Putative amastin-like surface protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein, putative

Species:

Leishmania major

UniProt:

Q4Q327_LEIMA

TriTrypDb:

LmjF.34.1560 , LMJLV39_000021000 , LMJSD75_340024700

Length:

191

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 12, no: 202
NetGPI	no	yes: 0, no: 214

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	191
GO:0110165	cellular anatomical entity	1	191

Expansion

Sequence features

Q4Q327

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q327

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_MDM2_SWIB_1	155	163	PF02201	0.492
DOC_CKS1_1	23	28	PF01111	0.361
DOC_MAPK_MEF2A_6	106	114	PF00069	0.558
DOC_PP2B_LxvP_1	169	172	PF13499	0.597
DOC_PP4_FxxP_1	30	33	PF00568	0.360
DOC_USP7_UBL2_3	179	183	PF12436	0.597
DOC_WW_Pin1_4	133	138	PF00397	0.252
DOC_WW_Pin1_4	183	188	PF00397	0.616
DOC_WW_Pin1_4	22	27	PF00397	0.364
LIG_14-3-3_CanoR_1	48	57	PF00244	0.327
LIG_14-3-3_CanoR_1	70	76	PF00244	0.284
LIG_BIR_II_1	1	5	PF00653	0.720
LIG_BRCT_BRCA1_1	33	37	PF00533	0.203
LIG_BRCT_BRCA1_1	53	57	PF00533	0.309
LIG_FHA_1	117	123	PF00498	0.381
LIG_FHA_1	37	43	PF00498	0.324
LIG_FHA_2	23	29	PF00498	0.386
LIG_FHA_2	33	39	PF00498	0.324
LIG_LIR_Apic_2	28	33	PF02991	0.372
LIG_LIR_Gen_1	54	64	PF02991	0.363
LIG_LIR_Gen_1	84	94	PF02991	0.268
LIG_LIR_LC3C_4	4	9	PF02991	0.221
LIG_LIR_Nem_3	53	59	PF02991	0.309
LIG_LIR_Nem_3	84	89	PF02991	0.270
LIG_MLH1_MIPbox_1	53	57	PF16413	0.198
LIG_Pex14_1	45	49	PF04695	0.382
LIG_Pex14_2	155	159	PF04695	0.416
LIG_SH2_CRK	3	7	PF00017	0.518
LIG_SH2_PTP2	10	13	PF00017	0.529
LIG_SH2_STAT5	10	13	PF00017	0.472
LIG_SH2_STAT5	56	59	PF00017	0.414
LIG_SH2_STAT5	88	91	PF00017	0.427
LIG_SH3_3	134	140	PF00018	0.369
LIG_SH3_3	181	187	PF00018	0.770
LIG_SH3_3	20	26	PF00018	0.367
LIG_SUMO_SIM_par_1	19	25	PF11976	0.327
LIG_TRAF2_1	188	191	PF00917	0.795
LIG_TYR_ITIM	8	13	PF00017	0.464
LIG_Vh1_VBS_1	5	23	PF01044	0.221
MOD_CDK_SPK_2	133	138	PF00069	0.195
MOD_CK1_1	40	46	PF00069	0.351
MOD_CK2_1	185	191	PF00069	0.852
MOD_GlcNHglycan	53	56	PF01048	0.457
MOD_GSK3_1	171	178	PF00069	0.732
MOD_GSK3_1	32	39	PF00069	0.309
MOD_GSK3_1	47	54	PF00069	0.318
MOD_NEK2_1	1	6	PF00069	0.673
MOD_NEK2_1	127	132	PF00069	0.472
MOD_NEK2_1	37	42	PF00069	0.309
MOD_NEK2_1	49	54	PF00069	0.338
MOD_NEK2_2	100	105	PF00069	0.352
MOD_NEK2_2	116	121	PF00069	0.341
MOD_NEK2_2	81	86	PF00069	0.447
MOD_PKA_2	47	53	PF00069	0.334
MOD_PKA_2	69	75	PF00069	0.292
MOD_Plk_1	143	149	PF00069	0.213
MOD_Plk_1	37	43	PF00069	0.353
MOD_Plk_1	60	66	PF00069	0.356
MOD_Plk_4	116	122	PF00069	0.307
MOD_Plk_4	143	149	PF00069	0.210
MOD_ProDKin_1	133	139	PF00069	0.252
MOD_ProDKin_1	183	189	PF00069	0.616
MOD_ProDKin_1	22	28	PF00069	0.364
TRG_ENDOCYTIC_2	10	13	PF00928	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	30%	100%
A0A0N0P547	Leptomonas seymouri	39%	100%
A0A0N0P6P9	Leptomonas seymouri	24%	83%
A0A0N0P993	Leptomonas seymouri	27%	85%
A0A0N1HWY5	Leptomonas seymouri	25%	98%
A0A0N1I295	Leptomonas seymouri	30%	100%
A0A0N1PAD5	Leptomonas seymouri	25%	76%
A0A0N1PDH0	Leptomonas seymouri	34%	95%
A0A0N1PFN2	Leptomonas seymouri	22%	100%
A0A0S4J784	Bodo saltans	24%	86%
A0A1X0NQ58	Trypanosomatidae	36%	100%
A0A1X0NUH1	Trypanosomatidae	31%	84%
A0A1X0NVN5	Trypanosomatidae	26%	100%
A0A1X0NVT7	Trypanosomatidae	28%	100%
A0A1X0NX02	Trypanosomatidae	28%	100%
A0A1X0P988	Trypanosomatidae	35%	100%
A0A381MTA7	Leishmania infantum	60%	99%
A0A381MTB8	Leishmania infantum	51%	99%
A0A381MTC7	Leishmania infantum	56%	93%
A0A381MTN2	Leishmania infantum	41%	98%
A0A381MVY0	Leishmania infantum	56%	99%
A0A3Q8ID16	Leishmania donovani	31%	100%
A0A3Q8IE85	Leishmania donovani	55%	100%
