Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania major

UniProt:

Q4Q348_LEIMA

TriTrypDb:

LmjF.34.1540 , LMJLV39_340023800 , LMJSD75_340023900

Length:

943

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	5
GO:0005875	microtubule associated complex	2	2
GO:0005929	cilium	4	2
GO:0032991	protein-containing complex	1	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0099080	supramolecular complex	2	5
GO:0099081	supramolecular polymer	3	5
GO:0099512	supramolecular fiber	4	5
GO:0099513	polymeric cytoskeletal fiber	5	5
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q348

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q348

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	10
GO:0007018	microtubule-based movement	3	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003774	cytoskeletal motor activity	1	10
GO:0003777	microtubule motor activity	2	10
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0005524	ATP binding	5	10
GO:0008017	microtubule binding	5	10
GO:0008092	cytoskeletal protein binding	3	10
GO:0015631	tubulin binding	4	10
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140657	ATP-dependent activity	1	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	483	487	PF00656	0.467
CLV_C14_Caspase3-7	532	536	PF00656	0.596
CLV_C14_Caspase3-7	86	90	PF00656	0.241
CLV_NRD_NRD_1	292	294	PF00675	0.307
CLV_NRD_NRD_1	46	48	PF00675	0.307
CLV_NRD_NRD_1	490	492	PF00675	0.468
CLV_NRD_NRD_1	555	557	PF00675	0.591
CLV_NRD_NRD_1	642	644	PF00675	0.598
CLV_NRD_NRD_1	684	686	PF00675	0.595
CLV_NRD_NRD_1	695	697	PF00675	0.578
CLV_PCSK_FUR_1	152	156	PF00082	0.292
CLV_PCSK_KEX2_1	154	156	PF00082	0.322
CLV_PCSK_KEX2_1	292	294	PF00082	0.307
CLV_PCSK_KEX2_1	490	492	PF00082	0.468
CLV_PCSK_KEX2_1	554	556	PF00082	0.682
CLV_PCSK_KEX2_1	694	696	PF00082	0.558
CLV_PCSK_KEX2_1	704	706	PF00082	0.505
CLV_PCSK_KEX2_1	933	935	PF00082	0.535
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.259
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.307
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.682
CLV_PCSK_PC1ET2_1	704	706	PF00082	0.551
CLV_PCSK_PC1ET2_1	933	935	PF00082	0.535
CLV_PCSK_PC7_1	700	706	PF00082	0.550
CLV_PCSK_SKI1_1	189	193	PF00082	0.287
CLV_PCSK_SKI1_1	258	262	PF00082	0.300
CLV_PCSK_SKI1_1	275	279	PF00082	0.395
CLV_PCSK_SKI1_1	327	331	PF00082	0.295
CLV_PCSK_SKI1_1	627	631	PF00082	0.592
CLV_PCSK_SKI1_1	686	690	PF00082	0.555
