Regulator_of_chromosome_condensation_(RCC1)_repea t

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulator of chromosome condensation (RCC1) repeat, putative

Species:

Leishmania major

UniProt:

Q4Q2Z9_LEIMA

TriTrypDb:

LmjF.34.2020 , LMJLV39_340024700 , LMJSD75_340025200

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005938	cell cortex	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.720
CLV_C14_Caspase3-7	34	38	PF00656	0.703
CLV_C14_Caspase3-7	341	345	PF00656	0.578
CLV_C14_Caspase3-7	576	580	PF00656	0.612
CLV_NRD_NRD_1	12	14	PF00675	0.587
CLV_NRD_NRD_1	290	292	PF00675	0.578
CLV_NRD_NRD_1	297	299	PF00675	0.481
CLV_NRD_NRD_1	346	348	PF00675	0.511
CLV_NRD_NRD_1	584	586	PF00675	0.640
CLV_PCSK_KEX2_1	12	14	PF00082	0.587
CLV_PCSK_KEX2_1	290	292	PF00082	0.567
CLV_PCSK_KEX2_1	297	299	PF00082	0.472
CLV_PCSK_KEX2_1	346	348	PF00082	0.529
CLV_PCSK_KEX2_1	56	58	PF00082	0.673
CLV_PCSK_KEX2_1	584	586	PF00082	0.697
CLV_PCSK_KEX2_1	71	73	PF00082	0.732
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.673
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.746
CLV_PCSK_SKI1_1	240	244	PF00082	0.646
CLV_PCSK_SKI1_1	298	302	PF00082	0.507
CLV_PCSK_SKI1_1	394	398	PF00082	0.574
CLV_PCSK_SKI1_1	431	435	PF00082	0.454
CLV_PCSK_SKI1_1	450	454	PF00082	0.299
CLV_PCSK_SKI1_1	64	68	PF00082	0.703
DEG_Nend_Nbox_1	1	3	PF02207	0.598
DEG_SCF_FBW7_2	40	46	PF00400	0.671
DEG_SPOP_SBC_1	112	116	PF00917	0.640
DEG_SPOP_SBC_1	201	205	PF00917	0.712
DOC_CKS1_1	293	298	PF01111	0.515
DOC_CKS1_1	40	45	PF01111	0.670
DOC_CYCLIN_RxL_1	260	272	PF00134	0.442
DOC_MAPK_DCC_7	450	460	PF00069	0.563
DOC_MAPK_gen_1	152	160	PF00069	0.511
DOC_PP1_RVXF_1	259	266	PF00149	0.488
DOC_PP1_RVXF_1	448	454	PF00149	0.515
DOC_PP4_FxxP_1	126	129	PF00568	0.532
DOC_PP4_FxxP_1	475	478	PF00568	0.742
DOC_USP7_MATH_1	138	142	PF00917	0.477
DOC_USP7_MATH_1	253	257	PF00917	0.556
DOC_USP7_MATH_1	31	35	PF00917	0.614
DOC_USP7_MATH_1	372	376	PF00917	0.342
DOC_USP7_MATH_1	420	424	PF00917	0.442
DOC_USP7_MATH_1	505	509	PF00917	0.622
DOC_USP7_MATH_1	577	581	PF00917	0.853
DOC_USP7_UBL2_3	397	401	PF12436	0.476
DOC_USP7_UBL2_3	588	592	PF12436	0.702
DOC_USP7_UBL2_3	609	613	PF12436	0.722
DOC_USP7_UBL2_3	86	90	PF12436	0.693
DOC_WW_Pin1_4	104	109	PF00397	0.725
DOC_WW_Pin1_4	292	297	PF00397	0.524
DOC_WW_Pin1_4	302	307	PF00397	0.466
DOC_WW_Pin1_4	39	44	PF00397	0.728
DOC_WW_Pin1_4	400	405	PF00397	0.426
DOC_WW_Pin1_4	453	458	PF00397	0.486
DOC_WW_Pin1_4	500	505	PF00397	0.774
DOC_WW_Pin1_4	548	553	PF00397	0.863
LIG_14-3-3_CanoR_1	12	16	PF00244	0.711