A0A3Q8IEC2	Leishmania donovani	52%	99%
A0A3Q8IEI1	Leishmania donovani	47%	99%
A0A3Q8IF65	Leishmania donovani	44%	97%
A0A3Q8IFB9	Leishmania donovani	28%	94%
A0A3Q8IFH7	Leishmania donovani	56%	93%
A0A3Q8IH65	Leishmania donovani	48%	99%
A0A3Q8IHN2	Leishmania donovani	45%	99%
A0A3Q8IHW7	Leishmania donovani	51%	100%
A0A3Q8IHZ6	Leishmania donovani	48%	91%
A0A3Q8IIH1	Leishmania donovani	49%	98%
A0A3Q8IL03	Leishmania donovani	51%	99%
A0A3Q8IMR4	Leishmania donovani	27%	100%
A0A3Q8IUK8	Leishmania donovani	55%	100%
A0A3Q8IUR5	Leishmania donovani	41%	98%
A0A3S5H662	Leishmania donovani	48%	95%
A0A3S5H663	Leishmania donovani	49%	95%
A0A3S5H665	Leishmania donovani	49%	95%
A0A3S5H666	Leishmania donovani	46%	99%
A0A3S5H667	Leishmania donovani	49%	94%
A0A3S5H7D2	Leishmania donovani	27%	100%
A0A3S5H7L2	Leishmania donovani	43%	93%
A0A3S5H7V9	Leishmania donovani	43%	96%
A0A3S5H7W2	Leishmania donovani	27%	99%
A0A3S5H7W6	Leishmania donovani	56%	96%
A0A3S7WQA0	Leishmania donovani	49%	94%
A0A3S7WQA8	Leishmania donovani	47%	100%
A0A3S7WQC1	Leishmania donovani	44%	99%
A0A3S7X2E6	Leishmania donovani	40%	99%
A0A3S7X357	Leishmania donovani	27%	86%
A0A3S7X453	Leishmania donovani	43%	97%
A0A3S7X472	Leishmania donovani	45%	96%
A0A3S7X7E5	Leishmania donovani	50%	76%
A0A3S7X7M4	Leishmania donovani	48%	91%
A0A3S7X7U1	Leishmania donovani	51%	91%
A0A3S7X7U4	Leishmania donovani	52%	74%
A0A3S7X7W2	Leishmania donovani	47%	91%
A0A3S7X7Y0	Leishmania donovani	53%	98%
A4H595	Leishmania braziliensis	43%	83%
A4H596	Leishmania braziliensis	45%	88%
A4H597	Leishmania braziliensis	44%	83%
A4H5D1	Leishmania braziliensis	54%	98%
A4H5D2	Leishmania braziliensis	34%	100%
A4H5G0	Leishmania braziliensis	45%	100%
A4H5G4	Leishmania braziliensis	43%	91%
A4H5G6	Leishmania braziliensis	43%	86%
A4H5G7	Leishmania braziliensis	45%	88%
A4H5G9	Leishmania braziliensis	49%	100%
A4H5H0	Leishmania braziliensis	49%	100%
A4H5H1	Leishmania braziliensis	44%	100%
A4H5H2	Leishmania braziliensis	43%	100%
A4H5H3	Leishmania braziliensis	37%	92%
A4H6C8	Leishmania braziliensis	40%	96%
A4H7D7	Leishmania braziliensis	49%	98%
A4H9E8	Leishmania braziliensis	55%	91%
A4H9E9	Leishmania braziliensis	48%	98%
A4HAJ4	Leishmania braziliensis	54%	91%
A4HAJ5	Leishmania braziliensis	45%	86%
A4HAJ6	Leishmania braziliensis	43%	83%
A4HAL1	Leishmania braziliensis	50%	100%
A4HAL2	Leishmania braziliensis	29%	99%
A4HAM2	Leishmania braziliensis	53%	99%
A4HAM4	Leishmania braziliensis	52%	99%
A4HAR1	Leishmania braziliensis	46%	99%
A4HAZ8	Leishmania braziliensis	46%	100%
A4HB00	Leishmania braziliensis	46%	99%
A4HB02	Leishmania braziliensis	44%	99%
A4HB47	Leishmania braziliensis	33%	94%
A4HBJ0	Leishmania braziliensis	47%	99%
A4HBJ1	Leishmania braziliensis	53%	99%
A4HBJ2	Leishmania braziliensis	47%	92%
A4HDI2	Leishmania braziliensis	29%	100%
A4HDI4	Leishmania braziliensis	28%	100%
A4HDL3	Leishmania braziliensis	29%	100%
A4HDL4	Leishmania braziliensis	28%	100%
A4HI43	Leishmania braziliensis	24%	90%
A4HTM3	Leishmania infantum	42%	99%
A4HTM4	Leishmania infantum	46%	100%
A4HTM5	Leishmania infantum	45%	99%
A4I0W3	Leishmania infantum	27%	100%
A4I0W4	Leishmania infantum	26%	100%
A4I0W5	Leishmania infantum	31%	100%
A4I4J2	Leishmania infantum	43%	93%
A4I4J3	Leishmania infantum	47%	74%
A4I5B9	Leishmania infantum	27%	86%
A4I6E5	Leishmania infantum	44%	96%
A4I9Q4	Leishmania infantum	49%	100%
A4I9R4	Leishmania infantum	27%	99%
A4I9R5	Leishmania infantum	28%	94%
A4I9R7	Leishmania infantum	52%	97%
A4I9W8	Leishmania infantum	49%	74%
A4I9X0	Leishmania infantum	46%	91%
A4IA59	Leishmania infantum	41%	73%
A4IAL7	Leishmania infantum	50%	100%
