Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q300_LEIMA

TriTrypDb:

LmjF.34.2010 , LMJLV39_340024600 , LMJSD75_340025100

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	5
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q300

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q300

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.514
CLV_NRD_NRD_1	84	86	PF00675	0.502
CLV_PCSK_KEX2_1	13	15	PF00082	0.514
CLV_PCSK_KEX2_1	84	86	PF00082	0.502
CLV_PCSK_SKI1_1	147	151	PF00082	0.724
CLV_PCSK_SKI1_1	78	82	PF00082	0.514
DEG_Nend_Nbox_1	1	3	PF02207	0.685
DOC_PP1_RVXF_1	120	127	PF00149	0.546
DOC_USP7_MATH_1	39	43	PF00917	0.795
DOC_WW_Pin1_4	152	157	PF00397	0.523
LIG_14-3-3_CanoR_1	26	30	PF00244	0.679
LIG_14-3-3_CanoR_1	84	94	PF00244	0.695
LIG_BRCT_BRCA1_1	129	133	PF00533	0.513
LIG_CSL_BTD_1	153	156	PF09270	0.524
LIG_deltaCOP1_diTrp_1	115	120	PF00928	0.630
LIG_deltaCOP1_diTrp_1	151	157	PF00928	0.451
LIG_FHA_2	102	108	PF00498	0.764
LIG_FHA_2	44	50	PF00498	0.755
LIG_LIR_Gen_1	115	126	PF02991	0.614
LIG_LIR_Gen_1	62	71	PF02991	0.728
LIG_LIR_Nem_3	115	121	PF02991	0.615
LIG_LIR_Nem_3	151	157	PF02991	0.451
LIG_LIR_Nem_3	62	66	PF02991	0.738
LIG_PCNA_PIPBox_1	73	82	PF02747	0.627
LIG_PCNA_yPIPBox_3	68	80	PF02747	0.632
LIG_SH2_STAT5	140	143	PF00017	0.520
LIG_SH2_STAT5	148	151	PF00017	0.454
LIG_SH2_STAT5	93	96	PF00017	0.719
LIG_SH3_1	150	156	PF00018	0.524
LIG_SH3_1	96	102	PF00018	0.688
LIG_SH3_2	153	158	PF14604	0.473
LIG_SH3_3	150	156	PF00018	0.524
LIG_SH3_3	27	33	PF00018	0.688
LIG_SH3_3	96	102	PF00018	0.766
LIG_TRAF2_1	55	58	PF00917	0.741
MOD_CDC14_SPxK_1	155	158	PF00782	0.470
MOD_CDK_SPxK_1	152	158	PF00069	0.470
MOD_CK1_1	87	93	PF00069	0.711
MOD_CK2_1	101	107	PF00069	0.764
MOD_CK2_1	32	38	PF00069	0.700
MOD_CK2_1	85	91	PF00069	0.687
MOD_Cter_Amidation	82	85	PF01082	0.440
MOD_GlcNHglycan	14	17	PF01048	0.585
MOD_GlcNHglycan	41	44	PF01048	0.526
MOD_GSK3_1	128	135	PF00069	0.416
MOD_GSK3_1	39	46	PF00069	0.745
MOD_GSK3_1	8	15	PF00069	0.693
MOD_LATS_1	54	60	PF00433	0.706
MOD_NEK2_1	127	132	PF00069	0.416
MOD_NEK2_1	133	138	PF00069	0.417
MOD_NEK2_1	7	12	PF00069	0.759
MOD_NEK2_2	8	13	PF00069	0.632
MOD_PIKK_1	69	75	PF00454	0.742
MOD_PKA_1	84	90	PF00069	0.645
MOD_PKA_2	12	18	PF00069	0.806
MOD_PKA_2	25	31	PF00069	0.643
MOD_PKA_2	84	90	PF00069	0.688
MOD_Plk_1	48	54	PF00069	0.748
MOD_Plk_2-3	32	38	PF00069	0.670
MOD_Plk_4	133	139	PF00069	0.408
MOD_Plk_4	59	65	PF00069	0.734
MOD_ProDKin_1	152	158	PF00069	0.525
MOD_SUMO_for_1	149	152	PF00179	0.522
MOD_SUMO_for_1	55	58	PF00179	0.715
TRG_ER_diArg_1	12	14	PF00400	0.730

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P996	Leptomonas seymouri	55%	97%
A0A3Q8INA7	Leishmania donovani	89%	100%
A4HAR4	Leishmania braziliensis	65%	96%
A4I9X8	Leishmania infantum	89%	100%
E9B4Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	96%