Putative ATP dependent DEAD-box helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP dependent DEAD-box helicase, putative

Species:

Leishmania major

UniProt:

Q4Q347_LEIMA

TriTrypDb:

LmjF.34.1550 , LMJLV39_340023900 , LMJSD75_340024000

Length:

777

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0000313	organellar ribosome	6	2
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005761	mitochondrial ribosome	7	2
GO:0005840	ribosome	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q347

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q347

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004386	helicase activity	2	8
GO:0005488	binding	1	5
GO:0043021	ribonucleoprotein complex binding	3	2
GO:0043022	ribosome binding	4	2
GO:0044877	protein-containing complex binding	2	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0140657	ATP-dependent activity	1	8
GO:0000166	nucleotide binding	3	3
GO:0003676	nucleic acid binding	3	3
GO:0005524	ATP binding	5	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.690
CLV_C14_Caspase3-7	225	229	PF00656	0.710
CLV_C14_Caspase3-7	618	622	PF00656	0.436
CLV_NRD_NRD_1	13	15	PF00675	0.606
CLV_NRD_NRD_1	132	134	PF00675	0.474
CLV_NRD_NRD_1	220	222	PF00675	0.663
CLV_NRD_NRD_1	326	328	PF00675	0.532
CLV_NRD_NRD_1	361	363	PF00675	0.478
CLV_NRD_NRD_1	365	367	PF00675	0.504
CLV_NRD_NRD_1	399	401	PF00675	0.357
CLV_NRD_NRD_1	539	541	PF00675	0.466
CLV_NRD_NRD_1	62	64	PF00675	0.546
CLV_NRD_NRD_1	686	688	PF00675	0.688
CLV_NRD_NRD_1	713	715	PF00675	0.515
CLV_NRD_NRD_1	770	772	PF00675	0.736
CLV_PCSK_FUR_1	11	15	PF00082	0.505
CLV_PCSK_FUR_1	60	64	PF00082	0.625
CLV_PCSK_KEX2_1	13	15	PF00082	0.606
CLV_PCSK_KEX2_1	132	134	PF00082	0.474
CLV_PCSK_KEX2_1	326	328	PF00082	0.567
CLV_PCSK_KEX2_1	361	363	PF00082	0.453
CLV_PCSK_KEX2_1	365	367	PF00082	0.482
CLV_PCSK_KEX2_1	399	401	PF00082	0.357
CLV_PCSK_KEX2_1	538	540	PF00082	0.516
CLV_PCSK_KEX2_1	62	64	PF00082	0.570
CLV_PCSK_KEX2_1	688	690	PF00082	0.688
CLV_PCSK_KEX2_1	713	715	PF00082	0.508
CLV_PCSK_KEX2_1	737	739	PF00082	0.567
CLV_PCSK_KEX2_1	752	754	PF00082	0.518
CLV_PCSK_KEX2_1	772	774	PF00082	0.743
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.700
CLV_PCSK_PC1ET2_1	737	739	PF00082	0.567
CLV_PCSK_PC1ET2_1	752	754	PF00082	0.518
CLV_PCSK_PC1ET2_1	772	774	PF00082	0.743
CLV_PCSK_PC7_1	361	367	PF00082	0.567
CLV_PCSK_SKI1_1	110	114	PF00082	0.671
CLV_PCSK_SKI1_1	178	182	PF00082	0.585
CLV_PCSK_SKI1_1	198	202	PF00082	0.362
CLV_PCSK_SKI1_1	365	369	PF00082	0.464
CLV_PCSK_SKI1_1	448	452	PF00082	0.443
CLV_PCSK_SKI1_1	46	50	PF00082	0.594
CLV_PCSK_SKI1_1	523	527	PF00082	0.527
CLV_PCSK_SKI1_1	565	569	PF00082	0.357
CLV_PCSK_SKI1_1	689	693	PF00082	0.569
CLV_PCSK_SKI1_1	738	742	PF00082	0.487
CLV_PCSK_SKI1_1	749	753	PF00082	0.428
CLV_PCSK_SKI1_1	85	89	PF00082	0.502
DEG_APCC_DBOX_1	537	545	PF00400	0.432
DEG_MDM2_SWIB_1	560	568	PF02201	0.403