A4IAM1	Leishmania infantum	43%	99%
A4IAM2	Leishmania infantum	44%	99%
C6K3X9	Leptomonas seymouri	27%	100%
E8NHC3	Leishmania infantum	48%	95%
E8NHD3	Leishmania infantum	43%	93%
E8NHD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	91%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	92%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	99%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	91%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	91%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	98%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	99%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	91%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	98%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	99%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	99%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	98%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	91%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	91%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	93%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	91%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	98%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	98%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	98%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	91%
E9AG81	Leishmania infantum	47%	94%
E9AG82	Leishmania infantum	48%	94%
E9AG83	Leishmania infantum	44%	96%
E9AG85	Leishmania infantum	48%	94%
E9AHI9	Leishmania infantum	40%	99%
E9AHT2	Leishmania infantum	50%	91%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	92%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	98%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	98%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	74%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	92%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	99%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	99%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	91%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	86%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	98%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	92%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	91%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	96%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	96%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	97%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	94%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	93%
Q4Q1U9	Leishmania major	72%	100%
Q4Q305	Leishmania major	66%	100%
Q4Q309	Leishmania major	66%	100%
Q4Q313	Leishmania major	65%	100%
Q4Q317	Leishmania major	48%	100%
Q4Q325	Leishmania major	58%	100%
Q4Q329	Leishmania major	67%	99%
Q4Q333	Leishmania major	67%	99%
Q4Q335	Leishmania major	67%	99%
Q4Q337	Leishmania major	60%	100%
Q4Q339	Leishmania major	66%	99%
Q4Q341	Leishmania major	67%	100%
Q4Q397	Leishmania major	53%	73%
Q4Q3A7	Leishmania major	30%	99%
Q4Q3A8	Leishmania major	29%	94%
Q4Q3A9	Leishmania major	52%	96%
Q4Q3F7	Leishmania major	53%	90%
Q4Q6L8	Leishmania major	42%	97%
Q4Q7L6	Leishmania major	28%	86%
Q4QAK4	Leishmania major	28%	100%
Q4QAK5	Leishmania major	29%	100%
Q4QAK6	Leishmania major	27%	100%
Q4QAK7	Leishmania major	29%	100%
Q4QI84	Leishmania major	47%	100%
Q4QI85	Leishmania major	46%	99%
Q4QI86	Leishmania major	49%	100%
Q4QI87	Leishmania major	47%	99%
Q4QI88	Leishmania major	46%	100%
Q4QI92	Leishmania major	45%	96%
Q4QI93	Leishmania major	45%	96%
Q4QI95	Leishmania major	48%	96%
Q4QI97	Leishmania major	48%	96%
Q4QIA0	Leishmania major	48%	94%
Q4QIA1	Leishmania major	48%	94%