TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2Z8_LEIMA

TriTrypDb:

LmjF.34.2030 , LMJLV39_340024800 , LMJSD75_340025300

Length:

1171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Z8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005516	calmodulin binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.739
CLV_C14_Caspase3-7	906	910	PF00656	0.489
CLV_NRD_NRD_1	1005	1007	PF00675	0.619
CLV_NRD_NRD_1	1035	1037	PF00675	0.677
CLV_NRD_NRD_1	1091	1093	PF00675	0.735
CLV_NRD_NRD_1	1106	1108	PF00675	0.544
CLV_NRD_NRD_1	1119	1121	PF00675	0.664
CLV_NRD_NRD_1	13	15	PF00675	0.568
CLV_NRD_NRD_1	147	149	PF00675	0.584
CLV_NRD_NRD_1	445	447	PF00675	0.839
CLV_NRD_NRD_1	466	468	PF00675	0.826
CLV_NRD_NRD_1	608	610	PF00675	0.593
CLV_NRD_NRD_1	62	64	PF00675	0.523
CLV_NRD_NRD_1	623	625	PF00675	0.591
CLV_NRD_NRD_1	700	702	PF00675	0.597
CLV_NRD_NRD_1	718	720	PF00675	0.606
CLV_NRD_NRD_1	744	746	PF00675	0.593
CLV_NRD_NRD_1	772	774	PF00675	0.607
CLV_NRD_NRD_1	837	839	PF00675	0.456
CLV_NRD_NRD_1	973	975	PF00675	0.579
CLV_PCSK_FUR_1	606	610	PF00082	0.674
CLV_PCSK_FUR_1	621	625	PF00082	0.469
CLV_PCSK_FUR_1	716	720	PF00082	0.617
CLV_PCSK_KEX2_1	1005	1007	PF00082	0.664
CLV_PCSK_KEX2_1	1119	1121	PF00082	0.720
CLV_PCSK_KEX2_1	13	15	PF00082	0.586
CLV_PCSK_KEX2_1	608	610	PF00082	0.593
CLV_PCSK_KEX2_1	62	64	PF00082	0.523
CLV_PCSK_KEX2_1	621	623	PF00082	0.588
CLV_PCSK_KEX2_1	700	702	PF00082	0.597
CLV_PCSK_KEX2_1	718	720	PF00082	0.606
CLV_PCSK_KEX2_1	743	745	PF00082	0.600
CLV_PCSK_KEX2_1	771	773	PF00082	0.608
CLV_PCSK_KEX2_1	836	838	PF00082	0.463
CLV_PCSK_KEX2_1	887	889	PF00082	0.760
CLV_PCSK_KEX2_1	972	974	PF00082	0.580
CLV_PCSK_PC1ET2_1	887	889	PF00082	0.760
CLV_PCSK_PC7_1	768	774	PF00082	0.564
CLV_PCSK_PC7_1	833	839	PF00082	0.446
CLV_PCSK_SKI1_1	13	17	PF00082	0.516
CLV_PCSK_SKI1_1	149	153	PF00082	0.656
CLV_PCSK_SKI1_1	169	173	PF00082	0.306
CLV_PCSK_SKI1_1	236	240	PF00082	0.650
CLV_PCSK_SKI1_1	530	534	PF00082	0.605
CLV_PCSK_SKI1_1	626	630	PF00082	0.636
CLV_PCSK_SKI1_1	72	76	PF00082	0.559
CLV_PCSK_SKI1_1	905	909	PF00082	0.700
CLV_PCSK_SKI1_1	986	990	PF00082	0.593
CLV_PCSK_SKI1_1	992	996	PF00082	0.570
CLV_Separin_Metazoa	969	973	PF03568	0.622