CLV_PCSK_SKI1_1	806	810	PF00082	0.514
DEG_APCC_DBOX_1	233	241	PF00400	0.264
DEG_APCC_DBOX_1	502	510	PF00400	0.423
DEG_APCC_KENBOX_2	522	526	PF00400	0.519
DEG_ODPH_VHL_1	645	658	PF01847	0.570
DEG_SPOP_SBC_1	597	601	PF00917	0.580
DEG_SPOP_SBC_1	647	651	PF00917	0.552
DEG_SPOP_SBC_1	869	873	PF00917	0.598
DOC_ANK_TNKS_1	154	161	PF00023	0.270
DOC_ANK_TNKS_1	642	649	PF00023	0.586
DOC_CKS1_1	719	724	PF01111	0.506
DOC_MAPK_gen_1	258	266	PF00069	0.290
DOC_MAPK_gen_1	292	298	PF00069	0.285
DOC_MAPK_gen_1	318	326	PF00069	0.277
DOC_MAPK_MEF2A_6	737	745	PF00069	0.540
DOC_PP1_RVXF_1	161	167	PF00149	0.277
DOC_PP1_RVXF_1	804	810	PF00149	0.454
DOC_USP7_MATH_1	134	138	PF00917	0.283
DOC_USP7_MATH_1	279	283	PF00917	0.298
DOC_USP7_MATH_1	401	405	PF00917	0.471
DOC_USP7_MATH_1	41	45	PF00917	0.270
DOC_USP7_MATH_1	426	430	PF00917	0.501
DOC_USP7_MATH_1	547	551	PF00917	0.592
DOC_USP7_MATH_1	569	573	PF00917	0.584
DOC_USP7_MATH_1	582	586	PF00917	0.565
DOC_USP7_MATH_1	592	596	PF00917	0.599
DOC_USP7_MATH_1	597	601	PF00917	0.550
DOC_USP7_MATH_1	647	651	PF00917	0.549
DOC_USP7_MATH_1	664	668	PF00917	0.469
DOC_USP7_MATH_1	735	739	PF00917	0.676
DOC_USP7_MATH_1	854	858	PF00917	0.625
DOC_USP7_MATH_1	928	932	PF00917	0.527
DOC_USP7_UBL2_3	620	624	PF12436	0.550
DOC_WW_Pin1_4	181	186	PF00397	0.277
DOC_WW_Pin1_4	340	345	PF00397	0.313
DOC_WW_Pin1_4	629	634	PF00397	0.588
DOC_WW_Pin1_4	637	642	PF00397	0.599
DOC_WW_Pin1_4	665	670	PF00397	0.563
DOC_WW_Pin1_4	718	723	PF00397	0.506
DOC_WW_Pin1_4	848	853	PF00397	0.598
LIG_14-3-3_CanoR_1	106	110	PF00244	0.278
LIG_14-3-3_CanoR_1	122	127	PF00244	0.393
LIG_14-3-3_CanoR_1	438	447	PF00244	0.604
LIG_14-3-3_CanoR_1	604	612	PF00244	0.613
LIG_14-3-3_CanoR_1	737	742	PF00244	0.547
LIG_14-3-3_CanoR_1	752	759	PF00244	0.519
LIG_14-3-3_CanoR_1	868	878	PF00244	0.610
LIG_Actin_WH2_2	135	150	PF00022	0.297
LIG_Actin_WH2_2	777	792	PF00022	0.491
LIG_APCC_ABBA_1	217	222	PF00400	0.319
LIG_BRCT_BRCA1_1	666	670	PF00533	0.561
LIG_eIF4E_1	783	789	PF01652	0.478
LIG_FHA_1	116	122	PF00498	0.269
LIG_FHA_1	201	207	PF00498	0.455
LIG_FHA_1	216	222	PF00498	0.269
LIG_FHA_1	266	272	PF00498	0.283
LIG_FHA_1	310	316	PF00498	0.288
LIG_FHA_1	321	327	PF00498	0.367
LIG_FHA_1	334	340	PF00498	0.319
LIG_FHA_1	351	357	PF00498	0.319
LIG_FHA_1	374	380	PF00498	0.451
LIG_FHA_1	439	445	PF00498	0.538
LIG_FHA_1	563	569	PF00498	0.597
LIG_FHA_1	760	766	PF00498	0.521
