positive regulation of cellular component organization	5	3
GO:0065007	biological regulation	1	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.491
CLV_NRD_NRD_1	117	119	PF00675	0.291
CLV_NRD_NRD_1	37	39	PF00675	0.290
CLV_PCSK_KEX2_1	117	119	PF00082	0.291
CLV_PCSK_SKI1_1	125	129	PF00082	0.293
CLV_PCSK_SKI1_1	18	22	PF00082	0.280
CLV_PCSK_SKI1_1	8	12	PF00082	0.280
DEG_Nend_UBRbox_2	1	3	PF02207	0.598
DOC_MAPK_gen_1	33	42	PF00069	0.522
DOC_PP1_RVXF_1	36	43	PF00149	0.543
DOC_USP7_MATH_1	73	77	PF00917	0.546
DOC_USP7_UBL2_3	14	18	PF12436	0.484
DOC_USP7_UBL2_3	31	35	PF12436	0.491
DOC_WW_Pin1_4	57	62	PF00397	0.558
LIG_14-3-3_CanoR_1	38	43	PF00244	0.491
LIG_14-3-3_CterR_2	125	129	PF00244	0.391
LIG_FHA_2	100	106	PF00498	0.491
LIG_FHA_2	19	25	PF00498	0.491
LIG_FHA_2	58	64	PF00498	0.597
LIG_FHA_2	76	82	PF00498	0.395
LIG_LIR_Gen_1	26	37	PF02991	0.491
LIG_LIR_Gen_1	4	10	PF02991	0.562
LIG_LIR_Gen_1	41	50	PF02991	0.491
LIG_LIR_Nem_3	26	32	PF02991	0.491
LIG_LIR_Nem_3	41	45	PF02991	0.491
LIG_PDZ_Class_2	124	129	PF00595	0.391
LIG_PTB_Apo_2	121	128	PF02174	0.519
LIG_SH2_STAT5	92	95	PF00017	0.491
MOD_CK1_1	19	25	PF00069	0.522
MOD_CK1_1	4	10	PF00069	0.517
MOD_CK1_1	75	81	PF00069	0.554
MOD_CK1_1	90	96	PF00069	0.377
MOD_CK2_1	38	44	PF00069	0.520
MOD_GlcNHglycan	75	78	PF01048	0.329
MOD_GSK3_1	16	23	PF00069	0.505
MOD_GSK3_1	75	82	PF00069	0.569
MOD_NEK2_1	1	6	PF00069	0.512
MOD_NEK2_1	27	32	PF00069	0.584
MOD_PKA_1	38	44	PF00069	0.491
MOD_Plk_1	1	7	PF00069	0.522
MOD_Plk_1	87	93	PF00069	0.522
MOD_ProDKin_1	57	63	PF00069	0.558
MOD_SUMO_rev_2	7	16	PF00179	0.491
MOD_SUMO_rev_2	81	91	PF00179	0.491
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI7	Leptomonas seymouri	79%	83%
A0A0N1PDJ8	Leptomonas seymouri	77%	83%
A0A1X0PAD0	Trypanosomatidae	69%	85%
A0A3R7N9A0	Trypanosoma rangeli	66%	85%
A0A3S7X7W0	Leishmania donovani	98%	91%
A4H7S1	Leishmania braziliensis	90%	69%
A4H7S2	Leishmania braziliensis	90%	84%
A4I9W4	Leishmania infantum	98%	84%
A4I9W5	Leishmania infantum	98%	91%
A4IIY2	Xenopus tropicalis	40%	73%
C9ZMR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	86%
E9B4X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	98%
Q0P5Y3	Mus musculus	39%	76%
Q2VPM9	Xenopus laevis	42%	73%
Q3T077	Bos taurus	39%	75%
Q3ZCC8	Bos taurus	37%	73%
Q4Q350	Leishmania major	98%	84%
Q5PPN5	Rattus norvegicus	38%	73%
Q9BW30	Homo sapiens	37%	73%
Q9CRB6	Mus musculus	38%	73%