DEG_APCC_DBOX_1	12	20	PF00400	0.558
DEG_APCC_DBOX_1	235	243	PF00400	0.656
DEG_APCC_DBOX_1	625	633	PF00400	0.721
DEG_APCC_DBOX_1	821	829	PF00400	0.530
DEG_Nend_UBRbox_2	1	3	PF02207	0.569
DEG_SPOP_SBC_1	1077	1081	PF00917	0.696
DEG_SPOP_SBC_1	36	40	PF00917	0.598
DEG_SPOP_SBC_1	487	491	PF00917	0.602
DEG_SPOP_SBC_1	891	895	PF00917	0.597
DOC_CYCLIN_RxL_1	766	780	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.734
DOC_MAPK_gen_1	1061	1070	PF00069	0.692
DOC_MAPK_gen_1	1092	1098	PF00069	0.730
DOC_MAPK_gen_1	1119	1127	PF00069	0.736
DOC_MAPK_gen_1	606	613	PF00069	0.673
DOC_MAPK_gen_1	621	631	PF00069	0.487
DOC_MAPK_gen_1	76	85	PF00069	0.595
DOC_MAPK_gen_1	768	776	PF00069	0.525
DOC_MAPK_gen_1	939	948	PF00069	0.674
DOC_MAPK_HePTP_8	619	631	PF00069	0.627
DOC_MAPK_MEF2A_6	1119	1127	PF00069	0.736
DOC_MAPK_MEF2A_6	622	631	PF00069	0.631
DOC_MAPK_MEF2A_6	751	760	PF00069	0.587
DOC_MAPK_MEF2A_6	939	948	PF00069	0.572
DOC_MAPK_NFAT4_5	624	632	PF00069	0.638
DOC_MAPK_NFAT4_5	941	949	PF00069	0.674
DOC_PP1_RVXF_1	825	831	PF00149	0.556
DOC_PP2B_LxvP_1	309	312	PF13499	0.728
DOC_PP2B_LxvP_1	332	335	PF13499	0.733
DOC_PP2B_PxIxI_1	733	739	PF00149	0.501
DOC_PP4_FxxP_1	244	247	PF00568	0.687
DOC_PP4_FxxP_1	429	432	PF00568	0.704
DOC_PP4_FxxP_1	85	88	PF00568	0.475
DOC_USP7_MATH_1	1077	1081	PF00917	0.658
DOC_USP7_MATH_1	312	316	PF00917	0.776
DOC_USP7_MATH_1	36	40	PF00917	0.613
DOC_USP7_MATH_1	405	409	PF00917	0.684
DOC_USP7_MATH_1	42	46	PF00917	0.510
DOC_USP7_MATH_1	450	454	PF00917	0.696
DOC_USP7_MATH_1	455	459	PF00917	0.734
DOC_USP7_MATH_1	487	491	PF00917	0.695
DOC_USP7_MATH_1	528	532	PF00917	0.700
DOC_USP7_MATH_1	637	641	PF00917	0.707
DOC_USP7_MATH_1	761	765	PF00917	0.677
DOC_USP7_MATH_1	777	781	PF00917	0.392
DOC_USP7_MATH_1	813	817	PF00917	0.413
DOC_USP7_MATH_1	88	92	PF00917	0.474
DOC_USP7_MATH_1	891	895	PF00917	0.651
DOC_USP7_MATH_1	907	911	PF00917	0.492
DOC_USP7_UBL2_3	1093	1097	PF12436	0.691
DOC_USP7_UBL2_3	506	510	PF12436	0.754
DOC_USP7_UBL2_3	513	517	PF12436	0.655
DOC_WW_Pin1_4	205	210	PF00397	0.828
DOC_WW_Pin1_4	220	225	PF00397	0.648
DOC_WW_Pin1_4	283	288	PF00397	0.668
DOC_WW_Pin1_4	304	309	PF00397	0.738
DOC_WW_Pin1_4	451	456	PF00397	0.661
DOC_WW_Pin1_4	467	472	PF00397	0.822