LIG_FHA_1	870	876	PF00498	0.593
LIG_FHA_2	438	444	PF00498	0.616
LIG_FHA_2	617	623	PF00498	0.592
LIG_FHA_2	649	655	PF00498	0.518
LIG_FHA_2	687	693	PF00498	0.509
LIG_FHA_2	725	731	PF00498	0.530
LIG_FHA_2	762	768	PF00498	0.503
LIG_FHA_2	94	100	PF00498	0.294
LIG_LIR_Apic_2	716	722	PF02991	0.514
LIG_LIR_Apic_2	730	735	PF02991	0.542
LIG_LIR_Gen_1	2	10	PF02991	0.436
LIG_LIR_Gen_1	476	483	PF02991	0.396
LIG_LIR_Gen_1	714	722	PF02991	0.459
LIG_LIR_Gen_1	890	900	PF02991	0.551
LIG_LIR_Nem_3	108	113	PF02991	0.342
LIG_LIR_Nem_3	190	196	PF02991	0.356
LIG_LIR_Nem_3	2	6	PF02991	0.548
LIG_LIR_Nem_3	476	481	PF02991	0.396
LIG_LIR_Nem_3	714	718	PF02991	0.522
LIG_LIR_Nem_3	726	731	PF02991	0.529
LIG_LIR_Nem_3	829	834	PF02991	0.455
LIG_LIR_Nem_3	890	895	PF02991	0.559
LIG_LIR_Nem_3	913	919	PF02991	0.535
LIG_LYPXL_yS_3	916	919	PF13949	0.539
LIG_NRBOX	321	327	PF00104	0.319
LIG_PCNA_PIPBox_1	198	207	PF02747	0.277
LIG_PCNA_yPIPBox_3	114	122	PF02747	0.277
LIG_PCNA_yPIPBox_3	471	484	PF02747	0.437
LIG_Pex14_2	105	109	PF04695	0.307
LIG_Rb_pABgroove_1	472	480	PF01858	0.385
LIG_Rb_pABgroove_1	67	75	PF01858	0.307
LIG_SH2_CRK	478	482	PF00017	0.391
LIG_SH2_CRK	719	723	PF00017	0.521
LIG_SH2_CRK	732	736	PF00017	0.539
LIG_SH2_CRK	831	835	PF00017	0.468
LIG_SH2_SRC	220	223	PF00017	0.307
LIG_SH2_SRC	783	786	PF00017	0.486
LIG_SH2_STAP1	715	719	PF00017	0.507
LIG_SH2_STAP1	728	732	PF00017	0.542
LIG_SH2_STAT3	731	734	PF00017	0.514
LIG_SH2_STAT3	903	906	PF00017	0.568
LIG_SH2_STAT5	103	106	PF00017	0.303
LIG_SH2_STAT5	220	223	PF00017	0.313
LIG_SH2_STAT5	348	351	PF00017	0.277
LIG_SH2_STAT5	783	786	PF00017	0.486
LIG_SH3_1	922	928	PF00018	0.588
LIG_SH3_3	609	615	PF00018	0.609
LIG_SH3_3	635	641	PF00018	0.609
LIG_SH3_3	740	746	PF00018	0.578
LIG_SH3_3	847	853	PF00018	0.602
LIG_SH3_3	863	869	PF00018	0.547
LIG_SH3_3	922	928	PF00018	0.577
LIG_SUMO_SIM_anti_2	235	241	PF11976	0.277
LIG_SUMO_SIM_anti_2	504	511	PF11976	0.452
LIG_SUMO_SIM_anti_2	740	745	PF11976	0.542
LIG_SUMO_SIM_par_1	440	449	PF11976	0.466
LIG_SUMO_SIM_par_1	761	767	PF11976	0.466
LIG_SxIP_EBH_1	868	881	PF03271	0.607
LIG_TRAF2_1	561	564	PF00917	0.579
LIG_UBA3_1	192	199	PF00899	0.307
LIG_UBA3_1	270	275	PF00899	0.277
MOD_CDC14_SPxK_1	640	643	PF00782	0.598
MOD_CDK_SPxK_1	637	643	PF00069	0.600
MOD_CDK_SPxxK_3	340	347	PF00069	0.269
MOD_CDK_SPxxK_3	637	644	PF00069	0.592
MOD_CK1_1	136	142	PF00069	0.302
MOD_CK1_1	210	216	PF00069	0.319