DEG_SPOP_SBC_1	4	8	PF00917	0.583
DOC_CYCLIN_RxL_1	735	742	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.486
DOC_MAPK_gen_1	326	334	PF00069	0.506
DOC_MAPK_gen_1	71	78	PF00069	0.513
DOC_MAPK_gen_1	749	757	PF00069	0.542
DOC_MAPK_MEF2A_6	284	292	PF00069	0.372
DOC_MAPK_MEF2A_6	448	455	PF00069	0.418
DOC_MAPK_MEF2A_6	727	735	PF00069	0.472
DOC_MAPK_NFAT4_5	448	456	PF00069	0.413
DOC_MAPK_RevD_3	524	539	PF00069	0.439
DOC_PP1_RVXF_1	509	515	PF00149	0.390
DOC_PP1_RVXF_1	521	528	PF00149	0.378
DOC_PP2B_LxvP_1	526	529	PF13499	0.459
DOC_PP4_FxxP_1	692	695	PF00568	0.562
DOC_USP7_MATH_1	134	138	PF00917	0.710
DOC_USP7_MATH_1	144	148	PF00917	0.610
DOC_USP7_MATH_1	150	154	PF00917	0.709
DOC_USP7_MATH_1	171	175	PF00917	0.592
DOC_USP7_MATH_1	214	218	PF00917	0.611
DOC_USP7_MATH_1	223	227	PF00917	0.720
DOC_USP7_MATH_1	230	234	PF00917	0.618
DOC_USP7_MATH_1	580	584	PF00917	0.375
DOC_USP7_UBL2_3	561	565	PF12436	0.564
DOC_USP7_UBL2_3	619	623	PF12436	0.482
DOC_USP7_UBL2_3	694	698	PF12436	0.545
DOC_WW_Pin1_4	139	144	PF00397	0.725
DOC_WW_Pin1_4	210	215	PF00397	0.619
DOC_WW_Pin1_4	703	708	PF00397	0.454
DOC_WW_Pin1_4	90	95	PF00397	0.578
LIG_14-3-3_CanoR_1	13	18	PF00244	0.645
LIG_14-3-3_CanoR_1	133	143	PF00244	0.769
LIG_14-3-3_CanoR_1	3	12	PF00244	0.766
LIG_14-3-3_CanoR_1	372	381	PF00244	0.305
LIG_14-3-3_CanoR_1	486	492	PF00244	0.514
LIG_14-3-3_CanoR_1	505	509	PF00244	0.484
LIG_14-3-3_CanoR_1	672	678	PF00244	0.640
LIG_Actin_WH2_2	383	401	PF00022	0.425
LIG_AP2alpha_2	765	767	PF02296	0.671
LIG_APCC_ABBA_1	548	553	PF00400	0.404
LIG_BIR_III_4	228	232	PF00653	0.666
LIG_BRCT_BRCA1_1	160	164	PF00533	0.687
LIG_BRCT_BRCA1_1	191	195	PF00533	0.539
LIG_BRCT_BRCA1_1	341	345	PF00533	0.488
LIG_BRCT_BRCA1_1	571	575	PF00533	0.397
LIG_BRCT_BRCA1_1	582	586	PF00533	0.351
LIG_BRCT_BRCA1_1	632	636	PF00533	0.581
LIG_deltaCOP1_diTrp_1	339	345	PF00928	0.404
LIG_deltaCOP1_diTrp_1	563	566	PF00928	0.413
LIG_FHA_1	119	125	PF00498	0.503
LIG_FHA_1	283	289	PF00498	0.381
LIG_FHA_1	31	37	PF00498	0.672
LIG_FHA_1	375	381	PF00498	0.447
LIG_FHA_1	40	46	PF00498	0.701
LIG_FHA_1	477	483	PF00498	0.488
LIG_FHA_1	52	58	PF00498	0.582
LIG_FHA_1	746	752	PF00498	0.475
LIG_FHA_2	179	185	PF00498	0.556
LIG_FHA_2	186	192	PF00498	0.548
LIG_FHA_2	346	352	PF00498	0.518
LIG_FHA_2	374	380	PF00498	0.333
LIG_FHA_2	757	763	PF00498	0.544
LIG_Integrin_RGDW_4	561	564	PF00362	0.420
LIG_LIR_Apic_2	690	695	PF02991	0.565
LIG_LIR_Gen_1	232	242	PF02991	0.474
LIG_LIR_Gen_1	339	349	PF02991	0.378
LIG_LIR_Gen_1	354	364	PF02991	0.530
LIG_LIR_Gen_1	391	398	PF02991	0.455
LIG_LIR_Gen_1	503	513	PF02991	0.415
LIG_LIR_Gen_1	563	574	PF02991	0.417
LIG_LIR_Gen_1	583	591	PF02991	0.351
LIG_LIR_Gen_1	592	600	PF02991	0.397
LIG_LIR_Nem_3	232	237	PF02991	0.486
LIG_LIR_Nem_3	273	279	PF02991	0.420
LIG_LIR_Nem_3	339	344	PF02991	0.375
LIG_LIR_Nem_3	351	356	PF02991	0.503
LIG_LIR_Nem_3	391	395	PF02991	0.459