DOC_WW_Pin1_4	491	496	PF00397	0.597
DOC_WW_Pin1_4	685	690	PF00397	0.559
DOC_WW_Pin1_4	876	881	PF00397	0.739
LIG_14-3-3_CanoR_1	1146	1152	PF00244	0.636
LIG_14-3-3_CanoR_1	13	23	PF00244	0.606
LIG_14-3-3_CanoR_1	313	321	PF00244	0.823
LIG_14-3-3_CanoR_1	328	336	PF00244	0.588
LIG_14-3-3_CanoR_1	350	358	PF00244	0.713
LIG_14-3-3_CanoR_1	373	379	PF00244	0.782
LIG_14-3-3_CanoR_1	428	432	PF00244	0.709
LIG_14-3-3_CanoR_1	542	546	PF00244	0.603
LIG_14-3-3_CanoR_1	584	593	PF00244	0.608
LIG_14-3-3_CanoR_1	667	673	PF00244	0.673
LIG_14-3-3_CanoR_1	827	831	PF00244	0.508
LIG_14-3-3_CanoR_1	892	898	PF00244	0.564
LIG_14-3-3_CanoR_1	986	995	PF00244	0.683
LIG_Actin_WH2_2	492	508	PF00022	0.587
LIG_APCC_ABBA_1	1047	1052	PF00400	0.565
LIG_APCC_ABBA_1	944	949	PF00400	0.562
LIG_APCC_ABBAyCdc20_2	542	548	PF00400	0.513
LIG_BIR_III_2	276	280	PF00653	0.745
LIG_CaM_IQ_9	703	718	PF13499	0.599
LIG_CaM_IQ_9	755	771	PF13499	0.580
LIG_CaM_IQ_9	783	799	PF13499	0.577
LIG_CaM_IQ_9	814	829	PF13499	0.548
LIG_CaM_IQ_9	994	1010	PF13499	0.600
LIG_FHA_1	1013	1019	PF00498	0.628
LIG_FHA_1	171	177	PF00498	0.463
LIG_FHA_1	388	394	PF00498	0.739
LIG_FHA_1	674	680	PF00498	0.567
LIG_FHA_1	804	810	PF00498	0.595
LIG_FHA_1	966	972	PF00498	0.622
LIG_FHA_2	1147	1153	PF00498	0.737
LIG_FHA_2	228	234	PF00498	0.661
LIG_FHA_2	314	320	PF00498	0.785
LIG_FHA_2	499	505	PF00498	0.732
LIG_FHA_2	904	910	PF00498	0.575
LIG_HCF-1_HBM_1	1152	1155	PF13415	0.635
LIG_LIR_Apic_2	1149	1154	PF02991	0.636
LIG_LIR_Apic_2	241	247	PF02991	0.681
LIG_LIR_Apic_2	82	88	PF02991	0.473
LIG_LIR_Gen_1	752	761	PF02991	0.599
LIG_LIR_Nem_3	1014	1020	PF02991	0.644
LIG_LIR_Nem_3	276	281	PF02991	0.663
LIG_LIR_Nem_3	752	756	PF02991	0.705
LIG_MYND_3	20	24	PF01753	0.588
LIG_PCNA_yPIPBox_3	1022	1034	PF02747	0.541
LIG_PTAP_UEV_1	524	529	PF05743	0.675
LIG_RPA_C_Fungi	1115	1127	PF08784	0.698
LIG_SH2_CRK	753	757	PF00017	0.702
LIG_SH2_GRB2like	1159	1162	PF00017	0.661
LIG_SH2_NCK_1	1151	1155	PF00017	0.634
LIG_SH2_PTP2	659	662	PF00017	0.577
LIG_SH2_PTP2	947	950	PF00017	0.666
LIG_SH2_SRC	1151	1154	PF00017	0.627
LIG_SH2_SRC	947	950	PF00017	0.666
LIG_SH2_STAP1	1020	1024	PF00017	0.715
LIG_SH2_STAP1	1101	1105	PF00017	0.660
LIG_SH2_STAP1	240	244	PF00017	0.572
