Tuzin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tuzin-like protein

Gene product:

tuzin-like protein

Species:

Leishmania major

UniProt:

Q4Q342_LEIMA

TriTrypDb:

LmjF.34.1950 , LMJLV39_360018500 , LMJSD75_340024800

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

Q4Q342

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q342

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.497
CLV_NRD_NRD_1	14	16	PF00675	0.520
CLV_NRD_NRD_1	212	214	PF00675	0.418
CLV_NRD_NRD_1	296	298	PF00675	0.462
CLV_NRD_NRD_1	337	339	PF00675	0.642
CLV_NRD_NRD_1	358	360	PF00675	0.738
CLV_NRD_NRD_1	375	377	PF00675	0.628
CLV_NRD_NRD_1	413	415	PF00675	0.553
CLV_NRD_NRD_1	521	523	PF00675	0.574
CLV_NRD_NRD_1	533	535	PF00675	0.498
CLV_NRD_NRD_1	590	592	PF00675	0.617
CLV_PCSK_KEX2_1	131	133	PF00082	0.514
CLV_PCSK_KEX2_1	139	141	PF00082	0.458
CLV_PCSK_KEX2_1	14	16	PF00082	0.520
CLV_PCSK_KEX2_1	296	298	PF00082	0.422
CLV_PCSK_KEX2_1	337	339	PF00082	0.676
CLV_PCSK_KEX2_1	375	377	PF00082	0.628
CLV_PCSK_KEX2_1	413	415	PF00082	0.631
CLV_PCSK_KEX2_1	521	523	PF00082	0.574
CLV_PCSK_KEX2_1	533	535	PF00082	0.498
CLV_PCSK_KEX2_1	590	592	PF00082	0.641
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.508
CLV_PCSK_SKI1_1	214	218	PF00082	0.459
CLV_PCSK_SKI1_1	306	310	PF00082	0.375
CLV_PCSK_SKI1_1	384	388	PF00082	0.622
CLV_PCSK_SKI1_1	462	466	PF00082	0.631
CLV_PCSK_SKI1_1	511	515	PF00082	0.632
CLV_PCSK_SKI1_1	534	538	PF00082	0.641
CLV_PCSK_SKI1_1	660	664	PF00082	0.660
CLV_Separin_Metazoa	125	129	PF03568	0.681
DEG_APCC_DBOX_1	271	279	PF00400	0.540
DEG_APCC_DBOX_1	383	391	PF00400	0.431
DOC_CYCLIN_RxL_1	211	219	PF00134	0.603
DOC_CYCLIN_yCln2_LP_2	506	512	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	640	646	PF00134	0.336
DOC_MAPK_DCC_7	467	477	PF00069	0.356
DOC_MAPK_gen_1	14	22	PF00069	0.703
DOC_MAPK_gen_1	249	258	PF00069	0.562
DOC_MAPK_gen_1	413	423	PF00069	0.362
DOC_MAPK_MEF2A_6	195	202	PF00069	0.566
DOC_MAPK_MEF2A_6	237	246	PF00069	0.536
DOC_PP1_RVXF_1	519	526	PF00149	0.357
DOC_PP2B_LxvP_1	506	509	PF13499	0.392
DOC_PP2B_LxvP_1	596	599	PF13499	0.477
DOC_USP7_MATH_1	401	405	PF00917	0.450
DOC_USP7_MATH_1	47	51	PF00917	0.710
DOC_USP7_MATH_1	83	87	PF00917	0.728
DOC_WW_Pin1_4	43	48	PF00397	0.785
DOC_WW_Pin1_4	511	516	PF00397	0.372
DOC_WW_Pin1_4	598	603	PF00397	0.390
DOC_WW_Pin1_4	76	81	PF00397	0.688
LIG_14-3-3_CanoR_1	116	122	PF00244	0.653
LIG_14-3-3_CanoR_1	154	158	PF00244	0.593
LIG_14-3-3_CanoR_1	38	42	PF00244	0.760
LIG_14-3-3_CanoR_1	384	392	PF00244	0.392
LIG_14-3-3_CanoR_1	462	467	PF00244	0.413
LIG_14-3-3_CanoR_1	559	566	PF00244	0.439
LIG_14-3-3_CanoR_1	608	614	PF00244	0.363
LIG_14-3-3_CanoR_1	95	103	PF00244	0.778
LIG_Actin_WH2_2	421	438	PF00022	0.366
LIG_BIR_III_4	622	626	PF00653	0.424
LIG_BRCT_BRCA1_1	611	615	PF00533	0.436
LIG_Clathr_ClatBox_1	146	150	PF01394	0.614