MOD_CK1_1	235	241	PF00069	0.278
MOD_CK1_1	29	35	PF00069	0.357
MOD_CK1_1	320	326	PF00069	0.388
MOD_CK1_1	334	340	PF00069	0.327
MOD_CK1_1	607	613	PF00069	0.634
MOD_CK1_1	632	638	PF00069	0.524
MOD_CK1_1	848	854	PF00069	0.609
MOD_CK1_1	857	863	PF00069	0.591
MOD_CK1_1	887	893	PF00069	0.737
MOD_CK2_1	181	187	PF00069	0.277
MOD_CK2_1	230	236	PF00069	0.295
MOD_CK2_1	401	407	PF00069	0.481
MOD_CK2_1	443	449	PF00069	0.488
MOD_CK2_1	648	654	PF00069	0.516
MOD_CK2_1	686	692	PF00069	0.512
MOD_CK2_1	811	817	PF00069	0.517
MOD_GlcNHglycan	193	196	PF01048	0.349
MOD_GlcNHglycan	255	258	PF01048	0.301
MOD_GlcNHglycan	28	31	PF01048	0.346
MOD_GlcNHglycan	281	284	PF01048	0.329
MOD_GlcNHglycan	571	575	PF01048	0.597
MOD_GlcNHglycan	583	587	PF01048	0.530
MOD_GlcNHglycan	593	597	PF01048	0.565
MOD_GlcNHglycan	616	619	PF01048	0.610
MOD_GlcNHglycan	847	850	PF01048	0.617
MOD_GlcNHglycan	854	857	PF01048	0.596
MOD_GlcNHglycan	860	863	PF01048	0.577
MOD_GlcNHglycan	878	881	PF01048	0.530
MOD_GlcNHglycan	889	892	PF01048	0.571
MOD_GSK3_1	101	108	PF00069	0.295
MOD_GSK3_1	133	140	PF00069	0.342
MOD_GSK3_1	249	256	PF00069	0.304
MOD_GSK3_1	275	282	PF00069	0.303
MOD_GSK3_1	426	433	PF00069	0.578
MOD_GSK3_1	523	530	PF00069	0.529
MOD_GSK3_1	592	599	PF00069	0.584
MOD_GSK3_1	603	610	PF00069	0.654
MOD_GSK3_1	848	855	PF00069	0.621
MOD_GSK3_1	857	864	PF00069	0.675
MOD_GSK3_1	883	890	PF00069	0.583
MOD_N-GLC_1	266	271	PF02516	0.319
MOD_N-GLC_1	540	545	PF02516	0.613
MOD_N-GLC_1	664	669	PF02516	0.564
MOD_N-GLC_1	811	816	PF02516	0.522
MOD_N-GLC_1	869	874	PF02516	0.606
MOD_N-GLC_1	908	913	PF02516	0.593
MOD_N-GLC_2	413	415	PF02516	0.493
MOD_NEK2_1	105	110	PF00069	0.330
MOD_NEK2_1	121	126	PF00069	0.330
MOD_NEK2_1	138	143	PF00069	0.483
MOD_NEK2_1	17	22	PF00069	0.306
MOD_NEK2_1	191	196	PF00069	0.272
MOD_NEK2_1	453	458	PF00069	0.449
MOD_NEK2_1	605	610	PF00069	0.579
MOD_NEK2_1	768	773	PF00069	0.507
MOD_NEK2_1	885	890	PF00069	0.582
MOD_NEK2_2	215	220	PF00069	0.426
MOD_NEK2_2	917	922	PF00069	0.552
MOD_NEK2_2	928	933	PF00069	0.490
MOD_PIKK_1	385	391	PF00454	0.383
MOD_PIKK_1	41	47	PF00454	0.285
MOD_PIKK_1	599	605	PF00454	0.578
MOD_PIKK_1	735	741	PF00454	0.554
MOD_PK_1	122	128	PF00069	0.240
MOD_PKA_1	490	496	PF00069	0.407
MOD_PKA_2	105	111	PF00069	0.278
MOD_PKA_2	121	127	PF00069	0.410
MOD_PKA_2	317	323	PF00069	0.325
MOD_PKA_2	437	443	PF00069	0.620
MOD_PKA_2	490	496	PF00069	0.407
MOD_PKA_2	547	553	PF00069	0.595
