Tuzin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tuzin-like protein

Gene product:

tuzin-like protein

Species:

Leishmania major

UniProt:

Q4Q310_LEIMA

TriTrypDb:

LmjF.34.1910 , LMJLV39_360018500 , LMJSD75_340024800

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

Q4Q310

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q310

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.498
CLV_NRD_NRD_1	14	16	PF00675	0.513
CLV_NRD_NRD_1	212	214	PF00675	0.434
CLV_NRD_NRD_1	296	298	PF00675	0.468
CLV_NRD_NRD_1	337	339	PF00675	0.641
CLV_NRD_NRD_1	358	360	PF00675	0.740
CLV_NRD_NRD_1	375	377	PF00675	0.634
CLV_NRD_NRD_1	413	415	PF00675	0.557
CLV_NRD_NRD_1	521	523	PF00675	0.572
CLV_NRD_NRD_1	533	535	PF00675	0.514
CLV_NRD_NRD_1	590	592	PF00675	0.620
CLV_PCSK_KEX2_1	131	133	PF00082	0.502
CLV_PCSK_KEX2_1	139	141	PF00082	0.459
CLV_PCSK_KEX2_1	14	16	PF00082	0.513
CLV_PCSK_KEX2_1	296	298	PF00082	0.427
CLV_PCSK_KEX2_1	337	339	PF00082	0.675
CLV_PCSK_KEX2_1	375	377	PF00082	0.634
CLV_PCSK_KEX2_1	413	415	PF00082	0.635
CLV_PCSK_KEX2_1	521	523	PF00082	0.572
CLV_PCSK_KEX2_1	533	535	PF00082	0.514
CLV_PCSK_KEX2_1	590	592	PF00082	0.644
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.497
CLV_PCSK_SKI1_1	214	218	PF00082	0.482
CLV_PCSK_SKI1_1	306	310	PF00082	0.378
CLV_PCSK_SKI1_1	384	388	PF00082	0.619
CLV_PCSK_SKI1_1	462	466	PF00082	0.636
CLV_PCSK_SKI1_1	511	515	PF00082	0.643
CLV_PCSK_SKI1_1	534	538	PF00082	0.661
CLV_PCSK_SKI1_1	660	664	PF00082	0.664
CLV_Separin_Metazoa	125	129	PF03568	0.672
DEG_APCC_DBOX_1	271	279	PF00400	0.560
DEG_APCC_DBOX_1	383	391	PF00400	0.429
DOC_CYCLIN_RxL_1	211	219	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	506	512	PF00134	0.329
DOC_CYCLIN_yCln2_LP_2	640	646	PF00134	0.364
DOC_MAPK_DCC_7	467	477	PF00069	0.362
DOC_MAPK_gen_1	14	22	PF00069	0.700
DOC_MAPK_gen_1	249	258	PF00069	0.601
DOC_MAPK_gen_1	413	423	PF00069	0.365
DOC_MAPK_MEF2A_6	195	202	PF00069	0.584
DOC_MAPK_MEF2A_6	237	246	PF00069	0.574
DOC_PP1_RVXF_1	519	526	PF00149	0.358
DOC_PP2B_LxvP_1	506	509	PF13499	0.393
DOC_PP2B_LxvP_1	596	599	PF13499	0.481
DOC_USP7_MATH_1	401	405	PF00917	0.461
DOC_USP7_MATH_1	47	51	PF00917	0.711
DOC_USP7_MATH_1	83	87	PF00917	0.720
DOC_WW_Pin1_4	43	48	PF00397	0.787
DOC_WW_Pin1_4	511	516	PF00397	0.381
DOC_WW_Pin1_4	598	603	PF00397	0.394
DOC_WW_Pin1_4	76	81	PF00397	0.681
LIG_14-3-3_CanoR_1	116	122	PF00244	0.637
LIG_14-3-3_CanoR_1	154	158	PF00244	0.598
LIG_14-3-3_CanoR_1	38	42	PF00244	0.762
LIG_14-3-3_CanoR_1	384	392	PF00244	0.391
LIG_14-3-3_CanoR_1	462	467	PF00244	0.418
LIG_14-3-3_CanoR_1	559	566	PF00244	0.464
LIG_14-3-3_CanoR_1	608	614	PF00244	0.365
LIG_14-3-3_CanoR_1	95	103	PF00244	0.770
LIG_Actin_WH2_2	421	438	PF00022	0.367
LIG_BIR_III_4	622	626	PF00653	0.429
LIG_BRCT_BRCA1_1	611	615	PF00533	0.441