LIG_14-3-3_CanoR_1	240	245	PF00244	0.627
LIG_14-3-3_CanoR_1	290	296	PF00244	0.557
LIG_14-3-3_CanoR_1	297	303	PF00244	0.462
LIG_14-3-3_CanoR_1	32	40	PF00244	0.728
LIG_14-3-3_CanoR_1	519	527	PF00244	0.760
LIG_14-3-3_CanoR_1	64	74	PF00244	0.705
LIG_Clathr_ClatBox_1	317	321	PF01394	0.493
LIG_FHA_1	114	120	PF00498	0.573
LIG_FHA_1	223	229	PF00498	0.629
LIG_FHA_1	277	283	PF00498	0.485
LIG_FHA_1	432	438	PF00498	0.493
LIG_FHA_1	522	528	PF00498	0.718
LIG_FHA_1	60	66	PF00498	0.676
LIG_FHA_2	1	7	PF00498	0.717
LIG_FHA_2	186	192	PF00498	0.507
LIG_FHA_2	39	45	PF00498	0.741
LIG_FHA_2	549	555	PF00498	0.736
LIG_FHA_2	562	568	PF00498	0.608
LIG_FHA_2	591	597	PF00498	0.695
LIG_Integrin_isoDGR_2	429	431	PF01839	0.501
LIG_LIR_Gen_1	181	191	PF02991	0.441
LIG_LIR_Gen_1	19	29	PF02991	0.538
LIG_LIR_Gen_1	6	15	PF02991	0.711
LIG_LIR_Nem_3	181	187	PF02991	0.437
LIG_LIR_Nem_3	272	277	PF02991	0.434
LIG_LIR_Nem_3	469	475	PF02991	0.583
LIG_LIR_Nem_3	6	11	PF02991	0.688
LIG_LRP6_Inhibitor_1	249	255	PF00058	0.638
LIG_PCNA_PIPBox_1	352	361	PF02747	0.552
LIG_PDZ_Class_1	624	629	PF00595	0.640
LIG_SH2_CRK	135	139	PF00017	0.500
LIG_SH2_NCK_1	135	139	PF00017	0.500
LIG_SH2_STAP1	468	472	PF00017	0.549
LIG_SH2_STAT3	350	353	PF00017	0.359
LIG_SH2_STAT3	359	362	PF00017	0.533
LIG_SH2_STAT5	131	134	PF00017	0.690
LIG_SH2_STAT5	350	353	PF00017	0.510
LIG_SH2_STAT5	359	362	PF00017	0.541
LIG_SH2_STAT5	426	429	PF00017	0.492
LIG_SH2_STAT5	468	471	PF00017	0.591
LIG_SH3_3	163	169	PF00018	0.513
LIG_SH3_3	290	296	PF00018	0.601
LIG_SH3_3	37	43	PF00018	0.662
LIG_SH3_3	449	455	PF00018	0.443
LIG_SH3_4	348	355	PF00018	0.564
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.566
LIG_SUMO_SIM_anti_2	23	30	PF11976	0.690
LIG_SUMO_SIM_anti_2	456	462	PF11976	0.604
LIG_SUMO_SIM_par_1	316	321	PF11976	0.500
LIG_TRAF2_1	520	523	PF00917	0.682
LIG_Vh1_VBS_1	109	127	PF01044	0.612
LIG_WRC_WIRS_1	157	162	PF05994	0.485
LIG_WRC_WIRS_1	326	331	PF05994	0.450
MOD_CAAXbox	626	629	PF01239	0.690
MOD_CDK_SPK_2	292	297	PF00069	0.506
MOD_CDK_SPxK_1	292	298	PF00069	0.502
MOD_CDK_SPxK_1	39	45	PF00069	0.670
MOD_CDK_SPxxK_3	302	309	PF00069	0.488
MOD_CK1_1	113	119	PF00069	0.629
MOD_CK1_1	143	149	PF00069	0.475
MOD_CK1_1	202	208	PF00069	0.693
MOD_CK1_1	248	254	PF00069	0.596
MOD_CK1_1	384	390	PF00069	0.445
MOD_CK1_1	500	506	PF00069	0.733
MOD_CK1_1	521	527	PF00069	0.716
MOD_CK1_1	530	536	PF00069	0.708
MOD_CK2_1	13	19	PF00069	0.667
MOD_CK2_1	38	44	PF00069	0.643
MOD_CK2_1	548	554	PF00069	0.718
MOD_CK2_1	577	583	PF00069	0.829
MOD_GlcNHglycan	15	18	PF01048	0.683
MOD_GlcNHglycan	161	164	PF01048	0.691