MOD_PKA_2	603	609	PF00069	0.549
MOD_PKA_2	680	686	PF00069	0.592
MOD_PKA_2	751	757	PF00069	0.582
MOD_PKA_2	812	818	PF00069	0.505
MOD_Plk_1	101	107	PF00069	0.317
MOD_Plk_1	235	241	PF00069	0.277
MOD_Plk_1	266	272	PF00069	0.319
MOD_Plk_1	373	379	PF00069	0.452
MOD_Plk_1	385	391	PF00069	0.354
MOD_Plk_1	523	529	PF00069	0.555
MOD_Plk_1	562	568	PF00069	0.582
MOD_Plk_1	917	923	PF00069	0.541
MOD_Plk_2-3	443	449	PF00069	0.465
MOD_Plk_2-3	531	537	PF00069	0.539
MOD_Plk_2-3	671	677	PF00069	0.546
MOD_Plk_2-3	93	99	PF00069	0.270
MOD_Plk_4	105	111	PF00069	0.337
MOD_Plk_4	17	23	PF00069	0.321
MOD_Plk_4	235	241	PF00069	0.277
MOD_Plk_4	266	272	PF00069	0.319
MOD_Plk_4	320	326	PF00069	0.313
MOD_Plk_4	334	340	PF00069	0.310
MOD_Plk_4	352	358	PF00069	0.401
MOD_Plk_4	374	380	PF00069	0.427
MOD_Plk_4	401	407	PF00069	0.481
MOD_Plk_4	453	459	PF00069	0.436
MOD_Plk_4	523	529	PF00069	0.633
MOD_Plk_4	648	654	PF00069	0.537
MOD_Plk_4	784	790	PF00069	0.476
MOD_ProDKin_1	181	187	PF00069	0.277
MOD_ProDKin_1	340	346	PF00069	0.313
MOD_ProDKin_1	629	635	PF00069	0.587
MOD_ProDKin_1	637	643	PF00069	0.600
MOD_ProDKin_1	665	671	PF00069	0.567
MOD_ProDKin_1	718	724	PF00069	0.505
MOD_ProDKin_1	848	854	PF00069	0.595
MOD_SUMO_for_1	172	175	PF00179	0.269
MOD_SUMO_for_1	390	393	PF00179	0.393
MOD_SUMO_rev_2	531	540	PF00179	0.605
MOD_SUMO_rev_2	617	625	PF00179	0.547
TRG_DiLeu_BaEn_1	246	251	PF01217	0.277
TRG_DiLeu_BaEn_4	385	391	PF01217	0.382
TRG_ENDOCYTIC_2	397	400	PF00928	0.418
TRG_ENDOCYTIC_2	478	481	PF00928	0.392
TRG_ENDOCYTIC_2	715	718	PF00928	0.454
TRG_ENDOCYTIC_2	831	834	PF00928	0.466
TRG_ENDOCYTIC_2	916	919	PF00928	0.539
TRG_ER_diArg_1	162	165	PF00400	0.375
TRG_ER_diArg_1	300	303	PF00400	0.274
TRG_ER_diArg_1	694	696	PF00400	0.564
TRG_ER_diArg_1	921	924	PF00400	0.608
TRG_NLS_Bipartite_1	685	707	PF00514	0.522
TRG_NLS_MonoCore_2	701	706	PF00514	0.486
TRG_NLS_MonoExtN_4	700	707	PF00514	0.503
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	806	810	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	821	825	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMQ7	Leptomonas seymouri	55%	88%
A0A3Q8IIF6	Leishmania donovani	91%	88%
A0A3S5H5N6	Leishmania donovani	29%	100%
A4H7S0	Leishmania braziliensis	65%	87%
A4HSQ9	Leishmania infantum	29%	100%
A4I9W6	Leishmania infantum	91%	88%
E9AKP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B4X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	87%