LIG_Clathr_ClatBox_1	423	427	PF01394	0.344
LIG_DCNL_PONY_1	1	4	PF03556	0.660
LIG_deltaCOP1_diTrp_1	647	650	PF00928	0.335
LIG_FHA_1	186	192	PF00498	0.579
LIG_FHA_1	328	334	PF00498	0.526
LIG_FHA_2	157	163	PF00498	0.737
LIG_FHA_2	345	351	PF00498	0.412
LIG_Integrin_RGD_1	140	142	PF01839	0.490
LIG_LIR_Apic_2	524	529	PF02991	0.365
LIG_LIR_Gen_1	188	193	PF02991	0.542
LIG_LIR_Gen_1	579	588	PF02991	0.426
LIG_LIR_Gen_1	7	18	PF02991	0.652
LIG_LIR_Nem_3	188	192	PF02991	0.541
LIG_LIR_Nem_3	524	528	PF02991	0.337
LIG_LIR_Nem_3	579	583	PF02991	0.418
LIG_PDZ_Class_2	659	664	PF00595	0.413
LIG_Pex14_2	247	251	PF04695	0.551
LIG_SH2_CRK	526	530	PF00017	0.383
LIG_SH2_CRK	580	584	PF00017	0.452
LIG_SH2_CRK	641	645	PF00017	0.377
LIG_SH2_NCK_1	641	645	PF00017	0.372
LIG_SH2_PTP2	189	192	PF00017	0.539
LIG_SH2_SRC	539	542	PF00017	0.483
LIG_SH2_SRC	641	644	PF00017	0.381
LIG_SH2_STAP1	580	584	PF00017	0.337
LIG_SH2_STAT3	336	339	PF00017	0.363
LIG_SH2_STAT5	189	192	PF00017	0.622
LIG_SH2_STAT5	257	260	PF00017	0.556
LIG_SH2_STAT5	327	330	PF00017	0.450
LIG_SH2_STAT5	526	529	PF00017	0.374
LIG_SH2_STAT5	580	583	PF00017	0.355
LIG_SH3_2	599	604	PF14604	0.383
LIG_SH3_3	230	236	PF00018	0.636
LIG_SH3_3	389	395	PF00018	0.414
LIG_SH3_3	596	602	PF00018	0.388
LIG_SH3_3	77	83	PF00018	0.686
LIG_Sin3_3	144	151	PF02671	0.615
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.683
LIG_SUMO_SIM_anti_2	240	246	PF11976	0.532
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.450
LIG_SUMO_SIM_anti_2	419	425	PF11976	0.338
LIG_SUMO_SIM_anti_2	491	498	PF11976	0.407
LIG_SUMO_SIM_anti_2	545	551	PF11976	0.391
LIG_SUMO_SIM_par_1	145	150	PF11976	0.660
LIG_SUMO_SIM_par_1	491	498	PF11976	0.328
LIG_TYR_ITIM	578	583	PF00017	0.523
LIG_TYR_ITIM	639	644	PF00017	0.416
LIG_UBA3_1	190	195	PF00899	0.558
MOD_CAAXbox	661	664	PF01239	0.516
MOD_CDC14_SPxK_1	601	604	PF00782	0.439
MOD_CDC14_SPxK_1	79	82	PF00782	0.601
MOD_CDK_SPK_2	76	81	PF00069	0.602
MOD_CDK_SPxK_1	598	604	PF00069	0.470
MOD_CDK_SPxK_1	76	82	PF00069	0.603
MOD_CK1_1	115	121	PF00069	0.683
MOD_CK1_1	201	207	PF00069	0.653
MOD_CK1_1	385	391	PF00069	0.516
MOD_CK1_1	40	46	PF00069	0.608
MOD_CK1_1	494	500	PF00069	0.491
MOD_CK1_1	58	64	PF00069	0.509
MOD_CK2_1	268	274	PF00069	0.452
MOD_CK2_1	344	350	PF00069	0.510
MOD_CK2_1	442	448	PF00069	0.408
MOD_CK2_1	98	104	PF00069	0.664
MOD_Cter_Amidation	129	132	PF01082	0.634
MOD_GlcNHglycan	164	167	PF01048	0.808
MOD_GlcNHglycan	171	174	PF01048	0.671
MOD_GlcNHglycan	218	221	PF01048	0.572
MOD_GlcNHglycan	403	406	PF01048	0.473
MOD_GlcNHglycan	49	52	PF01048	0.666
MOD_GlcNHglycan	57	60	PF01048	0.657
MOD_GSK3_1	33	40	PF00069	0.592
MOD_GSK3_1	344	351	PF00069	0.513
MOD_GSK3_1	43	50	PF00069	0.518
MOD_GSK3_1	462	469	PF00069	0.580
MOD_GSK3_1	621	628	PF00069	0.627
MOD_GSK3_1	94	101	PF00069	0.645
MOD_N-GLC_1	185	190	PF02516	0.470