MOD_GlcNHglycan	195	198	PF01048	0.470
MOD_GlcNHglycan	247	250	PF01048	0.702
MOD_GlcNHglycan	311	314	PF01048	0.481
MOD_GlcNHglycan	33	36	PF01048	0.500
MOD_GlcNHglycan	363	366	PF01048	0.419
MOD_GlcNHglycan	386	389	PF01048	0.408
MOD_GlcNHglycan	507	510	PF01048	0.633
MOD_GlcNHglycan	531	535	PF01048	0.692
MOD_GlcNHglycan	560	564	PF01048	0.822
MOD_GlcNHglycan	575	578	PF01048	0.610
MOD_GSK3_1	140	147	PF00069	0.486
MOD_GSK3_1	236	243	PF00069	0.577
MOD_GSK3_1	298	305	PF00069	0.515
MOD_GSK3_1	367	374	PF00069	0.347
MOD_GSK3_1	514	521	PF00069	0.700
MOD_GSK3_1	530	537	PF00069	0.713
MOD_GSK3_1	548	555	PF00069	0.680
MOD_GSK3_1	573	580	PF00069	0.768
MOD_N-GLC_1	144	149	PF02516	0.591
MOD_N-GLC_1	384	389	PF02516	0.391
MOD_N-GLC_1	437	442	PF02516	0.578
MOD_N-GLC_1	527	532	PF02516	0.795
MOD_N-GLC_1	534	539	PF02516	0.805
MOD_N-GLC_1	540	545	PF02516	0.797
MOD_N-GLC_1	548	553	PF02516	0.787
MOD_N-GLC_1	573	578	PF02516	0.733
MOD_NEK2_1	140	145	PF00069	0.497
MOD_NEK2_1	199	204	PF00069	0.711
MOD_NEK2_1	371	376	PF00069	0.331
MOD_NEK2_1	392	397	PF00069	0.440
MOD_NEK2_1	437	442	PF00069	0.613
MOD_NEK2_1	529	534	PF00069	0.717
MOD_NEK2_2	144	149	PF00069	0.573
MOD_NEK2_2	420	425	PF00069	0.419
MOD_PIKK_1	518	524	PF00454	0.769
MOD_PIKK_1	561	567	PF00454	0.739
MOD_PKA_2	11	17	PF00069	0.653
MOD_PKA_2	151	157	PF00069	0.492
MOD_PKA_2	31	37	PF00069	0.695
MOD_PKA_2	518	524	PF00069	0.724
MOD_Plk_1	144	150	PF00069	0.584
MOD_Plk_1	437	443	PF00069	0.608
MOD_Plk_1	522	528	PF00069	0.775
MOD_Plk_1	577	583	PF00069	0.829
MOD_Plk_2-3	466	472	PF00069	0.559
MOD_Plk_4	21	27	PF00069	0.667
MOD_Plk_4	222	228	PF00069	0.598
MOD_Plk_4	278	284	PF00069	0.425
MOD_Plk_4	420	426	PF00069	0.405
MOD_Plk_4	522	528	PF00069	0.747
MOD_ProDKin_1	104	110	PF00069	0.726
MOD_ProDKin_1	292	298	PF00069	0.521
MOD_ProDKin_1	302	308	PF00069	0.462
MOD_ProDKin_1	39	45	PF00069	0.730
MOD_ProDKin_1	400	406	PF00069	0.430
MOD_ProDKin_1	453	459	PF00069	0.497
MOD_ProDKin_1	500	506	PF00069	0.774
MOD_ProDKin_1	548	554	PF00069	0.864
TRG_ENDOCYTIC_2	274	277	PF00928	0.416
TRG_ER_diArg_1	11	13	PF00400	0.661
TRG_ER_diArg_1	172	175	PF00400	0.497
TRG_ER_diArg_1	296	298	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFG4	Leptomonas seymouri	64%	100%
A0A1X0PAD3	Trypanosomatidae	57%	100%
A0A3Q8IH78	Leishmania donovani	94%	100%
A0A422NXS0	Trypanosoma rangeli	53%	100%
A4HAR5	Leishmania braziliensis	75%	100%
A4I9X9	Leishmania infantum	94%	100%
C9ZMQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B4Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BIX4	Trypanosoma cruzi	57%	100%