LIG_LIR_Nem_3	503	509	PF02991	0.398
LIG_LIR_Nem_3	563	569	PF02991	0.368
LIG_LIR_Nem_3	583	589	PF02991	0.349
LIG_LIR_Nem_3	592	597	PF02991	0.405
LIG_LIR_Nem_3	703	708	PF02991	0.582
LIG_LIR_Nem_3	89	95	PF02991	0.628
LIG_NRBOX	508	514	PF00104	0.393
LIG_NRP_CendR_1	776	777	PF00754	0.551
LIG_PCNA_PIPBox_1	668	677	PF02747	0.495
LIG_Pex14_2	560	564	PF04695	0.453
LIG_REV1ctd_RIR_1	689	694	PF16727	0.588
LIG_RPA_C_Fungi	189	201	PF08784	0.631
LIG_SH2_CRK	251	255	PF00017	0.548
LIG_SH2_CRK	705	709	PF00017	0.556
LIG_SH2_NCK_1	705	709	PF00017	0.547
LIG_SH2_NCK_1	92	96	PF00017	0.678
LIG_SH2_STAP1	341	345	PF00017	0.488
LIG_SH2_STAP1	353	357	PF00017	0.278
LIG_SH2_STAP1	675	679	PF00017	0.667
LIG_SH2_STAT3	675	678	PF00017	0.544
LIG_SH2_STAT5	397	400	PF00017	0.391
LIG_SH2_STAT5	402	405	PF00017	0.340
LIG_SH2_STAT5	508	511	PF00017	0.390
LIG_SH2_STAT5	614	617	PF00017	0.406
LIG_SH2_STAT5	675	678	PF00017	0.564
LIG_SH2_STAT5	705	708	PF00017	0.538
LIG_SH3_3	331	337	PF00018	0.406
LIG_SH3_3	408	414	PF00018	0.460
LIG_SH3_3	482	488	PF00018	0.472
LIG_SH3_3	574	580	PF00018	0.459
LIG_SH3_4	474	481	PF00018	0.617
LIG_SH3_4	694	701	PF00018	0.537
LIG_SH3_5	337	341	PF00018	0.533
LIG_SUMO_SIM_par_1	120	126	PF11976	0.510
LIG_TRFH_1	100	104	PF08558	0.603
LIG_TRFH_1	663	667	PF08558	0.430
LIG_TYR_ITIM	90	95	PF00017	0.642
LIG_WRC_WIRS_1	494	499	PF05994	0.420
LIG_WRC_WIRS_1	586	591	PF05994	0.315
MOD_CDK_SPxxK_3	90	97	PF00069	0.591
MOD_CK1_1	137	143	PF00069	0.715
MOD_CK1_1	174	180	PF00069	0.692
MOD_CK1_1	203	209	PF00069	0.615
MOD_CK1_1	213	219	PF00069	0.602
MOD_CK1_1	282	288	PF00069	0.387
MOD_CK1_1	39	45	PF00069	0.561
MOD_CK2_1	132	138	PF00069	0.589
MOD_CK2_1	148	154	PF00069	0.732
MOD_CK2_1	185	191	PF00069	0.535
MOD_CK2_1	345	351	PF00069	0.507
MOD_CK2_1	352	358	PF00069	0.509
MOD_CK2_1	621	627	PF00069	0.427
MOD_CK2_1	756	762	PF00069	0.537
MOD_CK2_1	90	96	PF00069	0.589
MOD_GlcNHglycan	134	137	PF01048	0.761
MOD_GlcNHglycan	191	194	PF01048	0.587
MOD_GlcNHglycan	234	237	PF01048	0.466
MOD_GlcNHglycan	244	247	PF01048	0.474
MOD_GlcNHglycan	281	284	PF01048	0.381
MOD_GlcNHglycan	285	288	PF01048	0.360
MOD_GlcNHglycan	415	418	PF01048	0.538
MOD_GlcNHglycan	456	459	PF01048	0.375
MOD_GlcNHglycan	7	10	PF01048	0.772
MOD_GSK3_1	132	139	PF00069	0.702
MOD_GSK3_1	144	151	PF00069	0.518
MOD_GSK3_1	174	181	PF00069	0.605
MOD_GSK3_1	185	192	PF00069	0.521
MOD_GSK3_1	210	217	PF00069	0.620
MOD_GSK3_1	279	286	PF00069	0.427
MOD_GSK3_1	32	39	PF00069	0.661
MOD_GSK3_1	476	483	PF00069	0.514
MOD_GSK3_1	585	592	PF00069	0.432
MOD_LATS_1	717	723	PF00433	0.596
MOD_N-GLC_1	158	163	PF02516	0.531
MOD_N-GLC_1	39	44	PF02516	0.699
MOD_NEK2_1	12	17	PF00069	0.711
MOD_NEK2_1	164	169	PF00069	0.559
MOD_NEK2_1	242	247	PF00069	0.382
MOD_NEK2_1	306	311	PF00069	0.431
MOD_NEK2_1	317	322	PF00069	0.389
MOD_NEK2_1	345	350	PF00069	0.489
MOD_NEK2_1	373	378	PF00069	0.436
MOD_NEK2_1	435	440	PF00069	0.388
MOD_NEK2_2	493	498	PF00069	0.388
