Putative amastin-like surface protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein, putative

Species:

Leishmania major

UniProt:

Q4Q317_LEIMA

TriTrypDb:

LmjF.34.1840 , LMJLV39_340011100 , LMJSD75_340010700

Length:

202

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 200
NetGPI	no	yes: 0, no: 210

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	187
GO:0110165	cellular anatomical entity	1	187

Expansion

Sequence features

Q4Q317

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q317

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	2	4	PF00082	0.292
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.291
DEG_Nend_UBRbox_1	1	4	PF02207	0.628
DOC_CKS1_1	23	28	PF01111	0.334
DOC_MAPK_gen_1	2	9	PF00069	0.475
DOC_MAPK_MEF2A_6	109	117	PF00069	0.556
DOC_MAPK_MEF2A_6	2	11	PF00069	0.538
DOC_MAPK_NFAT4_5	2	10	PF00069	0.427
DOC_PP4_FxxP_1	103	106	PF00568	0.213
DOC_SPAK_OSR1_1	76	80	PF12202	0.208
DOC_WW_Pin1_4	22	27	PF00397	0.346
LIG_CaM_NSCaTE_8	162	169	PF13499	0.203
LIG_EH1_1	82	90	PF00400	0.339
LIG_FHA_1	120	126	PF00498	0.384
LIG_FHA_1	148	154	PF00498	0.319
LIG_FHA_1	172	178	PF00498	0.366
LIG_FHA_2	23	29	PF00498	0.380
LIG_FHA_2	56	62	PF00498	0.322
LIG_LIR_LC3C_4	4	9	PF02991	0.223
LIG_LIR_Nem_3	28	33	PF02991	0.339
LIG_Pex14_2	151	155	PF04695	0.461
LIG_Pex14_2	92	96	PF04695	0.368
LIG_SH2_PTP2	10	13	PF00017	0.514
LIG_SH2_SRC	196	199	PF00017	0.519
LIG_SH2_SRC	59	62	PF00017	0.204
LIG_SH2_STAP1	59	63	PF00017	0.313
LIG_SH2_STAT5	10	13	PF00017	0.459
LIG_SH2_STAT5	196	199	PF00017	0.533
LIG_SH2_STAT5	91	94	PF00017	0.378
LIG_SH3_3	20	26	PF00018	0.349
LIG_SUMO_SIM_par_1	169	174	PF11976	0.389
LIG_SUMO_SIM_par_1	19	25	PF11976	0.327
LIG_TRAF2_1	188	191	PF00917	0.713
LIG_TYR_ITIM	8	13	PF00017	0.447
LIG_Vh1_VBS_1	5	23	PF01044	0.222
MOD_CK2_1	185	191	PF00069	0.766
MOD_CK2_1	55	61	PF00069	0.368
MOD_GlcNHglycan	61	64	PF01048	0.497
MOD_GSK3_1	55	62	PF00069	0.307
MOD_N-GLC_1	184	189	PF02516	0.339
MOD_N-GLC_1	55	60	PF02516	0.588
MOD_NEK2_1	1	6	PF00069	0.650
MOD_NEK2_1	130	135	PF00069	0.497
MOD_NEK2_1	157	162	PF00069	0.291
MOD_NEK2_1	171	176	PF00069	0.372
MOD_NEK2_2	119	124	PF00069	0.351
MOD_PIKK_1	185	191	PF00454	0.535
MOD_Plk_1	147	153	PF00069	0.216
MOD_Plk_1	55	61	PF00069	0.405
MOD_Plk_4	119	125	PF00069	0.310
MOD_Plk_4	130	136	PF00069	0.353
MOD_Plk_4	177	183	PF00069	0.567
MOD_ProDKin_1	22	28	PF00069	0.346
TRG_ENDOCYTIC_2	10	13	PF00928	0.418
TRG_NES_CRM1_1	69	81	PF08389	0.196