LIG_SH2_STAP1	753	757	PF00017	0.598
LIG_SH2_STAT3	557	560	PF00017	0.703
LIG_SH2_STAT3	57	60	PF00017	0.440
LIG_SH2_STAT3	722	725	PF00017	0.545
LIG_SH2_STAT5	1156	1159	PF00017	0.662
LIG_SH2_STAT5	240	243	PF00017	0.571
LIG_SH2_STAT5	659	662	PF00017	0.577
LIG_SH2_STAT5	775	778	PF00017	0.564
LIG_SH2_STAT5	824	827	PF00017	0.599
LIG_SH2_STAT5	947	950	PF00017	0.564
LIG_SH3_2	308	313	PF14604	0.616
LIG_SH3_2	525	530	PF14604	0.708
LIG_SH3_3	305	311	PF00018	0.686
LIG_SH3_3	430	436	PF00018	0.730
LIG_SH3_3	438	444	PF00018	0.725
LIG_SH3_3	522	528	PF00018	0.723
LIG_SH3_3	640	646	PF00018	0.714
LIG_SH3_3	877	883	PF00018	0.770
LIG_SH3_4	513	520	PF00018	0.595
LIG_SUMO_SIM_anti_2	1067	1073	PF11976	0.707
LIG_SUMO_SIM_anti_2	494	501	PF11976	0.585
LIG_SUMO_SIM_par_1	1121	1128	PF11976	0.632
LIG_SUMO_SIM_par_1	172	178	PF11976	0.612
LIG_SUMO_SIM_par_1	734	739	PF11976	0.654
LIG_SUMO_SIM_par_1	845	850	PF11976	0.559
LIG_TRAF2_1	105	108	PF00917	0.604
LIG_TRAF2_1	1064	1067	PF00917	0.681
LIG_TRAF2_1	230	233	PF00917	0.681
LIG_TRAF2_1	958	961	PF00917	0.584
LIG_TRFH_1	429	433	PF08558	0.727
LIG_WW_3	310	314	PF00397	0.698
LIG_WW_3	431	435	PF00397	0.723
MOD_CDC14_SPxK_1	310	313	PF00782	0.696
MOD_CDK_SPxK_1	307	313	PF00069	0.695
MOD_CK1_1	1012	1018	PF00069	0.585
MOD_CK1_1	1079	1085	PF00069	0.707
MOD_CK1_1	307	313	PF00069	0.773
MOD_CK1_1	349	355	PF00069	0.681
MOD_CK1_1	35	41	PF00069	0.593
MOD_CK1_1	374	380	PF00069	0.692
MOD_CK1_1	470	476	PF00069	0.677
MOD_CK1_1	479	485	PF00069	0.637
MOD_CK1_1	685	691	PF00069	0.676
MOD_CK1_1	852	858	PF00069	0.487
MOD_CK1_1	874	880	PF00069	0.818
MOD_CK1_1	89	95	PF00069	0.452
MOD_CK2_1	1097	1103	PF00069	0.663
MOD_CK2_1	1146	1152	PF00069	0.738
MOD_CK2_1	141	147	PF00069	0.659
MOD_CK2_1	227	233	PF00069	0.644
MOD_CK2_1	317	323	PF00069	0.602
MOD_CK2_1	450	456	PF00069	0.608
MOD_CK2_1	482	488	PF00069	0.770
MOD_CK2_1	725	731	PF00069	0.540
MOD_CMANNOS	597	600	PF00535	0.582
MOD_CMANNOS	669	672	PF00535	0.469
MOD_GlcNHglycan	102	105	PF01048	0.481
MOD_GlcNHglycan	1081	1084	PF01048	0.707
MOD_GlcNHglycan	163	166	PF01048	0.607
MOD_GlcNHglycan	183	186	PF01048	0.722
MOD_GlcNHglycan	209	212	PF01048	0.683
MOD_GlcNHglycan	218	221	PF01048	0.773