MOD_N-GLC_1	516	521	PF02516	0.522
MOD_NEK2_1	126	131	PF00069	0.635
MOD_NEK2_1	176	181	PF00069	0.569
MOD_NEK2_1	216	221	PF00069	0.641
MOD_NEK2_1	382	387	PF00069	0.497
MOD_NEK2_1	442	447	PF00069	0.410
MOD_NEK2_1	516	521	PF00069	0.503
MOD_OFUCOSY	37	44	PF10250	0.559
MOD_PIKK_1	385	391	PF00454	0.549
MOD_PKA_2	115	121	PF00069	0.685
MOD_PKA_2	153	159	PF00069	0.563
MOD_PKA_2	37	43	PF00069	0.568
MOD_PKA_2	558	564	PF00069	0.543
MOD_PKA_2	94	100	PF00069	0.662
MOD_PKB_1	478	486	PF00069	0.436
MOD_Plk_1	185	191	PF00069	0.531
MOD_Plk_1	198	204	PF00069	0.494
MOD_Plk_1	431	437	PF00069	0.532
MOD_Plk_1	540	546	PF00069	0.491
MOD_Plk_2-3	274	280	PF00069	0.411
MOD_Plk_4	185	191	PF00069	0.519
MOD_Plk_4	491	497	PF00069	0.418
MOD_Plk_4	579	585	PF00069	0.594
MOD_Plk_4	625	631	PF00069	0.584
MOD_Plk_4	98	104	PF00069	0.602
MOD_ProDKin_1	43	49	PF00069	0.748
MOD_ProDKin_1	511	517	PF00069	0.444
MOD_ProDKin_1	598	604	PF00069	0.470
MOD_ProDKin_1	76	82	PF00069	0.613
TRG_DiLeu_BaEn_1	240	245	PF01217	0.542
TRG_DiLeu_BaEn_1	254	259	PF01217	0.433
TRG_DiLeu_BaEn_1	260	265	PF01217	0.396
TRG_DiLeu_BaEn_1	419	424	PF01217	0.400
TRG_DiLeu_BaEn_1	491	496	PF01217	0.444
TRG_ENDOCYTIC_2	189	192	PF00928	0.493
TRG_ENDOCYTIC_2	489	492	PF00928	0.431
TRG_ENDOCYTIC_2	580	583	PF00928	0.565
TRG_ENDOCYTIC_2	641	644	PF00928	0.450
TRG_ER_diArg_1	13	15	PF00400	0.662
TRG_ER_diArg_1	295	297	PF00400	0.579
TRG_ER_diArg_1	336	338	PF00400	0.584
TRG_ER_diArg_1	374	376	PF00400	0.562
TRG_ER_diArg_1	477	480	PF00400	0.433
TRG_ER_diArg_1	521	523	PF00400	0.452
TRG_ER_diArg_1	570	573	PF00400	0.555
TRG_ER_diArg_1	589	591	PF00400	0.565
TRG_ER_diArg_1	73	76	PF00400	0.621
TRG_NES_CRM1_1	263	276	PF08389	0.512
TRG_NES_CRM1_1	433	448	PF08389	0.432
TRG_NLS_MonoExtN_4	212	217	PF00514	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	63%	100%
A0A0N1PB02	Leptomonas seymouri	41%	100%
A0A0S4J6C6	Bodo saltans	37%	100%
A0A1X0P9A6	Trypanosomatidae	36%	97%
A0A3Q8IHH1	Leishmania donovani	83%	91%
A0A3R7K2Y9	Trypanosoma rangeli	40%	97%
A0A3S5H668	Leishmania donovani	39%	100%
A0A3S5H669	Leishmania donovani	39%	100%
A0A3S7X835	Leishmania donovani	41%	100%
A4H5C9	Leishmania braziliensis	38%	100%
A4H5D0	Leishmania braziliensis	40%	100%
A4HAZ7	Leishmania braziliensis	41%	100%
A4HAZ9	Leishmania braziliensis	43%	100%
A4HB01	Leishmania braziliensis	43%	100%
A4HTM0	Leishmania infantum	38%	100%
A4HTM1	Leishmania infantum	38%	100%
A4IA57	Leishmania infantum	41%	100%
C6K3V8	Leptomonas seymouri	38%	100%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	98%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
Q4Q1U8	Leishmania major	100%	100%
Q4Q2R4	Leishmania major	40%	100%
Q4Q310	Leishmania major	100%	100%
Q4Q312	Leishmania major	100%	100%
Q4Q340	Leishmania major	100%	100%
Q4QI90	Leishmania major	38%	100%
Q4QI91	Leishmania major	38%	100%