Pyroglutamyl-peptidase I (C15 family)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyroglutamyl-peptidase I (C15 family)

Species:

Leishmania major

UniProt:

Q4Q301_LEIMA

TriTrypDb:

LmjF.34.2000 , LMJLV39_340024500 , LMJSD75_340025000

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q301

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q301

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0008242	omega peptidase activity	4	2
GO:0016787	hydrolase activity	2	12
GO:0016920	pyroglutamyl-peptidase activity	5	2
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.683
CLV_PCSK_KEX2_1	38	40	PF00082	0.573
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.573
CLV_PCSK_SKI1_1	82	86	PF00082	0.416
DEG_Nend_Nbox_1	1	3	PF02207	0.709
DOC_MAPK_MEF2A_6	47	55	PF00069	0.526
DOC_MAPK_MEF2A_6	5	12	PF00069	0.397
DOC_PP4_FxxP_1	194	197	PF00568	0.561
DOC_WW_Pin1_4	142	147	PF00397	0.542
LIG_14-3-3_CanoR_1	240	249	PF00244	0.603
LIG_14-3-3_CanoR_1	47	55	PF00244	0.491
LIG_APCC_ABBA_1	132	137	PF00400	0.524
LIG_APCC_ABBA_1	88	93	PF00400	0.496
LIG_Clathr_ClatBox_1	97	101	PF01394	0.444
LIG_deltaCOP1_diTrp_1	164	169	PF00928	0.407
LIG_FHA_1	169	175	PF00498	0.601
LIG_FHA_1	18	24	PF00498	0.590
LIG_FHA_1	67	73	PF00498	0.560
LIG_FHA_1	92	98	PF00498	0.521
LIG_FHA_2	159	165	PF00498	0.579
LIG_FHA_2	173	179	PF00498	0.474
LIG_FHA_2	241	247	PF00498	0.610
LIG_FHA_2	47	53	PF00498	0.526
LIG_LIR_Apic_2	193	197	PF02991	0.376
LIG_LIR_Gen_1	107	115	PF02991	0.536
LIG_LIR_Gen_1	45	55	PF02991	0.477
LIG_LIR_Nem_3	107	112	PF02991	0.530
LIG_LIR_Nem_3	13	18	PF02991	0.377
LIG_LIR_Nem_3	45	51	PF02991	0.478
LIG_Pex14_2	135	139	PF04695	0.530
LIG_SH2_CRK	215	219	PF00017	0.373
LIG_SH2_CRK	253	257	PF00017	0.322
LIG_SH2_NCK_1	253	257	PF00017	0.322
LIG_SH2_STAT5	208	211	PF00017	0.347
LIG_SH2_STAT5	48	51	PF00017	0.491
LIG_SH2_STAT5	61	64	PF00017	0.295
LIG_SH3_3	121	127	PF00018	0.508
LIG_SH3_3	232	238	PF00018	0.396
LIG_SUMO_SIM_par_1	270	276	PF11976	0.501
LIG_TYR_ITIM	46	51	PF00017	0.423
LIG_WRC_WIRS_1	191	196	PF05994	0.402
MOD_CK1_1	181	187	PF00069	0.649
MOD_CK1_1	199	205	PF00069	0.376
MOD_CK1_1	54	60	PF00069	0.494
MOD_CK2_1	158	164	PF00069	0.543
MOD_CK2_1	172	178	PF00069	0.568
MOD_CK2_1	240	246	PF00069	0.554
MOD_CMANNOS	166	169	PF00535	0.409
MOD_GlcNHglycan	180	183	PF01048	0.749
MOD_GlcNHglycan	198	201	PF01048	0.241
MOD_GSK3_1	158	165	PF00069	0.501
MOD_GSK3_1	168	175	PF00069	0.579
MOD_GSK3_1	177	184	PF00069	0.547
MOD_GSK3_1	195	202	PF00069	0.549
MOD_GSK3_1	254	261	PF00069	0.507
MOD_N-GLC_1	158	163	PF02516	0.533
MOD_N-GLC_1	91	96	PF02516	0.478
MOD_NEK2_1	1	6	PF00069	0.548
MOD_NEK2_1	108	113	PF00069	0.530
MOD_NEK2_1	135	140	PF00069	0.500
MOD_NEK2_1	51	56	PF00069	0.472
MOD_NEK2_2	17	22	PF00069	0.589
MOD_PKA_2	46	52	PF00069	0.550
MOD_PKA_2	66	72	PF00069	0.331
MOD_Plk_1	158	164	PF00069	0.578
MOD_Plk_1	51	57	PF00069	0.432
MOD_Plk_4	135	141	PF00069	0.427
MOD_Plk_4	254	260	PF00069	0.466
MOD_Plk_4	270	276	PF00069	0.397
MOD_ProDKin_1	142	148	PF00069	0.536
MOD_SUMO_rev_2	110	120	PF00179	0.602
MOD_SUMO_rev_2	181	189	PF00179	0.732
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.531
TRG_ENDOCYTIC_2	15	18	PF00928	0.482
TRG_ENDOCYTIC_2	215	218	PF00928	0.355
TRG_ENDOCYTIC_2	229	232	PF00928	0.243
TRG_ENDOCYTIC_2	48	51	PF00928	0.457
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X3	Leptomonas seymouri	55%	99%
A0A0S4JYF2	Bodo saltans	28%	95%
A0A1X0P9S4	Trypanosomatidae	34%	100%
A0A3R7R5B2	Trypanosoma rangeli	29%	100%
A0A3S5H7W7	Leishmania donovani	89%	100%
A4HAR3	Leishmania braziliensis	71%	100%
A4I9X7	Leishmania infantum	90%	100%
C9ZMR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B4Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BNH8	Trypanosoma cruzi	29%	100%