MOD_GlcNHglycan	338	341	PF01048	0.669
MOD_GlcNHglycan	34	37	PF01048	0.477
MOD_GlcNHglycan	368	371	PF01048	0.668
MOD_GlcNHglycan	376	379	PF01048	0.646
MOD_GlcNHglycan	39	42	PF01048	0.499
MOD_GlcNHglycan	481	484	PF01048	0.691
MOD_GlcNHglycan	525	528	PF01048	0.796
MOD_GlcNHglycan	587	590	PF01048	0.494
MOD_GlcNHglycan	601	604	PF01048	0.505
MOD_GlcNHglycan	639	642	PF01048	0.748
MOD_GlcNHglycan	738	741	PF01048	0.651
MOD_GlcNHglycan	752	756	PF01048	0.528
MOD_GlcNHglycan	779	782	PF01048	0.442
MOD_GlcNHglycan	894	897	PF01048	0.809
MOD_GlcNHglycan	927	930	PF01048	0.628
MOD_GlcNHglycan	96	99	PF01048	0.410
MOD_GSK3_1	207	214	PF00069	0.798
MOD_GSK3_1	216	223	PF00069	0.736
MOD_GSK3_1	313	320	PF00069	0.748
MOD_GSK3_1	32	39	PF00069	0.681
MOD_GSK3_1	345	352	PF00069	0.726
MOD_GSK3_1	362	369	PF00069	0.567
MOD_GSK3_1	389	396	PF00069	0.737
MOD_GSK3_1	451	458	PF00069	0.642
MOD_GSK3_1	470	477	PF00069	0.803
MOD_GSK3_1	482	489	PF00069	0.597
MOD_GSK3_1	494	501	PF00069	0.624
MOD_GSK3_1	504	511	PF00069	0.600
MOD_GSK3_1	585	592	PF00069	0.627
MOD_GSK3_1	637	644	PF00069	0.710
MOD_GSK3_1	871	878	PF00069	0.771
MOD_GSK3_1	903	910	PF00069	0.616
MOD_N-GLC_1	366	371	PF02516	0.773
MOD_N-GLC_1	94	99	PF02516	0.458
MOD_NEK2_1	100	105	PF00069	0.503
MOD_NEK2_1	1018	1023	PF00069	0.599
MOD_NEK2_1	127	132	PF00069	0.423
MOD_NEK2_1	135	140	PF00069	0.450
MOD_NEK2_1	336	341	PF00069	0.733
MOD_NEK2_1	345	350	PF00069	0.815
MOD_NEK2_1	371	376	PF00069	0.732
MOD_NEK2_1	393	398	PF00069	0.819
MOD_NEK2_1	427	432	PF00069	0.713
MOD_NEK2_1	673	678	PF00069	0.685
MOD_NEK2_1	849	854	PF00069	0.534
MOD_NEK2_1	94	99	PF00069	0.458
MOD_NEK2_2	211	216	PF00069	0.608
MOD_NEK2_2	405	410	PF00069	0.673
MOD_NEK2_2	528	533	PF00069	0.676
MOD_NEK2_2	535	540	PF00069	0.640
MOD_NEK2_2	541	546	PF00069	0.606
MOD_NEK2_2	826	831	PF00069	0.503
MOD_NEK2_2	959	964	PF00069	0.714
MOD_PIKK_1	290	296	PF00454	0.762
MOD_PIKK_1	298	304	PF00454	0.671
MOD_PIKK_1	582	588	PF00454	0.703
MOD_PIKK_1	647	653	PF00454	0.636
MOD_PKA_2	1012	1018	PF00069	0.629
MOD_PKA_2	298	304	PF00069	0.821
MOD_PKA_2	312	318	PF00069	0.790
MOD_PKA_2	327	333	PF00069	0.599
MOD_PKA_2	349	355	PF00069	0.811
MOD_PKA_2	427	433	PF00069	0.653
MOD_PKA_2	541	547	PF00069	0.576