LIG_Clathr_ClatBox_1	146	150	PF01394	0.634
LIG_Clathr_ClatBox_1	423	427	PF01394	0.346
LIG_DCNL_PONY_1	1	4	PF03556	0.658
LIG_FHA_1	186	192	PF00498	0.592
LIG_FHA_1	328	334	PF00498	0.528
LIG_FHA_2	157	163	PF00498	0.734
LIG_FHA_2	345	351	PF00498	0.412
LIG_Integrin_RGD_1	140	142	PF01839	0.494
LIG_LIR_Apic_2	524	529	PF02991	0.369
LIG_LIR_Gen_1	188	193	PF02991	0.556
LIG_LIR_Gen_1	579	588	PF02991	0.428
LIG_LIR_Gen_1	7	18	PF02991	0.647
LIG_LIR_Nem_3	188	192	PF02991	0.558
LIG_LIR_Nem_3	524	528	PF02991	0.342
LIG_LIR_Nem_3	579	583	PF02991	0.420
LIG_PDZ_Class_2	659	664	PF00595	0.417
LIG_Pex14_2	247	251	PF04695	0.589
LIG_SH2_CRK	526	530	PF00017	0.388
LIG_SH2_CRK	580	584	PF00017	0.454
LIG_SH2_CRK	641	645	PF00017	0.409
LIG_SH2_NCK_1	641	645	PF00017	0.404
LIG_SH2_PTP2	189	192	PF00017	0.558
LIG_SH2_SRC	539	542	PF00017	0.498
LIG_SH2_SRC	641	644	PF00017	0.419
LIG_SH2_STAP1	580	584	PF00017	0.338
LIG_SH2_STAT3	336	339	PF00017	0.362
LIG_SH2_STAT5	189	192	PF00017	0.641
LIG_SH2_STAT5	257	260	PF00017	0.587
LIG_SH2_STAT5	327	330	PF00017	0.450
LIG_SH2_STAT5	526	529	PF00017	0.377
LIG_SH2_STAT5	580	583	PF00017	0.356
LIG_SH3_2	599	604	PF14604	0.387
LIG_SH3_3	230	236	PF00018	0.673
LIG_SH3_3	389	395	PF00018	0.411
LIG_SH3_3	596	602	PF00018	0.392
LIG_SH3_3	77	83	PF00018	0.676
LIG_Sin3_3	144	151	PF02671	0.634
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.699
LIG_SUMO_SIM_anti_2	240	246	PF11976	0.567
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.475
LIG_SUMO_SIM_anti_2	419	425	PF11976	0.341
LIG_SUMO_SIM_anti_2	491	498	PF11976	0.407
LIG_SUMO_SIM_anti_2	545	551	PF11976	0.404
LIG_SUMO_SIM_par_1	145	150	PF11976	0.678
LIG_SUMO_SIM_par_1	491	498	PF11976	0.327
LIG_TYR_ITIM	578	583	PF00017	0.526
LIG_TYR_ITIM	639	644	PF00017	0.460
LIG_UBA3_1	190	195	PF00899	0.583
MOD_CAAXbox	661	664	PF01239	0.520
MOD_CDC14_SPxK_1	601	604	PF00782	0.445
MOD_CDC14_SPxK_1	79	82	PF00782	0.592
MOD_CDK_SPK_2	76	81	PF00069	0.593
MOD_CDK_SPxK_1	598	604	PF00069	0.475
MOD_CDK_SPxK_1	76	82	PF00069	0.596
MOD_CK1_1	115	121	PF00069	0.661
MOD_CK1_1	201	207	PF00069	0.650
MOD_CK1_1	385	391	PF00069	0.512
MOD_CK1_1	40	46	PF00069	0.610
MOD_CK1_1	494	500	PF00069	0.490
MOD_CK1_1	58	64	PF00069	0.507
MOD_CK2_1	268	274	PF00069	0.477
MOD_CK2_1	344	350	PF00069	0.510
MOD_CK2_1	442	448	PF00069	0.411
MOD_CK2_1	98	104	PF00069	0.651
MOD_Cter_Amidation	129	132	PF01082	0.619
MOD_GlcNHglycan	164	167	PF01048	0.804
MOD_GlcNHglycan	171	174	PF01048	0.678
MOD_GlcNHglycan	218	221	PF01048	0.624
MOD_GlcNHglycan	403	406	PF01048	0.494
MOD_GlcNHglycan	49	52	PF01048	0.666
MOD_GlcNHglycan	57	60	PF01048	0.652
MOD_GSK3_1	33	40	PF00069	0.595
MOD_GSK3_1	344	351	PF00069	0.514
MOD_GSK3_1	43	50	PF00069	0.520
MOD_GSK3_1	462	469	PF00069	0.589
MOD_GSK3_1	621	628	PF00069	0.636
MOD_GSK3_1	94	101	PF00069	0.638
MOD_N-GLC_1	185	190	PF02516	0.485