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	31%	100%
A0A0N0P547	Leptomonas seymouri	38%	100%
A0A0N1PAD5	Leptomonas seymouri	22%	80%
A0A0N1PDH0	Leptomonas seymouri	34%	100%
A0A1X0NQ58	Trypanosomatidae	33%	100%
A0A1X0NUH1	Trypanosomatidae	26%	89%
A0A1X0NVN5	Trypanosomatidae	26%	100%
A0A1X0NVT7	Trypanosomatidae	28%	100%
A0A1X0NX02	Trypanosomatidae	30%	100%
A0A1X0P2R3	Trypanosomatidae	30%	96%
A0A1X0P988	Trypanosomatidae	35%	100%
A0A381MTA7	Leishmania infantum	48%	100%
A0A381MTB8	Leishmania infantum	78%	100%
A0A381MTC7	Leishmania infantum	49%	99%
A0A381MTN2	Leishmania infantum	41%	100%
A0A381MVY0	Leishmania infantum	45%	100%
A0A3Q8ID16	Leishmania donovani	28%	100%
A0A3Q8IE85	Leishmania donovani	52%	100%
A0A3Q8IEC2	Leishmania donovani	47%	100%
A0A3Q8IEI1	Leishmania donovani	46%	100%
A0A3Q8IF65	Leishmania donovani	41%	100%
A0A3Q8IFB9	Leishmania donovani	33%	100%
A0A3Q8IFH7	Leishmania donovani	49%	99%
A0A3Q8IFI8	Leishmania donovani	25%	100%
A0A3Q8IH65	Leishmania donovani	77%	100%
A0A3Q8IHN2	Leishmania donovani	42%	100%
A0A3Q8IHW7	Leishmania donovani	47%	100%
A0A3Q8IHZ6	Leishmania donovani	52%	96%
A0A3Q8IIH1	Leishmania donovani	74%	100%
A0A3Q8IL03	Leishmania donovani	44%	100%
A0A3Q8IUK8	Leishmania donovani	48%	100%
A0A3Q8IUR5	Leishmania donovani	41%	100%
A0A3S5H662	Leishmania donovani	44%	100%
A0A3S5H663	Leishmania donovani	46%	100%
A0A3S5H665	Leishmania donovani	44%	100%
A0A3S5H666	Leishmania donovani	43%	100%
A0A3S5H667	Leishmania donovani	44%	100%
A0A3S5H7D2	Leishmania donovani	29%	100%
A0A3S5H7L2	Leishmania donovani	46%	99%
A0A3S5H7V9	Leishmania donovani	40%	100%
A0A3S5H7W2	Leishmania donovani	28%	100%
A0A3S5H7W6	Leishmania donovani	48%	100%
A0A3S7WQA0	Leishmania donovani	44%	100%
A0A3S7WQA8	Leishmania donovani	50%	100%
A0A3S7WQC1	Leishmania donovani	45%	100%
A0A3S7X2E6	Leishmania donovani	43%	100%
A0A3S7X357	Leishmania donovani	24%	91%
A0A3S7X381	Leishmania donovani	25%	100%
A0A3S7X453	Leishmania donovani	40%	100%
A0A3S7X472	Leishmania donovani	39%	100%
A0A3S7X7E5	Leishmania donovani	45%	81%
A0A3S7X7M4	Leishmania donovani	52%	96%
A0A3S7X7U1	Leishmania donovani	46%	96%
A0A3S7X7U4	Leishmania donovani	49%	78%
A0A3S7X7W2	Leishmania donovani	42%	96%
A0A3S7X7Y0	Leishmania donovani	41%	100%
A4H595	Leishmania braziliensis	43%	87%
A4H596	Leishmania braziliensis	44%	93%
A4H597	Leishmania braziliensis	43%	87%
A4H5D1	Leishmania braziliensis	48%	100%
A4H5D2	Leishmania braziliensis	34%	100%
A4H5G0	Leishmania braziliensis	44%	100%
A4H5G4	Leishmania braziliensis	44%	96%
A4H5G6	Leishmania braziliensis	43%	91%
A4H5G7	Leishmania braziliensis	36%	93%
A4H5G9	Leishmania braziliensis	49%	100%
A4H5H0	Leishmania braziliensis	49%	100%
A4H5H1	Leishmania braziliensis	49%	100%
A4H5H2	Leishmania braziliensis	45%	100%
A4H5H3	Leishmania braziliensis	37%	98%
A4H6C8	Leishmania braziliensis	45%	100%
A4H7D7	Leishmania braziliensis	43%	100%
A4H9E8	Leishmania braziliensis	47%	97%
A4H9E9	Leishmania braziliensis	44%	100%
A4HAJ4	Leishmania braziliensis	46%	96%
A4HAJ5	Leishmania braziliensis	40%	91%
A4HAJ6	Leishmania braziliensis	42%	87%
A4HAL1	Leishmania braziliensis	39%	100%
A4HAL2	Leishmania braziliensis	31%	100%
A4HAM2	Leishmania braziliensis	44%	100%
A4HAM4	Leishmania braziliensis	43%	100%
A4HAR1	Leishmania braziliensis	41%	100%
A4HAZ8	Leishmania braziliensis	42%	100%
A4HB00	Leishmania braziliensis	42%	100%
A4HB02	Leishmania braziliensis	41%	100%
A4HBJ0	Leishmania braziliensis	49%	100%
A4HBJ1	Leishmania braziliensis	44%	100%
A4HBJ2	Leishmania braziliensis	46%	97%
A4HDI3	Leishmania braziliensis	29%	83%