MOD_NEK2_2	747	752	PF00069	0.467
MOD_PIKK_1	148	154	PF00454	0.631
MOD_PIKK_1	719	725	PF00454	0.596
MOD_PIKK_1	76	82	PF00454	0.648
MOD_PK_1	727	733	PF00069	0.479
MOD_PKA_1	13	19	PF00069	0.629
MOD_PKA_1	132	138	PF00069	0.486
MOD_PKA_1	365	371	PF00069	0.566
MOD_PKA_2	12	18	PF00069	0.678
MOD_PKA_2	132	138	PF00069	0.706
MOD_PKA_2	365	371	PF00069	0.547
MOD_PKA_2	4	10	PF00069	0.766
MOD_PKA_2	504	510	PF00069	0.482
MOD_PKA_2	516	522	PF00069	0.357
MOD_PKA_2	654	660	PF00069	0.502
MOD_PKB_1	3	11	PF00069	0.612
MOD_Plk_1	158	164	PF00069	0.663
MOD_Plk_1	171	177	PF00069	0.582
MOD_Plk_1	339	345	PF00069	0.384
MOD_Plk_1	88	94	PF00069	0.533
MOD_Plk_2-3	158	164	PF00069	0.615
MOD_Plk_2-3	352	358	PF00069	0.429
MOD_Plk_2-3	621	627	PF00069	0.524
MOD_Plk_2-3	630	636	PF00069	0.535
MOD_Plk_4	118	124	PF00069	0.655
MOD_Plk_4	144	150	PF00069	0.738
MOD_Plk_4	164	170	PF00069	0.639
MOD_Plk_4	185	191	PF00069	0.547
MOD_Plk_4	339	345	PF00069	0.471
MOD_Plk_4	352	358	PF00069	0.484
MOD_Plk_4	477	483	PF00069	0.503
MOD_Plk_4	727	733	PF00069	0.555
MOD_ProDKin_1	139	145	PF00069	0.728
MOD_ProDKin_1	210	216	PF00069	0.622
MOD_ProDKin_1	703	709	PF00069	0.449
MOD_ProDKin_1	90	96	PF00069	0.580
MOD_SUMO_rev_2	457	464	PF00179	0.534
MOD_SUMO_rev_2	558	567	PF00179	0.418
MOD_SUMO_rev_2	617	625	PF00179	0.468
MOD_SUMO_rev_2	765	774	PF00179	0.510
TRG_DiLeu_BaEn_1	53	58	PF01217	0.614
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.449
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.388
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.413
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.389
TRG_ENDOCYTIC_2	251	254	PF00928	0.585
TRG_ENDOCYTIC_2	341	344	PF00928	0.489
TRG_ENDOCYTIC_2	357	360	PF00928	0.429
TRG_ENDOCYTIC_2	69	72	PF00928	0.570
TRG_ENDOCYTIC_2	705	708	PF00928	0.540
TRG_ENDOCYTIC_2	754	757	PF00928	0.556
TRG_ENDOCYTIC_2	92	95	PF00928	0.634
TRG_ER_diArg_1	10	13	PF00400	0.593
TRG_ER_diArg_1	195	198	PF00400	0.512
TRG_ER_diArg_1	2	5	PF00400	0.741
TRG_ER_diArg_1	360	362	PF00400	0.476
TRG_ER_diArg_1	364	366	PF00400	0.470
TRG_ER_diArg_1	398	400	PF00400	0.368
TRG_ER_diArg_1	538	540	PF00400	0.531
TRG_ER_diArg_1	60	63	PF00400	0.638
TRG_ER_diArg_1	686	689	PF00400	0.583
TRG_ER_diArg_1	713	715	PF00400	0.495
TRG_ER_diArg_1	771	774	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	719	723	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	738	742	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC11	Leptomonas seymouri	72%	100%
A0A0S4IWL5	Bodo saltans	38%	87%
A0A1X0P9H1	Trypanosomatidae	57%	100%
A0A3R7MZ37	Trypanosoma rangeli	56%	100%
A0A3S7X7R6	Leishmania donovani	94%	100%
A4HAM5	Leishmania braziliensis	83%	100%
A4HAQ8	Leishmania braziliensis	72%	100%
C9ZMR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AHT4	Leishmania infantum	94%	100%
E9B4X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BT32	Trypanosoma cruzi	57%	100%