MOD_N-GLC_1	516	521	PF02516	0.527
MOD_NEK2_1	126	131	PF00069	0.621
MOD_NEK2_1	176	181	PF00069	0.594
MOD_NEK2_1	216	221	PF00069	0.687
MOD_NEK2_1	382	387	PF00069	0.496
MOD_NEK2_1	442	447	PF00069	0.413
MOD_NEK2_1	516	521	PF00069	0.508
MOD_OFUCOSY	37	44	PF10250	0.561
MOD_PIKK_1	385	391	PF00454	0.545
MOD_PKA_2	115	121	PF00069	0.663
MOD_PKA_2	153	159	PF00069	0.569
MOD_PKA_2	37	43	PF00069	0.570
MOD_PKA_2	558	564	PF00069	0.591
MOD_PKA_2	94	100	PF00069	0.654
MOD_PKB_1	478	486	PF00069	0.438
MOD_Plk_1	185	191	PF00069	0.546
MOD_Plk_1	198	204	PF00069	0.510
MOD_Plk_1	431	437	PF00069	0.533
MOD_Plk_1	540	546	PF00069	0.508
MOD_Plk_2-3	274	280	PF00069	0.444
MOD_Plk_4	185	191	PF00069	0.534
MOD_Plk_4	491	497	PF00069	0.419
MOD_Plk_4	579	585	PF00069	0.597
MOD_Plk_4	625	631	PF00069	0.592
MOD_Plk_4	98	104	PF00069	0.589
MOD_ProDKin_1	43	49	PF00069	0.751
MOD_ProDKin_1	511	517	PF00069	0.455
MOD_ProDKin_1	598	604	PF00069	0.475
MOD_ProDKin_1	76	82	PF00069	0.605
TRG_DiLeu_BaEn_1	240	245	PF01217	0.585
TRG_DiLeu_BaEn_1	254	259	PF01217	0.474
TRG_DiLeu_BaEn_1	260	265	PF01217	0.430
TRG_DiLeu_BaEn_1	419	424	PF01217	0.405
TRG_DiLeu_BaEn_1	491	496	PF01217	0.445
TRG_ENDOCYTIC_2	189	192	PF00928	0.520
TRG_ENDOCYTIC_2	489	492	PF00928	0.430
TRG_ENDOCYTIC_2	580	583	PF00928	0.567
TRG_ENDOCYTIC_2	641	644	PF00928	0.502
TRG_ER_diArg_1	13	15	PF00400	0.653
TRG_ER_diArg_1	295	297	PF00400	0.589
TRG_ER_diArg_1	336	338	PF00400	0.584
TRG_ER_diArg_1	374	376	PF00400	0.570
TRG_ER_diArg_1	477	480	PF00400	0.437
TRG_ER_diArg_1	521	523	PF00400	0.449
TRG_ER_diArg_1	570	573	PF00400	0.576
TRG_ER_diArg_1	589	591	PF00400	0.569
TRG_ER_diArg_1	73	76	PF00400	0.625
TRG_NES_CRM1_1	263	276	PF08389	0.542
TRG_NES_CRM1_1	433	448	PF08389	0.434
TRG_NLS_MonoExtN_4	212	217	PF00514	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	63%	100%
A0A0N1PB02	Leptomonas seymouri	40%	100%
A0A0S4J6C6	Bodo saltans	37%	100%
A0A1X0P9A6	Trypanosomatidae	36%	97%
A0A3Q8IHH1	Leishmania donovani	83%	91%
A0A3R7K2Y9	Trypanosoma rangeli	39%	97%
A0A3S5H668	Leishmania donovani	38%	100%
A0A3S5H669	Leishmania donovani	38%	100%
A0A3S7X835	Leishmania donovani	41%	100%
A4H5C9	Leishmania braziliensis	38%	100%
A4H5D0	Leishmania braziliensis	40%	100%
A4HAZ7	Leishmania braziliensis	41%	100%
A4HAZ9	Leishmania braziliensis	42%	100%
A4HB01	Leishmania braziliensis	43%	100%
A4HTM0	Leishmania infantum	38%	100%
A4HTM1	Leishmania infantum	38%	100%
A4IA57	Leishmania infantum	41%	100%
C6K3V8	Leptomonas seymouri	38%	100%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	98%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
Q4Q1U8	Leishmania major	99%	100%
Q4Q2R4	Leishmania major	40%	100%
Q4Q312	Leishmania major	100%	100%
Q4Q340	Leishmania major	100%	100%
Q4Q342	Leishmania major	100%	100%
Q4QI90	Leishmania major	38%	100%
Q4QI91	Leishmania major	37%	100%