A4HDI4	Leishmania braziliensis	29%	100%
A4HDL3	Leishmania braziliensis	30%	100%
A4HDL4	Leishmania braziliensis	29%	100%
A4HI41	Leishmania braziliensis	27%	100%
A4HI43	Leishmania braziliensis	22%	95%
A4HTM3	Leishmania infantum	44%	100%
A4HTM4	Leishmania infantum	47%	100%
A4HTM5	Leishmania infantum	46%	100%
A4I0W4	Leishmania infantum	29%	100%
A4I0W5	Leishmania infantum	28%	100%
A4I4J2	Leishmania infantum	46%	99%
A4I4J3	Leishmania infantum	45%	78%
A4I5B8	Leishmania infantum	24%	100%
A4I5B9	Leishmania infantum	24%	91%
A4I6E5	Leishmania infantum	39%	100%
A4I9Q4	Leishmania infantum	43%	100%
A4I9R4	Leishmania infantum	28%	100%
A4I9R5	Leishmania infantum	33%	100%
A4I9R7	Leishmania infantum	48%	100%
A4I9W8	Leishmania infantum	46%	78%
A4I9X0	Leishmania infantum	42%	96%
A4IA59	Leishmania infantum	41%	78%
A4IAL7	Leishmania infantum	47%	100%
A4IAM1	Leishmania infantum	46%	100%
A4IAM2	Leishmania infantum	42%	100%
C6K3X5	Leptomonas seymouri	26%	100%
C6K3X9	Leptomonas seymouri	23%	100%
E8NHC3	Leishmania infantum	42%	100%
E8NHD3	Leishmania infantum	46%	99%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	97%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	97%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	96%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	96%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	96%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	96%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	96%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	98%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	97%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	96%
E9AG81	Leishmania infantum	46%	99%
E9AG82	Leishmania infantum	46%	99%
E9AG83	Leishmania infantum	40%	100%
E9AG85	Leishmania infantum	46%	100%
E9AHI9	Leishmania infantum	43%	100%
E9AHT2	Leishmania infantum	54%	96%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	97%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	79%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	97%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	97%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B0L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B0L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	91%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	97%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	96%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	98%
Q4Q1U9	Leishmania major	48%	98%
Q4Q305	Leishmania major	53%	99%
Q4Q309	Leishmania major	49%	100%
Q4Q313	Leishmania major	53%	99%
Q4Q325	Leishmania major	57%	99%
Q4Q327	Leishmania major	48%	100%
Q4Q329	Leishmania major	53%	100%
Q4Q333	Leishmania major	53%	100%
Q4Q335	Leishmania major	53%	100%
Q4Q337	Leishmania major	50%	100%
Q4Q339	Leishmania major	53%	100%
Q4Q341	Leishmania major	60%	100%
Q4Q397	Leishmania major	52%	77%
Q4Q3A7	Leishmania major	32%	100%
Q4Q3A8	Leishmania major	33%	100%
Q4Q3A9	Leishmania major	48%	100%
Q4Q3F7	Leishmania major	49%	95%
Q4Q6L8	Leishmania major	38%	100%
Q4Q7L6	Leishmania major	26%	91%
Q4Q7L7	Leishmania major	24%	100%
Q4Q7L8	Leishmania major	24%	100%
Q4QAK5	Leishmania major	28%	100%
Q4QAK6	Leishmania major	30%	100%
Q4QI84	Leishmania major	50%	100%
Q4QI85	Leishmania major	50%	100%
Q4QI86	Leishmania major	50%	100%
Q4QI87	Leishmania major	51%	100%
Q4QI88	Leishmania major	46%	100%
Q4QI92	Leishmania major	43%	100%
Q4QI93	Leishmania major	43%	100%
Q4QI95	Leishmania major	47%	100%
Q4QI97	Leishmania major	46%	100%
Q4QIA0	Leishmania major	46%	99%
Q4QIA1	Leishmania major	46%	99%