MOD_PKA_2	826	832	PF00069	0.506
MOD_PKA_2	891	897	PF00069	0.612
MOD_PKA_2	950	956	PF00069	0.625
MOD_PKA_2	965	971	PF00069	0.531
MOD_Plk_1	1051	1057	PF00069	0.495
MOD_Plk_1	751	757	PF00069	0.666
MOD_Plk_1	849	855	PF00069	0.531
MOD_Plk_1	94	100	PF00069	0.518
MOD_Plk_2-3	504	510	PF00069	0.710
MOD_Plk_4	1029	1035	PF00069	0.566
MOD_Plk_4	15	21	PF00069	0.450
MOD_Plk_4	151	157	PF00069	0.530
MOD_Plk_4	170	176	PF00069	0.517
MOD_Plk_4	379	385	PF00069	0.797
MOD_Plk_4	389	395	PF00069	0.546
MOD_Plk_4	535	541	PF00069	0.709
MOD_Plk_4	79	85	PF00069	0.507
MOD_Plk_4	89	95	PF00069	0.459
MOD_ProDKin_1	205	211	PF00069	0.826
MOD_ProDKin_1	220	226	PF00069	0.646
MOD_ProDKin_1	283	289	PF00069	0.667
MOD_ProDKin_1	304	310	PF00069	0.739
MOD_ProDKin_1	451	457	PF00069	0.657
MOD_ProDKin_1	467	473	PF00069	0.825
MOD_ProDKin_1	491	497	PF00069	0.597
MOD_ProDKin_1	685	691	PF00069	0.559
MOD_ProDKin_1	876	882	PF00069	0.739
MOD_SUMO_rev_2	144	151	PF00179	0.657
MOD_SUMO_rev_2	562	568	PF00179	0.608
TRG_DiLeu_BaEn_1	1029	1034	PF01217	0.532
TRG_DiLeu_BaEn_1	752	757	PF01217	0.703
TRG_DiLeu_BaEn_2	123	129	PF01217	0.481
TRG_ENDOCYTIC_2	278	281	PF00928	0.593
TRG_ENDOCYTIC_2	753	756	PF00928	0.598
TRG_ENDOCYTIC_2	947	950	PF00928	0.666
TRG_ER_diArg_1	1004	1006	PF00400	0.643
TRG_ER_diArg_1	13	15	PF00400	0.574
TRG_ER_diArg_1	606	609	PF00400	0.600
TRG_ER_diArg_1	61	63	PF00400	0.501
TRG_ER_diArg_1	621	624	PF00400	0.574
TRG_ER_diArg_1	699	701	PF00400	0.578
TRG_ER_diArg_1	715	718	PF00400	0.607
TRG_ER_diArg_1	742	745	PF00400	0.717
TRG_ER_diArg_1	765	768	PF00400	0.576
TRG_ER_diArg_1	770	773	PF00400	0.604
TRG_ER_diArg_1	790	793	PF00400	0.355
TRG_ER_diArg_1	807	810	PF00400	0.524
TRG_ER_diArg_1	830	833	PF00400	0.575
TRG_ER_diArg_1	835	838	PF00400	0.591
TRG_ER_diArg_1	932	935	PF00400	0.619
TRG_ER_diArg_1	963	966	PF00400	0.608
TRG_ER_diArg_1	971	974	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	1022	1026	PF00026	0.664
TRG_Pf-PMV_PEXEL_1	1166	1171	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X5	Leptomonas seymouri	43%	95%
A0A3Q8IL14	Leishmania donovani	88%	100%
A4HAR6	Leishmania braziliensis	64%	100%
A4I9Y0	Leishmania infantum	89%	94%
E9B4Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%